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GTR Home > Tests > Guardant Reveal


Test name


Guardant Reveal

Purpose of the test


This is a clinical test intended for Help: Monitoring, Recurrence, Therapeutic management



Click Indication tab for more information.

How to order


Licensed physician contacts Guardant Health client services for ordering information.
Order URL Help: https://guardantreveal.com/

Specimen source

Peripheral (whole) blood


Molecular Genetics
MMethylation analysis
Next-Generation (NGS)/Massively parallel sequencing (MPS)
  • Other
  • None/not applicable
ESequence analysis of select exons
Next-Generation (NGS)/Massively parallel sequencing (MPS)
  • Other
  • None/not applicable

Summary of what is tested

Click Methodology tab for more information.

Clinical utility


Guidance for management

Clinical validity


A total of 252 prospective serial plasma specimens from 103 patients with colorectal cancer undergoing curative-intent surgery were analyzed and correlated with recurrence. Plasma-only MRD detection demonstrated favorable sensitivity and specificity for recurrence, comparable with tumor-informed approaches. Integrating analysis of epigenomic and genomic alterations enhanced sensitivity. These findings support the potential clinical utility of plasma-only ctDNA MRD detection.

  • Minimal Residual Disease Detection using a Plasma-only Circulating Tumor DNA Assay in Patients with Colorectal Cancer. - PubMed ID: 33926918

Testing strategy


An approved physician with a Guardant Health account uses the Guardant sample collection kit to obtain a whole blood sample from the patient. Following Guardant shipping instructions, the sample is sent directly to the laboratory at Guardant Health. Turn around time for testing is 14 days. 000 Licensed physician contacts Guardant Health client services for ordering information.

Test services

  • Liquid biopsy testing for somatic cancer gene variants
  • Liquid biopsy testing for MRD

Clinical resources

Practice guidelines

Consumer resources

IMPORTANT NOTE: NIH does not independently verify information submitted to the GTR; it relies on submitters to provide information that is accurate and not misleading. NIH makes no endorsements of tests or laboratories listed in the GTR. GTR is not a substitute for medical advice. Patients and consumers with specific questions about a genetic test should contact a health care provider or a genetics professional.