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Dilatative Cardiomyopathy Panel (DCM Panel)
Clinical Genetic Test
Help
offered by
Labor Dr. Wisplinghoff
View lab's test page
LinkOut
GTR Test Accession: Help GTR000607882.1
INHERITED DISEASEMUSCULOSKELETALCARDIOVASCULAR ... View more
Last updated in GTR: 2023-05-26
View version history
Last annual review date for the lab: 2023-05-26 LinkOut
At a Glance
Test purpose: Help
Diagnosis; Mutation Confirmation; Predictive
Conditions (43): Help
Dilated cardiomyopathy 1O; 3-methylglutaconic aciduria type 5; Arrhythmogenic cardiomyopathy with wooly hair and keratoderma; ...
Genes (43): Help
ABCC9 (12p12.1), ACTC1 (15q14), ACTN2 (1q43), ANKRD1 (10q23.31), BAG3 (10q26.11), ...
Methods (3): Help
Molecular Genetics - Deletion/duplication analysis: Multiplex Ligation-dependent Probe Amplification (MLPA); Next-Generation (NGS)/Massively parallel sequencing (MPS); ...
Target population: Help
Not provided
Clinical validity: Help
Not provided
Clinical utility: Help
Not provided
Ordering Information
Offered by: Help
Labor Dr. Wisplinghoff
View lab's website
View lab's test page
Specimen Source: Help
Who can order: Help
  • Genetic Counselor
  • Health Care Provider
  • Licensed Physician
Lab contact: Help
Lars-Erik Wehner, MD, Genetic Counselor
L.Wehner@wisplinghoff.de
+(49)-221-940505845
Sabrina Sauer, PhD, Staff
S.Sauer@wisplinghoff.de
+(49)-221-940505682
Ulrich Zechner, PhD, Lab Director
U.Zechner@wisplinghoff.de
+(49)-221-940505203
Contact Policy: Help
Laboratory can only accept contact from health care providers. Patients/families are encouraged to discuss genetic testing options with their health care provider.
How to Order: Help
Order URL
Test service: Help
Clinical Testing/Confirmation of Mutations Identified Previously
Genetic counseling
Informed consent required: Help
Yes
Pre-test genetic counseling required: Help
No
Post-test genetic counseling required: Help
No
Recommended fields not provided:
Test Order Code, Test strategy, Test development
Conditions Help
Total conditions: 43
Condition/Phenotype Identifier
Test Targets
Genes Help
Total genes: 43
Gene Associated Condition Germline or Somatic Allele (Lab-provided) Variant in NCBI
Methodology
Total methods: 3
Method Category Help
Test method Help
Instrument *
Deletion/duplication analysis
Multiplex Ligation-dependent Probe Amplification (MLPA)
Deletion/duplication analysis
Next-Generation (NGS)/Massively parallel sequencing (MPS)
Sequence analysis of the entire coding region
Next-Generation (NGS)/Massively parallel sequencing (MPS)
* Instrument: Not provided
Clinical Information
Test purpose: Help
Diagnosis; Mutation Confirmation; Predictive
Variant Interpretation:
What is the protocol for interpreting a variation as a VUS? Help
Variant classification is performed based on the criteria of ACMG (Richards et al., 2015) according to current knowledge. Variants of unknown significance could be reclassified at a later time point, if new information is published.

Will the lab re-contact the ordering physician if variant interpretation changes? Help
.
Recommended fields not provided:
Clinical validity, Clinical utility, Target population, Are family members with defined clinical status recruited to assess significance of VUS without charge?, Is research allowed on the sample after clinical testing is complete?, Sample negative report, Sample positive report
Technical Information
Availability: Help
Tests performed
Entire test performed in-house
Analytical Validity: Help
The analytical sensitivity and specificity of each of our NGS panels is determined by the analysis of publically available well characterized DNA samples from the 1000 genomes project.
Proficiency testing (PT):
Is proficiency testing performed for this test? Help
Yes

Method used for proficiency testing: Help
Formal PT program

PT Provider: Help
European Molecular Genetics Quality Network, EMQN
Recommended fields not provided:
Test Confirmation, Assay limitations, Description of internal test validation method, Citations for Analytical validity, Description of PT method, Major CAP category, CAP category, CAP test list
Regulatory Approval
FDA Review: Help
Not provided
Additional Information

IMPORTANT NOTE: NIH does not independently verify information submitted to GTR; it relies on submitters to provide information that is accurate and not misleading. NIH makes no endorsements of tests or laboratories listed in GTR. GTR is not a substitute for medical advice. Patients and consumers with specific questions about a genetic test should contact a health care provider or a genetics professional.