CNS Tumor Classification by Methylation Array - Clinical Genetic Test - GTR

chromosomal region/mitochondrion: classification prediction score indicating the resemblance to a CNS tumor subtype based on methylation profile.; classification prediction score indicating the resemblance to a CNS tumor subtype based on methylation profile.

Methods (1):

Molecular Genetics - Methylation analysis: Microarray

Target population:

Patients diagnosed with a CNS tumor.

Clinical validity:

Not provided

Clinical utility:

Not provided

Ordering Information

Offered by:

Institute for Genomic Medicine (IGM) Clinical Laboratory
View lab's website
View lab's test page

Test short name:

CNS Methyl Array

Manufacturer's name:

Illumina MethylationEPIC BeadChip

Specimen Source:

Fresh tissue
Frozen tissue
Paraffin block

Who can order:

Genetic Counselor
Health Care Provider
Licensed Physician
Nurse Practitioner

Test Order Code:

CTCMA
View other test codes

Contact Policy:

Laboratory can only accept contact from health care providers. Patients/families are encouraged to discuss genetic testing options with their health care provider.

How to Order:

Samples can be accepted 7 days a week (Monday - Sunday). All samples must be labeled with the name and at least one secondary identifier (e.g. MRN, DOB, SPID). Please Submit disease involved sample with a completed requisition form and a pathology report documenting the diagnosis. Please refer to our …

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Order URL

Informed consent required:

Pre-test genetic counseling required:

Post-test genetic counseling required:

Recommended fields not provided:

Lab contact for this test, Test strategy, Test development

Conditions

Total conditions: 9

Condition/Phenotype	Identifier

Test Targets

Chromosomal regions/Mitochondria

Total chromosomal regions/mitochondria: 2

Chromosomal region/Mitochondrion	Associated condition

Methodology

Total methods: 1

Method Category

Test method

Instrument *

Methylation analysis

Microarray

* Instrument: Not provided

Clinical Information

Test purpose:

Diagnosis; Drug Response; Prognostic; Therapeutic management

Target population:

Patients diagnosed with a CNS tumor.

Variant Interpretation:

Are family members with defined clinical status recruited to assess significance of VUS without charge?
No.

Will the lab re-contact the ordering physician if variant interpretation changes?
Not provided.

Recommended fields not provided:

Clinical validity, Clinical utility, What is the protocol for interpreting a variation as a VUS?, Will the lab re-contact the ordering physician if variant interpretation changes?, Is research allowed on the sample after clinical testing is complete?, Sample negative report, Sample positive report

Technical Information

Test Comments:

This Methylation Microarray Analysis is performed on Central Nervous System (CNS) tumors using the Illumina MethylationEPIC BeadChip platform and software developed by the German Cancer Research Center (DKFZ) to subtype CNS tumors (see references below). This array assesses a whole genome methylation profile (over 850,000 CpG sites) and compares it … View more

Availability:

Tests performed
Entire test performed in-house

Analytical Validity:

This Methylation Microarray Analysis is performed on Central Nervous System (CNS) tumors to subtype CNS tumors. This array assesses a whole genome methylation profile (over 850,000 CpG sites) and compares it to over 2,800 reference CNS cases to create a classification prediction score indicating the resemblance to a CNS tumor … View more

Assay limitations:

This analysis is intended to aid and refine the pathological diagnoses of CNS tumors. Results should be interpreted in conjunction with other laboratory findings, such as histology, and molecular testing. This analysis should NOT be used as a stand-alone diagnostic test. Patient samples of rare subtypes that are not in … View more

Proficiency testing (PT):

Is proficiency testing performed for this test?
Yes

Method used for proficiency testing:
Alternative Assessment

Recommended fields not provided:

Test Confirmation, Citations to support assay limitations, Description of internal test validation method, Citations for Analytical validity, PT Provider, Description of PT method, Major CAP category, CAP category, CAP test list

Regulatory Approval

FDA Review:

Not provided

Additional Information

Reviews:

PubMed Clinical Queries

Clinical resources:

Practice guidelines:

Consumer resources:

NCATS Office of Rare Diseases Research (GARD)

MedlinePlus

IMPORTANT NOTE: NIH does not independently verify information submitted to GTR; it relies on submitters to provide information that is accurate and not misleading. NIH makes no endorsements of tests or laboratories listed in GTR. GTR is not a substitute for medical advice. Patients and consumers with specific questions about a genetic test should contact a health care provider or a genetics professional.