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Arachnoid granulation

MedGen UID:
1003015
Concept ID:
CN323156
Finding
HPO: HP:0034454

Definition

Arachnoid granulations (AGs) are tufts of arachnoid membrane invaginated into the dural sinuses through which cerebrospinal fluid (CSF) enters the venous system. The lesions are primarily located in the parasagittal region along the superior sagittal sinus, which is occasionally seen at the transverse sinus. Normally dural venous sinus AGs typically range from 2 to 8 mm in size, but may grow enough to expand the dural sinuses, and even the inner table, diploic space and outer table of the skull. [from HPO]

Conditions with this feature

Intellectual developmental disorder, autosomal recessive 71
MedGen UID:
1673448
Concept ID:
C5193133
Disease or Syndrome

Professional guidelines

PubMed

Drocton GT, Copelan A, Eisenmenger L, Villanueva-Meyer JE, Dillon WP, Shah VN, Meisel K, Amans M
Interv Neuroradiol 2021 Feb;27(1):129-136. Epub 2020 Sep 20 doi: 10.1177/1591019920956860. PMID: 32954924Free PMC Article

Recent clinical studies

Etiology

Smith ER, Caton MT, Villanueva-Meyer JE, Remer J, Eisenmenger LB, Baker A, Shah VN, Tu-Chan A, Meisel K, Amans MR
Neuroradiology 2022 Sep;64(9):1747-1754. Epub 2022 Mar 25 doi: 10.1007/s00234-022-02934-9. PMID: 35333949Free PMC Article
Gozgec E, Ogul H, Izgi E, Kantarci M
Acta Radiol 2021 Jun;62(6):799-806. Epub 2020 Jul 19 doi: 10.1177/0284185120941829. PMID: 32686459
Sade R, Ogul H, Polat G, Pirimoglu B, Kantarcı M
Acta Neurol Belg 2019 Jun;119(2):225-231. Epub 2018 May 24 doi: 10.1007/s13760-018-0946-4. PMID: 29797238
Lublinsky S, Kesler A, Friedman A, Horev A, Shelef I
J Magn Reson Imaging 2018 Apr;47(4):913-927. Epub 2017 Sep 27 doi: 10.1002/jmri.25857. PMID: 28960686
Watane GV, Patel B, Brown D, Taheri MR
J Comput Assist Tomogr 2018 Mar/Apr;42(2):282-285. doi: 10.1097/RCT.0000000000000668. PMID: 28937488

Diagnosis

Mehta RI, Mehta RI
Int J Mol Sci 2023 Aug 21;24(16) doi: 10.3390/ijms241613014. PMID: 37629195Free PMC Article
Smith ER, Caton MT, Villanueva-Meyer JE, Remer J, Eisenmenger LB, Baker A, Shah VN, Tu-Chan A, Meisel K, Amans MR
Neuroradiology 2022 Sep;64(9):1747-1754. Epub 2022 Mar 25 doi: 10.1007/s00234-022-02934-9. PMID: 35333949Free PMC Article
Eristavi A, Sabin I, Al-Sarraj S, Aizpurua M
Br J Neurosurg 2020 Oct;34(5):500-501. Epub 2019 Jan 29 doi: 10.1080/02688697.2018.1519113. PMID: 30691312
Freeman CW, Lazor JW, Loevner LA, Nabavizadeh SA
J Neuroimaging 2019 Nov;29(6):673-688. Epub 2019 Sep 17 doi: 10.1111/jon.12664. PMID: 31529762
Watane GV, Patel B, Brown D, Taheri MR
J Comput Assist Tomogr 2018 Mar/Apr;42(2):282-285. doi: 10.1097/RCT.0000000000000668. PMID: 28937488

Therapy

Gadot R, Hoang AN, Raper DMS, Sweeney AD, Juliano M, Lustrin E, Tanweer O
Otol Neurotol 2023 Jan 1;44(1):86-89. Epub 2022 Nov 4 doi: 10.1097/MAO.0000000000003741. PMID: 36509447
Lylyk P, Lylyk I, Bleise C, Scrivano E, Lylyk PN, Beneduce B, Heilman CB, Malek AM
J Neurointerv Surg 2022 May;14(5):495-9. Epub 2021 Dec 3 doi: 10.1136/neurintsurg-2021-018136. PMID: 34862267Free PMC Article
Heilman CB, Basil GW, Beneduce BM, Malek AM
J Neurointerv Surg 2019 Jun;11(6):598-602. Epub 2019 Jan 9 doi: 10.1136/neurintsurg-2018-014445. PMID: 30626626
Park H, Lim GY, Eom TH
Childs Nerv Syst 2018 Dec;34(12):2525-2527. Epub 2018 Jul 17 doi: 10.1007/s00381-018-3898-3. PMID: 30019113
Westhout FD, Linskey ME
Surg Neurol 2008 Mar;69(3):288-92; discussion 292. Epub 2007 Oct 31 doi: 10.1016/j.surneu.2007.01.068. PMID: 17976699

Prognosis

Nakamichi R, Taoka T, Kawai H, Yoshida T, Sone M, Naganawa S
Jpn J Radiol 2021 Oct;39(10):927-937. Epub 2021 May 29 doi: 10.1007/s11604-021-01137-1. PMID: 34050492Free PMC Article
Bateman GA, Lechner-Scott J, Bateman AR, Attia J, Lea RA
Mult Scler Relat Disord 2020 Nov;46:102524. Epub 2020 Sep 19 doi: 10.1016/j.msard.2020.102524. PMID: 32971498
Lublinsky S, Kesler A, Friedman A, Horev A, Shelef I
J Magn Reson Imaging 2018 Apr;47(4):913-927. Epub 2017 Sep 27 doi: 10.1002/jmri.25857. PMID: 28960686

Clinical prediction guides

Mehta RI, Mangla R, Mehta RI
Int J Mol Sci 2023 Jul 13;24(14) doi: 10.3390/ijms241411410. PMID: 37511166Free PMC Article
Nakamichi R, Taoka T, Kawai H, Yoshida T, Sone M, Naganawa S
Jpn J Radiol 2021 Oct;39(10):927-937. Epub 2021 May 29 doi: 10.1007/s11604-021-01137-1. PMID: 34050492Free PMC Article
Brzegowy K, Solewski B, Zarzecki MP, Musiał A, Kasprzycki T, Popiela T, Walocha JA
World Neurosurg 2021 Mar;147:e334-e342. Epub 2020 Dec 17 doi: 10.1016/j.wneu.2020.12.057. PMID: 33346053
Watane GV, Patel B, Brown D, Taheri MR
J Comput Assist Tomogr 2018 Mar/Apr;42(2):282-285. doi: 10.1097/RCT.0000000000000668. PMID: 28937488
Remenschneider AK, Kozin ED, Curtin H, Santos F
Laryngoscope 2015 Aug;125(8):1798-806. Epub 2015 Jun 8 doi: 10.1002/lary.25366. PMID: 26059539

Recent systematic reviews

Mehta RI, Mehta RI
Int J Mol Sci 2023 Aug 21;24(16) doi: 10.3390/ijms241613014. PMID: 37629195Free PMC Article

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