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gefitinib response - Efficacy

MedGen UID:
1003295
•Concept ID:
CN322733
•
Sign or Symptom

Professional guidelines

PubMed

Drug-drug interactions with proton pump inhibitors in cancer patients: an underrecognized cause of treatment failure.
Raoul JL, Moreau-Bachelard C, Gilabert M, Edeline J, Frénel JS
ESMO Open 2023 Feb;8(1):100880. Epub 2023 Feb 8 doi: 10.1016/j.esmoop.2023.100880. PMID: 36764092Free PMC Article
Targeted Drug/Gene/Photodynamic Therapy via a Stimuli-Responsive Dendritic-Polymer-Based Nanococktail for Treatment of EGFR-TKI-Resistant Non-Small-Cell Lung Cancer.
Huang J, Zhuang C, Chen J, Chen X, Li X, Zhang T, Wang B, Feng Q, Zheng X, Gong M, Gong Q, Xiao K, Luo K, Li W
Adv Mater 2022 Jul;34(27):e2201516. Epub 2022 May 31 doi: 10.1002/adma.202201516. PMID: 35481881
Targeting EGFR T790M mutation in NSCLC: From biology to evaluation and treatment.
Passaro A, Guerini-Rocco E, Pochesci A, Vacirca D, Spitaleri G, Catania CM, Rappa A, Barberis M, de Marinis F
Pharmacol Res 2017 Mar;117:406-415. Epub 2017 Jan 12 doi: 10.1016/j.phrs.2017.01.003. PMID: 28089942

Recent clinical studies

Etiology

Current State and Future Directions of EGFR-Directed Therapy in Head and Neck Cancer.
Tathineni P, Joshi N, Jelinek MJ
Curr Treat Options Oncol 2023 Jun;24(6):680-692. Epub 2023 Apr 17 doi: 10.1007/s11864-023-01080-5. PMID: 37067660
Characterization of stem cell landscape and identification of stemness-relevant prognostic gene signature to aid immunotherapy in colorectal cancer.
Zheng H, Liu H, Li H, Dou W, Wang J, Zhang J, Liu T, Wu Y, Liu Y, Wang X
Stem Cell Res Ther 2022 Jun 9;13(1):244. doi: 10.1186/s13287-022-02913-0. PMID: 35681225Free PMC Article
AENEAS: A Randomized Phase III Trial of Aumolertinib Versus Gefitinib as First-Line Therapy for Locally Advanced or MetastaticNon-Small-Cell Lung Cancer With EGFR Exon 19 Deletion or L858R Mutations.
Lu S, Dong X, Jian H, Chen J, Chen G, Sun Y, Ji Y, Wang Z, Shi J, Lu J, Chen S, Lv D, Zhang G, Liu C, Li J, Yu X, Lin Z, Yu Z, Wang Z, Cui J, Xu X, Fang J, Feng J, Xu Z, Ma R, Hu J, Yang N, Zhou X, Wu X, Hu C, Zhang Z, Lu Y, Hu Y, Jiang L, Wang Q, Guo R, Zhou J, Li B, Hu C, Tong W, Zhang H, Ma L, Chen Y, Jie Z, Yao Y, Zhang L, Jie W, Li W, Xiong J, Ye X, Duan J, Yang H, Sun M, Sun C, Wei H, Li C, Ali SM, Miller VA, Wu Q
J Clin Oncol 2022 Sep 20;40(27):3162-3171. Epub 2022 May 17 doi: 10.1200/JCO.21.02641. PMID: 35580297Free PMC Article
Osimertinib in Untreated EGFR-Mutated Advanced Non-Small-Cell Lung Cancer.
Soria JC, Ohe Y, Vansteenkiste J, Reungwetwattana T, Chewaskulyong B, Lee KH, Dechaphunkul A, Imamura F, Nogami N, Kurata T, Okamoto I, Zhou C, Cho BC, Cheng Y, Cho EK, Voon PJ, Planchard D, Su WC, Gray JE, Lee SM, Hodge R, Marotti M, Rukazenkov Y, Ramalingam SS; FLAURA Investigators
N Engl J Med 2018 Jan 11;378(2):113-125. Epub 2017 Nov 18 doi: 10.1056/NEJMoa1713137. PMID: 29151359
Comparison of gefitinib, erlotinib and afatinib in non-small cell lung cancer: A meta-analysis.
Yang Z, Hackshaw A, Feng Q, Fu X, Zhang Y, Mao C, Tang J
Int J Cancer 2017 Jun 15;140(12):2805-2819. Epub 2017 Mar 27 doi: 10.1002/ijc.30691. PMID: 28295308

Diagnosis

EGFR-T790M Mutation-Derived Interactome Rerouted EGFR Translocation Contributing to Gefitinib Resistance in Non-Small Cell Lung Cancer.
Wu PS, Lin MH, Hsiao JC, Lin PY, Pan SH, Chen YJ
Mol Cell Proteomics 2023 Sep;22(9):100624. Epub 2023 Jul 24 doi: 10.1016/j.mcpro.2023.100624. PMID: 37495186Free PMC Article
Characterization of stem cell landscape and identification of stemness-relevant prognostic gene signature to aid immunotherapy in colorectal cancer.
Zheng H, Liu H, Li H, Dou W, Wang J, Zhang J, Liu T, Wu Y, Liu Y, Wang X
Stem Cell Res Ther 2022 Jun 9;13(1):244. doi: 10.1186/s13287-022-02913-0. PMID: 35681225Free PMC Article
Gefitinib Alone Versus Gefitinib Plus Chemotherapy for Non-Small-Cell Lung Cancer With Mutated Epidermal Growth Factor Receptor: NEJ009 Study.
Hosomi Y, Morita S, Sugawara S, Kato T, Fukuhara T, Gemma A, Takahashi K, Fujita Y, Harada T, Minato K, Takamura K, Hagiwara K, Kobayashi K, Nukiwa T, Inoue A; North-East Japan Study Group
J Clin Oncol 2020 Jan 10;38(2):115-123. Epub 2019 Nov 4 doi: 10.1200/JCO.19.01488. PMID: 31682542
EGFR tyrosine kinase inhibitors: difference in efficacy and resistance.
Robinson KW, Sandler AB
Curr Oncol Rep 2013 Aug;15(4):396-404. doi: 10.1007/s11912-013-0323-7. PMID: 23674236
Role of genotyping in non-small cell lung cancer treatment: current status.
Bonanno L, Favaretto A, Rugge M, Taron M, Rosell R
Drugs 2011 Dec 3;71(17):2231-46. doi: 10.2165/11597700-000000000-00000. PMID: 22085382

Therapy

Lazertinib Versus Gefitinib as First-Line Treatment in Patients With EGFR-Mutated Advanced Non-Small-Cell Lung Cancer: Results From LASER301.
Cho BC, Ahn MJ, Kang JH, Soo RA, Reungwetwattana T, Yang JC, Cicin I, Kim DW, Wu YL, Lu S, Lee KH, Pang YK, Zimina A, Fong CH, Poddubskaya E, Sezer A, How SH, Danchaivijitr P, Kim Y, Lim Y, An T, Lee H, Byun HM, Zaric B
J Clin Oncol 2023 Sep 10;41(26):4208-4217. Epub 2023 Jun 28 doi: 10.1200/JCO.23.00515. PMID: 37379502
AENEAS: A Randomized Phase III Trial of Aumolertinib Versus Gefitinib as First-Line Therapy for Locally Advanced or MetastaticNon-Small-Cell Lung Cancer With EGFR Exon 19 Deletion or L858R Mutations.
Lu S, Dong X, Jian H, Chen J, Chen G, Sun Y, Ji Y, Wang Z, Shi J, Lu J, Chen S, Lv D, Zhang G, Liu C, Li J, Yu X, Lin Z, Yu Z, Wang Z, Cui J, Xu X, Fang J, Feng J, Xu Z, Ma R, Hu J, Yang N, Zhou X, Wu X, Hu C, Zhang Z, Lu Y, Hu Y, Jiang L, Wang Q, Guo R, Zhou J, Li B, Hu C, Tong W, Zhang H, Ma L, Chen Y, Jie Z, Yao Y, Zhang L, Jie W, Li W, Xiong J, Ye X, Duan J, Yang H, Sun M, Sun C, Wei H, Li C, Ali SM, Miller VA, Wu Q
J Clin Oncol 2022 Sep 20;40(27):3162-3171. Epub 2022 May 17 doi: 10.1200/JCO.21.02641. PMID: 35580297Free PMC Article
Osimertinib in Untreated EGFR-Mutated Advanced Non-Small-Cell Lung Cancer.
Soria JC, Ohe Y, Vansteenkiste J, Reungwetwattana T, Chewaskulyong B, Lee KH, Dechaphunkul A, Imamura F, Nogami N, Kurata T, Okamoto I, Zhou C, Cho BC, Cheng Y, Cho EK, Voon PJ, Planchard D, Su WC, Gray JE, Lee SM, Hodge R, Marotti M, Rukazenkov Y, Ramalingam SS; FLAURA Investigators
N Engl J Med 2018 Jan 11;378(2):113-125. Epub 2017 Nov 18 doi: 10.1056/NEJMoa1713137. PMID: 29151359
Comparison of gefitinib, erlotinib and afatinib in non-small cell lung cancer: A meta-analysis.
Yang Z, Hackshaw A, Feng Q, Fu X, Zhang Y, Mao C, Tang J
Int J Cancer 2017 Jun 15;140(12):2805-2819. Epub 2017 Mar 27 doi: 10.1002/ijc.30691. PMID: 28295308
The need for third-line treatment in non-small cell lung cancer: an overview of new options.
Syrigos KN, Saif MW, Karapanagiotou EM, Oikonomopoulos G, De Marinis F
Anticancer Res 2011 Feb;31(2):649-59. PMID: 21378351

Prognosis

Colorectal Cancer Organoid-Stroma Biobank Allows Subtype-Specific Assessment of Individualized Therapy Responses.
Farin HF, Mosa MH, Ndreshkjana B, Grebbin BM, Ritter B, Menche C, Kennel KB, Ziegler PK, Szabó L, Bollrath J, Rieder D, Michels BE, Kress A, Bozlar M, Darvishi T, Stier S, Kur IM, Bankov K, Kesselring R, Fichtner-Feigl S, Brüne B, Goetze TO, Al-Batran SE, Brandts CH, Bechstein WO, Wild PJ, Weigert A, Müller S, Knapp S, Trajanoski Z, Greten FR
Cancer Discov 2023 Oct 5;13(10):2192-2211. doi: 10.1158/2159-8290.CD-23-0050. PMID: 37489084Free PMC Article
Characterization of stem cell landscape and identification of stemness-relevant prognostic gene signature to aid immunotherapy in colorectal cancer.
Zheng H, Liu H, Li H, Dou W, Wang J, Zhang J, Liu T, Wu Y, Liu Y, Wang X
Stem Cell Res Ther 2022 Jun 9;13(1):244. doi: 10.1186/s13287-022-02913-0. PMID: 35681225Free PMC Article
Osimertinib in Untreated EGFR-Mutated Advanced Non-Small-Cell Lung Cancer.
Soria JC, Ohe Y, Vansteenkiste J, Reungwetwattana T, Chewaskulyong B, Lee KH, Dechaphunkul A, Imamura F, Nogami N, Kurata T, Okamoto I, Zhou C, Cho BC, Cheng Y, Cho EK, Voon PJ, Planchard D, Su WC, Gray JE, Lee SM, Hodge R, Marotti M, Rukazenkov Y, Ramalingam SS; FLAURA Investigators
N Engl J Med 2018 Jan 11;378(2):113-125. Epub 2017 Nov 18 doi: 10.1056/NEJMoa1713137. PMID: 29151359
Companion biomarkers: paving the pathway to personalized treatment for cancer.
Duffy MJ, Crown J
Clin Chem 2013 Oct;59(10):1447-56. Epub 2013 May 8 doi: 10.1373/clinchem.2012.200477. PMID: 23656699
CYP450 pharmacogenetics for personalizing cancer therapy.
van Schaik RH
Drug Resist Updat 2008 Jun;11(3):77-98. Epub 2008 May 19 doi: 10.1016/j.drup.2008.03.002. PMID: 18486526

Clinical prediction guides

Lazertinib Versus Gefitinib as First-Line Treatment in Patients With EGFR-Mutated Advanced Non-Small-Cell Lung Cancer: Results From LASER301.
Cho BC, Ahn MJ, Kang JH, Soo RA, Reungwetwattana T, Yang JC, Cicin I, Kim DW, Wu YL, Lu S, Lee KH, Pang YK, Zimina A, Fong CH, Poddubskaya E, Sezer A, How SH, Danchaivijitr P, Kim Y, Lim Y, An T, Lee H, Byun HM, Zaric B
J Clin Oncol 2023 Sep 10;41(26):4208-4217. Epub 2023 Jun 28 doi: 10.1200/JCO.23.00515. PMID: 37379502
Characterization of stem cell landscape and identification of stemness-relevant prognostic gene signature to aid immunotherapy in colorectal cancer.
Zheng H, Liu H, Li H, Dou W, Wang J, Zhang J, Liu T, Wu Y, Liu Y, Wang X
Stem Cell Res Ther 2022 Jun 9;13(1):244. doi: 10.1186/s13287-022-02913-0. PMID: 35681225Free PMC Article
AENEAS: A Randomized Phase III Trial of Aumolertinib Versus Gefitinib as First-Line Therapy for Locally Advanced or MetastaticNon-Small-Cell Lung Cancer With EGFR Exon 19 Deletion or L858R Mutations.
Lu S, Dong X, Jian H, Chen J, Chen G, Sun Y, Ji Y, Wang Z, Shi J, Lu J, Chen S, Lv D, Zhang G, Liu C, Li J, Yu X, Lin Z, Yu Z, Wang Z, Cui J, Xu X, Fang J, Feng J, Xu Z, Ma R, Hu J, Yang N, Zhou X, Wu X, Hu C, Zhang Z, Lu Y, Hu Y, Jiang L, Wang Q, Guo R, Zhou J, Li B, Hu C, Tong W, Zhang H, Ma L, Chen Y, Jie Z, Yao Y, Zhang L, Jie W, Li W, Xiong J, Ye X, Duan J, Yang H, Sun M, Sun C, Wei H, Li C, Ali SM, Miller VA, Wu Q
J Clin Oncol 2022 Sep 20;40(27):3162-3171. Epub 2022 May 17 doi: 10.1200/JCO.21.02641. PMID: 35580297Free PMC Article
Companion biomarkers: paving the pathway to personalized treatment for cancer.
Duffy MJ, Crown J
Clin Chem 2013 Oct;59(10):1447-56. Epub 2013 May 8 doi: 10.1373/clinchem.2012.200477. PMID: 23656699
CYP450 pharmacogenetics for personalizing cancer therapy.
van Schaik RH
Drug Resist Updat 2008 Jun;11(3):77-98. Epub 2008 May 19 doi: 10.1016/j.drup.2008.03.002. PMID: 18486526

Recent systematic reviews

Systemic treatment and radiotherapy for patients with non-small cell lung cancer (NSCLC) and HIV infection - A systematic review.
Brandão M, Durieux V, Auprih M, Fozza A, Dauby N, Cuccia F, Aspeslagh S, Verhaert M, Giaj-Levra N
Lung Cancer 2023 Apr;178:75-86. Epub 2023 Jan 21 doi: 10.1016/j.lungcan.2023.01.010. PMID: 36806897
Efficacy and safety of EGFR inhibitors and radiotherapy in locally advanced non-small-cell lung cancer: a meta-analysis.
Li X, Wang F, Jia H, Lian Z, Ren K, Yuan Z, Wang P, Zhao L
Future Oncol 2022 Sep;18(27):3055-3065. Epub 2022 Aug 10 doi: 10.2217/fon-2022-0491. PMID: 35947522
Comparison of the efficacy and safety of first-line treatments based on clinicopathological characteristics for patients with advanced epidermal growth factor receptor mutated non-small-cell lung cancer: A systematic review and network meta-analysis.
Yang F, Zhang W, Shang X, Liu N, Ma X, Qin J, Zhang Y, Liu Y, Wang X
Crit Rev Oncol Hematol 2022 Sep;177:103760. Epub 2022 Jul 21 doi: 10.1016/j.critrevonc.2022.103760. PMID: 35870763
Efficacy and safety of first line treatments for patients with advanced epidermal growth factor receptor mutated, non-small cell lung cancer: systematic review and network meta-analysis.
Zhao Y, Liu J, Cai X, Pan Z, Liu J, Yin W, Chen H, Xie Z, Liang H, Wang W, Guo Z, Zhao S, Liang W, He J
BMJ 2019 Oct 7;367:l5460. doi: 10.1136/bmj.l5460. PMID: 31591158Free PMC Article
Comparison of gefitinib, erlotinib and afatinib in non-small cell lung cancer: A meta-analysis.
Yang Z, Hackshaw A, Feng Q, Fu X, Zhang Y, Mao C, Tang J
Int J Cancer 2017 Jun 15;140(12):2805-2819. Epub 2017 Mar 27 doi: 10.1002/ijc.30691. PMID: 28295308

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