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Brain stem infarction

MedGen UID:
101068
•Concept ID:
C0521542
•
Disease or Syndrome
Synonyms: Brain Stem Infarct; Brain Stem Infarction; Brain Stem Infarctions; Brain Stem Infarcts; Brainstem Infarction; Brainstem Infarctions; Brainstem Stroke; Infarct, Brain Stem; Infarction, Brain Stem; Infarction, Brainstem; Infarctions, Brain Stem; Infarctions, Brainstem; Infarcts, Brain Stem; Stem Infarct, Brain; Stem Infarcts, Brain; Stroke, Brainstem
SNOMED CT: Brain stem infarction (95457000); Brain stem infarct (95457000); Brain stem stroke (95457000); Infarction of brain stem (95457000)
 
Monarch Initiative: MONDO:0006686

Definition

Infarctions that occur in the brain stem which is comprised of the midbrain; pons; and medulla oblongata. There are several named syndromes characterized by their distinctive clinical manifestations and specific sites of ischemic injury. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBrain stem infarction

Professional guidelines

PubMed

Endovascular management of vertebral artery dissecting aneurysms: review of 25 patients.
Taha MM, Sakaida H, Asakura F, Maeda M, Toma N, Yamamoto A, Kawaguchi K, Matsushima S, Taki W
Turk Neurosurg 2010 Apr;20(2):126-35. doi: 10.5137/1019-5149.JTN.2790-09. PMID: 20401839
Classification and treatment of vertebral dissecting aneurysm.
Sano H, Kato Y, Okuma I, Yamaguchi S, Ninomiya T, Arunkumar R, Kanno T
Surg Neurol 1997 Dec;48(6):598-605. doi: 10.1016/s0090-3019(97)00022-0. PMID: 9400642
Cisternal puncture complications. Treatment of coccidioidal meningitis with amphotericin B.
Keane JR
Calif Med 1973 Sep;119(3):10-5. PMID: 4741057Free PMC Article

Recent clinical studies

Etiology

Improved Detectability of Brain Stem Ischemia by Combining Axial and Coronal Diffusion-Weighted Imaging.
Steffen P, Beyer LS, McDonough R, Thaler C, Faizy T, Fiehler J, Gbadamosi J, Habermann CR, Schönfeld MH
Stroke 2021 May;52(5):1843-1846. Epub 2021 Apr 5 doi: 10.1161/STROKEAHA.120.032457. PMID: 33813862
Brain stem infarction in a 6-year-old boy with Down syndrome.
Imagi T, Matsushita T, Matsushita M, Yae Y, Yokochi T, Kawano G, Akita Y, Ohbu K, Matsuishi T
Brain Dev 2019 Jun;41(6):555-558. Epub 2019 Mar 8 doi: 10.1016/j.braindev.2019.02.013. PMID: 30857880
"Invisible" brain stem infarction at the first day.
Tsuyusaki Y, Sakakibara R, Kishi M, Tateno F, Aiba Y, Ogata T, Nagao T, Terada H, Inaoka T
J Stroke Cerebrovasc Dis 2014 Aug;23(7):1903-7. Epub 2014 May 6 doi: 10.1016/j.jstrokecerebrovasdis.2014.02.010. PMID: 24809672
Isolated third, fourth, and sixth cranial nerve palsies from presumed microvascular versus other causes: a prospective study.
Tamhankar MA, Biousse V, Ying GS, Prasad S, Subramanian PS, Lee MS, Eggenberger E, Moss HE, Pineles S, Bennett J, Osborne B, Volpe NJ, Liu GT, Bruce BB, Newman NJ, Galetta SL, Balcer LJ
Ophthalmology 2013 Nov;120(11):2264-9. Epub 2013 Jun 6 doi: 10.1016/j.ophtha.2013.04.009. PMID: 23747163Free PMC Article
Characteristics and survival of patients with brain stem infarction.
Fogelhol R, Aho K
Stroke 1975 May-Jun;6(3):328-33. doi: 10.1161/01.str.6.3.328. PMID: 1154470

Diagnosis

Childhood pheochromocytoma crisis complicated with brain stem infarction: A case report.
Xie F, Zhao Q, Pan W, Zhang A, Li K
Medicine (Baltimore) 2022 Dec 23;101(51):e32479. doi: 10.1097/MD.0000000000032479. PMID: 36595857Free PMC Article
Improved Detectability of Brain Stem Ischemia by Combining Axial and Coronal Diffusion-Weighted Imaging.
Steffen P, Beyer LS, McDonough R, Thaler C, Faizy T, Fiehler J, Gbadamosi J, Habermann CR, Schönfeld MH
Stroke 2021 May;52(5):1843-1846. Epub 2021 Apr 5 doi: 10.1161/STROKEAHA.120.032457. PMID: 33813862
"Invisible" brain stem infarction at the first day.
Tsuyusaki Y, Sakakibara R, Kishi M, Tateno F, Aiba Y, Ogata T, Nagao T, Terada H, Inaoka T
J Stroke Cerebrovasc Dis 2014 Aug;23(7):1903-7. Epub 2014 May 6 doi: 10.1016/j.jstrokecerebrovasdis.2014.02.010. PMID: 24809672
Isolated third, fourth, and sixth cranial nerve palsies from presumed microvascular versus other causes: a prospective study.
Tamhankar MA, Biousse V, Ying GS, Prasad S, Subramanian PS, Lee MS, Eggenberger E, Moss HE, Pineles S, Bennett J, Osborne B, Volpe NJ, Liu GT, Bruce BB, Newman NJ, Galetta SL, Balcer LJ
Ophthalmology 2013 Nov;120(11):2264-9. Epub 2013 Jun 6 doi: 10.1016/j.ophtha.2013.04.009. PMID: 23747163Free PMC Article
Fatal diquat intoxication.
Jović-Stosić J, Babić G, Todorović V
Vojnosanit Pregl 2009 Jun;66(6):477-81. doi: 10.2298/vsp0906477j. PMID: 19583147

Therapy

Brainstem infarction associated with HHV-6 infection in an infant.
Wada A, Muramatsu K, Sunaga Y, Mizuno T, Takei M, Ogasawara S, Uchida M, Tsukida K, Tashiro M
Brain Dev 2018 Mar;40(3):242-246. Epub 2017 Sep 25 doi: 10.1016/j.braindev.2017.09.005. PMID: 28958731
Molecular hydrogen in sports medicine: new therapeutic perspectives.
Ostojic SM
Int J Sports Med 2015 Apr;36(4):273-9. Epub 2014 Dec 19 doi: 10.1055/s-0034-1395509. PMID: 25525953
Molecular hydrogen as an emerging therapeutic medical gas for neurodegenerative and other diseases.
Ohno K, Ito M, Ichihara M, Ito M
Oxid Med Cell Longev 2012;2012:353152. Epub 2012 Jun 8 doi: 10.1155/2012/353152. PMID: 22720117Free PMC Article
Fatal diquat intoxication.
Jović-Stosić J, Babić G, Todorović V
Vojnosanit Pregl 2009 Jun;66(6):477-81. doi: 10.2298/vsp0906477j. PMID: 19583147
Pediatric brain stem infarction caused by a basilar and vertebral artery occlusion: case report.
Ishikawa T, Sasaki H, Makino K, Gotoh S, Takamura H, Takei H
Neurosurgery 1992 Aug;31(2):365-8. doi: 10.1227/00006123-199208000-00026. PMID: 1513445

Prognosis

Post-Stroke Cognitive Impairment is Frequent After Infra-Tentorial Infarct.
Moliis H, Jokinen H, Parkkonen E, Kaste M, Erkinjuntti T, Melkas S
J Stroke Cerebrovasc Dis 2021 Dec;30(12):106108. Epub 2021 Sep 20 doi: 10.1016/j.jstrokecerebrovasdis.2021.106108. PMID: 34547675
Clinical and Radiological Characteristics Associated with Respiratory Failure in Unilateral Lateral Medullary Infarction.
Pavšič K, Fabjan A, Zgonc V, Šurlan Popović K, Pretnar Oblak J, Bajrović FF
J Stroke Cerebrovasc Dis 2021 Sep;30(9):105947. Epub 2021 Jun 27 doi: 10.1016/j.jstrokecerebrovasdis.2021.105947. PMID: 34192618
Improved Detectability of Brain Stem Ischemia by Combining Axial and Coronal Diffusion-Weighted Imaging.
Steffen P, Beyer LS, McDonough R, Thaler C, Faizy T, Fiehler J, Gbadamosi J, Habermann CR, Schönfeld MH
Stroke 2021 May;52(5):1843-1846. Epub 2021 Apr 5 doi: 10.1161/STROKEAHA.120.032457. PMID: 33813862
Fatal diquat intoxication.
Jović-Stosić J, Babić G, Todorović V
Vojnosanit Pregl 2009 Jun;66(6):477-81. doi: 10.2298/vsp0906477j. PMID: 19583147
Characteristics and survival of patients with brain stem infarction.
Fogelhol R, Aho K
Stroke 1975 May-Jun;6(3):328-33. doi: 10.1161/01.str.6.3.328. PMID: 1154470

Clinical prediction guides

Clinical and Radiological Characteristics Associated with Respiratory Failure in Unilateral Lateral Medullary Infarction.
Pavšič K, Fabjan A, Zgonc V, Šurlan Popović K, Pretnar Oblak J, Bajrović FF
J Stroke Cerebrovasc Dis 2021 Sep;30(9):105947. Epub 2021 Jun 27 doi: 10.1016/j.jstrokecerebrovasdis.2021.105947. PMID: 34192618
Improved Detectability of Brain Stem Ischemia by Combining Axial and Coronal Diffusion-Weighted Imaging.
Steffen P, Beyer LS, McDonough R, Thaler C, Faizy T, Fiehler J, Gbadamosi J, Habermann CR, Schönfeld MH
Stroke 2021 May;52(5):1843-1846. Epub 2021 Apr 5 doi: 10.1161/STROKEAHA.120.032457. PMID: 33813862
Molecular hydrogen in sports medicine: new therapeutic perspectives.
Ostojic SM
Int J Sports Med 2015 Apr;36(4):273-9. Epub 2014 Dec 19 doi: 10.1055/s-0034-1395509. PMID: 25525953
Isolated third, fourth, and sixth cranial nerve palsies from presumed microvascular versus other causes: a prospective study.
Tamhankar MA, Biousse V, Ying GS, Prasad S, Subramanian PS, Lee MS, Eggenberger E, Moss HE, Pineles S, Bennett J, Osborne B, Volpe NJ, Liu GT, Bruce BB, Newman NJ, Galetta SL, Balcer LJ
Ophthalmology 2013 Nov;120(11):2264-9. Epub 2013 Jun 6 doi: 10.1016/j.ophtha.2013.04.009. PMID: 23747163Free PMC Article
Molecular hydrogen as an emerging therapeutic medical gas for neurodegenerative and other diseases.
Ohno K, Ito M, Ichihara M, Ito M
Oxid Med Cell Longev 2012;2012:353152. Epub 2012 Jun 8 doi: 10.1155/2012/353152. PMID: 22720117Free PMC Article

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