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Ectopic aldosterone secretion

MedGen UID:
101082
•Concept ID:
C0521797
•
Pathologic Function
Synonyms: Ectopic Aldosterone Secretion; Ectopic Aldosterone Secretion Syndrome
SNOMED CT: Ectopic aldosterone secretion (95835004)

Definition

A syndrome characterized by abnormal secretion of aldosterone in conjunction with neoplastic growth occurring anywhere in the body. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEctopic aldosterone secretion

Professional guidelines

PubMed

Long-term treatment of congestive heart failure with oral ibopamine. Effects of rhythm disorders and neurohormonal alterations.
Caponnetto S, Terrachini V, Canale C, Bruzzone F, Masperone MA, Pastorino L, Licciardello L, Marchetti GV
Cardiology 1990;77 Suppl 5:43-8. doi: 10.1159/000174695. PMID: 1980633
Urinary excretion rates of 15 free steroids: potential utility in differential diagnosis of Cushing's syndrome.
Schöneshöfer M, Weber B, Oelkers W, Nahoul K, Mantero F
Clin Chem 1986 Jan;32(1 Pt 1):93-6. PMID: 3940740

Recent clinical studies

Etiology

What We Know about and What Is New in Primary Aldosteronism.
Ekman N, Grossman AB, Dworakowska D
Int J Mol Sci 2024 Jan 11;25(2) doi: 10.3390/ijms25020900. PMID: 38255973Free PMC Article
Hyperplasia in glands with hormone excess.
Marx SJ
Endocr Relat Cancer 2016 Jan;23(1):R1-14. Epub 2015 Sep 25 doi: 10.1530/ERC-15-0171. PMID: 26407873Free PMC Article
Ectopic fat storage, insulin resistance, and hypertension.
Sironi AM, Sicari R, Folli F, Gastaldelli A
Curr Pharm Des 2011;17(28):3074-80. doi: 10.2174/138161211798157720. PMID: 21861830
Glucocorticoid-remediable aldosteronism.
McMahon GT, Dluhy RG
Arq Bras Endocrinol Metabol 2004 Oct;48(5):682-6. Epub 2005 Mar 7 doi: 10.1590/s0004-27302004000500014. PMID: 15761539
Steroids and hypertension.
Mantero F, Armanini D, Boscaro M, Carpenè G, Fallo F, Opocher G, Rocco S, Scaroni C, Sonino N
J Steroid Biochem Mol Biol 1991;40(1-3):35-44. doi: 10.1016/0960-0760(91)90165-2. PMID: 1958539

Diagnosis

What We Know about and What Is New in Primary Aldosteronism.
Ekman N, Grossman AB, Dworakowska D
Int J Mol Sci 2024 Jan 11;25(2) doi: 10.3390/ijms25020900. PMID: 38255973Free PMC Article
Obesity-related glomerulopathy: Current approaches and future perspectives.
Martínez-Montoro JI, Morales E, Cornejo-Pareja I, Tinahones FJ, Fernández-García JC
Obes Rev 2022 Jul;23(7):e13450. Epub 2022 Apr 1 doi: 10.1111/obr.13450. PMID: 35362662Free PMC Article
Obesity-related glomerulopathy: clinical and pathologic characteristics and pathogenesis.
D'Agati VD, Chagnac A, de Vries AP, Levi M, Porrini E, Herman-Edelstein M, Praga M
Nat Rev Nephrol 2016 Aug;12(8):453-71. Epub 2016 Jun 6 doi: 10.1038/nrneph.2016.75. PMID: 27263398
Glucocorticoid-remediable aldosteronism.
Halperin F, Dluhy RG
Endocrinol Metab Clin North Am 2011 Jun;40(2):333-41, viii. doi: 10.1016/j.ecl.2011.01.012. PMID: 21565670
Glucocorticoid-remediable aldosteronism.
McMahon GT, Dluhy RG
Arq Bras Endocrinol Metabol 2004 Oct;48(5):682-6. Epub 2005 Mar 7 doi: 10.1590/s0004-27302004000500014. PMID: 15761539

Therapy

Obesity-related glomerulopathy: Current approaches and future perspectives.
Martínez-Montoro JI, Morales E, Cornejo-Pareja I, Tinahones FJ, Fernández-García JC
Obes Rev 2022 Jul;23(7):e13450. Epub 2022 Apr 1 doi: 10.1111/obr.13450. PMID: 35362662Free PMC Article
Glucocorticoid-remediable aldosteronism.
Halperin F, Dluhy RG
Endocrinol Metab Clin North Am 2011 Jun;40(2):333-41, viii. doi: 10.1016/j.ecl.2011.01.012. PMID: 21565670
Glucocorticoid-remediable aldosteronism.
McMahon GT, Dluhy RG
Arq Bras Endocrinol Metabol 2004 Oct;48(5):682-6. Epub 2005 Mar 7 doi: 10.1590/s0004-27302004000500014. PMID: 15761539
Glucocorticoid-remediable aldosteronism.
McMahon GT, Dluhy RG
Cardiol Rev 2004 Jan-Feb;12(1):44-8. doi: 10.1097/01.crd.0000096417.42861.ce. PMID: 14667264
Glucocorticoid-remediable aldosteronism.
Williams GH, Dluhy RG
J Endocrinol Invest 1995 Jul-Aug;18(7):512-7. doi: 10.1007/BF03349762. PMID: 9221269

Prognosis

ACTH-secreting parotid acinic cell carcinoma unusually reported as a paraneoplastic syndrome.
Amoateng MD, Hasbani GE, Vera A, Vargas J, Rodriguez A, Cheriyan R, Siddiqui I, Hulinsky I
Endocr Regul 2022 Jul 13;56(3):163-167. doi: 10.2478/enr-2022-0017. PMID: 35843712
Molecular Mechanisms of Obesity-Linked Cardiac Dysfunction: An Up-Date on Current Knowledge.
Gutiérrez-Cuevas J, Sandoval-Rodriguez A, Meza-Rios A, Monroy-Ramírez HC, Galicia-Moreno M, García-Bañuelos J, Santos A, Armendariz-Borunda J
Cells 2021 Mar 12;10(3) doi: 10.3390/cells10030629. PMID: 33809061Free PMC Article
Radiologically defined lipid-poor adrenal adenomas: histopathological characteristics.
De Leo A, Mosconi C, Zavatta G, Tucci L, Nanni C, Selva S, Balacchi C, Ceccarelli C, Santini D, Pantaleo MA, Minni F, Fanti S, Golfieri R, Pagotto U, Vicennati V, Di Dalmazi G
J Endocrinol Invest 2020 Sep;43(9):1197-1204. Epub 2020 Feb 15 doi: 10.1007/s40618-020-01198-5. PMID: 32062826
The current role of venous sampling in the localization of endocrine disease.
Lau JH, Drake W, Matson M
Cardiovasc Intervent Radiol 2007 Jul-Aug;30(4):555-70. doi: 10.1007/s00270-007-9028-3. PMID: 17546403
From big fat cells to high blood pressure: a pathway to obesity-associated hypertension.
Pausova Z
Curr Opin Nephrol Hypertens 2006 Mar;15(2):173-8. doi: 10.1097/01.mnh.0000214775.42103.a5. PMID: 16481885

Clinical prediction guides

Case Report: Ectopic Adrenocortical Carcinoma in the Ovary.
Tsai WH, Chen TC, Dai SH, Zeng YH
Front Endocrinol (Lausanne) 2021;12:662377. Epub 2021 Mar 19 doi: 10.3389/fendo.2021.662377. PMID: 33815299Free PMC Article
Radiologically defined lipid-poor adrenal adenomas: histopathological characteristics.
De Leo A, Mosconi C, Zavatta G, Tucci L, Nanni C, Selva S, Balacchi C, Ceccarelli C, Santini D, Pantaleo MA, Minni F, Fanti S, Golfieri R, Pagotto U, Vicennati V, Di Dalmazi G
J Endocrinol Invest 2020 Sep;43(9):1197-1204. Epub 2020 Feb 15 doi: 10.1007/s40618-020-01198-5. PMID: 32062826
NHA2 promotes cyst development in an in vitro model of polycystic kidney disease.
Prasad H, Dang DK, Kondapalli KC, Natarajan N, Cebotaru V, Rao R
J Physiol 2019 Jan;597(2):499-519. Epub 2018 Oct 17 doi: 10.1113/JP276796. PMID: 30242840Free PMC Article
Plasma Steroid Metabolome Profiling for Diagnosis and Subtyping Patients with Cushing Syndrome.
Eisenhofer G, Masjkur J, Peitzsch M, Di Dalmazi G, Bidlingmaier M, Grüber M, Fazel J, Osswald A, Beuschlein F, Reincke M
Clin Chem 2018 Mar;64(3):586-596. Epub 2017 Dec 5 doi: 10.1373/clinchem.2017.282582. PMID: 29208661
The current role of venous sampling in the localization of endocrine disease.
Lau JH, Drake W, Matson M
Cardiovasc Intervent Radiol 2007 Jul-Aug;30(4):555-70. doi: 10.1007/s00270-007-9028-3. PMID: 17546403

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