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Mucocele of salivary gland

MedGen UID:
10117
•Concept ID:
C0026686
•
Anatomical Abnormality
Synonyms: mucocele of salivary gland; mucous retention cyst of salivary gland; Ptyalocele; ranula; Salivary cyst; Salivary Cyst; salivary cyst; salivary gland mucocele; Sialocele
SNOMED CT: Mucocele of salivary gland (69825009); Sialocele (69825009); Salivary cyst (69825009); Ptyalocele (69825009)
 
Monarch Initiative: MONDO:0001600

Definition

A benign cyst located in the salivary gland that is lined by epithelium and filled with mucoid fluid, tissue, or other material; it is usually caused by duct obstruction. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMucocele of salivary gland

Professional guidelines

PubMed

Management of Mucoceles, Sialoceles, and Ranulas.
Bowers EMR, Schaitkin B
Otolaryngol Clin North Am 2021 Jun;54(3):543-551. doi: 10.1016/j.otc.2021.03.002. PMID: 34024482
Conventional surgical treatment of oral mucocele: a series of 23 cases.
Bahadure RN, Fulzele P, Thosar N, Badole G, Baliga S
Eur J Paediatr Dent 2012 Jun;13(2):143-6. PMID: 22762178
Modern management and pathophysiology of ranula: literature review.
Harrison JD
Head Neck 2010 Oct;32(10):1310-20. doi: 10.1002/hed.21326. PMID: 20054853

Recent clinical studies

Etiology

Prevalence of oral and maxillofacial lesions in children and adolescents at a regional Brazilian oral pathology service: a retrospective study and the relevant literature review.
Melo G, Batistella EÂ, Bett JVS, Grando LJ, Rivero ERC
Eur Arch Paediatr Dent 2023 Aug;24(4):451-459. Epub 2023 Apr 26 doi: 10.1007/s40368-023-00800-7. PMID: 37099119
A Review of Oral Chronic Graft-Versus-Host Disease: Considerations for dental hygiene practice.
Johnson LB, Oh U, Rothen M, Sroussi HY, Dean DR, Lloid CM, Cintron K, Lee SJ, Cutler CS, Treister NS
J Dent Hyg 2022 Apr;96(2):6-17. PMID: 35418491Free PMC Article
Identification of predictive variables for the recurrence of oral mucocele.
Choi YJ, Byun JS, Choi JK, Jung JK
Med Oral Patol Oral Cir Bucal 2019 Mar 1;24(2):e231-e235. doi: 10.4317/medoral.22690. PMID: 30818316Free PMC Article
Results of cystadenolymphoma treatment of superficial parotid gland.
Ślęzak A, Kaźmierczak W, Kaźmierczak H
Otolaryngol Pol 2018 Sep 10;72(6):23-30. doi: 10.5604/01.3001.0012.4667. PMID: 30647197
Non-neoplastic salivary gland diseases.
Arduino PG, Carrozzo M, Pentenero M, Bertolusso G, Gandolfo S
Minerva Stomatol 2006 May;55(5):249-70. PMID: 16688102

Diagnosis

Analysis of effects and indications of cryosurgery for oral mucoceles.
Tsunoda N, Kawai T, Obara M, Suzuki S, Miyamoto I, Takeda Y, Yamada H
J Stomatol Oral Maxillofac Surg 2021 Jun;122(3):267-272. Epub 2020 Jul 1 doi: 10.1016/j.jormas.2020.06.013. PMID: 32622002
Soft Tissue Disorders of the Mouth.
Diebold S, Overbeck M
Emerg Med Clin North Am 2019 Feb;37(1):55-68. doi: 10.1016/j.emc.2018.09.006. PMID: 30454780
Salivary gland diseases: infections, sialolithiasis and mucoceles.
Delli K, Spijkervet FK, Vissink A
Monogr Oral Sci 2014;24:135-48. Epub 2014 May 23 doi: 10.1159/000358794. PMID: 24862601
Pseudotumors and mimickers of malignancy of the head and neck pathology.
Michal M, Kacerovská D, Kazakov DV, Skálová A
Cesk Patol 2012 Oct;48(4):190-7. PMID: 23121028
Mucocele of the glands of Blandin-Nuhn--clinical, pathological, and therapeutical aspects.
Adachi P, Soubhia AM, Horikawa FK, Shinohara EH
Oral Maxillofac Surg 2011 Mar;15(1):11-3. doi: 10.1007/s10006-010-0221-1. PMID: 20393765

Therapy

Analysis of effects and indications of cryosurgery for oral mucoceles.
Tsunoda N, Kawai T, Obara M, Suzuki S, Miyamoto I, Takeda Y, Yamada H
J Stomatol Oral Maxillofac Surg 2021 Jun;122(3):267-272. Epub 2020 Jul 1 doi: 10.1016/j.jormas.2020.06.013. PMID: 32622002
The efficacy of polidocanol sclerotherapy in mucocele of the minor salivary gland.
Liu JL, Zhang AQ, Jiang LC, Li KY, Liu FZ, Yuan DY, Xu K, Fan QC, Liu XB, Zou B, Meng Z, Feng Y, Zhang B
J Oral Pathol Med 2018 Oct;47(9):895-899. Epub 2018 Jul 28 doi: 10.1111/jop.12764. PMID: 29998466
The Application of Absolute Ethanol in the Treatment of Mucocele of the Glands of Blandin-Nuhn.
Zhang J, Wang C
J Craniofac Surg 2016 Oct;27(7):e641-e642. doi: 10.1097/SCS.0000000000002993. PMID: 27526250Free PMC Article
Treatment of salivary mucocele of the lower lip by OK-432.
Ohta N, Fukase S, Suzuki Y, Aoyagi M
Auris Nasus Larynx 2011 Apr;38(2):240-3. Epub 2010 Aug 19 doi: 10.1016/j.anl.2010.07.003. PMID: 20727698
Non-neoplastic salivary gland diseases.
Arduino PG, Carrozzo M, Pentenero M, Bertolusso G, Gandolfo S
Minerva Stomatol 2006 May;55(5):249-70. PMID: 16688102

Prognosis

Oral mucoceles: A Brazillian Multicenter Study of 1,901 Cases.
Miranda GGB, Chaves-Junior SC, Lopes MP, Rocha TBD, Colares DF, Ito FA, Cavalcante IL, Cavalcante RB, Andrade BAB, Nonaka CFW, Alves PM, Albuquerque-Júnior RLC, Cunha JLS
Braz Dent J 2022 Sep-Oct;33(5):81-90. doi: 10.1590/0103-6440202204965. PMID: 36287502Free PMC Article
Retrospective Study of Buccal Mucosal Salivary Neoplasms.
Alramadhan SA, Fitzpatrick SG, Cohen DM, Bhattacharyya I, Islam MN
Head Neck Pathol 2020 Dec;14(4):1013-1020. Epub 2020 Jun 6 doi: 10.1007/s12105-020-01190-8. PMID: 32506376Free PMC Article
Identification of predictive variables for the recurrence of oral mucocele.
Choi YJ, Byun JS, Choi JK, Jung JK
Med Oral Patol Oral Cir Bucal 2019 Mar 1;24(2):e231-e235. doi: 10.4317/medoral.22690. PMID: 30818316Free PMC Article
Oral mucocele/ranula: Another human immunodeficiency virus-related salivary gland disease?
Syebele K, Munzhelele TI
Laryngoscope 2015 May;125(5):1130-6. Epub 2014 Nov 28 doi: 10.1002/lary.25058. PMID: 25446909
Treatment of salivary mucocele of the lower lip by OK-432.
Ohta N, Fukase S, Suzuki Y, Aoyagi M
Auris Nasus Larynx 2011 Apr;38(2):240-3. Epub 2010 Aug 19 doi: 10.1016/j.anl.2010.07.003. PMID: 20727698

Clinical prediction guides

Identification of predictive variables for the recurrence of oral mucocele.
Choi YJ, Byun JS, Choi JK, Jung JK
Med Oral Patol Oral Cir Bucal 2019 Mar 1;24(2):e231-e235. doi: 10.4317/medoral.22690. PMID: 30818316Free PMC Article
The efficacy of polidocanol sclerotherapy in mucocele of the minor salivary gland.
Liu JL, Zhang AQ, Jiang LC, Li KY, Liu FZ, Yuan DY, Xu K, Fan QC, Liu XB, Zou B, Meng Z, Feng Y, Zhang B
J Oral Pathol Med 2018 Oct;47(9):895-899. Epub 2018 Jul 28 doi: 10.1111/jop.12764. PMID: 29998466
Salivary gland diseases: infections, sialolithiasis and mucoceles.
Delli K, Spijkervet FK, Vissink A
Monogr Oral Sci 2014;24:135-48. Epub 2014 May 23 doi: 10.1159/000358794. PMID: 24862601
Treatment of salivary mucocele of the lower lip by OK-432.
Ohta N, Fukase S, Suzuki Y, Aoyagi M
Auris Nasus Larynx 2011 Apr;38(2):240-3. Epub 2010 Aug 19 doi: 10.1016/j.anl.2010.07.003. PMID: 20727698
Mucocele of the gland of Blandin-Nuhn: histological and clinical findings.
de Camargo Moraes P, Bönecker M, Furuse C, Thomaz LA, Teixeira RG, de Araújo VC
Clin Oral Investig 2009 Sep;13(3):351-3. Epub 2009 Jan 27 doi: 10.1007/s00784-009-0252-x. PMID: 19172313

Recent systematic reviews

Oral diseases: a 14-year experience of a Chilean institution with a systematic review from eight countries.
Rivera C, Jones-Herrera C, Vargas P, Venegas B, Droguett D
Med Oral Patol Oral Cir Bucal 2017 May 1;22(3):e297-e306. doi: 10.4317/medoral.21665. PMID: 28390130Free PMC Article

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