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Degenerative Disease of Nervous System, Unspecified

MedGen UID:
101195
Concept ID:
C0524851
Disease or Syndrome
Synonyms: Degenerative Condition, Neurologic; Degenerative Conditions, Neurologic; Degenerative Diseases, Nervous System; Degenerative Diseases, Neurologic; Degenerative Neurologic Disease; Degenerative Neurologic Diseases; Degenerative Neurologic Disorder; Degenerative Neurologic Disorders; Nervous System Degenerative Diseases; Neurodegenerative Disease; Neurodegenerative Diseases; Neurodegenerative Disorder; Neurodegenerative Disorders; Neurologic Degenerative Condition; Neurologic Degenerative Conditions; Neurologic Degenerative Disease; Neurologic Degenerative Diseases; Neurologic Disease, Degenerative; Neurologic Diseases, Degenerative; Neurologic Disorder, Degenerative; Neurologic Disorders, Degenerative

Definition

Hereditary and sporadic conditions which are characterized by progressive nervous system dysfunction. These disorders are often associated with atrophy of the affected central or peripheral nervous system structures. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDegenerative Disease of Nervous System, Unspecified

Professional guidelines

PubMed

Wenning GK, Stankovic I, Vignatelli L, Fanciulli A, Calandra-Buonaura G, Seppi K, Palma JA, Meissner WG, Krismer F, Berg D, Cortelli P, Freeman R, Halliday G, Höglinger G, Lang A, Ling H, Litvan I, Low P, Miki Y, Panicker J, Pellecchia MT, Quinn N, Sakakibara R, Stamelou M, Tolosa E, Tsuji S, Warner T, Poewe W, Kaufmann H
Mov Disord 2022 Jun;37(6):1131-1148. Epub 2022 Apr 21 doi: 10.1002/mds.29005. PMID: 35445419Free PMC Article
Northrup H, Aronow ME, Bebin EM, Bissler J, Darling TN, de Vries PJ, Frost MD, Fuchs Z, Gosnell ES, Gupta N, Jansen AC, Jóźwiak S, Kingswood JC, Knilans TK, McCormack FX, Pounders A, Roberds SL, Rodriguez-Buritica DF, Roth J, Sampson JR, Sparagana S, Thiele EA, Weiner HL, Wheless JW, Towbin AJ, Krueger DA; International Tuberous Sclerosis Complex Consensus Group
Pediatr Neurol 2021 Oct;123:50-66. Epub 2021 Jul 24 doi: 10.1016/j.pediatrneurol.2021.07.011. PMID: 34399110
Postuma RB, Berg D, Stern M, Poewe W, Olanow CW, Oertel W, Obeso J, Marek K, Litvan I, Lang AE, Halliday G, Goetz CG, Gasser T, Dubois B, Chan P, Bloem BR, Adler CH, Deuschl G
Mov Disord 2015 Oct;30(12):1591-601. doi: 10.1002/mds.26424. PMID: 26474316

Recent clinical studies

Etiology

Guo J, Huang X, Dou L, Yan M, Shen T, Tang W, Li J
Signal Transduct Target Ther 2022 Dec 16;7(1):391. doi: 10.1038/s41392-022-01251-0. PMID: 36522308Free PMC Article
Breijyeh Z, Karaman R
Molecules 2020 Dec 8;25(24) doi: 10.3390/molecules25245789. PMID: 33302541Free PMC Article
Hou Y, Dan X, Babbar M, Wei Y, Hasselbalch SG, Croteau DL, Bohr VA
Nat Rev Neurol 2019 Oct;15(10):565-581. Epub 2019 Sep 9 doi: 10.1038/s41582-019-0244-7. PMID: 31501588
Kritsilis M, V Rizou S, Koutsoudaki PN, Evangelou K, Gorgoulis VG, Papadopoulos D
Int J Mol Sci 2018 Sep 27;19(10) doi: 10.3390/ijms19102937. PMID: 30261683Free PMC Article
Lin MT, Beal MF
Nature 2006 Oct 19;443(7113):787-95. doi: 10.1038/nature05292. PMID: 17051205

Diagnosis

Neri S, Mastroianni G, Gardella E, Aguglia U, Rubboli G
Epileptic Disord 2022 Apr 1;24(2):249-273. doi: 10.1684/epd.2021.1406. PMID: 35596580
Vaquer-Alicea J, Diamond MI
Annu Rev Biochem 2019 Jun 20;88:785-810. Epub 2019 Mar 27 doi: 10.1146/annurev-biochem-061516-045049. PMID: 30917002
Marin C, Vilas D, Langdon C, Alobid I, López-Chacón M, Haehner A, Hummel T, Mullol J
Curr Allergy Asthma Rep 2018 Jun 15;18(8):42. doi: 10.1007/s11882-018-0796-4. PMID: 29904888
Erkkinen MG, Kim MO, Geschwind MD
Cold Spring Harb Perspect Biol 2018 Apr 2;10(4) doi: 10.1101/cshperspect.a033118. PMID: 28716886Free PMC Article
Kuruppu DK, Matthews BR
Semin Neurol 2013 Sep;33(4):365-85. Epub 2013 Nov 14 doi: 10.1055/s-0033-1359320. PMID: 24234358Free PMC Article

Therapy

Walsh SC, Murphy E, Devane D, Sampson EL, Connolly S, Carney P, O'Shea E
Cochrane Database Syst Rev 2021 Sep 28;9(9):CD011513. doi: 10.1002/14651858.CD011513.pub3. PMID: 34582034Free PMC Article
Robledinos-Antón N, Fernández-Ginés R, Manda G, Cuadrado A
Oxid Med Cell Longev 2019;2019:9372182. Epub 2019 Jul 14 doi: 10.1155/2019/9372182. PMID: 31396308Free PMC Article
Platten M, Nollen EAA, Röhrig UF, Fallarino F, Opitz CA
Nat Rev Drug Discov 2019 May;18(5):379-401. doi: 10.1038/s41573-019-0016-5. PMID: 30760888
Tardiolo G, Bramanti P, Mazzon E
Molecules 2018 Dec 13;23(12) doi: 10.3390/molecules23123305. PMID: 30551603Free PMC Article
Grosso G, Godos J, Galvano F, Giovannucci EL
Annu Rev Nutr 2017 Aug 21;37:131-156. doi: 10.1146/annurev-nutr-071816-064941. PMID: 28826374

Prognosis

Ben-Shlomo Y, Darweesh S, Llibre-Guerra J, Marras C, San Luciano M, Tanner C
Lancet 2024 Jan 20;403(10423):283-292. doi: 10.1016/S0140-6736(23)01419-8. PMID: 38245248
Shan Z, Wang F, Li Y, Baden MY, Bhupathiraju SN, Wang DD, Sun Q, Rexrode KM, Rimm EB, Qi L, Tabung FK, Giovannucci EL, Willett WC, Manson JE, Qi Q, Hu FB
JAMA Intern Med 2023 Feb 1;183(2):142-153. doi: 10.1001/jamainternmed.2022.6117. PMID: 36622660Free PMC Article
Kritsilis M, V Rizou S, Koutsoudaki PN, Evangelou K, Gorgoulis VG, Papadopoulos D
Int J Mol Sci 2018 Sep 27;19(10) doi: 10.3390/ijms19102937. PMID: 30261683Free PMC Article
van Es MA, Hardiman O, Chio A, Al-Chalabi A, Pasterkamp RJ, Veldink JH, van den Berg LH
Lancet 2017 Nov 4;390(10107):2084-2098. Epub 2017 May 25 doi: 10.1016/S0140-6736(17)31287-4. PMID: 28552366
Elbaz A, Carcaillon L, Kab S, Moisan F
Rev Neurol (Paris) 2016 Jan;172(1):14-26. Epub 2015 Dec 21 doi: 10.1016/j.neurol.2015.09.012. PMID: 26718594

Clinical prediction guides

Moujalled D, Strasser A, Liddell JR
Cell Death Differ 2021 Jul;28(7):2029-2044. Epub 2021 Jun 7 doi: 10.1038/s41418-021-00814-y. PMID: 34099897Free PMC Article
Subhramanyam CS, Wang C, Hu Q, Dheen ST
Semin Cell Dev Biol 2019 Oct;94:112-120. Epub 2019 May 11 doi: 10.1016/j.semcdb.2019.05.004. PMID: 31077796
Marin C, Vilas D, Langdon C, Alobid I, López-Chacón M, Haehner A, Hummel T, Mullol J
Curr Allergy Asthma Rep 2018 Jun 15;18(8):42. doi: 10.1007/s11882-018-0796-4. PMID: 29904888
Stephenson J, Nutma E, van der Valk P, Amor S
Immunology 2018 Jun;154(2):204-219. Epub 2018 Apr 17 doi: 10.1111/imm.12922. PMID: 29513402Free PMC Article
Dugger BN, Dickson DW
Cold Spring Harb Perspect Biol 2017 Jul 5;9(7) doi: 10.1101/cshperspect.a028035. PMID: 28062563Free PMC Article

Recent systematic reviews

Wenning GK, Stankovic I, Vignatelli L, Fanciulli A, Calandra-Buonaura G, Seppi K, Palma JA, Meissner WG, Krismer F, Berg D, Cortelli P, Freeman R, Halliday G, Höglinger G, Lang A, Ling H, Litvan I, Low P, Miki Y, Panicker J, Pellecchia MT, Quinn N, Sakakibara R, Stamelou M, Tolosa E, Tsuji S, Warner T, Poewe W, Kaufmann H
Mov Disord 2022 Jun;37(6):1131-1148. Epub 2022 Apr 21 doi: 10.1002/mds.29005. PMID: 35445419Free PMC Article
Solch RJ, Aigbogun JO, Voyiadjis AG, Talkington GM, Darensbourg RM, O'Connell S, Pickett KM, Perez SR, Maraganore DM
J Neurol Sci 2022 Mar 15;434:120166. Epub 2022 Jan 26 doi: 10.1016/j.jns.2022.120166. PMID: 35144237
Schindler A, Pizzorni N, Cereda E, Cosentino G, Avenali M, Montomoli C, Abbruzzese G, Antonini A, Barbiera F, Benazzo M, Benarroch E, Bertino G, Clavè P, Cortelli P, Eleopra R, Ferrari C, Hamdy S, Huckabee ML, Lopiano L, Marchese-Ragona R, Masiero S, Michou E, Occhini A, Pacchetti C, Pfeiffer RF, Restivo DA, Rondanelli M, Ruoppolo G, Sandrini G, Schapira A, Stocchi F, Tolosa E, Valentino F, Zamboni M, Zangaglia R, Zappia M, Tassorelli C, Alfonsi E
J Neurol Sci 2021 Nov 15;430:120008. Epub 2021 Sep 27 doi: 10.1016/j.jns.2021.120008. PMID: 34624796
Hampel H, Hardy J, Blennow K, Chen C, Perry G, Kim SH, Villemagne VL, Aisen P, Vendruscolo M, Iwatsubo T, Masters CL, Cho M, Lannfelt L, Cummings JL, Vergallo A
Mol Psychiatry 2021 Oct;26(10):5481-5503. Epub 2021 Aug 30 doi: 10.1038/s41380-021-01249-0. PMID: 34456336Free PMC Article
Bianchi VE, Herrera PF, Laura R
Nutr Neurosci 2021 Oct;24(10):810-834. Epub 2019 Nov 4 doi: 10.1080/1028415X.2019.1681088. PMID: 31684843

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