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Lower respiratory tract infection

MedGen UID:
101764
Concept ID:
C0149725
Disease or Syndrome
Synonym: Lower respiratory tract infections
SNOMED CT: LRTI - Lower respiratory tract infection (50417007); Lower respiratory tract infection (50417007); Lower respiratory infection (50417007); Chest cold (50417007)

Definition

An acute or chronic, viral or bacterial infectious process that affects the lower respiratory tract. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLower respiratory tract infection

Professional guidelines

PubMed

Chalmers SJ, Wylam ME
Methods Mol Biol 2020;2069:229-251. doi: 10.1007/978-1-4939-9849-4_16. PMID: 31523777
Joseph MM, Edwards A
Pediatr Emerg Med Pract 2019 Oct;16(10):1-24. Epub 2019 Oct 2 PMID: 31557431
Midulla F, Petrarca L, Frassanito A, Di Mattia G, Zicari AM, Nenna R
Minerva Pediatr 2018 Dec;70(6):600-611. Epub 2018 Oct 18 doi: 10.23736/S0026-4946.18.05334-3. PMID: 30334624

Recent clinical studies

Etiology

Hammitt LL, Dagan R, Yuan Y, Baca Cots M, Bosheva M, Madhi SA, Muller WJ, Zar HJ, Brooks D, Grenham A, Wählby Hamrén U, Mankad VS, Ren P, Takas T, Abram ME, Leach A, Griffin MP, Villafana T; MELODY Study Group
N Engl J Med 2022 Mar 3;386(9):837-846. doi: 10.1056/NEJMoa2110275. PMID: 35235726
Claassen-Weitz S, Lim KYL, Mullally C, Zar HJ, Nicol MP
Clin Microbiol Infect 2021 Sep;27(9):1262-1270. Epub 2021 Jun 7 doi: 10.1016/j.cmi.2021.05.034. PMID: 34111578Free PMC Article
Griffin MP, Yuan Y, Takas T, Domachowske JB, Madhi SA, Manzoni P, Simões EAF, Esser MT, Khan AA, Dubovsky F, Villafana T, DeVincenzo JP; Nirsevimab Study Group
N Engl J Med 2020 Jul 30;383(5):415-425. doi: 10.1056/NEJMoa1913556. PMID: 32726528
Midulla F, Petrarca L, Frassanito A, Di Mattia G, Zicari AM, Nenna R
Minerva Pediatr 2018 Dec;70(6):600-611. Epub 2018 Oct 18 doi: 10.23736/S0026-4946.18.05334-3. PMID: 30334624
Smith DK, Seales S, Budzik C
Am Fam Physician 2017 Jan 15;95(2):94-99. PMID: 28084708

Diagnosis

Zheng Y, Qiu X, Wang T, Zhang J
Front Cell Infect Microbiol 2021;11:694756. Epub 2021 Sep 9 doi: 10.3389/fcimb.2021.694756. PMID: 34568089Free PMC Article
Joseph MM, Edwards A
Pediatr Emerg Med Pract 2019 Oct;16(10):1-24. Epub 2019 Oct 2 PMID: 31557431
Walter JM, Wunderink RG
Infect Dis Clin North Am 2017 Sep;31(3):455-474. Epub 2017 Jul 5 doi: 10.1016/j.idc.2017.05.004. PMID: 28687214Free PMC Article
Smith DK, Seales S, Budzik C
Am Fam Physician 2017 Jan 15;95(2):94-99. PMID: 28084708
Reynolds JH, McDonald G, Alton H, Gordon SB
Br J Radiol 2010 Dec;83(996):998-1009. doi: 10.1259/bjr/31200593. PMID: 21088086Free PMC Article

Therapy

Simões EAF, Madhi SA, Muller WJ, Atanasova V, Bosheva M, Cabañas F, Baca Cots M, Domachowske JB, Garcia-Garcia ML, Grantina I, Nguyen KA, Zar HJ, Berglind A, Cummings C, Griffin MP, Takas T, Yuan Y, Wählby Hamrén U, Leach A, Villafana T
Lancet Child Adolesc Health 2023 Mar;7(3):180-189. Epub 2023 Jan 9 doi: 10.1016/S2352-4642(22)00321-2. PMID: 36634694Free PMC Article
Hammitt LL, Dagan R, Yuan Y, Baca Cots M, Bosheva M, Madhi SA, Muller WJ, Zar HJ, Brooks D, Grenham A, Wählby Hamrén U, Mankad VS, Ren P, Takas T, Abram ME, Leach A, Griffin MP, Villafana T; MELODY Study Group
N Engl J Med 2022 Mar 3;386(9):837-846. doi: 10.1056/NEJMoa2110275. PMID: 35235726
Griffin MP, Yuan Y, Takas T, Domachowske JB, Madhi SA, Manzoni P, Simões EAF, Esser MT, Khan AA, Dubovsky F, Villafana T, DeVincenzo JP; Nirsevimab Study Group
N Engl J Med 2020 Jul 30;383(5):415-425. doi: 10.1056/NEJMoa1913556. PMID: 32726528
Beigel JH, Tomashek KM, Dodd LE, Mehta AK, Zingman BS, Kalil AC, Hohmann E, Chu HY, Luetkemeyer A, Kline S, Lopez de Castilla D, Finberg RW, Dierberg K, Tapson V, Hsieh L, Patterson TF, Paredes R, Sweeney DA, Short WR, Touloumi G, Lye DC, Ohmagari N, Oh MD, Ruiz-Palacios GM, Benfield T, Fätkenheuer G, Kortepeter MG, Atmar RL, Creech CB, Lundgren J, Babiker AG, Pett S, Neaton JD, Burgess TH, Bonnett T, Green M, Makowski M, Osinusi A, Nayak S, Lane HC; ACTT-1 Study Group Members
N Engl J Med 2020 Nov 5;383(19):1813-1826. Epub 2020 Oct 8 doi: 10.1056/NEJMoa2007764. PMID: 32445440Free PMC Article
Gautret P, Lagier JC, Parola P, Hoang VT, Meddeb L, Mailhe M, Doudier B, Courjon J, Giordanengo V, Vieira VE, Tissot Dupont H, Honoré S, Colson P, Chabrière E, La Scola B, Rolain JM, Brouqui P, Raoult D
Int J Antimicrob Agents 2020 Jul;56(1):105949. Epub 2020 Mar 20 doi: 10.1016/j.ijantimicag.2020.105949. PMID: 32205204Free PMC Article

Prognosis

Rai E, Alaraimi R, Al Aamri I
Paediatr Anaesth 2022 Feb;32(2):181-190. Epub 2021 Dec 27 doi: 10.1111/pan.14382. PMID: 34927318
Griffin MP, Yuan Y, Takas T, Domachowske JB, Madhi SA, Manzoni P, Simões EAF, Esser MT, Khan AA, Dubovsky F, Villafana T, DeVincenzo JP; Nirsevimab Study Group
N Engl J Med 2020 Jul 30;383(5):415-425. doi: 10.1056/NEJMoa1913556. PMID: 32726528
Götzinger F, Santiago-García B, Noguera-Julián A, Lanaspa M, Lancella L, Calò Carducci FI, Gabrovska N, Velizarova S, Prunk P, Osterman V, Krivec U, Lo Vecchio A, Shingadia D, Soriano-Arandes A, Melendo S, Lanari M, Pierantoni L, Wagner N, L'Huillier AG, Heininger U, Ritz N, Bandi S, Krajcar N, Roglić S, Santos M, Christiaens C, Creuven M, Buonsenso D, Welch SB, Bogyi M, Brinkmann F, Tebruegge M; ptbnet COVID-19 Study Group
Lancet Child Adolesc Health 2020 Sep;4(9):653-661. Epub 2020 Jun 25 doi: 10.1016/S2352-4642(20)30177-2. PMID: 32593339Free PMC Article
Puccio G, Alliet P, Cajozzo C, Janssens E, Corsello G, Sprenger N, Wernimont S, Egli D, Gosoniu L, Steenhout P
J Pediatr Gastroenterol Nutr 2017 Apr;64(4):624-631. doi: 10.1097/MPG.0000000000001520. PMID: 28107288Free PMC Article
van Rhee F, Wong RS, Munshi N, Rossi JF, Ke XY, Fosså A, Simpson D, Capra M, Liu T, Hsieh RK, Goh YT, Zhu J, Cho SG, Ren H, Cavet J, Bandekar R, Rothman M, Puchalski TA, Reddy M, van de Velde H, Vermeulen J, Casper C
Lancet Oncol 2014 Aug;15(9):966-74. Epub 2014 Jul 17 doi: 10.1016/S1470-2045(14)70319-5. PMID: 25042199

Clinical prediction guides

Tsalik EL, Rouphael NG, Sadikot RT, Rodriguez-Barradas MC, McClain MT, Wilkins DM, Woods CW, Swamy GK, Walter EB, El Sahly HM, Keitel WA, Mulligan MJ, Tuyishimire B, Serti E, Hamasaki T, Evans SR, Ghazaryan V, Lee MS, Lautenbach E; TRAP-LRTI Study Group; Antibacterial Resistance Leadership Group
Lancet Infect Dis 2023 Apr;23(4):484-495. Epub 2022 Dec 13 doi: 10.1016/S1473-3099(22)00735-6. PMID: 36525985Free PMC Article
Claassen-Weitz S, Lim KYL, Mullally C, Zar HJ, Nicol MP
Clin Microbiol Infect 2021 Sep;27(9):1262-1270. Epub 2021 Jun 7 doi: 10.1016/j.cmi.2021.05.034. PMID: 34111578Free PMC Article
Tumbarello M, Raffaelli F, Giannella M, Mantengoli E, Mularoni A, Venditti M, De Rosa FG, Sarmati L, Bassetti M, Brindicci G, Rossi M, Luzzati R, Grossi PA, Corona A, Capone A, Falcone M, Mussini C, Trecarichi EM, Cascio A, Guffanti E, Russo A, De Pascale G, Tascini C, Gentile I, Losito AR, Bussini L, Corti G, Ceccarelli G, Corcione S, Compagno M, Giacobbe DR, Saracino A, Fantoni M, Antinori S, Peghin M, Bonfanti P, Oliva A, De Gasperi A, Tiseo G, Rovelli C, Meschiari M, Shbaklo N, Spanu T, Cauda R, Viale P
Clin Infect Dis 2021 Nov 2;73(9):1664-1676. doi: 10.1093/cid/ciab176. PMID: 33618353
Langelier C, Kalantar KL, Moazed F, Wilson MR, Crawford ED, Deiss T, Belzer A, Bolourchi S, Caldera S, Fung M, Jauregui A, Malcolm K, Lyden A, Khan L, Vessel K, Quan J, Zinter M, Chiu CY, Chow ED, Wilson J, Miller S, Matthay MA, Pollard KS, Christenson S, Calfee CS, DeRisi JL
Proc Natl Acad Sci U S A 2018 Dec 26;115(52):E12353-E12362. Epub 2018 Nov 27 doi: 10.1073/pnas.1809700115. PMID: 30482864Free PMC Article
Lozano JM
BMJ Clin Evid 2007 Oct 10;2007 PMID: 19450362Free PMC Article

Recent systematic reviews

Padhani ZA, Moazzam Z, Ashraf A, Bilal H, Salam RA, Das JK, Bhutta ZA
Cochrane Database Syst Rev 2021 Nov 18;11(11):CD013134. doi: 10.1002/14651858.CD013134.pub3. PMID: 34791642Free PMC Article
Garegnani L, Styrmisdóttir L, Roson Rodriguez P, Escobar Liquitay CM, Esteban I, Franco JV
Cochrane Database Syst Rev 2021 Nov 16;11(11):CD013757. doi: 10.1002/14651858.CD013757.pub2. PMID: 34783356Free PMC Article
Claassen-Weitz S, Lim KYL, Mullally C, Zar HJ, Nicol MP
Clin Microbiol Infect 2021 Sep;27(9):1262-1270. Epub 2021 Jun 7 doi: 10.1016/j.cmi.2021.05.034. PMID: 34111578Free PMC Article
Carreras G, Lugo A, Gallus S, Cortini B, Fernández E, López MJ, Soriano JB, López-Nicolás A, Semple S, Gorini G; TackSHS Project Investigators
Prev Med 2019 Dec;129:105833. Epub 2019 Sep 7 doi: 10.1016/j.ypmed.2019.105833. PMID: 31505203
Gadomski AM, Scribani MB
Cochrane Database Syst Rev 2014 Jun 17;2014(6):CD001266. doi: 10.1002/14651858.CD001266.pub4. PMID: 24937099Free PMC Article

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