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Skin Granuloma

MedGen UID:
101797
•Concept ID:
C0151684
•
Finding
Synonyms: Granuloma of Skin; Granuloma of the Skin

Definition

A granuloma located in the skin. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSkin Granuloma

Professional guidelines

PubMed

Granuloma Annulare: An Updated Review of Epidemiology, Pathogenesis, and Treatment Options.
Joshi TP, Duvic M
Am J Clin Dermatol 2022 Jan;23(1):37-50. Epub 2021 Sep 8 doi: 10.1007/s40257-021-00636-1. PMID: 34495491Free PMC Article
2021 American College of Rheumatology/Vasculitis Foundation Guideline for the Management of Antineutrophil Cytoplasmic Antibody-Associated Vasculitis.
Chung SA, Langford CA, Maz M, Abril A, Gorelik M, Guyatt G, Archer AM, Conn DL, Full KA, Grayson PC, Ibarra MF, Imundo LF, Kim S, Merkel PA, Rhee RL, Seo P, Stone JH, Sule S, Sundel RP, Vitobaldi OI, Warner A, Byram K, Dua AB, Husainat N, James KE, Kalot MA, Lin YC, Springer JM, Turgunbaev M, Villa-Forte A, Turner AS, Mustafa RA
Arthritis Rheumatol 2021 Aug;73(8):1366-1383. Epub 2021 Jul 8 doi: 10.1002/art.41773. PMID: 34235894
Annular Lesions: Diagnosis and Treatment.
Trayes KP, Savage K, Studdiford JS
Am Fam Physician 2018 Sep 1;98(5):283-291. PMID: 30216021

Recent clinical studies

Etiology

Macrophage Biology in Human Granulomatous Skin Inflammation.
Klapproth H, Huerta Arana M, Fabri M
Int J Mol Sci 2023 Feb 27;24(5) doi: 10.3390/ijms24054624. PMID: 36902053Free PMC Article
Case report: Persistent shedding of a live vaccine-derived rubella virus in a young man with severe combined immunodeficiency and cutaneous granuloma.
Bonner KE, Sukerman E, Liko J, Lanzieri TM, Sutton M, DeBess E, Leesman C, Icenogle J, Hao L, Chen MH, Faisthalab R, Leman RF, Cieslak PR, DeRavin SS, Perelygina L
Front Immunol 2022;13:1075351. Epub 2022 Dec 8 doi: 10.3389/fimmu.2022.1075351. PMID: 36569925Free PMC Article
Childhood tuberculosis in Sweden. An epidemiological study made six years after the cessation of general BCG vaccination of the newborn.
Romanus V
Tubercle 1983 Jun;64(2):101-10. doi: 10.1016/0041-3879(83)90034-x. PMID: 6604357

Diagnosis

High frequency ultrasound: a novel instrument to quantify granuloma burden in cutaneous sarcoidosis.
Noe MH, Rodriguez O, Taylor L, Sultan L, Sehgal C, Schultz S, Gelfand JM, Judson MA, Rosenbach M
Sarcoidosis Vasc Diffuse Lung Dis 2017;34(2):136-141. Epub 2017 Aug 25 doi: 10.36141/svdld.v34i2.5720. PMID: 29628755Free PMC Article
Cutaneous granulomas in common variable immunodeficiency: case report and review of literature.
Aghamohammadi A, Abolhassani H, Rezaei N, Kalantari N, Tamizifar B, Cheraghi T, Parvaneh N, Yeganeh M, Moazzami K, Ebrahimi-Daryani N, Anaraki MR
Acta Dermatovenerol Croat 2010;18(2):107-13. PMID: 20624361
Posterior fossa dermoid cyst associated with dermal fistula: report of 2 cases and review of the literature.
Goffin J, Plets C, Van Calenbergh F, Weyns F, Van Havenbergh T, Eeckels R, Casaer P, Hunnick K, Wilms G, Marchal G
Childs Nerv Syst 1993 Jun;9(3):179-81. doi: 10.1007/BF00272273. PMID: 8374925
Visceral and skin granuloma annulare, diabetes, and polyendocrine disease.
Thomas DJ, Rademaker M, Munro DD, Levison DA, Besser GM
Br Med J (Clin Res Ed) 1986 Oct 18;293(6553):977-8. doi: 10.1136/bmj.293.6553.977. PMID: 3094761Free PMC Article
Aquarium-borne Mycobacterium marinum granulomas.
Engbaek HC, Thormann J, Vergmann B
Scand J Infect Dis 1980;12(1):74-8. doi: 10.3109/inf.1980.12.issue-1.14. PMID: 7189291

Therapy

Case report: Persistent shedding of a live vaccine-derived rubella virus in a young man with severe combined immunodeficiency and cutaneous granuloma.
Bonner KE, Sukerman E, Liko J, Lanzieri TM, Sutton M, DeBess E, Leesman C, Icenogle J, Hao L, Chen MH, Faisthalab R, Leman RF, Cieslak PR, DeRavin SS, Perelygina L
Front Immunol 2022;13:1075351. Epub 2022 Dec 8 doi: 10.3389/fimmu.2022.1075351. PMID: 36569925Free PMC Article
Intermediate Uveitis Associated with Tattooing of Eyebrows as a Manifestation of Systemic Sarcoidosis: Report of Two Cases.
Ebrahimiadib N, Adelpour F, Ghahari M, Mehrpour M
Ocul Immunol Inflamm 2021 Jul 4;29(5):902-905. Epub 2020 Jan 16 doi: 10.1080/09273948.2019.1699581. PMID: 31944169
Granuloma-like lesion at subcutaneous immunoglobulin site in a common variable immunodeficiency patient.
Gupta A, Wang B, Gupta S
Immunotherapy 2019 Oct;11(14):1177-1180. Epub 2019 Sep 3 doi: 10.2217/imt-2019-0109. PMID: 31478429
Elemental mercury-induced skin granuloma: a case report and review of the literature.
Bradberry SM, Feldman MA, Braithwaite RA, Shortland-Webb W, Vale JA
J Toxicol Clin Toxicol 1996;34(2):209-16. doi: 10.3109/15563659609013772. PMID: 8618256
Aquarium-borne Mycobacterium marinum granulomas.
Engbaek HC, Thormann J, Vergmann B
Scand J Infect Dis 1980;12(1):74-8. doi: 10.3109/inf.1980.12.issue-1.14. PMID: 7189291

Prognosis

High frequency ultrasound: a novel instrument to quantify granuloma burden in cutaneous sarcoidosis.
Noe MH, Rodriguez O, Taylor L, Sultan L, Sehgal C, Schultz S, Gelfand JM, Judson MA, Rosenbach M
Sarcoidosis Vasc Diffuse Lung Dis 2017;34(2):136-141. Epub 2017 Aug 25 doi: 10.36141/svdld.v34i2.5720. PMID: 29628755Free PMC Article
Diffuse alveolar hemorrhage emerging one week after starting high-dose corticosteroid therapy for granulomatosis with polyangiitis (GPA) with systemic lupus erythematosus (SLE).
Fukui S, Iwamoto N, Tsuji S, Umeda M, Nishino A, Nakashima Y, Suzuki T, Horai Y, Koga T, Kawashiri SY, Ichinose K, Hirai Y, Tamai M, Nakamura H, Origuchi T, Kawakami A
Intern Med 2015;54(20):2681-6. Epub 2015 Oct 15 doi: 10.2169/internalmedicine.54.5299. PMID: 26466711

Clinical prediction guides

High frequency ultrasound: a novel instrument to quantify granuloma burden in cutaneous sarcoidosis.
Noe MH, Rodriguez O, Taylor L, Sultan L, Sehgal C, Schultz S, Gelfand JM, Judson MA, Rosenbach M
Sarcoidosis Vasc Diffuse Lung Dis 2017;34(2):136-141. Epub 2017 Aug 25 doi: 10.36141/svdld.v34i2.5720. PMID: 29628755Free PMC Article
PLAID: a Syndrome of Complex Patterns of Disease and Unique Phenotypes.
Milner JD
J Clin Immunol 2015 Aug;35(6):527-30. Epub 2015 Jul 25 doi: 10.1007/s10875-015-0177-x. PMID: 26206677Free PMC Article
Alternariasis: ultrastructure of skin granuloma.
Bourlond A
J Cutan Pathol 1983 Apr;10(2):123-32. doi: 10.1111/j.1600-0560.1983.tb01485.x. PMID: 6853794

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