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Postcholecystectomy syndrome

MedGen UID:
101815
•Concept ID:
C0152099
•
Disease or Syndrome
Synonyms: Post Cholecystectomy Syndrome; Post-Cholecystectomy Syndrome; Post-Cholecystectomy Syndromes; Postcholecystectomy Syndrome; Postcholecystectomy Syndromes; Syndrome, Post-Cholecystectomy; Syndrome, Postcholecystectomy; Syndromes, Post-Cholecystectomy; Syndromes, Postcholecystectomy
SNOMED CT: Post-cholecystectomy syndrome (90782003); Postcholecystectomy syndrome (90782003)
 
Monarch Initiative: MONDO:0006916

Definition

Abdominal symptoms after removal of the gallbladder. The common postoperative symptoms are often the same as those present before the operation, such as colic, bloating, nausea, and vomiting. There is pain on palpation of the right upper quadrant and sometimes jaundice. The term is often used, inaccurately, to describe such postoperative symptoms not due to gallbladder removal. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPostcholecystectomy syndrome

Professional guidelines

PubMed

Management of Postcholecystectomy Complications.
Feng XC, Phillips E, Shouhed D
Surg Clin North Am 2021 Oct;101(5):889-910. Epub 2021 Aug 7 doi: 10.1016/j.suc.2021.06.012. PMID: 34537150
Management of Postcholecystectomy Biliary Complications: A Narrative Review.
Ahmad DS, Faulx A
Am J Gastroenterol 2020 Aug;115(8):1191-1198. doi: 10.14309/ajg.0000000000000704. PMID: 32483004
Surgical and endoscopic management of remnant cystic duct lithiasis after cholecystectomy--a case series.
Phillips MR, Joseph M, Dellon ES, Grimm I, Farrell TM, Rupp CC
J Gastrointest Surg 2014 Jul;18(7):1278-83. Epub 2014 May 9 doi: 10.1007/s11605-014-2530-4. PMID: 24810238

Recent clinical studies

Etiology

Residual Gallbladder and Cystic Duct Stump Stone after Cholecystectomy: Laparoscopic Management.
Popescu RC, Leopa N, Dumitru A, Dan C, Dosa A, Bosneagu R, Iordache IE, Botea F
Chirurgia (Bucur) 2021 Aug;116(4):484-491. doi: 10.21614/chirurgia.116.4.484. PMID: 34498567
Association between dietary intake and postlaparoscopic cholecystectomic symptoms in patients with gallbladder disease.
Shin Y, Choi D, Lee KG, Choi HS, Park Y
Korean J Intern Med 2018 Jul;33(4):829-836. Epub 2017 Nov 10 doi: 10.3904/kjim.2016.223. PMID: 29117670Free PMC Article
Sphincter of Oddi disorder (SOD): Is it necessary to investigate and treat?
Kumar S, Agrawal M, Bhartiya SK, Basu S, Shukla VK
Trop Gastroenterol 2015 Jul-Sep;36(3):145-55. doi: 10.7869/tg.276. PMID: 27522733
Gallstone disease in children.
Svensson J, Makin E
Semin Pediatr Surg 2012 Aug;21(3):255-65. doi: 10.1053/j.sempedsurg.2012.05.008. PMID: 22800978
Postcholecystectomy syndrome (PCS).
Jaunoo SS, Mohandas S, Almond LM
Int J Surg 2010;8(1):15-7. Epub 2009 Oct 24 doi: 10.1016/j.ijsu.2009.10.008. PMID: 19857610

Diagnosis

Postcholecystectomy syndrome: biliary-related complications.
Sangiorgio G, Zanghì M, Dionigi G, Zanghì G
Minerva Surg 2023 Dec;78(6):684-691. Epub 2023 Jul 24 doi: 10.23736/S2724-5691.23.09942-2. PMID: 37486191
Management of Postcholecystectomy Complications.
Feng XC, Phillips E, Shouhed D
Surg Clin North Am 2021 Oct;101(5):889-910. Epub 2021 Aug 7 doi: 10.1016/j.suc.2021.06.012. PMID: 34537150
Management of Postcholecystectomy Biliary Complications: A Narrative Review.
Ahmad DS, Faulx A
Am J Gastroenterol 2020 Aug;115(8):1191-1198. doi: 10.14309/ajg.0000000000000704. PMID: 32483004
Biliary causes of postcholecystectomy syndrome.
Schofer JM
J Emerg Med 2010 Oct;39(4):406-10. Epub 2008 Aug 23 doi: 10.1016/j.jemermed.2007.11.090. PMID: 18722735
Pneumobilia: benign or life-threatening.
Sherman SC, Tran H
J Emerg Med 2006 Feb;30(2):147-53. doi: 10.1016/j.jemermed.2005.05.016. PMID: 16567248

Therapy

Postcholecystectomy syndrome: biliary-related complications.
Sangiorgio G, Zanghì M, Dionigi G, Zanghì G
Minerva Surg 2023 Dec;78(6):684-691. Epub 2023 Jul 24 doi: 10.23736/S2724-5691.23.09942-2. PMID: 37486191
Do not get stumped: multimodality imaging findings of early and late post-cholecystectomy complications.
Maddu K, Polireddy K, Hsu D, Hoff C
Emerg Radiol 2023 Jun;30(3):351-362. Epub 2023 Apr 12 doi: 10.1007/s10140-023-02131-y. PMID: 37043146
Management of Postcholecystectomy Complications.
Feng XC, Phillips E, Shouhed D
Surg Clin North Am 2021 Oct;101(5):889-910. Epub 2021 Aug 7 doi: 10.1016/j.suc.2021.06.012. PMID: 34537150
Acupuncture for the postcholecystectomy syndrome: Protocol for a systematic review and meta-analysis.
Yin Z, Cheng Y, Xiao Q, Xu G, Yang H, Zhou J, Fu Y, Chen J, Zhao L, Liang F
Medicine (Baltimore) 2019 Aug;98(32):e16769. doi: 10.1097/MD.0000000000016769. PMID: 31393398Free PMC Article
Gallstone disease in children.
Svensson J, Makin E
Semin Pediatr Surg 2012 Aug;21(3):255-65. doi: 10.1053/j.sempedsurg.2012.05.008. PMID: 22800978

Prognosis

Prevalence and predictors of postcholecystectomy syndrome in Nepalese patients after 1 week of laparoscopic cholecystectomy: a cross-sectional study.
Shrestha R, Chayaput P, Wongkongkam K, Chanruangvanich W
Sci Rep 2024 Feb 28;14(1):4903. doi: 10.1038/s41598-024-55625-1. PMID: 38418688Free PMC Article
Postcholecystectomy syndrome (PCS).
Jaunoo SS, Mohandas S, Almond LM
Int J Surg 2010;8(1):15-7. Epub 2009 Oct 24 doi: 10.1016/j.ijsu.2009.10.008. PMID: 19857610
Postcholecystectomy syndrome - an algorithmic approach.
Filip M, Saftoiu A, Popescu C, Gheonea DI, Iordache S, Sandulescu L, Ciurea T
J Gastrointestin Liver Dis 2009 Mar;18(1):67-71. PMID: 19337637
Postcholecystectomy abdominal bile collections.
Lee CM, Stewart L, Way LW
Arch Surg 2000 May;135(5):538-42; discussion 542-4. doi: 10.1001/archsurg.135.5.538. PMID: 10807277
The postcholecystectomy syndrome.
Christiansen J, Schmidt A
Acta Chir Scand 1971;137(8):789-93. PMID: 5148858

Clinical prediction guides

Prevalence and predictors of postcholecystectomy syndrome in Nepalese patients after 1 week of laparoscopic cholecystectomy: a cross-sectional study.
Shrestha R, Chayaput P, Wongkongkam K, Chanruangvanich W
Sci Rep 2024 Feb 28;14(1):4903. doi: 10.1038/s41598-024-55625-1. PMID: 38418688Free PMC Article
Early visceral pain predicts chronic pain after laparoscopic cholecystectomy.
Blichfeldt-Eckhardt MR, Ording H, Andersen C, Licht PB, Toft P
Pain 2014 Nov;155(11):2400-7. Epub 2014 Sep 22 doi: 10.1016/j.pain.2014.09.019. PMID: 25250720
Postcholecystectomy syndrome - an algorithmic approach.
Filip M, Saftoiu A, Popescu C, Gheonea DI, Iordache S, Sandulescu L, Ciurea T
J Gastrointestin Liver Dis 2009 Mar;18(1):67-71. PMID: 19337637
Sump syndrome: endoscopic treatment and late recurrence.
Mavrogiannis C, Liatsos C, Romanos A, Goulas S, Dourakis S, Nakos A, Karvountzis G
Am J Gastroenterol 1999 Apr;94(4):972-5. doi: 10.1111/j.1572-0241.1999.998_t.x. PMID: 10201467
The postcholecystectomy syndrome. A role for duodenogastric reflux.
Abu Farsakh NA, Stietieh M, Abu Farsakh FA
J Clin Gastroenterol 1996 Apr;22(3):197-201. doi: 10.1097/00004836-199604000-00009. PMID: 8724257

Recent systematic reviews

A systematic review of the aetiology and management of post cholecystectomy syndrome.
Isherwood J, Oakland K, Khanna A
Surgeon 2019 Feb;17(1):33-42. Epub 2018 May 2 doi: 10.1016/j.surge.2018.04.001. PMID: 29730174

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