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Classic Hodgkin lymphoma, nodular sclerosis type

MedGen UID:
101830
•Concept ID:
C0152268
•
Neoplastic Process
Synonyms: classic Hodgkin lymphoma, nodular sclerosis type; Classical Hodgkin lymphoma, nodular sclerosis; Hodgkin disease, nodular sclerosis; Hodgkin lymphoma, nodular sclerosis; Hodgkin's disease, nodular sclerosis; Hodgkin's disease, nodular sclerosis (clinical); Hodgkin's Nodular Sclerosis; Nodular Sclerosis Classic Hodgkin Lymphoma; Nodular Sclerosis Hodgkin Lymphoma; Nodular Sclerosis Hodgkin's Disease; Nodular Sclerosis Hodgkin's Lymphoma
SNOMED CT: Hodgkin's disease, nodular sclerosis (118608000); Hodgkin's disease, nodular sclerosis (clinical) (118608000); Classical Hodgkin lymphoma, nodular sclerosis (52248008); Hodgkin lymphoma, nodular sclerosis (52248008); Hodgkin disease, nodular sclerosis (118608000)
 
Monarch Initiative: MONDO:0020327
Orphanet: ORPHA98843

Definition

A subtype of classic Hodgkin lymphoma characterized by collagen bands that surround at least one nodule, and Hodgkin and Reed-Sternberg cells with lacunar type morphology. (WHO, 2008) [from NCI]

Professional guidelines

PubMed

Hodgkin's disease: classification and differential diagnosis.
Harris NL
Mod Pathol 1999 Feb;12(2):159-75. PMID: 10071341

Recent clinical studies

Etiology

Cytologic manifestations of Hodgkin lymphoma in serous effusions.
AbdullGaffar B, Raman L
Diagn Cytopathol 2022 Sep;50(9):E255-E263. Epub 2022 May 17 doi: 10.1002/dc.24976. PMID: 35581946
Clinicopathological features of syncytial variant nodular sclerosis Hodgkin lymphoma.
Zhang Q, Kim DH, Xu Y, Wang W, Medeiros LJ
Hum Pathol 2022 Jan;119:105-113. Epub 2021 Nov 19 doi: 10.1016/j.humpath.2021.11.007. PMID: 34801601
Secondary skin involvement in classic Hodgkin lymphoma: Results of an international collaborative cutaneous lymphoma working group study of 25 patients.
Gru AA, Bacchi CE, Pulitzer M, Bhagat G, Kempf W, Robson A, Plaza JA, Pincus L, Raghavan S, Xu M, Vencato da Silva T, Salavaggione AL, Subtil A, Battistella M
J Cutan Pathol 2021 Nov;48(11):1367-1378. Epub 2021 Jul 5 doi: 10.1111/cup.14077. PMID: 34089205Free PMC Article
Lymphoma subtypes in India: a tertiary care center review.
Jain S, Lone MR, Goswami A, Mandal T, Panda AK, Ramteke P, Srivastav T, Sharma MC, Gogia A, Sharma A, Bakhshi S, Mahapatra M, Kumar L, Mallick S
Clin Exp Med 2021 May;21(2):315-321. Epub 2021 Jan 22 doi: 10.1007/s10238-021-00683-2. PMID: 33481141
Pediatric lymphomas in Brazil.
Gualco G, Klumb CE, Barber GN, Weiss LM, Bacchi CE
Clinics (Sao Paulo) 2010;65(12):1267-77. doi: 10.1590/s1807-59322010001200008. PMID: 21340214Free PMC Article

Diagnosis

Male Breast Imaging Uncovers Lymphoma.
Abunimer L, O'Brien SR, Calisi N
J Radiol Case Rep 2023 Feb;17(2):1-8. Epub 2023 Feb 28 doi: 10.3941/jrcr.v17i2.4508. PMID: 36876300Free PMC Article
Composite Classic Hodgkin Lymphoma and Follicular Lymphoma: A Clinicopathologic Study of 22 Cases With Review of 27 Additional Cases in the Literature.
Huang Y, Hu S, Larson DP, Shi M, He R, Dave BJ, Greiner TC, Fu K, McPhail ED, Ketterling RP, Medeiros LJ, Yuan J
Am J Surg Pathol 2022 Jun 1;46(6):793-800. Epub 2022 Jan 24 doi: 10.1097/PAS.0000000000001828. PMID: 35067515
Syncytial variant of nodular sclerosis Hodgkin lymphoma: an under-emphasized variant.
Wang W, Zhang Q, Medeiros LJ
Hum Pathol 2021 Nov;117:115-125. Epub 2021 May 28 doi: 10.1016/j.humpath.2021.05.008. PMID: 34058246
Hodgkin's disease: classification and differential diagnosis.
Harris NL
Mod Pathol 1999 Feb;12(2):159-75. PMID: 10071341
Pathology and "molecular histology' of Hodgkin's disease and the border to non-Hodgkin's lymphomas.
Hansmann ML, Küppers R
Baillieres Clin Haematol 1996 Sep;9(3):459-77. doi: 10.1016/s0950-3536(96)80021-7. PMID: 8922240

Therapy

Difficult Diagnosis between B Cell Lymphoma and Classical Hodgkin's Lymphoma.
Rentas Torres Y, Rodríguez-López JL, Valentin M, Silva H
Bol Asoc Med P R 2015 Jul-Sep;107(3):98-101. PMID: 26742206
IL-6-positive classical Hodgkin's lymphoma co-occurring with plasma cell type of Castleman's disease: report of a case.
Momoi A, Kojima M, Sakai T, Ajiro J, Isahai N, Nagai K, Aoki S
Int J Hematol 2013 Feb;97(2):275-9. Epub 2013 Jan 29 doi: 10.1007/s12185-013-1262-7. PMID: 23359301
Gray zone lymphoma: better treated like hodgkin lymphoma or mediastinal large B-cell lymphoma?
Dunleavy K, Grant C, Eberle FC, Pittaluga S, Jaffe ES, Wilson WH
Curr Hematol Malig Rep 2012 Sep;7(3):241-7. doi: 10.1007/s11899-012-0130-5. PMID: 22833351Free PMC Article
Cytotoxic molecule-positive classical Hodgkin's lymphoma: a clinicopathological comparison with cytotoxic molecule-positive peripheral T-cell lymphoma of not otherwise specified type.
Asano N, Kinoshita T, Tamaru J, Ohshima K, Yoshino T, Niitsu N, Tsukamoto N, Hirabayashi K, Izutsu K, Taniwaki M, Morishima Y, Nakamura S
Haematologica 2011 Nov;96(11):1636-43. Epub 2011 Aug 22 doi: 10.3324/haematol.2011.041079. PMID: 21859738Free PMC Article
Nodular type of lymphocyte predominant Hodgkin's disease. A clinical study of 50 cases.
Pappa VI, Norton AJ, Gupta RK, Wilson AM, Rohatiner AZ, Lister TA
Ann Oncol 1995 Jul;6(6):559-65. doi: 10.1093/oxfordjournals.annonc.a059244. PMID: 8573534

Prognosis

Clinicopathological features of syncytial variant nodular sclerosis Hodgkin lymphoma.
Zhang Q, Kim DH, Xu Y, Wang W, Medeiros LJ
Hum Pathol 2022 Jan;119:105-113. Epub 2021 Nov 19 doi: 10.1016/j.humpath.2021.11.007. PMID: 34801601
HIV-associated Hodgkin lymphoma: a clinicopathologic and immunophenotypic study of 45 cases.
Thompson LD, Fisher SI, Chu WS, Nelson A, Abbondanzo SL
Am J Clin Pathol 2004 May;121(5):727-38. doi: 10.1309/PNVQ-0PQG-XHVY-6L7G. PMID: 15151213
The many faces of Hodgkin's disease around the world: what have we learned from its pathology?
Harris NL
Ann Oncol 1998;9 Suppl 5:S45-56. doi: 10.1093/annonc/9.suppl_5.s45. PMID: 9926237
Pathology and "molecular histology' of Hodgkin's disease and the border to non-Hodgkin's lymphomas.
Hansmann ML, Küppers R
Baillieres Clin Haematol 1996 Sep;9(3):459-77. doi: 10.1016/s0950-3536(96)80021-7. PMID: 8922240
Nodular lymphocyte predominance Hodgkin's disease. A distinct clinicopathological entity.
Mason DY, Banks PM, Chan J, Cleary ML, Delsol G, de Wolf Peeters C, Falini B, Gatter K, Grogan TM, Harris NL
Am J Surg Pathol 1994 May;18(5):526-30. doi: 10.1097/00000478-199405000-00014. PMID: 8172327

Clinical prediction guides

Cytologic manifestations of Hodgkin lymphoma in serous effusions.
AbdullGaffar B, Raman L
Diagn Cytopathol 2022 Sep;50(9):E255-E263. Epub 2022 May 17 doi: 10.1002/dc.24976. PMID: 35581946
Secondary skin involvement in classic Hodgkin lymphoma: Results of an international collaborative cutaneous lymphoma working group study of 25 patients.
Gru AA, Bacchi CE, Pulitzer M, Bhagat G, Kempf W, Robson A, Plaza JA, Pincus L, Raghavan S, Xu M, Vencato da Silva T, Salavaggione AL, Subtil A, Battistella M
J Cutan Pathol 2021 Nov;48(11):1367-1378. Epub 2021 Jul 5 doi: 10.1111/cup.14077. PMID: 34089205Free PMC Article
Involvement of human herpesvirus-6 variant B in classic Hodgkin's lymphoma via DR7 oncoprotein.
Lacroix A, Collot-Teixeira S, Mardivirin L, Jaccard A, Petit B, Piguet C, Sturtz F, Preux PM, Bordessoule D, Ranger-Rogez S
Clin Cancer Res 2010 Oct 1;16(19):4711-21. Epub 2010 Sep 21 doi: 10.1158/1078-0432.CCR-10-0470. PMID: 20858841
Initial lesions of classical Hodgkin's lymphoma of the nodular sclerosis type.
Audouin J, Le Tourneau A, Molina T, Diebold J
Arkh Patol 2006 Sep-Oct;68(5):53-9. PMID: 17144534
Nodular type of lymphocyte predominant Hodgkin's disease. A clinical study of 50 cases.
Pappa VI, Norton AJ, Gupta RK, Wilson AM, Rohatiner AZ, Lister TA
Ann Oncol 1995 Jul;6(6):559-65. doi: 10.1093/oxfordjournals.annonc.a059244. PMID: 8573534

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