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neonatal abstinence syndrome

MedGen UID:
10207
•Concept ID:
C0027609
•
Disease or Syndrome
Synonyms: Abstinence Syndrome, Neonatal; Abstinence Syndromes, Neonatal; Neonatal Abstinence Syndrome; Neonatal Abstinence Syndromes; Neonatal Substance Withdrawal; Neonatal Substance Withdrawals; Neonatal Withdrawal Syndrome; Neonatal Withdrawal Syndromes; Substance Withdrawal, Neonatal; Substance Withdrawals, Neonatal; Syndrome, Neonatal Abstinence; Syndrome, Neonatal Withdrawal; Syndromes, Neonatal Abstinence; Syndromes, Neonatal Withdrawal; Withdrawal Syndrome, Neonatal; Withdrawal Syndromes, Neonatal; Withdrawal, Neonatal Substance
SNOMED CT: Neonatal withdrawal syndrome (414819007); Neonatal abstinence syndrome (414819007); Neonatal withdrawal symptoms from maternal use of drugs of addiction (414819007); Substance withdrawal syndrome in neonate of dependent mother (414819007); Substance withdrawal syndrome in newborn (414819007); Neonatal substance withdrawal syndrome (414819007)
 
Monarch Initiative: MONDO:0005566

Definition

A constellation of neurobehavioral features observed in a neonate following antenatal exposure to drugs including opioids, benzodiazepines, and selective serotonin reuptake inhibitors. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVneonatal abstinence syndrome

Professional guidelines

PubMed

Medication Use and Pain Management in Pregnancy: A Critical Review.
Black E, Khor KE, Kennedy D, Chutatape A, Sharma S, Vancaillie T, Demirkol A
Pain Pract 2019 Nov;19(8):875-899. Epub 2019 Aug 13 doi: 10.1111/papr.12814. PMID: 31242344
Eat, Sleep, Console Approach: A Family-Centered Model for the Treatment of Neonatal Abstinence Syndrome.
Grisham LM, Stephen MM, Coykendall MR, Kane MF, Maurer JA, Bader MY
Adv Neonatal Care 2019 Apr;19(2):138-144. doi: 10.1097/ANC.0000000000000581. PMID: 30855311
Neonatal Abstinence Syndrome: Advances in Diagnosis and Treatment.
Wachman EM, Schiff DM, Silverstein M
JAMA 2018 Apr 3;319(13):1362-1374. doi: 10.1001/jama.2018.2640. PMID: 29614184

Recent clinical studies

Etiology

Eat, Sleep, Console Approach: A Family-Centered Model for the Treatment of Neonatal Abstinence Syndrome.
Grisham LM, Stephen MM, Coykendall MR, Kane MF, Maurer JA, Bader MY
Adv Neonatal Care 2019 Apr;19(2):138-144. doi: 10.1097/ANC.0000000000000581. PMID: 30855311
After NAS.
Oei JL
Semin Fetal Neonatal Med 2019 Apr;24(2):161-165. Epub 2019 Feb 15 doi: 10.1016/j.siny.2019.01.012. PMID: 30797731
A Novel Approach to Assessing Infants With Neonatal Abstinence Syndrome.
Grossman MR, Lipshaw MJ, Osborn RR, Berkwitt AK
Hosp Pediatr 2018 Jan;8(1):1-6. doi: 10.1542/hpeds.2017-0128. PMID: 29263121
Neonatal abstinence syndrome.
Kocherlakota P
Pediatrics 2014 Aug;134(2):e547-61. doi: 10.1542/peds.2013-3524. PMID: 25070299
Prenatal substance abuse: short- and long-term effects on the exposed fetus.
Behnke M, Smith VC; Committee on Substance Abuse; Committee on Fetus and Newborn
Pediatrics 2013 Mar;131(3):e1009-24. Epub 2013 Feb 25 doi: 10.1542/peds.2012-3931. PMID: 23439891Free PMC Article

Diagnosis

The Eat, Sleep, Console Method: A Literature Review.
Nicholson S, Waskosky A
Neonatal Netw 2022 Nov 11;41(6):333-340. doi: 10.1891/NN-2021-0003. PMID: 36446434
Neonatal Opioid Withdrawal Syndrome.
Patrick SW, Barfield WD, Poindexter BB; COMMITTEE ON FETUS AND NEWBORN, COMMITTEE ON SUBSTANCE USE AND PREVENTION
Pediatrics 2020 Nov;146(5) doi: 10.1542/peds.2020-029074. PMID: 33106341
Neonatal Abstinence Syndrome.
Jansson LM, Patrick SW
Pediatr Clin North Am 2019 Apr;66(2):353-367. doi: 10.1016/j.pcl.2018.12.006. PMID: 30819342Free PMC Article
Neonatal Abstinence Syndrome: Advances in Diagnosis and Treatment.
Wachman EM, Schiff DM, Silverstein M
JAMA 2018 Apr 3;319(13):1362-1374. doi: 10.1001/jama.2018.2640. PMID: 29614184
Neonatal abstinence syndrome.
Kocherlakota P
Pediatrics 2014 Aug;134(2):e547-61. doi: 10.1542/peds.2013-3524. PMID: 25070299

Therapy

Neonatal Abstinence Syndrome: Review of Epidemiology, Care Models, and Current Understanding of Outcomes.
MacMillan KDL
Clin Perinatol 2019 Dec;46(4):817-832. Epub 2019 Aug 14 doi: 10.1016/j.clp.2019.08.012. PMID: 31653310
Neonatal Abstinence Syndrome.
Jansson LM, Patrick SW
Pediatr Clin North Am 2019 Apr;66(2):353-367. doi: 10.1016/j.pcl.2018.12.006. PMID: 30819342Free PMC Article
Pharmacological and non-pharmacological treatments for the Neonatal Abstinence Syndrome (NAS).
Mangat AK, Schmölzer GM, Kraft WK
Semin Fetal Neonatal Med 2019 Apr;24(2):133-141. Epub 2019 Feb 5 doi: 10.1016/j.siny.2019.01.009. PMID: 30745219Free PMC Article
Neonatal Abstinence Syndrome: Advances in Diagnosis and Treatment.
Wachman EM, Schiff DM, Silverstein M
JAMA 2018 Apr 3;319(13):1362-1374. doi: 10.1001/jama.2018.2640. PMID: 29614184
Neonatal abstinence syndrome.
Kocherlakota P
Pediatrics 2014 Aug;134(2):e547-61. doi: 10.1542/peds.2013-3524. PMID: 25070299

Prognosis

Medication Use and Pain Management in Pregnancy: A Critical Review.
Black E, Khor KE, Kennedy D, Chutatape A, Sharma S, Vancaillie T, Demirkol A
Pain Pract 2019 Nov;19(8):875-899. Epub 2019 Aug 13 doi: 10.1111/papr.12814. PMID: 31242344
The genetics and epigenetics of Neonatal Abstinence Syndrome.
Wachman EM, Farrer LA
Semin Fetal Neonatal Med 2019 Apr;24(2):105-110. Epub 2019 Jan 25 doi: 10.1016/j.siny.2019.01.002. PMID: 30709700
Neonatal Abstinence Syndrome: Advances in Diagnosis and Treatment.
Wachman EM, Schiff DM, Silverstein M
JAMA 2018 Apr 3;319(13):1362-1374. doi: 10.1001/jama.2018.2640. PMID: 29614184
A Novel Approach to Assessing Infants With Neonatal Abstinence Syndrome.
Grossman MR, Lipshaw MJ, Osborn RR, Berkwitt AK
Hosp Pediatr 2018 Jan;8(1):1-6. doi: 10.1542/hpeds.2017-0128. PMID: 29263121
Neonatal Abstinence Syndrome.
McQueen K, Murphy-Oikonen J
N Engl J Med 2016 Dec 22;375(25):2468-2479. doi: 10.1056/NEJMra1600879. PMID: 28002715

Clinical prediction guides

The Eat, Sleep, Console Method: A Literature Review.
Nicholson S, Waskosky A
Neonatal Netw 2022 Nov 11;41(6):333-340. doi: 10.1891/NN-2021-0003. PMID: 36446434
Therapeutic approaches for neonatal abstinence syndrome: a systematic review of randomized clinical trials.
Ghazanfarpour M, Najafi MN, Roozbeh N, Mashhadi ME, Keramat-Roudi A, Mégarbane B, Tsatsakis A, Moghaddam MMM, Rezaee R
Daru 2019 Jun;27(1):423-431. Epub 2019 May 15 doi: 10.1007/s40199-019-00266-3. PMID: 31093953Free PMC Article
Pharmacological and non-pharmacological treatments for the Neonatal Abstinence Syndrome (NAS).
Mangat AK, Schmölzer GM, Kraft WK
Semin Fetal Neonatal Med 2019 Apr;24(2):133-141. Epub 2019 Feb 5 doi: 10.1016/j.siny.2019.01.009. PMID: 30745219Free PMC Article
Neonatal Abstinence Syndrome: Advances in Diagnosis and Treatment.
Wachman EM, Schiff DM, Silverstein M
JAMA 2018 Apr 3;319(13):1362-1374. doi: 10.1001/jama.2018.2640. PMID: 29614184
Neonatal abstinence syndrome.
Kocherlakota P
Pediatrics 2014 Aug;134(2):e547-61. doi: 10.1542/peds.2013-3524. PMID: 25070299

Recent systematic reviews

Neonatal abstinence syndrome: a systematic review of current databases and registries.
Zakerabasali S, Safdari R, Kadivar M, Rostam Niakan Kalhori S, Mokhtaran M, Karbasi Z, Sayarifard A, Abhari S
J Matern Fetal Neonatal Med 2021 Mar;34(6):979-992. Epub 2019 May 27 doi: 10.1080/14767058.2019.1618827. PMID: 31092074
Non-pharmacological care for opioid withdrawal in newborns.
Pahl A, Young L, Buus-Frank ME, Marcellus L, Soll R
Cochrane Database Syst Rev 2020 Dec 21;12(12):CD013217. doi: 10.1002/14651858.CD013217.pub2. PMID: 33348423Free PMC Article
Therapeutic approaches for neonatal abstinence syndrome: a systematic review of randomized clinical trials.
Ghazanfarpour M, Najafi MN, Roozbeh N, Mashhadi ME, Keramat-Roudi A, Mégarbane B, Tsatsakis A, Moghaddam MMM, Rezaee R
Daru 2019 Jun;27(1):423-431. Epub 2019 May 15 doi: 10.1007/s40199-019-00266-3. PMID: 31093953Free PMC Article
Role of Clonidine in Neonatal Abstinence Syndrome: A Systematic Review.
Streetz VN, Gildon BL, Thompson DF
Ann Pharmacother 2016 Apr;50(4):301-10. Epub 2016 Jan 18 doi: 10.1177/1060028015626438. PMID: 26783353
Swaddling: a systematic review.
van Sleuwen BE, Engelberts AC, Boere-Boonekamp MM, Kuis W, Schulpen TW, L'Hoir MP
Pediatrics 2007 Oct;120(4):e1097-106. doi: 10.1542/peds.2006-2083. PMID: 17908730

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