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Disseminated candidiasis

MedGen UID:
102260
•Concept ID:
C0153252
•
Disease or Syndrome
Synonyms: Systemic candida infections; Systemic candidiasis
SNOMED CT: Disseminated candidiasis (70572005); Systemic candidiasis (70572005); Disseminated candidosis (70572005); Invasive candidiasis (70572005); Disseminated candida (70572005)
 
Monarch Initiative: MONDO:0042233

Definition

A fungal infection by any of the Candida species in two or more non-contiguous sterile body compartments. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDisseminated candidiasis

Professional guidelines

PubMed

BET-HDAC Dual Inhibitors for Combinational Treatment of Breast Cancer and Concurrent Candidiasis.
Huang Y, Liu N, Pan Z, Li Z, Sheng C
J Med Chem 2023 Jan 26;66(2):1239-1253. Epub 2023 Jan 9 doi: 10.1021/acs.jmedchem.2c01191. PMID: 36622852
Single or 2-Dose Micafungin Regimen for Treatment of Invasive Candidiasis: Therapia Sterilisans Magna!
Gumbo T
Clin Infect Dis 2015 Dec 1;61 Suppl 6:S635-42. doi: 10.1093/cid/civ715. PMID: 26567282
Current treatment strategies for disseminated candidiasis.
Spellberg BJ, Filler SG, Edwards JE Jr
Clin Infect Dis 2006 Jan 15;42(2):244-51. Epub 2005 Dec 2 doi: 10.1086/499057. PMID: 16355336

Recent clinical studies

Etiology

Invasive candidiasis.
Lass-Flörl C, Kanj SS, Govender NP, Thompson GR 3rd, Ostrosky-Zeichner L, Govrins MA
Nat Rev Dis Primers 2024 Mar 21;10(1):20. doi: 10.1038/s41572-024-00503-3. PMID: 38514673
β-1,2-Oligomannan phosphorylase-mediated synthesis of potential oligosaccharide vaccine candidates.
Ahmadipour S, Winsbury R, Köhler D, Pergolizzi G, Nepogodiev SA, Chessa S, Dedola S, Wang M, Voglmeir J, Field RA
Carbohydr Res 2023 Jun;528:108807. Epub 2023 Apr 14 doi: 10.1016/j.carres.2023.108807. PMID: 37094534
Candida urinary tract infections in adults.
Odabasi Z, Mert A
World J Urol 2020 Nov;38(11):2699-2707. Epub 2019 Oct 25 doi: 10.1007/s00345-019-02991-5. PMID: 31654220
"Candida Albicans Interactions With The Host: Crossing The Intestinal Epithelial Barrier".
Basmaciyan L, Bon F, Paradis T, Lapaquette P, Dalle F
Tissue Barriers 2019;7(2):1612661. Epub 2019 Jun 12 doi: 10.1080/21688370.2019.1612661. PMID: 31189436Free PMC Article
Candida urinary tract infections--epidemiology.
Sobel JD, Fisher JF, Kauffman CA, Newman CA
Clin Infect Dis 2011 May;52 Suppl 6:S433-6. doi: 10.1093/cid/cir109. PMID: 21498836

Diagnosis

Invasive candidiasis.
Lass-Flörl C, Kanj SS, Govender NP, Thompson GR 3rd, Ostrosky-Zeichner L, Govrins MA
Nat Rev Dis Primers 2024 Mar 21;10(1):20. doi: 10.1038/s41572-024-00503-3. PMID: 38514673
Somatic GATA2 mutations define a subgroup of myeloid malignancy patients at high risk for invasive fungal disease.
Vedula RS, Cheng MP, Ronayne CE, Farmakiotis D, Ho VT, Koo S, Marty FM, Lindsley RC, Bold TD
Blood Adv 2021 Jan 12;5(1):54-60. doi: 10.1182/bloodadvances.2020002854. PMID: 33570623Free PMC Article
Candida urinary tract infections in adults.
Odabasi Z, Mert A
World J Urol 2020 Nov;38(11):2699-2707. Epub 2019 Oct 25 doi: 10.1007/s00345-019-02991-5. PMID: 31654220
Diagnosing fungal infections in neutropenic patients.
Gardner A
Clin J Oncol Nurs 2007 Feb;11(1):29-32. doi: 10.1188/07.CJON.29-32. PMID: 17441394
Endogenous candidal endophthalmitis.
Deutsch D, Adler S, Teller J, Savir H
Ann Ophthalmol 1989 Jul;21(7):260-5, 268. PMID: 2789011

Therapy

Invasive candidiasis.
Lass-Flörl C, Kanj SS, Govender NP, Thompson GR 3rd, Ostrosky-Zeichner L, Govrins MA
Nat Rev Dis Primers 2024 Mar 21;10(1):20. doi: 10.1038/s41572-024-00503-3. PMID: 38514673
Candida urinary tract infections in adults.
Odabasi Z, Mert A
World J Urol 2020 Nov;38(11):2699-2707. Epub 2019 Oct 25 doi: 10.1007/s00345-019-02991-5. PMID: 31654220
Fungal vaccines, mechanism of actions and immunology: A comprehensive review.
Nami S, Mohammadi R, Vakili M, Khezripour K, Mirzaei H, Morovati H
Biomed Pharmacother 2019 Jan;109:333-344. Epub 2018 Nov 3 doi: 10.1016/j.biopha.2018.10.075. PMID: 30399567
Use of T2MR in invasive candidiasis with and without candidemia.
Zacharioudakis IM, Zervou FN, Mylonakis E
Future Microbiol 2018 Aug;13:1165-1173. Epub 2018 May 24 doi: 10.2217/fmb-2018-0079. PMID: 29792512
Gastric candidiasis.
Piken E, Dwyer R, Zablen MA
JAMA 1978 Nov 10;240(20):2181-2. PMID: 309011

Prognosis

Pharmacological Basis of CD101 Efficacy: Exposure Shape Matters.
Lakota EA, Bader JC, Ong V, Bartizal K, Miesel L, Andes DR, Bhavnani SM, Rubino CM, Ambrose PG, Lepak AJ
Antimicrob Agents Chemother 2017 Nov;61(11) Epub 2017 Oct 24 doi: 10.1128/AAC.00758-17. PMID: 28848022Free PMC Article
Candidemia in immunocompromised patients.
Meunier F, Aoun M, Bitar N
Clin Infect Dis 1992 Mar;14 Suppl 1:S120-5. doi: 10.1093/clinids/14.supplement_1.s120. PMID: 1562683
Endogenous candidal endophthalmitis.
Deutsch D, Adler S, Teller J, Savir H
Ann Ophthalmol 1989 Jul;21(7):260-5, 268. PMID: 2789011
Infantile endogenous Candida endophthalmitis presenting as a cataract.
Clinch TE, Duker JS, Eagle RC Jr, Calhoun JH, Augsburger JJ, Fischer DH
Surv Ophthalmol 1989 Sep-Oct;34(2):107-12. doi: 10.1016/0039-6257(89)90038-6. PMID: 2686054
Systemic candidiasis in cancer patients.
Maksymiuk AW, Thongprasert S, Hopfer R, Luna M, Fainstein V, Bodey GP
Am J Med 1984 Oct 30;77(4D):20-7. PMID: 6093530

Clinical prediction guides

Clinical features and outcome of hepatosplenic fungal infections in children with haematological malignancies.
Madney Y, Shalaby L, Elanany M, Adel N, Nasr E, Alsheshtawi K, Younes A, Hafez H
Mycoses 2020 Jan;63(1):30-37. Epub 2019 Nov 13 doi: 10.1111/myc.13002. PMID: 31514231
Pharmacological Basis of CD101 Efficacy: Exposure Shape Matters.
Lakota EA, Bader JC, Ong V, Bartizal K, Miesel L, Andes DR, Bhavnani SM, Rubino CM, Ambrose PG, Lepak AJ
Antimicrob Agents Chemother 2017 Nov;61(11) Epub 2017 Oct 24 doi: 10.1128/AAC.00758-17. PMID: 28848022Free PMC Article
Lysine enhances the effect of amphotericin B against Candida albicans in vitro.
Zhao L, Jiang J, Zhu Z, Liao Z, Yao X, Yang Y, Cao Y, Jiang Y
Acta Biochim Biophys Sin (Shanghai) 2016 Feb;48(2):182-93. Epub 2015 Dec 28 doi: 10.1093/abbs/gmv125. PMID: 26711896
BCG-induced trained immunity in NK cells: Role for non-specific protection to infection.
Kleinnijenhuis J, Quintin J, Preijers F, Joosten LA, Jacobs C, Xavier RJ, van der Meer JW, van Crevel R, Netea MG
Clin Immunol 2014 Dec;155(2):213-9. Epub 2014 Oct 25 doi: 10.1016/j.clim.2014.10.005. PMID: 25451159Free PMC Article
Candidemia in immunocompromised patients.
Meunier F, Aoun M, Bitar N
Clin Infect Dis 1992 Mar;14 Suppl 1:S120-5. doi: 10.1093/clinids/14.supplement_1.s120. PMID: 1562683

Recent systematic reviews

Acute disseminated candidiasis with skin lesions: a systematic review.
Guarana M, Nucci M
Clin Microbiol Infect 2018 Mar;24(3):246-250. Epub 2017 Aug 25 doi: 10.1016/j.cmi.2017.08.016. PMID: 28847765

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