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Malignant Hypopharyngeal Neoplasm

MedGen UID:
102266
•Concept ID:
C0153398
•
Neoplastic Process
Synonyms: Cancer, Hypopharyngeal; Cancers, Hypopharyngeal; Hypopharyngeal Cancer; Hypopharyngeal Cancers
SNOMED CT: Malignant tumor of laryngopharynx (363399006); Malignant neoplasm of laryngopharynx (363399006); Malignant tumor of hypopharynx (363399006)

Definition

A primary or metastatic malignant neoplasm that affects the hypopharynx. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMalignant Hypopharyngeal Neoplasm

Professional guidelines

PubMed

Swallowing disorders after treatment for head and neck cancer.
Pezdirec M, Strojan P, Boltezar IH
Radiol Oncol 2019 Jun 1;53(2):225-230. doi: 10.2478/raon-2019-0028. PMID: 31194691Free PMC Article
Treatment Options for Hypopharyngeal Cancer.
Eckel HE, Bradley PJ
Adv Otorhinolaryngol 2019;83:47-53. Epub 2019 Feb 12 doi: 10.1159/000492308. PMID: 30943512
Delineation of the primary tumour Clinical Target Volumes (CTV-P) in laryngeal, hypopharyngeal, oropharyngeal and oral cavity squamous cell carcinoma: AIRO, CACA, DAHANCA, EORTC, GEORCC, GORTEC, HKNPCSG, HNCIG, IAG-KHT, LPRHHT, NCIC CTG, NCRI, NRG Oncology, PHNS, SBRT, SOMERA, SRO, SSHNO, TROG consensus guidelines.
Grégoire V, Evans M, Le QT, Bourhis J, Budach V, Chen A, Eisbruch A, Feng M, Giralt J, Gupta T, Hamoir M, Helito JK, Hu C, Hunter K, Johansen J, Kaanders J, Laskar SG, Lee A, Maingon P, Mäkitie A, Micciche' F, Nicolai P, O'Sullivan B, Poitevin A, Porceddu S, Składowski K, Tribius S, Waldron J, Wee J, Yao M, Yom SS, Zimmermann F, Grau C
Radiother Oncol 2018 Jan;126(1):3-24. Epub 2017 Nov 24 doi: 10.1016/j.radonc.2017.10.016. PMID: 29180076

Recent clinical studies

Etiology

Socioeconomic disparities in treatment and survival in patients with hypopharyngeal malignancy.
Agarwal P, Bloom J, Zhou Y, Zhao R, Huang S, Yajima M, Devaiah AK
Head Neck 2023 Oct;45(10):2670-2679. Epub 2023 Aug 28 doi: 10.1002/hed.27492. PMID: 37638612
Symptoms and Signs, Staging and Co-Morbidity of Hypopharyngeal Cancer.
Bradley PJ
Adv Otorhinolaryngol 2019;83:15-26. Epub 2019 Feb 12 doi: 10.1159/000492304. PMID: 30943511
Hypopharyngeal carcinoma: Do you know your guidelines?
Kwon DI, Miles BA; Education Committee of the American Head and Neck Society (AHNS)
Head Neck 2019 Mar;41(3):569-576. Epub 2018 Dec 20 doi: 10.1002/hed.24752. PMID: 30570183
Liposarcoma of Hypopharynx and Esophagus: a Unique Entity?
Riva G, Sensini M, Corvino A, Garzaro M, Pecorari G
J Gastrointest Cancer 2016 Jun;47(2):135-42. doi: 10.1007/s12029-016-9808-6. PMID: 26875081
Salvage surgery in post-chemoradiation laryngeal and hypopharyngeal carcinoma: outcome and review.
Putten L, Bree R, Doornaert PA, Buter J, Eerenstein SE, Rietveld DH, Kuik DJ, Leemans CR
Acta Otorhinolaryngol Ital 2015 Jun;35(3):162-72. PMID: 26246660Free PMC Article

Diagnosis

MR Imaging of Laryngeal and Hypopharyngeal Cancer.
Becker M, Monnier Y, de Vito C
Magn Reson Imaging Clin N Am 2022 Feb;30(1):53-72. doi: 10.1016/j.mric.2021.08.002. PMID: 34802581
Treatment Options for Hypopharyngeal Cancer.
Eckel HE, Bradley PJ
Adv Otorhinolaryngol 2019;83:47-53. Epub 2019 Feb 12 doi: 10.1159/000492308. PMID: 30943512
Symptoms and Signs, Staging and Co-Morbidity of Hypopharyngeal Cancer.
Bradley PJ
Adv Otorhinolaryngol 2019;83:15-26. Epub 2019 Feb 12 doi: 10.1159/000492304. PMID: 30943511
Hypopharyngeal cancer.
Wycliffe ND, Grover RS, Kim PD, Simental A Jr
Top Magn Reson Imaging 2007 Aug;18(4):243-58. doi: 10.1097/RMR.0b013e3181570c3f. PMID: 17893590
Larynx and hypopharynx.
Becker M
Radiol Clin North Am 1998 Sep;36(5):891-920, vi. doi: 10.1016/s0033-8389(05)70068-3. PMID: 9747193

Therapy

Neutrophil-to-lymphocyte and hypopharyngeal cancer prognosis: System review and meta-analysis.
Hu X, Tian T, Zhang X, Sun Q, Chen Y, Jiang W
Head Neck 2023 Feb;45(2):492-502. Epub 2022 Nov 11 doi: 10.1002/hed.27246. PMID: 36367335
Cancer of the Larynx and Hypopharynx.
Echanique KA, Evans LK, Han AY, Chhetri DK, St John MA
Hematol Oncol Clin North Am 2021 Oct;35(5):933-947. Epub 2021 Jul 14 doi: 10.1016/j.hoc.2021.05.005. PMID: 34272102
Treatment Options for Hypopharyngeal Cancer.
Eckel HE, Bradley PJ
Adv Otorhinolaryngol 2019;83:47-53. Epub 2019 Feb 12 doi: 10.1159/000492308. PMID: 30943512
Hypopharyngeal cancer: A state of the art review.
Garneau JC, Bakst RL, Miles BA
Oral Oncol 2018 Nov;86:244-250. Epub 2018 Oct 4 doi: 10.1016/j.oraloncology.2018.09.025. PMID: 30409307
Hypopharyngeal carcinoma.
Hinerman RW, Amdur RJ, Mendenhall WM, Villaret DB, Robbins KT
Curr Treat Options Oncol 2002 Feb;3(1):41-9. doi: 10.1007/s11864-002-0040-1. PMID: 12057086

Prognosis

Symptoms and Signs, Staging and Co-Morbidity of Hypopharyngeal Cancer.
Bradley PJ
Adv Otorhinolaryngol 2019;83:15-26. Epub 2019 Feb 12 doi: 10.1159/000492304. PMID: 30943511
Natural History of Treated and Untreated Hypopharyngeal Cancer.
Eckel HE, Bradley PJ
Adv Otorhinolaryngol 2019;83:27-34. Epub 2019 Feb 12 doi: 10.1159/000492305. PMID: 30943503
Hypopharyngeal carcinoma: Do you know your guidelines?
Kwon DI, Miles BA; Education Committee of the American Head and Neck Society (AHNS)
Head Neck 2019 Mar;41(3):569-576. Epub 2018 Dec 20 doi: 10.1002/hed.24752. PMID: 30570183
Management of advanced hypopharyngeal and laryngeal cancer with and without cartilage invasion.
Scherl C, Mantsopoulos K, Semrau S, Fietkau R, Kapsreiter M, Koch M, Traxdorf M, Grundtner P, Iro H
Auris Nasus Larynx 2017 Jun;44(3):333-339. Epub 2016 Aug 25 doi: 10.1016/j.anl.2016.08.002. PMID: 27569289
Salvage surgery in post-chemoradiation laryngeal and hypopharyngeal carcinoma: outcome and review.
Putten L, Bree R, Doornaert PA, Buter J, Eerenstein SE, Rietveld DH, Kuik DJ, Leemans CR
Acta Otorhinolaryngol Ital 2015 Jun;35(3):162-72. PMID: 26246660Free PMC Article

Clinical prediction guides

Socioeconomic disparities in treatment and survival in patients with hypopharyngeal malignancy.
Agarwal P, Bloom J, Zhou Y, Zhao R, Huang S, Yajima M, Devaiah AK
Head Neck 2023 Oct;45(10):2670-2679. Epub 2023 Aug 28 doi: 10.1002/hed.27492. PMID: 37638612
N6-methyladenosine modification of circCUX1 confers radioresistance of hypopharyngeal squamous cell carcinoma through caspase1 pathway.
Wu P, Fang X, Liu Y, Tang Y, Wang W, Li X, Fan Y
Cell Death Dis 2021 Mar 19;12(4):298. doi: 10.1038/s41419-021-03558-2. PMID: 33741902Free PMC Article
Swallowing disorders after treatment for head and neck cancer.
Pezdirec M, Strojan P, Boltezar IH
Radiol Oncol 2019 Jun 1;53(2):225-230. doi: 10.2478/raon-2019-0028. PMID: 31194691Free PMC Article
Symptoms and Signs, Staging and Co-Morbidity of Hypopharyngeal Cancer.
Bradley PJ
Adv Otorhinolaryngol 2019;83:15-26. Epub 2019 Feb 12 doi: 10.1159/000492304. PMID: 30943511
Salvage surgery in post-chemoradiation laryngeal and hypopharyngeal carcinoma: outcome and review.
Putten L, Bree R, Doornaert PA, Buter J, Eerenstein SE, Rietveld DH, Kuik DJ, Leemans CR
Acta Otorhinolaryngol Ital 2015 Jun;35(3):162-72. PMID: 26246660Free PMC Article

Recent systematic reviews

Neutrophil-to-lymphocyte and hypopharyngeal cancer prognosis: System review and meta-analysis.
Hu X, Tian T, Zhang X, Sun Q, Chen Y, Jiang W
Head Neck 2023 Feb;45(2):492-502. Epub 2022 Nov 11 doi: 10.1002/hed.27246. PMID: 36367335
Lymphoepithelial carcinoma of larynx and hypopharynx: a systematic review and pooled analysis.
Petruzzi G, Costantino A, De Virgilio A, Zocchi J, Campo F, Mercante G, Spriano G, Pellini R
Eur Arch Otorhinolaryngol 2022 Mar;279(3):1157-1166. Epub 2021 Aug 2 doi: 10.1007/s00405-021-07011-0. PMID: 34338877
The primary site of head and neck squamous cell carcinoma predicts survival benefits of EGFR inhibitors: A systematic review and meta-analysis.
Nie D, Wang X, Sun M, Feng Z, Pei F, Liu W, Wang Z, Han F
Radiother Oncol 2021 May;158:13-20. Epub 2021 Feb 13 doi: 10.1016/j.radonc.2021.02.001. PMID: 33587969
Gastroesophageal reflux disease and head and neck cancers: A systematic review and meta-analysis.
Eells AC, Mackintosh C, Marks L, Marino MJ
Am J Otolaryngol 2020 Nov-Dec;41(6):102653. Epub 2020 Aug 5 doi: 10.1016/j.amjoto.2020.102653. PMID: 32841763
Liposarcoma of Hypopharynx and Esophagus: a Unique Entity?
Riva G, Sensini M, Corvino A, Garzaro M, Pecorari G
J Gastrointest Cancer 2016 Jun;47(2):135-42. doi: 10.1007/s12029-016-9808-6. PMID: 26875081

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