U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Pyriform sinus cancer

MedGen UID:
102267
•Concept ID:
C0153400
•
Neoplastic Process
Synonyms: Malignant Neoplasm of Pyriform Fossa; malignant neoplasm of pyriform fossa; Malignant Neoplasm of Pyriform Sinus; malignant neoplasm of pyriform sinus; Malignant Neoplasm of the Pyriform Fossa; malignant neoplasm of the pyriform fossa; Malignant Neoplasm of the Pyriform Sinus; malignant neoplasm of the pyriform sinus; Malignant Pyriform Fossa Neoplasm; malignant pyriform fossa neoplasm; Malignant Pyriform Fossa Tumor; malignant pyriform fossa tumor; malignant pyriform fossa tumour; Malignant Pyriform Sinus Neoplasm; malignant pyriform sinus neoplasm; Malignant Pyriform Sinus Tumor; malignant pyriform sinus tumor; malignant pyriform sinus tumour; Malignant tumor of pyriform fossa; Malignant Tumor of Pyriform Fossa; malignant tumor of pyriform fossa; Malignant tumor of pyriform sinus; Malignant Tumor of Pyriform Sinus; malignant tumor of pyriform sinus; Malignant Tumor of the Pyriform Fossa; malignant tumor of the pyriform fossa; Malignant Tumor of the Pyriform Sinus; malignant tumor of the pyriform sinus; malignant tumour of pyriform fossa; malignant tumour of pyriform sinus; malignant tumour of the pyriform fossa; malignant tumour of the pyriform sinus; pyriform sinus cancer
SNOMED CT: Malignant tumor of pyriform sinus (363401000); Malignant tumor of pyriform fossa (363401000)
 
Monarch Initiative: MONDO:0004733

Definition

A primary or metastatic malignant neoplasm that affects the pyriform sinus. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPyriform sinus cancer

Professional guidelines

PubMed

Therapeutic Management of Pyriform Sinus Cancer.
Donnadieu J, Klopp-Dutote N, Biet-Hornstein A, Strunski V, Mortuaire G, Page C
Otolaryngol Head Neck Surg 2017 Mar;156(3):498-503. Epub 2017 Jan 10 doi: 10.1177/0194599816686335. PMID: 28072556
Early stage squamous cell carcinoma of the pyriform sinus: a review of treatment options.
Krstevska V
Indian J Cancer 2012 Apr-Jun;49(2):236-44. doi: 10.4103/0019-509X.102920. PMID: 23107977
Surgical treatment of pyriform sinus cancer: a retrospective study.
Yates A, Crumley RL
Laryngoscope 1984 Dec;94(12 Pt 1):1586-90. PMID: 6503579

Recent clinical studies

Etiology

Organ preservation surgery for pyriform sinus carcinoma with vocal cord fixation: functional and oncological outcomes.
Xu S, Huang Y, Huang H, Qian J, Wang K, Wu Y, Wang X, Xu Z, Liu S, Liu J
Eur Arch Otorhinolaryngol 2022 Jul;279(7):3611-3617. Epub 2021 Nov 25 doi: 10.1007/s00405-021-07182-w. PMID: 34825265
Hypopharyngeal carcinoma: Do you know your guidelines?
Kwon DI, Miles BA; Education Committee of the American Head and Neck Society (AHNS)
Head Neck 2019 Mar;41(3):569-576. Epub 2018 Dec 20 doi: 10.1002/hed.24752. PMID: 30570183
Therapeutic Management of Pyriform Sinus Cancer.
Donnadieu J, Klopp-Dutote N, Biet-Hornstein A, Strunski V, Mortuaire G, Page C
Otolaryngol Head Neck Surg 2017 Mar;156(3):498-503. Epub 2017 Jan 10 doi: 10.1177/0194599816686335. PMID: 28072556
Early stage squamous cell carcinoma of the pyriform sinus: a review of treatment options.
Krstevska V
Indian J Cancer 2012 Apr-Jun;49(2):236-44. doi: 10.4103/0019-509X.102920. PMID: 23107977
Pyriform sinus cancer: a clinical and laboratory study.
Kirchner JA
Ann Otol Rhinol Laryngol 1975 Nov-Dec;84(6):793-803. doi: 10.1177/000348947508400611. PMID: 1200569

Diagnosis

Hypopharyngeal carcinoma: Do you know your guidelines?
Kwon DI, Miles BA; Education Committee of the American Head and Neck Society (AHNS)
Head Neck 2019 Mar;41(3):569-576. Epub 2018 Dec 20 doi: 10.1002/hed.24752. PMID: 30570183
Early stage squamous cell carcinoma of the pyriform sinus: a review of treatment options.
Krstevska V
Indian J Cancer 2012 Apr-Jun;49(2):236-44. doi: 10.4103/0019-509X.102920. PMID: 23107977
Unknown primary head and neck cancer treated with intensity-modulated radiation therapy: to what extent the volume should be irradiated.
Lu H, Yao M, Tan H
Oral Oncol 2009 Jun;45(6):474-9. Epub 2008 Sep 18 doi: 10.1016/j.oraloncology.2008.06.006. PMID: 18804408
Outcome of pyriform sinus cancer: a retrospective institutional review.
Marks SC, Lolachi CM, Shamsa F, Robinson K, Aref A, Jacobs JR
Laryngoscope 1996 Jan;106(1 Pt 1):27-31. doi: 10.1097/00005537-199601000-00006. PMID: 8544623
Discrepancies between clinical and histopathologic diagnoses in T3 pyriform sinus cancer.
Tani M, Amatsu M
Laryngoscope 1987 Jan;97(1):93-6. doi: 10.1288/00005537-198701000-00018. PMID: 3796180

Therapy

Oncological and functional outcomes of trans-oral robotic surgery for pyriform sinus carcinoma: A French GETTEC group study.
Mazerolle P, Philouze P, Garrel R, Aubry K, Morinière S, El Bedoui S, Ton Van J, Ferron C, Malard O, Jegoux F, Berard E, Vergez S
Oral Oncol 2018 Nov;86:165-170. Epub 2018 Sep 25 doi: 10.1016/j.oraloncology.2018.09.014. PMID: 30409296
Clinical outcomes of weekly cisplatin chemoradiotherapy for patients with pyriform sinus cancer.
Sakashita T, Homma A, Hatakeyama H, Furusawa J, Kano S, Mizumachi T, Iizuka S, Onimaru R, Tsuchiya K, Yasuda K, Shirato H, Fukuda S
Int J Clin Oncol 2015 Dec;20(6):1081-5. Epub 2015 Mar 25 doi: 10.1007/s10147-015-0821-8. PMID: 25804347
A pyriform sinus cancer organ preservation strategy comprising induction chemotherapy with docetaxel, cisplatin, and 5-fluorouracil, followed by potentiated radiotherapy: a multicenter, retrospective study.
Céruse P, Cosmidis A, Belot A, Rabilloud M, Fuchsmann C, Poupart M, Ramade A, Tartas S, Favrel V, Pommier P, Zrounba P, Fayette J
Anticancer Drugs 2014 Sep;25(8):970-5. doi: 10.1097/CAD.0000000000000126. PMID: 24849707
Early stage squamous cell carcinoma of the pyriform sinus: a review of treatment options.
Krstevska V
Indian J Cancer 2012 Apr-Jun;49(2):236-44. doi: 10.4103/0019-509X.102920. PMID: 23107977
Larynx preservation in pyriform sinus cancer: preliminary results of a European Organization for Research and Treatment of Cancer phase III trial. EORTC Head and Neck Cancer Cooperative Group.
Lefebvre JL, Chevalier D, Luboinski B, Kirkpatrick A, Collette L, Sahmoud T
J Natl Cancer Inst 1996 Jul 3;88(13):890-9. doi: 10.1093/jnci/88.13.890. PMID: 8656441

Prognosis

Hypopharyngeal carcinoma: Do you know your guidelines?
Kwon DI, Miles BA; Education Committee of the American Head and Neck Society (AHNS)
Head Neck 2019 Mar;41(3):569-576. Epub 2018 Dec 20 doi: 10.1002/hed.24752. PMID: 30570183
Oncological and functional outcomes of trans-oral robotic surgery for pyriform sinus carcinoma: A French GETTEC group study.
Mazerolle P, Philouze P, Garrel R, Aubry K, Morinière S, El Bedoui S, Ton Van J, Ferron C, Malard O, Jegoux F, Berard E, Vergez S
Oral Oncol 2018 Nov;86:165-170. Epub 2018 Sep 25 doi: 10.1016/j.oraloncology.2018.09.014. PMID: 30409296
Therapeutic Management of Pyriform Sinus Cancer.
Donnadieu J, Klopp-Dutote N, Biet-Hornstein A, Strunski V, Mortuaire G, Page C
Otolaryngol Head Neck Surg 2017 Mar;156(3):498-503. Epub 2017 Jan 10 doi: 10.1177/0194599816686335. PMID: 28072556
A pyriform sinus cancer organ preservation strategy comprising induction chemotherapy with docetaxel, cisplatin, and 5-fluorouracil, followed by potentiated radiotherapy: a multicenter, retrospective study.
Céruse P, Cosmidis A, Belot A, Rabilloud M, Fuchsmann C, Poupart M, Ramade A, Tartas S, Favrel V, Pommier P, Zrounba P, Fayette J
Anticancer Drugs 2014 Sep;25(8):970-5. doi: 10.1097/CAD.0000000000000126. PMID: 24849707
Early stage squamous cell carcinoma of the pyriform sinus: a review of treatment options.
Krstevska V
Indian J Cancer 2012 Apr-Jun;49(2):236-44. doi: 10.4103/0019-509X.102920. PMID: 23107977

Clinical prediction guides

Lymph node ratio predicts recurrence-free survival and disease-specific survival of patients with pyriform sinus squamous cell carcinoma.
Liu Y, Huang H, Liu J, Wang X, Liu S
Asian J Surg 2023 Jun;46(6):2277-2283. Epub 2022 Sep 29 doi: 10.1016/j.asjsur.2022.09.048. PMID: 36184282
Clinical outcomes of weekly cisplatin chemoradiotherapy for patients with pyriform sinus cancer.
Sakashita T, Homma A, Hatakeyama H, Furusawa J, Kano S, Mizumachi T, Iizuka S, Onimaru R, Tsuchiya K, Yasuda K, Shirato H, Fukuda S
Int J Clin Oncol 2015 Dec;20(6):1081-5. Epub 2015 Mar 25 doi: 10.1007/s10147-015-0821-8. PMID: 25804347
A pyriform sinus cancer organ preservation strategy comprising induction chemotherapy with docetaxel, cisplatin, and 5-fluorouracil, followed by potentiated radiotherapy: a multicenter, retrospective study.
Céruse P, Cosmidis A, Belot A, Rabilloud M, Fuchsmann C, Poupart M, Ramade A, Tartas S, Favrel V, Pommier P, Zrounba P, Fayette J
Anticancer Drugs 2014 Sep;25(8):970-5. doi: 10.1097/CAD.0000000000000126. PMID: 24849707
Larynx preservation in pyriform sinus cancer: preliminary results of a European Organization for Research and Treatment of Cancer phase III trial. EORTC Head and Neck Cancer Cooperative Group.
Lefebvre JL, Chevalier D, Luboinski B, Kirkpatrick A, Collette L, Sahmoud T
J Natl Cancer Inst 1996 Jul 3;88(13):890-9. doi: 10.1093/jnci/88.13.890. PMID: 8656441
The prognostic significance of lymph node involvement in pyriform sinus and supraglottic cancers.
Hahn SS, Spaulding CA, Kim JA, Constable WC
Int J Radiat Oncol Biol Phys 1987 Aug;13(8):1143-7. doi: 10.1016/0360-3016(87)90186-6. PMID: 3610702

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...