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Malignant Splenic Neoplasm

MedGen UID:
102271
•Concept ID:
C0153470
•
Neoplastic Process
Synonyms: Cancer of Spleen; Cancer of the Spleen; Cancer, Spleen; Cancer, Splenic; Cancers, Spleen; Cancers, Splenic; Spleen Cancer; Spleen Cancers; Splenic Cancer; Splenic Cancers
SNOMED CT: Malignant tumor of spleen (363499005)

Definition

A malignant neoplasm affecting the spleen. Representative examples include leukemias, lymphomas, and sarcomas. [from NCI]

Professional guidelines

PubMed

Hepatosplenic T-cell lymphoma: treatment challenges.
Bron D, De Leval L, Michiels S, Wittnebel S; EuroBloodNet for rare diseases
Curr Opin Oncol 2021 Sep 1;33(5):406-411. doi: 10.1097/CCO.0000000000000775. PMID: 34409955
Hairy cell leukemia: 2020 update on diagnosis, risk stratification, and treatment.
Maitre E, Cornet E, Troussard X
Am J Hematol 2019 Dec;94(12):1413-1422. Epub 2019 Oct 31 doi: 10.1002/ajh.25653. PMID: 31591741
2015 ESC Guidelines for the management of infective endocarditis: The Task Force for the Management of Infective Endocarditis of the European Society of Cardiology (ESC). Endorsed by: European Association for Cardio-Thoracic Surgery (EACTS), the European Association of Nuclear Medicine (EANM).
Habib G, Lancellotti P, Antunes MJ, Bongiorni MG, Casalta JP, Del Zotti F, Dulgheru R, El Khoury G, Erba PA, Iung B, Miro JM, Mulder BJ, Plonska-Gosciniak E, Price S, Roos-Hesselink J, Snygg-Martin U, Thuny F, Tornos Mas P, Vilacosta I, Zamorano JL; ESC Scientific Document Group
Eur Heart J 2015 Nov 21;36(44):3075-3128. Epub 2015 Aug 29 doi: 10.1093/eurheartj/ehv319. PMID: 26320109

Recent clinical studies

Etiology

Risk-tailored treatment of splenic marginal zone lymphoma.
Castelli R, Balzarotti M, Salvi E, Simona Rossi R, Lambertenghi Deliliers G, Bergamaschini L, Gidaro A
Anticancer Drugs 2022 Jan 1;33(1):e36-e42. doi: 10.1097/CAD.0000000000001165. PMID: 34407041
Spleen angiosarcoma: a world review.
Juin Hsien BL, Shelat VG
Expert Rev Gastroenterol Hepatol 2021 Oct;15(10):1115-1141. Epub 2021 Jul 22 doi: 10.1080/17474124.2021.1945920. PMID: 34160346
Imaging findings of benign and malignant pediatric splenic lesions.
Ozkale Yavuz O, Ozcan HN, Oguz B, Ayaz E, Ekinci S, Ciftci TT, Haliloglu M
Abdom Radiol (NY) 2021 Jul;46(7):3245-3252. Epub 2021 Mar 4 doi: 10.1007/s00261-021-03004-z. PMID: 33661318
Contemporary management of nodal and primary splenic marginal zone lymphoma.
Leslie LA, Feldman TA, McNeill A, Timberg M, Iida H, Goy AH
Expert Rev Hematol 2019 Dec;12(12):1011-1022. Epub 2019 Nov 12 doi: 10.1080/17474086.2020.1681962. PMID: 31619091
IMMEDIATE AND LATE RESULTS OF THE COMBINED GASTRECTOMY PERFORMANCE FOR LOCALLY—SPREAD GASTRIC CANCER.
Oliynyk YY
Klin Khir 2016 Oct;(10):9-11. PMID: 30479104

Diagnosis

Diagnosis and treatment of focal splenic lesions.
Malgras B, Najah H, Dohan A, Barat M, Soyer P
J Visc Surg 2022 Apr;159(2):121-135. Epub 2022 Mar 3 doi: 10.1016/j.jviscsurg.2021.11.010. PMID: 35249857
A Review on Splenic Diffuse Red Pulp Small B-Cell Lymphoma.
Yilmaz E, Chhina A, Nava VE, Aggarwal A
Curr Oncol 2021 Dec 6;28(6):5148-5154. doi: 10.3390/curroncol28060431. PMID: 34940070Free PMC Article
Spleen angiosarcoma: a world review.
Juin Hsien BL, Shelat VG
Expert Rev Gastroenterol Hepatol 2021 Oct;15(10):1115-1141. Epub 2021 Jul 22 doi: 10.1080/17474124.2021.1945920. PMID: 34160346
Splenic lymphangioma.
Ioannidis I, Kahn AG
Arch Pathol Lab Med 2015 Feb;139(2):278-82. doi: 10.5858/arpa.2013-0656-RS. PMID: 25611113
Nonneoplastic, benign, and malignant splenic diseases: cross-sectional imaging findings and rare disease entities.
Thipphavong S, Duigenan S, Schindera ST, Gee MS, Philips S
AJR Am J Roentgenol 2014 Aug;203(2):315-22. doi: 10.2214/AJR.13.11777. PMID: 25055265

Therapy

Genetic and phenotypic attributes of splenic marginal zone lymphoma.
Bonfiglio F, Bruscaggin A, Guidetti F, Terzi di Bergamo L, Faderl M, Spina V, Condoluci A, Bonomini L, Forestieri G, Koch R, Piffaretti D, Pini K, Pirosa MC, Cittone MG, Arribas A, Lucioni M, Ghilardi G, Wu W, Arcaini L, Baptista MJ, Bastidas G, Bea S, Boldorini R, Broccoli A, Buehler MM, Canzonieri V, Cascione L, Ceriani L, Cogliatti S, Corradini P, Derenzini E, Devizzi L, Dietrich S, Elia AR, Facchetti F, Gaidano G, Garcia JF, Gerber B, Ghia P, Gomes da Silva M, Gritti G, Guidetti A, Hitz F, Inghirami G, Ladetto M, Lopez-Guillermo A, Lucchini E, Maiorana A, Marasca R, Matutes E, Meignin V, Merli M, Moccia A, Mollejo M, Montalban C, Novak U, Oscier DG, Passamonti F, Piazza F, Pizzolitto S, Rambaldi A, Sabattini E, Salles G, Santambrogio E, Scarfò L, Stathis A, Stüssi G, Geyer JT, Tapia G, Tarella C, Thieblemont C, Tousseyn T, Tucci A, Vanini G, Visco C, Vitolo U, Walewska R, Zaja F, Zenz T, Zinzani PL, Khiabanian H, Calcinotto A, Bertoni F, Bhagat G, Campo E, De Leval L, Dirnhofer S, Pileri SA, Piris MA, Traverse-Glehen A, Tzankov A, Paulli M, Ponzoni M, Mazzucchelli L, Cavalli F, Zucca E, Rossi D
Blood 2022 Feb 3;139(5):732-747. doi: 10.1182/blood.2021012386. PMID: 34653238
Organ-specific cholesterol metabolic aberration fuels liver metastasis of colorectal cancer.
Zhang KL, Zhu WW, Wang SH, Gao C, Pan JJ, Du ZG, Lu L, Jia HL, Dong QZ, Chen JH, Lu M, Qin LX
Theranostics 2021;11(13):6560-6572. Epub 2021 Apr 27 doi: 10.7150/thno.55609. PMID: 33995676Free PMC Article
Dermatomyositis.
Vizán-Caravaca JR, Cascales-Vallejo AI, Aroza-Espinar M
Med Clin (Barc) 2019 Jan 18;152(2):e11. doi: 10.1016/j.medcli.2018.03.024. PMID: 29759882
Immune checkpoint therapy in liver cancer.
Xu F, Jin T, Zhu Y, Dai C
J Exp Clin Cancer Res 2018 May 29;37(1):110. doi: 10.1186/s13046-018-0777-4. PMID: 29843754Free PMC Article
Splenic marginal zone lymphoma: from genetics to management.
Arcaini L, Rossi D, Paulli M
Blood 2016 Apr 28;127(17):2072-81. Epub 2016 Mar 17 doi: 10.1182/blood-2015-11-624312. PMID: 26989207

Prognosis

Hepatosplenic T-cell lymphoma: a rare but challenging entity.
Pro B, Allen P, Behdad A
Blood 2020 Oct 29;136(18):2018-2026. doi: 10.1182/blood.2019004118. PMID: 32756940Free PMC Article
Contemporary management of nodal and primary splenic marginal zone lymphoma.
Leslie LA, Feldman TA, McNeill A, Timberg M, Iida H, Goy AH
Expert Rev Hematol 2019 Dec;12(12):1011-1022. Epub 2019 Nov 12 doi: 10.1080/17474086.2020.1681962. PMID: 31619091
Molecular pathogenesis of splenic and nodal marginal zone lymphoma.
Spina V, Rossi D
Best Pract Res Clin Haematol 2017 Mar-Jun;30(1-2):5-12. Epub 2016 Nov 4 doi: 10.1016/j.beha.2016.09.004. PMID: 28288716
Splenic marginal zone lymphoma: from genetics to management.
Arcaini L, Rossi D, Paulli M
Blood 2016 Apr 28;127(17):2072-81. Epub 2016 Mar 17 doi: 10.1182/blood-2015-11-624312. PMID: 26989207
Splenic lymphangioma.
Ioannidis I, Kahn AG
Arch Pathol Lab Med 2015 Feb;139(2):278-82. doi: 10.5858/arpa.2013-0656-RS. PMID: 25611113

Clinical prediction guides

Comparison of laparoscopic and open colectomy for splenic flexure colon cancer: a systematic review and meta-analysis.
Wu J, Li B, Tu S, Zheng B, Chen B
Int J Colorectal Dis 2022 Apr;37(4):757-767. Epub 2022 Mar 18 doi: 10.1007/s00384-022-04127-5. PMID: 35303158
Risk-tailored treatment of splenic marginal zone lymphoma.
Castelli R, Balzarotti M, Salvi E, Simona Rossi R, Lambertenghi Deliliers G, Bergamaschini L, Gidaro A
Anticancer Drugs 2022 Jan 1;33(1):e36-e42. doi: 10.1097/CAD.0000000000001165. PMID: 34407041
Localized malignant mesothelioma, an unusual and poorly characterized neoplasm of serosal origin: best current evidence from the literature and the International Mesothelioma Panel.
Marchevsky AM, Khoor A, Walts AE, Nicholson AG, Zhang YZ, Roggli V, Carney J, Roden AC, Tazelaar HD, Larsen BT, LeStang N, Chirieac LR, Klebe S, Tsao MS, De Perrot M, Pierre A, Hwang DM, Hung YP, Mino-Kenudson M, Travis W, Sauter J, Beasley MB, Galateau-Sallé F
Mod Pathol 2020 Feb;33(2):281-296. Epub 2019 Sep 4 doi: 10.1038/s41379-019-0352-3. PMID: 31485011Free PMC Article
Contemporary management of nodal and primary splenic marginal zone lymphoma.
Leslie LA, Feldman TA, McNeill A, Timberg M, Iida H, Goy AH
Expert Rev Hematol 2019 Dec;12(12):1011-1022. Epub 2019 Nov 12 doi: 10.1080/17474086.2020.1681962. PMID: 31619091
IMMEDIATE AND LATE RESULTS OF THE COMBINED GASTRECTOMY PERFORMANCE FOR LOCALLY—SPREAD GASTRIC CANCER.
Oliynyk YY
Klin Khir 2016 Oct;(10):9-11. PMID: 30479104

Recent systematic reviews

Splenic vessels preserving versus Warshaw technique in spleen preserving distal pancreatectomy: A systematic review and meta-analysis.
Hang K, Zhou L, Liu H, Huang Y, Zhang H, Tan C, Xiong J, Li K
Int J Surg 2022 Jul;103:106686. Epub 2022 May 20 doi: 10.1016/j.ijsu.2022.106686. PMID: 35605839
Comparison of laparoscopic and open colectomy for splenic flexure colon cancer: a systematic review and meta-analysis.
Wu J, Li B, Tu S, Zheng B, Chen B
Int J Colorectal Dis 2022 Apr;37(4):757-767. Epub 2022 Mar 18 doi: 10.1007/s00384-022-04127-5. PMID: 35303158
Surgical approaches for minimally invasive distal pancreatectomy: A systematic review.
Ban D, Garbarino GM, Ishikawa Y, Honda G, Jang JY, Kang CM, Maekawa A, Murase Y, Nagakawa Y, Nishino H, Ohtsuka T, Yiengpruksawan A, Endo I, Tsuchida A, Nakamura M; Study group of Precision Anatomy for Minimally Invasive Hepato-Biliary-Pancreatic surgery (PAM-HBP surgery)
J Hepatobiliary Pancreat Sci 2022 Jan;29(1):151-160. Epub 2021 Feb 25 doi: 10.1002/jhbp.902. PMID: 33527758
Splenic irradiation for splenomegaly: A systematic review.
Zaorsky NG, Williams GR, Barta SK, Esnaola NF, Kropf PL, Hayes SB, Meyer JE
Cancer Treat Rev 2017 Feb;53:47-52. Epub 2016 Dec 22 doi: 10.1016/j.ctrv.2016.11.016. PMID: 28063304Free PMC Article
Splenic Preservation Versus Splenectomy During Distal Pancreatectomy: A Systematic Review and Meta-analysis.
Shi N, Liu SL, Li YT, You L, Dai MH, Zhao YP
Ann Surg Oncol 2016 Feb;23(2):365-74. doi: 10.1245/s10434-015-4870-z. PMID: 26493758

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