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Malignant Exocervical Neoplasm

MedGen UID:
102275
•Concept ID:
C0153570
•
Neoplastic Process
Synonyms: Cancer of exocervix; Malignant Exocervical Tumor; Malignant Exocervix Neoplasm; Malignant Exocervix Tumor; Malignant neoplasm of exocervix; Malignant Neoplasm of Exocervix; Malignant Neoplasm of the Exocervix; Malignant Neoplasm of the Uterine Exocervix; Malignant Neoplasm of Uterine Exocervix; Malignant Tumor of Exocervix; Malignant Tumor of the Exocervix; Malignant Tumor of the Uterine Exocervix; Malignant Tumor of Uterine Exocervix; Malignant Uterine Exocervix Neoplasm; Malignant Uterine Exocervix Tumor
SNOMED CT: Malignant neoplasm of exocervix (372099007); Cancer of exocervix (372099007)

Definition

A malignant neoplasm that affects the exocervix. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMalignant Exocervical Neoplasm

Professional guidelines

PubMed

Human papilloma virus risk factors for infection and genotype distribution in aboriginal women from Northern Argentina.
Deluca GD, Basiletti J, González JV, Díaz Vásquez N, Lucero RH, Picconi MA
Medicina (B Aires) 2012;72(6):461-6. PMID: 23241287
HSP60 and HSP10 as diagnostic and prognostic tools in the management of exocervical carcinoma.
Cappello F
Gynecol Oncol 2003 Dec;91(3):661. doi: 10.1016/j.ygyno.2003.08.009. PMID: 14675699
Diagnosis, treatment and follow-up of H.P.V.-C.I.N.
Mateos Burguillo JF, Rodriguez Zarauz R, Uguet de Resayre C, Bajo Arenas JM
Eur J Gynaecol Oncol 1995;16(1):48-53. PMID: 7744116

Recent clinical studies

Etiology

Do fertile women have an inferior treatment for high-grade precancerous lesions?
Kim M, Cho HY, Lee J, Suh DH, Kim K, No JH, Kim YB
J Obstet Gynaecol Res 2018 Apr;44(4):772-777. Epub 2018 Jan 25 doi: 10.1111/jog.13582. PMID: 29369475
Endocervical margin involvement as an important risk factor for abnormal cytology after LLETZ.
Cho HY, Kim YB, Hong No J, Kim K
Int J Gynecol Pathol 2012 Jul;31(4):377-81. doi: 10.1097/PGP.0b013e31823ef970. PMID: 22653353
Atypical Papanicolaou smear in pregnancy.
Connolly TP, Evans AC
Clin Med Res 2005 Feb;3(1):13-8. doi: 10.3121/cmr.3.1.13. PMID: 15962016Free PMC Article
Management of early-stage cervical carcinoma by modified (Type II) radical hysterectomy.
Michalas S, Rodolakis A, Voulgaris Z, Vlachos G, Giannakoulis N, Diakomanolis E
Gynecol Oncol 2002 Jun;85(3):415-22. doi: 10.1006/gyno.2002.6633. PMID: 12051867
Transformation zone location and intraepithelial neoplasia of the cervix uteri.
Autier P, Coibion M, Huet F, Grivegnee AR
Br J Cancer 1996 Aug;74(3):488-90. doi: 10.1038/bjc.1996.388. PMID: 8695371Free PMC Article

Diagnosis

Atypical Papanicolaou smear in pregnancy.
Connolly TP, Evans AC
Clin Med Res 2005 Feb;3(1):13-8. doi: 10.3121/cmr.3.1.13. PMID: 15962016Free PMC Article
Ten kilodalton heat shock protein (HSP10) is overexpressed during carcinogenesis of large bowel and uterine exocervix.
Cappello F, Bellafiore M, David S, Anzalone R, Zummo G
Cancer Lett 2003 Jun 30;196(1):35-41. doi: 10.1016/s0304-3835(03)00212-x. PMID: 12860287
Association of human papillomavirus viral load with HPV16 and high-grade intraepithelial lesion.
Abba MC, Mourón SA, Gómez MA, Dulout FN, Golijow CD
Int J Gynecol Cancer 2003 Mar-Apr;13(2):154-8. doi: 10.1046/j.1525-1438.2003.13011.x. PMID: 12657116
Management of early-stage cervical carcinoma by modified (Type II) radical hysterectomy.
Michalas S, Rodolakis A, Voulgaris Z, Vlachos G, Giannakoulis N, Diakomanolis E
Gynecol Oncol 2002 Jun;85(3):415-22. doi: 10.1006/gyno.2002.6633. PMID: 12051867
Transformation zone location and intraepithelial neoplasia of the cervix uteri.
Autier P, Coibion M, Huet F, Grivegnee AR
Br J Cancer 1996 Aug;74(3):488-90. doi: 10.1038/bjc.1996.388. PMID: 8695371Free PMC Article

Therapy

Do fertile women have an inferior treatment for high-grade precancerous lesions?
Kim M, Cho HY, Lee J, Suh DH, Kim K, No JH, Kim YB
J Obstet Gynaecol Res 2018 Apr;44(4):772-777. Epub 2018 Jan 25 doi: 10.1111/jog.13582. PMID: 29369475
Hsp60 and Hspl0 as antitumor molecular agents.
Cappello F, Czarnecka AM, La Rocca G, Di Stefano A, Zummo G, Macario AJ
Cancer Biol Ther 2007 Apr;6(4):487-9. doi: 10.4161/cbt.6.4.4087. PMID: 17457039
Comparative study of laparoscopico-vaginal radical hysterectomy and abdominal radical hysterectomy in patients with early cervical cancer.
Nam JH, Kim JH, Kim DY, Kim MK, Yoo HJ, Kim YM, Kim YT, Mok JE
Gynecol Oncol 2004 Jan;92(1):277-83. doi: 10.1016/j.ygyno.2003.09.003. PMID: 14751171
Management of early-stage cervical carcinoma by modified (Type II) radical hysterectomy.
Michalas S, Rodolakis A, Voulgaris Z, Vlachos G, Giannakoulis N, Diakomanolis E
Gynecol Oncol 2002 Jun;85(3):415-22. doi: 10.1006/gyno.2002.6633. PMID: 12051867
Pure cutting current for loop excision of squamous intraepithelial lesions.
McLucas B, McGill J
J Reprod Med 1994 May;39(5):373-6. PMID: 8064704

Prognosis

Ten kilodalton heat shock protein (HSP10) is overexpressed during carcinogenesis of large bowel and uterine exocervix.
Cappello F, Bellafiore M, David S, Anzalone R, Zummo G
Cancer Lett 2003 Jun 30;196(1):35-41. doi: 10.1016/s0304-3835(03)00212-x. PMID: 12860287
Management of early-stage cervical carcinoma by modified (Type II) radical hysterectomy.
Michalas S, Rodolakis A, Voulgaris Z, Vlachos G, Giannakoulis N, Diakomanolis E
Gynecol Oncol 2002 Jun;85(3):415-22. doi: 10.1006/gyno.2002.6633. PMID: 12051867
Diagnosis, treatment and follow-up of H.P.V.-C.I.N.
Mateos Burguillo JF, Rodriguez Zarauz R, Uguet de Resayre C, Bajo Arenas JM
Eur J Gynaecol Oncol 1995;16(1):48-53. PMID: 7744116
Pure cutting current for loop excision of squamous intraepithelial lesions.
McLucas B, McGill J
J Reprod Med 1994 May;39(5):373-6. PMID: 8064704
Cervical intraepithelial neoplasia in adolescents.
Jones DE, Russo JF, Dombroski RA, Lentz SS
J Adolesc Health Care 1984 Oct;5(4):243-7. doi: 10.1016/s0197-0070(84)80125-4. PMID: 6490479

Clinical prediction guides

Do fertile women have an inferior treatment for high-grade precancerous lesions?
Kim M, Cho HY, Lee J, Suh DH, Kim K, No JH, Kim YB
J Obstet Gynaecol Res 2018 Apr;44(4):772-777. Epub 2018 Jan 25 doi: 10.1111/jog.13582. PMID: 29369475
Ten kilodalton heat shock protein (HSP10) is overexpressed during carcinogenesis of large bowel and uterine exocervix.
Cappello F, Bellafiore M, David S, Anzalone R, Zummo G
Cancer Lett 2003 Jun 30;196(1):35-41. doi: 10.1016/s0304-3835(03)00212-x. PMID: 12860287
Association of human papillomavirus viral load with HPV16 and high-grade intraepithelial lesion.
Abba MC, Mourón SA, Gómez MA, Dulout FN, Golijow CD
Int J Gynecol Cancer 2003 Mar-Apr;13(2):154-8. doi: 10.1046/j.1525-1438.2003.13011.x. PMID: 12657116
Management of early-stage cervical carcinoma by modified (Type II) radical hysterectomy.
Michalas S, Rodolakis A, Voulgaris Z, Vlachos G, Giannakoulis N, Diakomanolis E
Gynecol Oncol 2002 Jun;85(3):415-22. doi: 10.1006/gyno.2002.6633. PMID: 12051867
Integrin beta 4 expression in the neoplastic progression of cervical epithelium.
Carico E, French D, Bucci B, Falcioni R, Vecchione A, Mariani-Costantini R
Gynecol Oncol 1993 Apr;49(1):61-6. doi: 10.1006/gyno.1993.1087. PMID: 7683305

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