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Metastatic Malignant Neoplasm in the Mediastinum

MedGen UID:
102285
•Concept ID:
C0153677
•
Neoplastic Process
Synonyms: Cancer metastatic to mediastinum; Mediastinal metastasis; Metastases to Mediastinum; Metastases to the Mediastinum; Metastasis to mediastinum; Metastasis to the Mediastinum; Metastatic malignant neoplasm of mediastinum; Metastatic malignant neoplasm to mediastinum; Metastatic Malignant Neoplasm to the Mediastinum; Metastatic Neoplasm to the Mediastinum; Metastatic Tumor to the Mediastinum; Secondary malignant neoplasm of mediastinum; Secondary malignant tumor of mediastinum
SNOMED CT: Secondary malignant tumor of mediastinum (94409002); Metastasis to mediastinum (94409002); Mediastinal metastasis (94409002); Secondary malignant neoplasm of mediastinum (94409002); Metastatic malignant neoplasm to mediastinum (94409002); Cancer metastatic to mediastinum (94409002); Metastatic malignant neoplasm of mediastinum (94409002)

Definition

The spread of a malignant neoplasm to the mediastinum from an adjacent or distant anatomic site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Malignant Neoplasm in the Mediastinum

Professional guidelines

PubMed

Current topics and management of head and neck sarcomas.
Kobayashi K, Hanai N, Yoshimoto S, Saito Y, Homma A
Jpn J Clin Oncol 2023 Aug 30;53(9):743-756. doi: 10.1093/jjco/hyad048. PMID: 37309253Free PMC Article
Methods for staging non-small cell lung cancer: Diagnosis and management of lung cancer, 3rd ed: American College of Chest Physicians evidence-based clinical practice guidelines.
Silvestri GA, Gonzalez AV, Jantz MA, Margolis ML, Gould MK, Tanoue LT, Harris LJ, Detterbeck FC
Chest 2013 May;143(5 Suppl):e211S-e250S. doi: 10.1378/chest.12-2355. PMID: 23649440
Thymoma: Diagnosis and treatment.
Singh G, Rumende CM, Amin Z
Acta Med Indones 2011 Jan;43(1):74-8. PMID: 21339550

Recent clinical studies

Etiology

Transbronchial mediastinal cryobiopsy in the diagnosis of mediastinal lesions: a randomised trial.
Zhang J, Guo JR, Huang ZS, Fu WL, Wu XL, Wu N, Kuebler WM, Herth FJF, Fan Y
Eur Respir J 2021 Dec;58(6) Epub 2021 Dec 9 doi: 10.1183/13993003.00055-2021. PMID: 33958432
Common and rare carcinomas of the thymus.
Roden AC, Szolkowska M
Virchows Arch 2021 Jan;478(1):111-128. Epub 2021 Jan 3 doi: 10.1007/s00428-020-03000-6. PMID: 33389148
N2 disease in non-small-cell lung cancer: straight to surgery?
Sanchez-Lorente D, Guzman R, Boada M, Guirao A, Carriel N, Molins L
Future Oncol 2018 Mar;14(6s):13-16. doi: 10.2217/fon-2017-0387. PMID: 29664353
Controversies in the management of stage III non-small-cell lung cancer.
Biswas T, Sharma N, Machtay M
Expert Rev Anticancer Ther 2014 Mar;14(3):333-47. Epub 2014 Jan 8 doi: 10.1586/14737140.2014.867809. PMID: 24397773
CT of pheochromocytoma.
Thomas JL, Bernardino ME, Samaan NA, Hickey RC
AJR Am J Roentgenol 1980 Sep;135(3):477-82. doi: 10.2214/ajr.135.3.477. PMID: 6773365

Diagnosis

Approach to Mediastinal Fine Needle Aspiration Cytology.
Li Z, Xu H, Fan F
Adv Anat Pathol 2022 Nov 1;29(6):337-348. Epub 2022 Jul 18 doi: 10.1097/PAP.0000000000000355. PMID: 35838636
Mediastinal Lymphoproliferative Disorders.
Pina-Oviedo S
Adv Anat Pathol 2021 Sep 1;28(5):307-334. doi: 10.1097/PAP.0000000000000305. PMID: 34074861
Transbronchial mediastinal cryobiopsy in the diagnosis of mediastinal lesions: a randomised trial.
Zhang J, Guo JR, Huang ZS, Fu WL, Wu XL, Wu N, Kuebler WM, Herth FJF, Fan Y
Eur Respir J 2021 Dec;58(6) Epub 2021 Dec 9 doi: 10.1183/13993003.00055-2021. PMID: 33958432
Preoperative staging of the mediastinum is an essential and multidisciplinary task.
Sanz-Santos J, Call S
Respirology 2020 Nov;25 Suppl 2:37-48. Epub 2020 Jul 12 doi: 10.1111/resp.13901. PMID: 32656946
Thymoma: Diagnosis and treatment.
Singh G, Rumende CM, Amin Z
Acta Med Indones 2011 Jan;43(1):74-8. PMID: 21339550

Therapy

Transbronchial mediastinal cryobiopsy in the diagnosis of mediastinal lesions: a randomised trial.
Zhang J, Guo JR, Huang ZS, Fu WL, Wu XL, Wu N, Kuebler WM, Herth FJF, Fan Y
Eur Respir J 2021 Dec;58(6) Epub 2021 Dec 9 doi: 10.1183/13993003.00055-2021. PMID: 33958432
Preoperative staging of the mediastinum is an essential and multidisciplinary task.
Sanz-Santos J, Call S
Respirology 2020 Nov;25 Suppl 2:37-48. Epub 2020 Jul 12 doi: 10.1111/resp.13901. PMID: 32656946
Methods for staging non-small cell lung cancer: Diagnosis and management of lung cancer, 3rd ed: American College of Chest Physicians evidence-based clinical practice guidelines.
Silvestri GA, Gonzalez AV, Jantz MA, Margolis ML, Gould MK, Tanoue LT, Harris LJ, Detterbeck FC
Chest 2013 May;143(5 Suppl):e211S-e250S. doi: 10.1378/chest.12-2355. PMID: 23649440
Thymoma: Diagnosis and treatment.
Singh G, Rumende CM, Amin Z
Acta Med Indones 2011 Jan;43(1):74-8. PMID: 21339550
Malignant respiratory-digestive fistulas.
Rodriguez AN, Diaz-Jimenez JP
Curr Opin Pulm Med 2010 Jul;16(4):329-33. doi: 10.1097/MCP.0b013e3283390de8. PMID: 20531081

Prognosis

Preoperative staging of the mediastinum is an essential and multidisciplinary task.
Sanz-Santos J, Call S
Respirology 2020 Nov;25 Suppl 2:37-48. Epub 2020 Jul 12 doi: 10.1111/resp.13901. PMID: 32656946
The role of endobronchial ultrasound/esophageal ultrasound for evaluation of the mediastinum in lung cancer.
Czarnecka K, Yasufuku K
Expert Rev Respir Med 2014 Dec;8(6):763-76. doi: 10.1586/17476348.2014.985210. PMID: 25395019
The role of surgery in patients with clinical n2 disease.
Mehran R
Thorac Surg Clin 2013 Aug;23(3):327-35. Epub 2013 Jun 4 doi: 10.1016/j.thorsurg.2013.04.007. PMID: 23931016
Multidisciplinary treatment of malignant thymoma.
Spaggiari L, Casiraghi M, Guarize J
Curr Opin Oncol 2012 Mar;24(2):117-22. doi: 10.1097/CCO.0b013e32834ea6bb. PMID: 22143371
CT of pheochromocytoma.
Thomas JL, Bernardino ME, Samaan NA, Hickey RC
AJR Am J Roentgenol 1980 Sep;135(3):477-82. doi: 10.2214/ajr.135.3.477. PMID: 6773365

Clinical prediction guides

Conventional and radiomic features to predict pathology in the preoperative assessment of anterior mediastinal masses.
Mayoral M, Pagano AM, Araujo-Filho JAB, Zheng J, Perez-Johnston R, Tan KS, Gibbs P, Fernandes Shepherd A, Rimner A, Simone II CB, Riely G, Huang J, Ginsberg MS
Lung Cancer 2023 Apr;178:206-212. Epub 2023 Feb 21 doi: 10.1016/j.lungcan.2023.02.014. PMID: 36871345Free PMC Article
Transbronchial mediastinal cryobiopsy in the diagnosis of mediastinal lesions: a randomised trial.
Zhang J, Guo JR, Huang ZS, Fu WL, Wu XL, Wu N, Kuebler WM, Herth FJF, Fan Y
Eur Respir J 2021 Dec;58(6) Epub 2021 Dec 9 doi: 10.1183/13993003.00055-2021. PMID: 33958432
Cervicothoracoscopic Approach in Esophagectomy.
Okamura A, Watanabe M, Imamura Y, Hayami M, Yuda M, Yamashita K, Shoji Y, Mine S
Ann Surg Oncol 2018 Jan;25(1):333. Epub 2017 Oct 30 doi: 10.1245/s10434-017-6119-5. PMID: 29086127
Transcervical extended mediastinal lymphadenectomy.
Zieliński M
Thorac Surg Clin 2010 May;20(2):215-23. doi: 10.1016/j.thorsurg.2010.02.007. PMID: 20451132
Mediastinal tumors.
Thomas CR Jr, Bonomi PD
Curr Opin Oncol 1991 Apr;3(2):335-43. doi: 10.1097/00001622-199104000-00015. PMID: 1648973

Recent systematic reviews

Risk of extracolonic second primary cancers following a primary colorectal cancer: a systematic review and meta-analysis.
Robertson D, Ng SK, Baade PD, Lam AK
Int J Colorectal Dis 2022 Mar;37(3):541-551. Epub 2022 Feb 12 doi: 10.1007/s00384-022-04105-x. PMID: 35152308Free PMC Article
A Systematic Review on Intensity Modulated Radiation Therapy for Mediastinal Hodgkin's Lymphoma.
Buglione M, Guerini AE, Filippi AR, Spiazzi L, Pasinetti N, Magli A, Toraci C, Borghetti P, Triggiani L, Alghisi A, Costantino G, Bertagna F, Giaj Levra N, Pegurri L, Magrini SM
Crit Rev Oncol Hematol 2021 Nov;167:103437. Epub 2021 Aug 3 doi: 10.1016/j.critrevonc.2021.103437. PMID: 34358649
Preoperative Staging by EBUS in cN0/N1 Lung Cancer: Systematic Review and Meta-Analysis.
Leong TL, Loveland PM, Gorelik A, Irving L, Steinfort DP
J Bronchology Interv Pulmonol 2019 Jul;26(3):155-165. doi: 10.1097/LBR.0000000000000545. PMID: 30119069
Endosonography Versus Mediastinoscopy in Mediastinal Staging of Lung Cancer: Systematic Review and Meta-Analysis.
Sehgal IS, Dhooria S, Aggarwal AN, Behera D, Agarwal R
Ann Thorac Surg 2016 Nov;102(5):1747-1755. doi: 10.1016/j.athoracsur.2016.05.110. PMID: 27637288
Status and prognosis of lymph node metastasis in patients with cardia cancer - a systematic review.
Okholm C, Svendsen LB, Achiam MP
Surg Oncol 2014 Sep;23(3):140-6. Epub 2014 Jun 11 doi: 10.1016/j.suronc.2014.06.001. PMID: 24953457

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