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Metastatic malignant neoplasm to bone

MedGen UID:
102288
•Concept ID:
C0153690
•
Neoplastic Process
Synonyms: Bone Metastases; Bone Metastasis; Bony metastasis; Cancer metastatic to bone; Metastatic Cancer to the Bone; Metastatic Malignant Neoplasm in the Bone; Metastatic malignant neoplasm of bone; Metastatic Malignant Neoplasm to the Bone; Metastatic Neoplasm to the Bone; Metastatic tumor of bone; Metastatic Tumor to the Bone; Osseous metastasis; Secondary cancer of bone; Secondary malignant neoplasm of bone; Secondary malignant neoplasm of bone and bone marrow; Secondary Malignant Neoplasm of Bone and Bone Marrow; Tumor metastatic to bone
SNOMED CT: Metastatic tumor of bone (94222008); Secondary cancer of bone (94222008); Secondary malignant neoplasm of bone and bone marrow (94222008); Osseous metastasis (94222008); Bony metastasis (94222008); Secondary malignant neoplasm of bone (94222008); Metastatic malignant neoplasm to bone (94222008); Cancer metastatic to bone (94222008); Tumor metastatic to bone (94222008); Metastatic malignant neoplasm of bone (94222008)

Definition

The spread of a malignant neoplasm from a primary site to the skeletal system. The majority of metastatic neoplasms to the bone are carcinomas. [from NCI]

Professional guidelines

PubMed

Mechanisms, Diagnosis and Treatment of Bone Metastases.
Ban J, Fock V, Aryee DNT, Kovar H
Cells 2021 Oct 29;10(11) doi: 10.3390/cells10112944. PMID: 34831167Free PMC Article
The Diagnosis and Treatment of Prostate Cancer: A Review.
Litwin MS, Tan HJ
JAMA 2017 Jun 27;317(24):2532-2542. doi: 10.1001/jama.2017.7248. PMID: 28655021
Advances in diagnosis and treatment of metastatic cervical cancer.
Li H, Wu X, Cheng X
J Gynecol Oncol 2016 Jul;27(4):e43. doi: 10.3802/jgo.2016.27.e43. PMID: 27171673Free PMC Article

Recent clinical studies

Etiology

Advances in Osteosarcoma.
Panez-Toro I, Muñoz-García J, Vargas-Franco JW, Renodon-Cornière A, Heymann MF, Lézot F, Heymann D
Curr Osteoporos Rep 2023 Aug;21(4):330-343. Epub 2023 Jun 17 doi: 10.1007/s11914-023-00803-9. PMID: 37329384Free PMC Article
Bone Metastasis of Breast Cancer.
Tahara RK, Brewer TM, Theriault RL, Ueno NT
Adv Exp Med Biol 2019;1152:105-129. doi: 10.1007/978-3-030-20301-6_7. PMID: 31456182
Understanding the Bone in Cancer Metastasis.
Fornetti J, Welm AL, Stewart SA
J Bone Miner Res 2018 Dec;33(12):2099-2113. Epub 2018 Nov 26 doi: 10.1002/jbmr.3618. PMID: 30476357
Animal models for bone tissue engineering and modelling disease.
McGovern JA, Griffin M, Hutmacher DW
Dis Model Mech 2018 Apr 23;11(4) doi: 10.1242/dmm.033084. PMID: 29685995Free PMC Article
Hypoxia and Bone Metastatic Disease.
Johnson RW, Sowder ME, Giaccia AJ
Curr Osteoporos Rep 2017 Aug;15(4):231-238. doi: 10.1007/s11914-017-0378-8. PMID: 28597139Free PMC Article

Diagnosis

Advances in Osteosarcoma.
Panez-Toro I, Muñoz-García J, Vargas-Franco JW, Renodon-Cornière A, Heymann MF, Lézot F, Heymann D
Curr Osteoporos Rep 2023 Aug;21(4):330-343. Epub 2023 Jun 17 doi: 10.1007/s11914-023-00803-9. PMID: 37329384Free PMC Article
Chondroblastoma: An Update.
Chen W, DiFrancesco LM
Arch Pathol Lab Med 2017 Jun;141(6):867-871. doi: 10.5858/arpa.2016-0281-RS. PMID: 28557595
Skeletal Scintigraphy.
Montilla-Soler JL, Makanji R
Cancer Control 2017 Apr;24(2):137-146. doi: 10.1177/107327481702400206. PMID: 28441368
Autophagy in osteosarcoma.
O'Farrill JS, Gordon N
Adv Exp Med Biol 2014;804:147-60. doi: 10.1007/978-3-319-04843-7_8. PMID: 24924173
Acrometastases.
Mavrogenis AF, Mimidis G, Kokkalis ZT, Karampi ES, Karampela I, Papagelopoulos PJ, Armaganidis A
Eur J Orthop Surg Traumatol 2014 Apr;24(3):279-83. Epub 2013 Sep 8 doi: 10.1007/s00590-013-1311-1. PMID: 24013815

Therapy

Advances in Osteosarcoma.
Panez-Toro I, Muñoz-García J, Vargas-Franco JW, Renodon-Cornière A, Heymann MF, Lézot F, Heymann D
Curr Osteoporos Rep 2023 Aug;21(4):330-343. Epub 2023 Jun 17 doi: 10.1007/s11914-023-00803-9. PMID: 37329384Free PMC Article
Prostate cancer and bone: clinical presentation and molecular mechanisms.
Wells KV, Krackeler ML, Jathal MK, Parikh M, Ghosh PM, Leach JK, Genetos DC
Endocr Relat Cancer 2023 Sep 1;30(9) Epub 2023 Jul 25 doi: 10.1530/ERC-22-0360. PMID: 37226936Free PMC Article
Bone metastasis: mechanisms, therapies, and biomarkers.
Clézardin P, Coleman R, Puppo M, Ottewell P, Bonnelye E, Paycha F, Confavreux CB, Holen I
Physiol Rev 2021 Jul 1;101(3):797-855. Epub 2020 Dec 24 doi: 10.1152/physrev.00012.2019. PMID: 33356915
Skeletal Scintigraphy.
Montilla-Soler JL, Makanji R
Cancer Control 2017 Apr;24(2):137-146. doi: 10.1177/107327481702400206. PMID: 28441368
Bisphosphonates: mechanism of action and role in clinical practice.
Drake MT, Clarke BL, Khosla S
Mayo Clin Proc 2008 Sep;83(9):1032-45. doi: 10.4065/83.9.1032. PMID: 18775204Free PMC Article

Prognosis

Mammary tumour cells remodel the bone marrow vascular microenvironment to support metastasis.
Yip RKH, Rimes JS, Capaldo BD, Vaillant F, Mouchemore KA, Pal B, Chen Y, Surgenor E, Murphy AJ, Anderson RL, Smyth GK, Lindeman GJ, Hawkins ED, Visvader JE
Nat Commun 2021 Nov 26;12(1):6920. doi: 10.1038/s41467-021-26556-6. PMID: 34836954Free PMC Article
Hypoxic Microenvironment and Metastatic Bone Disease.
Hiraga T
Int J Mol Sci 2018 Nov 9;19(11) doi: 10.3390/ijms19113523. PMID: 30423905Free PMC Article
Hallmarks of Bone Metastasis.
Johnson RW, Suva LJ
Calcif Tissue Int 2018 Feb;102(2):141-151. Epub 2017 Nov 14 doi: 10.1007/s00223-017-0362-4. PMID: 29138883Free PMC Article
Acrometastases.
Mavrogenis AF, Mimidis G, Kokkalis ZT, Karampi ES, Karampela I, Papagelopoulos PJ, Armaganidis A
Eur J Orthop Surg Traumatol 2014 Apr;24(3):279-83. Epub 2013 Sep 8 doi: 10.1007/s00590-013-1311-1. PMID: 24013815
Bisphosphonates in oncology.
Coleman RE, McCloskey EV
Bone 2011 Jul;49(1):71-6. Epub 2011 Feb 21 doi: 10.1016/j.bone.2011.02.003. PMID: 21320652

Clinical prediction guides

Non-bone metastatic cancers promote osteocyte-induced bone destruction.
Pin F, Prideaux M, Huot JR, Essex AL, Plotkin LI, Bonetto A, Bonewald LF
Cancer Lett 2021 Nov 1;520:80-90. Epub 2021 Jul 4 doi: 10.1016/j.canlet.2021.06.030. PMID: 34233150Free PMC Article
Molecular Imaging of Bone Metastases and Their Response to Therapy.
Cook GJR, Goh V
J Nucl Med 2020 Jun;61(6):799-806. Epub 2020 Apr 3 doi: 10.2967/jnumed.119.234260. PMID: 32245899
Novel Techniques to Study the Bone-Tumor Microenvironment.
Shupp AB, Kolb AD, Bussard KM
Adv Exp Med Biol 2020;1225:1-18. doi: 10.1007/978-3-030-35727-6_1. PMID: 32030644
MicroRNAs in osteosarcomagenesis.
Kafchinski LA, Jones KB
Adv Exp Med Biol 2014;804:119-27. doi: 10.1007/978-3-319-04843-7_6. PMID: 24924171
Osteosarcoma.
Gorlick R, Khanna C
J Bone Miner Res 2010 Apr;25(4):683-91. doi: 10.1002/jbmr.77. PMID: 20205169

Recent systematic reviews

Management of Metastatic Clear Cell Renal Cell Carcinoma: ASCO Guideline.
Rathmell WK, Rumble RB, Van Veldhuizen PJ, Al-Ahmadie H, Emamekhoo H, Hauke RJ, Louie AV, Milowsky MI, Molina AM, Rose TL, Siva S, Zaorsky NG, Zhang T, Qamar R, Kungel TM, Lewis B, Singer EA
J Clin Oncol 2022 Sep 1;40(25):2957-2995. Epub 2022 Jun 21 doi: 10.1200/JCO.22.00868. PMID: 35728020
Use of Adjuvant Bisphosphonates and Other Bone-Modifying Agents in Breast Cancer: ASCO-OH (CCO) Guideline Update.
Eisen A, Somerfield MR, Accordino MK, Blanchette PS, Clemons MJ, Dhesy-Thind S, Dillmon MS, D'Oronzo S, Fletcher GG, Frank ES, Hallmeyer S, Makhoul I, Moy B, Thawer A, Wu JY, Van Poznak CH
J Clin Oncol 2022 Mar 1;40(7):787-800. Epub 2022 Jan 18 doi: 10.1200/JCO.21.02647. PMID: 35041467
Radiotherapy of oligometastatic prostate cancer: a systematic review.
Rogowski P, Roach M 3rd, Schmidt-Hegemann NS, Trapp C, von Bestenbostel R, Shi R, Buchner A, Stief C, Belka C, Li M
Radiat Oncol 2021 Mar 9;16(1):50. doi: 10.1186/s13014-021-01776-8. PMID: 33750437Free PMC Article
Management of Male Breast Cancer: ASCO Guideline.
Hassett MJ, Somerfield MR, Baker ER, Cardoso F, Kansal KJ, Kwait DC, Plichta JK, Ricker C, Roshal A, Ruddy KJ, Safer JD, Van Poznak C, Yung RL, Giordano SH
J Clin Oncol 2020 Jun 1;38(16):1849-1863. Epub 2020 Feb 14 doi: 10.1200/JCO.19.03120. PMID: 32058842
Prostate Radiotherapy for Metastatic Hormone-sensitive Prostate Cancer: A STOPCAP Systematic Review and Meta-analysis.
Burdett S, Boevé LM, Ingleby FC, Fisher DJ, Rydzewska LH, Vale CL, van Andel G, Clarke NW, Hulshof MC, James ND, Parker CC, Parmar MK, Sweeney CJ, Sydes MR, Tombal B, Verhagen PC, Tierney JF; STOPCAP M1 Radiotherapy Collaborators
Eur Urol 2019 Jul;76(1):115-124. Epub 2019 Feb 28 doi: 10.1016/j.eururo.2019.02.003. PMID: 30826218Free PMC Article

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