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Benign neoplasm of esophagus

MedGen UID:
102297
•Concept ID:
C0153942
•
Neoplastic Process
Synonyms: Benign Esophageal Neoplasm; benign esophageal neoplasm; Benign Esophageal Tumor; benign esophageal tumor; Benign Esophagus Neoplasm; benign esophagus neoplasm; Benign Esophagus Tumor; benign esophagus tumor; Benign Neoplasm of Esophagus; benign neoplasm of esophagus; Benign Neoplasm of the Esophagus; benign neoplasm of the esophagus; Benign tumor of esophagus; Benign Tumor of Esophagus; benign tumor of esophagus; Benign Tumor of the Esophagus; benign tumor of the esophagus; esophagus benign neoplasm
SNOMED CT: Benign tumor of esophagus (92091003); Benign neoplasm of esophagus (92091003)
 
Monarch Initiative: MONDO:0021459

Definition

A non-metastasizing neoplasm arising from the esophageal wall. [from NCI]

Professional guidelines

PubMed

AGA Clinical Practice Update on the Personalized Approach to the Evaluation and Management of GERD: Expert Review.
Yadlapati R, Gyawali CP, Pandolfino JE; CGIT GERD Consensus Conference Participants
Clin Gastroenterol Hepatol 2022 May;20(5):984-994.e1. Epub 2022 Feb 2 doi: 10.1016/j.cgh.2022.01.025. PMID: 35123084Free PMC Article
Recent progress in multidisciplinary treatment for patients with esophageal cancer.
Watanabe M, Otake R, Kozuki R, Toihata T, Takahashi K, Okamura A, Imamura Y
Surg Today 2020 Jan;50(1):12-20. Epub 2019 Sep 18 doi: 10.1007/s00595-019-01878-7. PMID: 31535225Free PMC Article
Cancer of the gastroesophageal junction: a diagnosis, classification, and management review.
Chevallay M, Bollschweiler E, Chandramohan SM, Schmidt T, Koch O, Demanzoni G, Mönig S, Allum W
Ann N Y Acad Sci 2018 Dec;1434(1):132-138. Epub 2018 Aug 23 doi: 10.1111/nyas.13954. PMID: 30138540

Recent clinical studies

Etiology

Molecular phenotyping reveals the identity of Barrett's esophagus and its malignant transition.
Nowicki-Osuch K, Zhuang L, Jammula S, Bleaney CW, Mahbubani KT, Devonshire G, Katz-Summercorn A, Eling N, Wilbrey-Clark A, Madissoon E, Gamble J, Di Pietro M, O'Donovan M, Meyer KB, Saeb-Parsy K, Sharrocks AD, Teichmann SA, Marioni JC, Fitzgerald RC
Science 2021 Aug 13;373(6556):760-767. doi: 10.1126/science.abd1449. PMID: 34385390
Esophageal Cancer: Tumor-Node-Metastasis Staging.
Betancourt-Cuellar SL, Benveniste MFK, Palacio DP, Hofstetter WL
Radiol Clin North Am 2021 Mar;59(2):219-229. doi: 10.1016/j.rcl.2020.11.008. PMID: 33551083
Early esophageal cancer: the significance of surgery, endoscopy, and chemoradiation.
Mönig S, Chevallay M, Niclauss N, Zilli T, Fang W, Bansal A, Hoeppner J
Ann N Y Acad Sci 2018 Dec;1434(1):115-123. Epub 2018 Aug 23 doi: 10.1111/nyas.13955. PMID: 30138532
ESOPEC: prospective randomized controlled multicenter phase III trial comparing perioperative chemotherapy (FLOT protocol) to neoadjuvant chemoradiation (CROSS protocol) in patients with adenocarcinoma of the esophagus (NCT02509286).
Hoeppner J, Lordick F, Brunner T, Glatz T, Bronsert P, Röthling N, Schmoor C, Lorenz D, Ell C, Hopt UT, Siewert JR
BMC Cancer 2016 Jul 19;16:503. doi: 10.1186/s12885-016-2564-y. PMID: 27435280Free PMC Article
Achalasia.
Reynolds JC, Parkman HP
Gastroenterol Clin North Am 1989 Jun;18(2):223-55. PMID: 2668168

Diagnosis

Foreword: Esophageal Surgery.
Martin RF
Surg Clin North Am 2021 Jun;101(3):xiii-xv. doi: 10.1016/j.suc.2021.04.001. PMID: 34048772
Esophageal Cancer: Tumor-Node-Metastasis Staging.
Betancourt-Cuellar SL, Benveniste MFK, Palacio DP, Hofstetter WL
Radiol Clin North Am 2021 Mar;59(2):219-229. doi: 10.1016/j.rcl.2020.11.008. PMID: 33551083
Early esophageal cancer: the significance of surgery, endoscopy, and chemoradiation.
Mönig S, Chevallay M, Niclauss N, Zilli T, Fang W, Bansal A, Hoeppner J
Ann N Y Acad Sci 2018 Dec;1434(1):115-123. Epub 2018 Aug 23 doi: 10.1111/nyas.13955. PMID: 30138532
Barrett's esophagus.
Bremner CG, Bremner RM
Surg Clin North Am 1997 Oct;77(5):1115-37. doi: 10.1016/s0039-6109(05)70608-3. PMID: 9347834
Achalasia.
Reynolds JC, Parkman HP
Gastroenterol Clin North Am 1989 Jun;18(2):223-55. PMID: 2668168

Therapy

MATTERHORN: phase III study of durvalumab plus FLOT chemotherapy in resectable gastric/gastroesophageal junction cancer.
Janjigian YY, Van Cutsem E, Muro K, Wainberg Z, Al-Batran SE, Hyung WJ, Molena D, Marcovitz M, Ruscica D, Robbins SH, Negro A, Tabernero J
Future Oncol 2022 Jun;18(20):2465-2473. Epub 2022 May 10 doi: 10.2217/fon-2022-0093. PMID: 35535555
Assessment of Pembrolizumab Therapy for the Treatment of Microsatellite Instability-High Gastric or Gastroesophageal Junction Cancer Among Patients in the KEYNOTE-059, KEYNOTE-061, and KEYNOTE-062 Clinical Trials.
Chao J, Fuchs CS, Shitara K, Tabernero J, Muro K, Van Cutsem E, Bang YJ, De Vita F, Landers G, Yen CJ, Chau I, Elme A, Lee J, Özgüroglu M, Catenacci D, Yoon HH, Chen E, Adelberg D, Shih CS, Shah S, Bhagia P, Wainberg ZA
JAMA Oncol 2021 Jun 1;7(6):895-902. doi: 10.1001/jamaoncol.2021.0275. PMID: 33792646Free PMC Article
Recent progress in multidisciplinary treatment for patients with esophageal cancer.
Watanabe M, Otake R, Kozuki R, Toihata T, Takahashi K, Okamura A, Imamura Y
Surg Today 2020 Jan;50(1):12-20. Epub 2019 Sep 18 doi: 10.1007/s00595-019-01878-7. PMID: 31535225Free PMC Article
Endoscopic Management of Early Adenocarcinoma and Squamous Cell Carcinoma of the Esophagus: Screening, Diagnosis, and Therapy.
di Pietro M, Canto MI, Fitzgerald RC
Gastroenterology 2018 Jan;154(2):421-436. Epub 2017 Aug 2 doi: 10.1053/j.gastro.2017.07.041. PMID: 28778650Free PMC Article
Esophageal Cancer.
Short MW, Burgers KG, Fry VT
Am Fam Physician 2017 Jan 1;95(1):22-28. PMID: 28075104

Prognosis

Neoplastic and pre-neoplastic lesions of the oesophagus and gastro-oesophageal junction.
Grillo F, Mastracci L, Saragoni L, Vanoli A, Limarzi F, Gullo I, Ferro J, Paudice M, Parente P, Fassan M
Pathologica 2020 Sep;112(3):138-152. doi: 10.32074/1591-951X-164. PMID: 33179618Free PMC Article
A phase 3 study of nivolumab in previously treated advanced gastric or gastroesophageal junction cancer (ATTRACTION-2): 2-year update data.
Chen LT, Satoh T, Ryu MH, Chao Y, Kato K, Chung HC, Chen JS, Muro K, Kang WK, Yeh KH, Yoshikawa T, Oh SC, Bai LY, Tamura T, Lee KW, Hamamoto Y, Kim JG, Chin K, Oh DY, Minashi K, Cho JY, Tsuda M, Sameshima H, Kang YK, Boku N
Gastric Cancer 2020 May;23(3):510-519. Epub 2019 Dec 20 doi: 10.1007/s10120-019-01034-7. PMID: 31863227Free PMC Article
Esophagojejunal anastomotic leakage following gastrectomy for gastric cancer.
Makuuchi R, Irino T, Tanizawa Y, Bando E, Kawamura T, Terashima M
Surg Today 2019 Mar;49(3):187-196. Epub 2018 Oct 13 doi: 10.1007/s00595-018-1726-8. PMID: 30317492
The relevance and implications of signet-ring cell adenocarcinoma of the oesophagus.
Bleaney CW, Barrow M, Hayes S, Ang Y
J Clin Pathol 2018 Mar;71(3):201-206. Epub 2017 Dec 6 doi: 10.1136/jclinpath-2017-204863. PMID: 29212656
Barrett's oesophagus: Current controversies.
Amadi C, Gatenby P
World J Gastroenterol 2017 Jul 28;23(28):5051-5067. doi: 10.3748/wjg.v23.i28.5051. PMID: 28811703Free PMC Article

Clinical prediction guides

SIRGs score may be a predictor of prognosis and immunotherapy response for esophagogastric junction adenocarcinoma.
OuYang LY, Deng ZJ, You YF, Fang JM, Chen XJ, Liu JJ, Li XZ, Lian L, Chen S
Front Immunol 2022;13:977894. Epub 2022 Aug 16 doi: 10.3389/fimmu.2022.977894. PMID: 36052090Free PMC Article
Neuroendocrine neoplasms of the esophagus and stomach.
Mastracci L, Rindi G, Grillo F, Solcia E, Campora M, Fassan M, Parente P, Vanoli A, La Rosa S
Pathologica 2021 Feb;113(1):5-11. doi: 10.32074/1591-951X-229. PMID: 33686305Free PMC Article
Management of Barrett's esophagus with low-grade dysplasia.
Harrison M, Allen JE, Gorrepati VS, López-Jamar JME, Sharma P
Dis Esophagus 2018 Apr 1;31(4) doi: 10.1093/dote/doy004. PMID: 29506235
Barrett's Esophagus: A Comprehensive and Contemporary Review for Pathologists.
Naini BV, Souza RF, Odze RD
Am J Surg Pathol 2016 May;40(5):e45-66. doi: 10.1097/PAS.0000000000000598. PMID: 26813745Free PMC Article
Magnitude of Missed Esophageal Adenocarcinoma After Barrett's Esophagus Diagnosis: A Systematic Review and Meta-analysis.
Visrodia K, Singh S, Krishnamoorthi R, Ahlquist DA, Wang KK, Iyer PG, Katzka DA
Gastroenterology 2016 Mar;150(3):599-607.e7; quiz e14-5. Epub 2015 Nov 24 doi: 10.1053/j.gastro.2015.11.040. PMID: 26619962Free PMC Article

Recent systematic reviews

Serum 25-Hydroxyvitamin D and Cancer Risk: A Systematic Review of Mendelian Randomization Studies.
Lawler T, Warren Andersen S
Nutrients 2023 Jan 13;15(2) doi: 10.3390/nu15020422. PMID: 36678292Free PMC Article
Appraising the causal role of smoking in multiple diseases: A systematic review and meta-analysis of Mendelian randomization studies.
Larsson SC, Burgess S
EBioMedicine 2022 Aug;82:104154. Epub 2022 Jul 8 doi: 10.1016/j.ebiom.2022.104154. PMID: 35816897Free PMC Article
Adjuvant and neoadjuvant breast cancer treatments: A systematic review of their effects on mortality.
Kerr AJ, Dodwell D, McGale P, Holt F, Duane F, Mannu G, Darby SC, Taylor CW
Cancer Treat Rev 2022 Apr;105:102375. Epub 2022 Mar 4 doi: 10.1016/j.ctrv.2022.102375. PMID: 35367784Free PMC Article
Work stress and the risk of cancer: A meta-analysis of observational studies.
Yang T, Qiao Y, Xiang S, Li W, Gan Y, Chen Y
Int J Cancer 2019 May 15;144(10):2390-2400. Epub 2018 Dec 8 doi: 10.1002/ijc.31955. PMID: 30484859
Alcohol consumption and risk of cancer: a systematic literature review.
de Menezes RF, Bergmann A, Thuler LC
Asian Pac J Cancer Prev 2013;14(9):4965-72. doi: 10.7314/apjcp.2013.14.9.4965. PMID: 24175760

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