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Benign neoplasm of mediastinum

MedGen UID:
102298
Concept ID:
C0153956
Neoplastic Process
Synonyms: Benign Mediastinal Neoplasm; benign mediastinal neoplasm; Benign Mediastinal Neoplasms NOS; Benign Mediastinal Tumor; benign mediastinal tumor; benign mediastinal tumour; Benign Neoplasm of Mediastinum; benign neoplasm of mediastinum; Benign Neoplasm of the Mediastinum; benign neoplasm of the mediastinum; Benign tumor of mediastinum; Benign Tumor of Mediastinum; benign tumor of mediastinum; Benign Tumor of the Mediastinum; benign tumor of the mediastinum; benign tumour of mediastinum; benign tumour of the mediastinum; mediastinum benign neoplasm
SNOMED CT: Benign tumor of mediastinum (92214000); Benign neoplasm of mediastinum (92214000)
 
Monarch Initiative: MONDO:0021521

Definition

A neoplasm that arises from the mediastinum and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. Representative examples include lipoma, leiomyoma, and schwannoma. [from NCI]

Professional guidelines

PubMed

Tamanna MT, Egbune C
Cancer Treat Res 2023;185:79-89. doi: 10.1007/978-3-031-27156-4_5. PMID: 37306905
Kim JH, Choe J, Kim HK, Lee HY
Korean J Radiol 2023 Jan;24(1):62-78. doi: 10.3348/kjr.2022.0606. PMID: 36606621Free PMC Article
Ahmed Z, Afridi SS, Shahid Z, Zamani Z, Rehman S, Aiman W, Khan M, Mir MA, Awan FT, Anwer F, Iftikhar R
Clin Lymphoma Myeloma Leuk 2021 Nov;21(11):e865-e875. Epub 2021 Jun 24 doi: 10.1016/j.clml.2021.06.012. PMID: 34330673

Recent clinical studies

Etiology

Botana-Rial M, Lojo-Rodríguez I, Leiro-Fernández V, Ramos-Hernández C, González-Montaos A, Pazos-Area L, Núñez-Delgado M, Fernández-Villar A
Respir Med 2023 Nov;218:107389. Epub 2023 Aug 12 doi: 10.1016/j.rmed.2023.107389. PMID: 37579981
Sreedher G, Tadros SS, Janitz E
Pediatr Radiol 2022 Sep;52(10):1935-1947. Epub 2022 Jun 8 doi: 10.1007/s00247-022-05409-4. PMID: 35674800
Choi JH, Ro JY
Semin Diagn Pathol 2022 Mar;39(2):120-130. Epub 2021 Jun 15 doi: 10.1053/j.semdp.2021.06.007. PMID: 34167847
Carter BW, Benveniste MF, Madan R, Godoy MC, de Groot PM, Truong MT, Rosado-de-Christenson ML, Marom EM
Radiographics 2017 Mar-Apr;37(2):413-436. Epub 2017 Jan 27 doi: 10.1148/rg.2017160095. PMID: 28129068
Stigt JA, Boers JE, Oostdijk AH, van den Berg JW, Groen HJ
J Thorac Oncol 2011 Aug;6(8):1345-9. doi: 10.1097/JTO.0b013e31821d41c8. PMID: 21587083

Diagnosis

Dunne EG, Fick CN, Jones DR
J Clin Oncol 2023 Aug 1;41(22):3785-3790. Epub 2023 Jun 2 doi: 10.1200/JCO.23.00867. PMID: 37267507Free PMC Article
Sreedher G, Tadros SS, Janitz E
Pediatr Radiol 2022 Sep;52(10):1935-1947. Epub 2022 Jun 8 doi: 10.1007/s00247-022-05409-4. PMID: 35674800
Marx A, Chan JKC, Chalabreysse L, Dacic S, Detterbeck F, French CA, Hornick JL, Inagaki H, Jain D, Lazar AJ, Marino M, Marom EM, Moreira AL, Nicholson AG, Noguchi M, Nonaka D, Papotti MG, Porubsky S, Sholl LM, Tateyama H, Thomas de Montpréville V, Travis WD, Rajan A, Roden AC, Ströbel P
J Thorac Oncol 2022 Feb;17(2):200-213. Epub 2021 Oct 22 doi: 10.1016/j.jtho.2021.10.010. PMID: 34695605
Garrana SH, Rosado-de-Christenson ML
Radiol Clin North Am 2021 Mar;59(2):155-168. Epub 2021 Jan 11 doi: 10.1016/j.rcl.2020.10.003. PMID: 33551078
Carter BW, Benveniste MF, Madan R, Godoy MC, de Groot PM, Truong MT, Rosado-de-Christenson ML, Marom EM
Radiographics 2017 Mar-Apr;37(2):413-436. Epub 2017 Jan 27 doi: 10.1148/rg.2017160095. PMID: 28129068

Therapy

Dunne EG, Fick CN, Jones DR
J Clin Oncol 2023 Aug 1;41(22):3785-3790. Epub 2023 Jun 2 doi: 10.1200/JCO.23.00867. PMID: 37267507Free PMC Article
Fan Y, Zhang AM, Wu XL, Huang ZS, Kontogianni K, Sun K, Fu WL, Wu N, Kuebler WM, Herth FJF
Lancet Respir Med 2023 Mar;11(3):256-264. Epub 2022 Oct 22 doi: 10.1016/S2213-2600(22)00392-7. PMID: 36279880
Le Pechoux C, Pourel N, Barlesi F, Lerouge D, Antoni D, Lamezec B, Nestle U, Boisselier P, Dansin E, Paumier A, Peignaux K, Thillays F, Zalcman G, Madelaine J, Pichon E, Larrouy A, Lavole A, Argo-Leignel D, Derollez M, Faivre-Finn C, Hatton MQ, Riesterer O, Bouvier-Morel E, Dunant A, Edwards JG, Thomas PA, Mercier O, Bardet A
Lancet Oncol 2022 Jan;23(1):104-114. Epub 2021 Dec 15 doi: 10.1016/S1470-2045(21)00606-9. PMID: 34919827
Savage KJ
Blood 2022 Sep 1;140(9):955-970. doi: 10.1182/blood.2020008376. PMID: 34496020
Zhang J, Guo JR, Huang ZS, Fu WL, Wu XL, Wu N, Kuebler WM, Herth FJF, Fan Y
Eur Respir J 2021 Dec;58(6) Epub 2021 Dec 9 doi: 10.1183/13993003.00055-2021. PMID: 33958432

Prognosis

Demirkol B, Tanrıverdi E, Gül Ş, Koç AS, Akgün E, Yardımcı AH, Baydili KN, Çetinkaya E
Turk J Med Sci 2023 Jun;53(3):712-720. Epub 2023 Jun 19 doi: 10.55730/1300-0144.5634. PMID: 37476908Free PMC Article
D'Andrilli A, Maurizi G, Venuta F, Rendina EA
Gen Thorac Cardiovasc Surg 2020 Jul;68(7):725-732. Epub 2019 Dec 3 doi: 10.1007/s11748-019-01263-8. PMID: 31797211
Stigt JA, Boers JE, Oostdijk AH, van den Berg JW, Groen HJ
J Thorac Oncol 2011 Aug;6(8):1345-9. doi: 10.1097/JTO.0b013e31821d41c8. PMID: 21587083
Henzler T, Schmid-Bindert G, Schoenberg SO, Fink C
Eur J Radiol 2010 Dec;76(3):329-36. doi: 10.1016/j.ejrad.2010.05.005. PMID: 20627435
Herth FJ, Ernst A, Eberhardt R
Curr Opin Pulm Med 2009 Jul;15(4):308-12. doi: 10.1097/MCP.0b013e32832cbee6. PMID: 19436205

Clinical prediction guides

Oliver ER, Didier RA, Horii SC, Hedrick HL, Khalek N, DeBari SE, Adzick NS, Coleman BG
Pediatr Radiol 2022 Nov;52(12):2319-2328. Epub 2022 Apr 26 doi: 10.1007/s00247-022-05367-x. PMID: 35471666
Zhang J, Guo JR, Huang ZS, Fu WL, Wu XL, Wu N, Kuebler WM, Herth FJF, Fan Y
Eur Respir J 2021 Dec;58(6) Epub 2021 Dec 9 doi: 10.1183/13993003.00055-2021. PMID: 33958432
Candoli P, Ceron L, Trisolini R, Romagnoli M, Michieletto L, Scarlata S, Galasso T, Leoncini F, Pasini V, Dennetta D, Marchesani F, Zotti M, Corbetta L
Panminerva Med 2019 Sep;61(3):249-279. Epub 2018 Nov 9 doi: 10.23736/S0031-0808.18.03570-X. PMID: 30421897
Kondo K
Gen Thorac Cardiovasc Surg 2014 Aug;62(8):468-74. Epub 2014 Jun 10 doi: 10.1007/s11748-014-0420-z. PMID: 24913632
Styczynski J, Lasek W, Wysocki M
Int J Pediatr Otorhinolaryngol 2005 Jun;69(6):847-52. Epub 2005 Feb 24 doi: 10.1016/j.ijporl.2005.01.003. PMID: 15885340

Recent systematic reviews

Botana-Rial M, Lojo-Rodríguez I, Leiro-Fernández V, Ramos-Hernández C, González-Montaos A, Pazos-Area L, Núñez-Delgado M, Fernández-Villar A
Respir Med 2023 Nov;218:107389. Epub 2023 Aug 12 doi: 10.1016/j.rmed.2023.107389. PMID: 37579981
Robertson D, Ng SK, Baade PD, Lam AK
Int J Colorectal Dis 2022 Mar;37(3):541-551. Epub 2022 Feb 12 doi: 10.1007/s00384-022-04105-x. PMID: 35152308Free PMC Article
Buglione M, Guerini AE, Filippi AR, Spiazzi L, Pasinetti N, Magli A, Toraci C, Borghetti P, Triggiani L, Alghisi A, Costantino G, Bertagna F, Giaj Levra N, Pegurri L, Magrini SM
Crit Rev Oncol Hematol 2021 Nov;167:103437. Epub 2021 Aug 3 doi: 10.1016/j.critrevonc.2021.103437. PMID: 34358649
Sehgal IS, Dhooria S, Aggarwal AN, Behera D, Agarwal R
Ann Thorac Surg 2016 Nov;102(5):1747-1755. doi: 10.1016/j.athoracsur.2016.05.110. PMID: 27637288
Okholm C, Svendsen LB, Achiam MP
Surg Oncol 2014 Sep;23(3):140-6. Epub 2014 Jun 11 doi: 10.1016/j.suronc.2014.06.001. PMID: 24953457

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