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Vulvar benign neoplasm

MedGen UID:
102301
Concept ID:
C0154003
Neoplastic Process
Synonyms: Benign Neoplasm of the Vulva; benign neoplasm of the vulva; Benign neoplasm of vulva; Benign Neoplasm of Vulva; benign neoplasm of vulva; Benign Tumor of the Vulva; benign tumor of the vulva; Benign tumor of vulva; Benign Tumor of Vulva; benign tumor of vulva; benign tumour of the vulva; benign tumour of vulva; Benign Vulva Neoplasm; benign vulva neoplasm; Benign Vulva Tumor; benign vulva tumor; benign vulva tumour; Benign Vulval Neoplasm; benign vulval neoplasm; Benign Vulvar Neoplasm; benign vulvar neoplasm; Benign Vulvar Tumor; benign vulvar tumor; benign vulvar tumour; mammalian vulva benign neoplasm; vulva benign neoplasm; vulvar benign neoplasm
SNOMED CT: Benign tumor of vulva (92486005); Benign neoplasm of vulva (92486005)
 
Monarch Initiative: MONDO:0000643

Definition

A neoplasm that arises from the vulva and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. Representative examples include cellular angiofibroma, melanocytic nevus, nodular hidradenoma, and Bartholin gland adenoma. [from NCI]

Professional guidelines

PubMed

Ishizuki S, Nakamura Y
Curr Oncol 2021 Aug 5;28(4):2969-2986. doi: 10.3390/curroncol28040260. PMID: 34436026Free PMC Article
Merlo S
Radiol Oncol 2020 Sep 22;54(4):371-376. doi: 10.2478/raon-2020-0053. PMID: 32960779Free PMC Article
Gaffney DK, King B, Viswanathan AN, Barkati M, Beriwal S, Eifel P, Erickson B, Fyles A, Goulart J, Harkenrider M, Jhingran A, Klopp A, Koh WJ, Lim K, Petersen I, Portelance L, Small W Jr, Stewart A, Wiebe E, Wolfson A, Yashar C, Bosch W
Int J Radiat Oncol Biol Phys 2016 Jul 15;95(4):1191-200. Epub 2016 Feb 21 doi: 10.1016/j.ijrobp.2016.02.043. PMID: 27130794Free PMC Article

Recent clinical studies

Etiology

Parra-Herran C, Nucci MR, Singh N, Rakislova N, Howitt BE, Hoang L, Gilks CB, Bosse T, Watkins JC
Mod Pathol 2022 Oct;35(10):1317-1326. Epub 2022 Apr 18 doi: 10.1038/s41379-022-01079-7. PMID: 35437330
Sanchez I, Raffi J, Kraus CN
Urology 2022 Jul;165:31-35. Epub 2022 Feb 23 doi: 10.1016/j.urology.2022.02.007. PMID: 35218865
Olawaiye AB, Cuello MA, Rogers LJ
Int J Gynaecol Obstet 2021 Oct;155 Suppl 1(Suppl 1):7-18. doi: 10.1002/ijgo.13881. PMID: 34669204Free PMC Article
Lee A, Fischer G
Am J Clin Dermatol 2018 Oct;19(5):695-706. doi: 10.1007/s40257-018-0364-7. PMID: 29987650
Faubion SS, Larkin LC, Stuenkel CA, Bachmann GA, Chism LA, Kagan R, Kaunitz AM, Krychman ML, Parish SJ, Partridge AH, Pinkerton JV, Rowen TS, Shapiro M, Simon JA, Goldfarb SB, Kingsberg SA
Menopause 2018 Jun;25(6):596-608. doi: 10.1097/GME.0000000000001121. PMID: 29762200

Diagnosis

Parra-Herran C, Nucci MR, Singh N, Rakislova N, Howitt BE, Hoang L, Gilks CB, Bosse T, Watkins JC
Mod Pathol 2022 Oct;35(10):1317-1326. Epub 2022 Apr 18 doi: 10.1038/s41379-022-01079-7. PMID: 35437330
Olawaiye AB, Cuello MA, Rogers LJ
Int J Gynaecol Obstet 2021 Oct;155 Suppl 1(Suppl 1):7-18. doi: 10.1002/ijgo.13881. PMID: 34669204Free PMC Article
Wohlmuth C, Wohlmuth-Wieser I
Am J Clin Dermatol 2021 Sep;22(5):639-651. Epub 2021 Jun 14 doi: 10.1007/s40257-021-00614-7. PMID: 34125416Free PMC Article
Michalski BM, Pfeifer JD, Mutch D, Council ML
Dermatol Surg 2021 Feb 1;47(2):174-183. doi: 10.1097/DSS.0000000000002584. PMID: 32947298
Lee A, Fischer G
Am J Clin Dermatol 2018 Oct;19(5):695-706. doi: 10.1007/s40257-018-0364-7. PMID: 29987650

Therapy

Michalski BM, Pfeifer JD, Mutch D, Council ML
Dermatol Surg 2021 Feb 1;47(2):174-183. doi: 10.1097/DSS.0000000000002584. PMID: 32947298
J Eur Acad Dermatol Venereol 2020 Apr;34(4):665. doi: 10.1111/jdv.16353. PMID: 32227421
Illingworth B, Stocking K, Showell M, Kirk E, Duffy J
BJOG 2020 May;127(6):671-678. Epub 2020 Feb 4 doi: 10.1111/1471-0528.16079. PMID: 31876985
Moncayo VM, Grady EE, Alazraki NP, Aarsvold JN
Semin Nucl Med 2020 Jan;50(1):56-74. doi: 10.1053/j.semnuclmed.2019.10.001. PMID: 31843062
Lee A, Fischer G
Am J Clin Dermatol 2018 Oct;19(5):695-706. doi: 10.1007/s40257-018-0364-7. PMID: 29987650

Prognosis

Heller A, Breitner D, Cracchiolo B, Heller DS
J Low Genit Tract Dis 2022 Apr 1;26(2):152-155. doi: 10.1097/LGT.0000000000000660. PMID: 35256567
Wohlmuth C, Wohlmuth-Wieser I
Am J Clin Dermatol 2021 Sep;22(5):639-651. Epub 2021 Jun 14 doi: 10.1007/s40257-021-00614-7. PMID: 34125416Free PMC Article
Lee A, Fischer G
Am J Clin Dermatol 2018 Oct;19(5):695-706. doi: 10.1007/s40257-018-0364-7. PMID: 29987650
Di Donato V, Casorelli A, Bardhi E, Vena F, Marchetti C, Muzii L, Benedetti Panici P
Crit Rev Oncol Hematol 2017 Sep;117:1-11. Epub 2017 Jun 13 doi: 10.1016/j.critrevonc.2017.06.005. PMID: 28807231
Dellinger TH, Hakim AA, Lee SJ, Wakabayashi MT, Morgan RJ, Han ES
J Natl Compr Canc Netw 2017 Jan;15(1):121-128. doi: 10.6004/jnccn.2017.0009. PMID: 28040722

Clinical prediction guides

Flipo R, Bani MA, Rejaibi S, Talhi N, Sastre-Garau X
Int J Gynecol Pathol 2022 Jan 1;41(1):86-92. doi: 10.1097/PGP.0000000000000771. PMID: 33770062
Lyra J, Melo C, Figueiredo R, Polonia-Valente R, Falcão V, Beires J, Vieira-Baptista P
J Low Genit Tract Dis 2021 Jan 1;25(1):71-75. doi: 10.1097/LGT.0000000000000581. PMID: 33214502
Marcoval J, Penín RM, Vidal A, Bermejo J
Actas Dermosifiliogr (Engl Ed) 2020 May;111(4):306-312. Epub 2020 Apr 9 doi: 10.1016/j.ad.2019.09.003. PMID: 32278442
St Claire K, Hoover A, Ashack K, Khachemoune A
Dermatol Online J 2019 Apr 15;25(4) PMID: 31046904
Khanna N, Rauh LA, Lachiewicz MP, Horowitz IR
J Surg Oncol 2016 Mar;113(3):304-9. Epub 2016 Feb 8 doi: 10.1002/jso.24108. PMID: 26852901

Recent systematic reviews

Li Z, Liu P, Wang Z, Zhang Z, Chen Z, Chu R, Li G, Han Q, Zhao Y, Li L, Miao J, Kong B, Song K
Lancet Oncol 2023 Apr;24(4):403-414. Epub 2023 Mar 15 doi: 10.1016/S1470-2045(23)00066-9. PMID: 36933562
Kechagias KS, Kalliala I, Bowden SJ, Athanasiou A, Paraskevaidi M, Paraskevaidis E, Dillner J, Nieminen P, Strander B, Sasieni P, Veroniki AA, Kyrgiou M
BMJ 2022 Aug 3;378:e070135. doi: 10.1136/bmj-2022-070135. PMID: 35922074Free PMC Article
Kalliala I, Athanasiou A, Veroniki AA, Salanti G, Efthimiou O, Raftis N, Bowden S, Paraskevaidi M, Aro K, Arbyn M, Bennett P, Nieminen P, Paraskevaidis E, Kyrgiou M
Ann Oncol 2020 Feb;31(2):213-227. Epub 2020 Jan 3 doi: 10.1016/j.annonc.2019.11.004. PMID: 31959338Free PMC Article
Illingworth B, Stocking K, Showell M, Kirk E, Duffy J
BJOG 2020 May;127(6):671-678. Epub 2020 Feb 4 doi: 10.1111/1471-0528.16079. PMID: 31876985
Makris GM, Poulakaki N, Papanota AM, Kotsifa E, Sergentanis TN, Psaltopoulou T
Dermatol Surg 2017 Jan;43(1):107-115. doi: 10.1097/DSS.0000000000000944. PMID: 27755170

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