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Vulvar benign neoplasm

MedGen UID:
102301
•Concept ID:
C0154003
•
Neoplastic Process
Synonyms: Benign Neoplasm of the Vulva; benign neoplasm of the vulva; Benign neoplasm of vulva; Benign Neoplasm of Vulva; benign neoplasm of vulva; Benign Tumor of the Vulva; benign tumor of the vulva; Benign tumor of vulva; Benign Tumor of Vulva; benign tumor of vulva; benign tumour of the vulva; benign tumour of vulva; Benign Vulva Neoplasm; benign vulva neoplasm; Benign Vulva Tumor; benign vulva tumor; benign vulva tumour; Benign Vulval Neoplasm; benign vulval neoplasm; Benign Vulvar Neoplasm; benign vulvar neoplasm; Benign Vulvar Tumor; benign vulvar tumor; benign vulvar tumour; mammalian vulva benign neoplasm; vulva benign neoplasm; vulvar benign neoplasm
SNOMED CT: Benign tumor of vulva (92486005); Benign neoplasm of vulva (92486005)
 
Monarch Initiative: MONDO:0000643

Definition

A neoplasm that arises from the vulva and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. Representative examples include cellular angiofibroma, melanocytic nevus, nodular hidradenoma, and Bartholin gland adenoma. [from NCI]

Professional guidelines

PubMed

International Anal Neoplasia Society's consensus guidelines for anal cancer screening.
Stier EA, Clarke MA, Deshmukh AA, Wentzensen N, Liu Y, Poynten IM, Cavallari EN, Fink V, Barroso LF, Clifford GM, Cuming T, Goldstone SE, Hillman RJ, Rosa-Cunha I, La Rosa L, Palefsky JM, Plotzker R, Roberts JM, Jay N
Int J Cancer 2024 May 15;154(10):1694-1702. Epub 2024 Jan 31 doi: 10.1002/ijc.34850. PMID: 38297406
Extramammary Paget's Disease: Diagnosis, Pathogenesis, and Treatment with Focus on Recent Developments.
Ishizuki S, Nakamura Y
Curr Oncol 2021 Aug 5;28(4):2969-2986. doi: 10.3390/curroncol28040260. PMID: 34436026Free PMC Article
Consensus Recommendations for Radiation Therapy Contouring and Treatment of Vulvar Carcinoma.
Gaffney DK, King B, Viswanathan AN, Barkati M, Beriwal S, Eifel P, Erickson B, Fyles A, Goulart J, Harkenrider M, Jhingran A, Klopp A, Koh WJ, Lim K, Petersen I, Portelance L, Small W Jr, Stewart A, Wiebe E, Wolfson A, Yashar C, Bosch W
Int J Radiat Oncol Biol Phys 2016 Jul 15;95(4):1191-200. Epub 2016 Feb 21 doi: 10.1016/j.ijrobp.2016.02.043. PMID: 27130794Free PMC Article

Recent clinical studies

Etiology

HPV-independent, p53-wild-type vulvar intraepithelial neoplasia: a review of nomenclature and the journey to characterize verruciform and acanthotic precursor lesions of the vulva.
Parra-Herran C, Nucci MR, Singh N, Rakislova N, Howitt BE, Hoang L, Gilks CB, Bosse T, Watkins JC
Mod Pathol 2022 Oct;35(10):1317-1326. Epub 2022 Apr 18 doi: 10.1038/s41379-022-01079-7. PMID: 35437330
Cancer of the vulva: 2021 update.
Olawaiye AB, Cuello MA, Rogers LJ
Int J Gynaecol Obstet 2021 Oct;155 Suppl 1(Suppl 1):7-18. doi: 10.1002/ijgo.13881. PMID: 34669204Free PMC Article
Human Papillomavirus-Independent Squamous Lesions of the Vulva.
Watkins JC
Surg Pathol Clin 2019 Jun;12(2):249-261. Epub 2019 Apr 5 doi: 10.1016/j.path.2019.01.001. PMID: 31097103
Diagnosis and Treatment of Vulvar Lichen Sclerosus: An Update for Dermatologists.
Lee A, Fischer G
Am J Clin Dermatol 2018 Oct;19(5):695-706. doi: 10.1007/s40257-018-0364-7. PMID: 29987650
Lichen sclerosus.
Murphy R
Dermatol Clin 2010 Oct;28(4):707-15. doi: 10.1016/j.det.2010.07.006. PMID: 20883914

Diagnosis

HPV-independent, p53-wild-type vulvar intraepithelial neoplasia: a review of nomenclature and the journey to characterize verruciform and acanthotic precursor lesions of the vulva.
Parra-Herran C, Nucci MR, Singh N, Rakislova N, Howitt BE, Hoang L, Gilks CB, Bosse T, Watkins JC
Mod Pathol 2022 Oct;35(10):1317-1326. Epub 2022 Apr 18 doi: 10.1038/s41379-022-01079-7. PMID: 35437330
Cancer of the vulva: 2021 update.
Olawaiye AB, Cuello MA, Rogers LJ
Int J Gynaecol Obstet 2021 Oct;155 Suppl 1(Suppl 1):7-18. doi: 10.1002/ijgo.13881. PMID: 34669204Free PMC Article
Vulvar Melanoma: Molecular Characteristics, Diagnosis, Surgical Management, and Medical Treatment.
Wohlmuth C, Wohlmuth-Wieser I
Am J Clin Dermatol 2021 Sep;22(5):639-651. Epub 2021 Jun 14 doi: 10.1007/s40257-021-00614-7. PMID: 34125416Free PMC Article
Cancer of the Vulva: A Review.
Michalski BM, Pfeifer JD, Mutch D, Council ML
Dermatol Surg 2021 Feb 1;47(2):174-183. doi: 10.1097/DSS.0000000000002584. PMID: 32947298
Diagnosis and Treatment of Vulvar Lichen Sclerosus: An Update for Dermatologists.
Lee A, Fischer G
Am J Clin Dermatol 2018 Oct;19(5):695-706. doi: 10.1007/s40257-018-0364-7. PMID: 29987650

Therapy

Cancer of the Vulva: A Review.
Michalski BM, Pfeifer JD, Mutch D, Council ML
Dermatol Surg 2021 Feb 1;47(2):174-183. doi: 10.1097/DSS.0000000000002584. PMID: 32947298
Editor's picks.
J Eur Acad Dermatol Venereol 2020 Apr;34(4):665. doi: 10.1111/jdv.16353. PMID: 32227421
Sentinel-Lymph-Node Multicenter Trials.
Moncayo VM, Grady EE, Alazraki NP, Aarsvold JN
Semin Nucl Med 2020 Jan;50(1):56-74. doi: 10.1053/j.semnuclmed.2019.10.001. PMID: 31843062
Diagnosis and Treatment of Vulvar Lichen Sclerosus: An Update for Dermatologists.
Lee A, Fischer G
Am J Clin Dermatol 2018 Oct;19(5):695-706. doi: 10.1007/s40257-018-0364-7. PMID: 29987650
ENDOCRINE DILEMMA: Managing menopausal symptoms after breast cancer.
Eden J
Eur J Endocrinol 2016 Mar;174(3):R71-7. Epub 2015 Oct 14 doi: 10.1530/EJE-15-0814. PMID: 26466611

Prognosis

Vulvar Melanoma: Molecular Characteristics, Diagnosis, Surgical Management, and Medical Treatment.
Wohlmuth C, Wohlmuth-Wieser I
Am J Clin Dermatol 2021 Sep;22(5):639-651. Epub 2021 Jun 14 doi: 10.1007/s40257-021-00614-7. PMID: 34125416Free PMC Article
Diagnosis and Treatment of Vulvar Lichen Sclerosus: An Update for Dermatologists.
Lee A, Fischer G
Am J Clin Dermatol 2018 Oct;19(5):695-706. doi: 10.1007/s40257-018-0364-7. PMID: 29987650
Hereditary esophageal-vulvar syndrome.
Hoelscher AC, Hoelscher AH, Drebber U, Bludau M, Schroeder W
Ann Thorac Surg 2012 Sep;94(3):e65-7. doi: 10.1016/j.athoracsur.2012.02.078. PMID: 22916782
Lichen sclerosus.
Murphy R
Dermatol Clin 2010 Oct;28(4):707-15. doi: 10.1016/j.det.2010.07.006. PMID: 20883914
Malignancy.
Penn I
Surg Clin North Am 1994 Oct;74(5):1247-57. PMID: 7940072

Clinical prediction guides

Extramammary Paget disease.
St Claire K, Hoover A, Ashack K, Khachemoune A
Dermatol Online J 2019 Apr 15;25(4) PMID: 31046904
Lichen sclerosus and risk of cancer.
Halonen P, Jakobsson M, Heikinheimo O, Riska A, Gissler M, Pukkala E
Int J Cancer 2017 May 1;140(9):1998-2002. Epub 2017 Feb 10 doi: 10.1002/ijc.30621. PMID: 28124469
Margins for cervical and vulvar cancer.
Khanna N, Rauh LA, Lachiewicz MP, Horowitz IR
J Surg Oncol 2016 Mar;113(3):304-9. Epub 2016 Feb 8 doi: 10.1002/jso.24108. PMID: 26852901
Vulvar angioleiomyoma.
Terada S, Suzuki N, Uchide K, Akasofu K
Arch Gynecol Obstet 1993;253(1):51-8. doi: 10.1007/BF02770634. PMID: 8392314
HISTIOCYTOSIS X (EOSINOPHILIC GRANULOMA OF BONE, LETTERER-SIWE DISEASE, AND SCHUELLER-CHRISTIAN DISEASE). FURTHER OBSERVATIONS OF PATHOLOGICAL AND CLINICAL IMPORTANCE.
LICHTENSTEIN L
J Bone Joint Surg Am 1964 Jan;46:76-90. PMID: 14104316

Recent systematic reviews

Prevalence of human papillomavirus DNA and p16(INK4a) positivity in vulvar cancer and vulvar intraepithelial neoplasia: a systematic review and meta-analysis.
Li Z, Liu P, Wang Z, Zhang Z, Chen Z, Chu R, Li G, Han Q, Zhao Y, Li L, Miao J, Kong B, Song K
Lancet Oncol 2023 Apr;24(4):403-414. Epub 2023 Mar 15 doi: 10.1016/S1470-2045(23)00066-9. PMID: 36933562
A systematic review of laser therapy for vulvar skin conditions.
Kim K, Desai M, Elsensohn A, Kraus CN
J Am Acad Dermatol 2023 May;88(5):1200-1201. Epub 2023 Jan 11 doi: 10.1016/j.jaad.2023.01.003. PMID: 36639033
Role of human papillomavirus (HPV) vaccination on HPV infection and recurrence of HPV related disease after local surgical treatment: systematic review and meta-analysis.
Kechagias KS, Kalliala I, Bowden SJ, Athanasiou A, Paraskevaidi M, Paraskevaidis E, Dillner J, Nieminen P, Strander B, Sasieni P, Veroniki AA, Kyrgiou M
BMJ 2022 Aug 3;378:e070135. doi: 10.1136/bmj-2022-070135. PMID: 35922074Free PMC Article
Mohs micrographic surgery for vulvar malignancies: A systematic review.
Shwe S, Elsensohn AN, Ortiz C, Kraus CN
J Am Acad Dermatol 2022 Jul;87(1):159-162. Epub 2021 Jul 6 doi: 10.1016/j.jaad.2021.06.875. PMID: 34237353
Incidence and mortality from cervical cancer and other malignancies after treatment of cervical intraepithelial neoplasia: a systematic review and meta-analysis of the literature.
Kalliala I, Athanasiou A, Veroniki AA, Salanti G, Efthimiou O, Raftis N, Bowden S, Paraskevaidi M, Aro K, Arbyn M, Bennett P, Nieminen P, Paraskevaidis E, Kyrgiou M
Ann Oncol 2020 Feb;31(2):213-227. Epub 2020 Jan 3 doi: 10.1016/j.annonc.2019.11.004. PMID: 31959338Free PMC Article

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