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Necrobiosis

MedGen UID:
102470
•Concept ID:
C0162812
•
Pathologic Function
Synonyms: Disorder, Necrobiotic; Disorders, Necrobiotic; Necrobioses; Necrobiotic Disorder; Necrobiotic Disorders
SNOMED CT: Necrobiosis (68463000)

Definition

A group of disorders characterized by swelling, basophilia, and distortion of collagen bundles in the dermis. [from MeSH]

Professional guidelines

PubMed

Treatment options for necrobiosis lipoidica: a systematic review.
Nihal A, Caplan AS, Rosenbach M, Damsky W, Mangold AR, Shields BE
Int J Dermatol 2023 Dec;62(12):1529-1537. Epub 2023 Sep 29 doi: 10.1111/ijd.16856. PMID: 37772666
Laser and light therapies for the treatment of necrobiosis lipoidica.
Rajabi-Estarabadi A, Aickara DJ, Hirsch M, Williams NM, Maranda EL, Van Badiavas E
Lasers Med Sci 2021 Apr;36(3):497-506. Epub 2020 Sep 24 doi: 10.1007/s10103-020-03147-3. PMID: 32970197
Update: Treatment of necrobiosis lipoidica.
Peckruhn M, Tittelbach J, Elsner P
J Dtsch Dermatol Ges 2017 Feb;15(2):151-157. doi: 10.1111/ddg.13186. PMID: 28214312

Recent clinical studies

Etiology

The Immunogenetics of Granulomatous Diseases.
Kök GF, Türsen Ü
Adv Exp Med Biol 2022;1367:349-368. doi: 10.1007/978-3-030-92616-8_13. PMID: 35286702
Cutaneous Granulomatosis: a Comprehensive Review.
Terziroli Beretta-Piccoli B, Mainetti C, Peeters MA, Laffitte E
Clin Rev Allergy Immunol 2018 Feb;54(1):131-146. doi: 10.1007/s12016-017-8666-8. PMID: 29352388
What is new in the histogenesis of granulomatous skin diseases?
Asai J
J Dermatol 2017 Mar;44(3):297-303. doi: 10.1111/1346-8138.13662. PMID: 28256762
Granulomatous & histiocytic dermatitides.
Wick MR
Semin Diagn Pathol 2017 May;34(3):301-311. Epub 2016 Dec 14 doi: 10.1053/j.semdp.2016.12.003. PMID: 28094163
Necrobiosis lipoidica.
Grillo E, Rodriguez-Muñoz D, González-Garcia A, Jaén P
Aust Fam Physician 2014 Mar;43(3):129-30. PMID: 24600675

Diagnosis

Cutaneous Manifestations of Diabetes Mellitus and Prediabetes.
Sanches MM, Roda Â, Pimenta R, Filipe PL, Freitas JP
Acta Med Port 2019 Jun 28;32(6):459-465. doi: 10.20344/amp.10738. PMID: 31292028
Cutaneous Granulomatosis: a Comprehensive Review.
Terziroli Beretta-Piccoli B, Mainetti C, Peeters MA, Laffitte E
Clin Rev Allergy Immunol 2018 Feb;54(1):131-146. doi: 10.1007/s12016-017-8666-8. PMID: 29352388
Cutaneous Manifestations of Diabetes Mellitus: A Review.
Lima AL, Illing T, Schliemann S, Elsner P
Am J Clin Dermatol 2017 Aug;18(4):541-553. doi: 10.1007/s40257-017-0275-z. PMID: 28374407
Panniculitis: A summary.
Wick MR
Semin Diagn Pathol 2017 May;34(3):261-272. Epub 2016 Dec 27 doi: 10.1053/j.semdp.2016.12.004. PMID: 28129926
Atypical ulcers.
Hoffman MD
Dermatol Ther 2013 May-Jun;26(3):222-35. doi: 10.1111/dth.12048. PMID: 23742283

Therapy

Pentoxifylline in dermatology.
Balazic E, Axler E, Konisky H, Khanna U, Kobets K
J Cosmet Dermatol 2023 Feb;22(2):410-417. Epub 2022 Oct 31 doi: 10.1111/jocd.15445. PMID: 36208009
Cutaneous Manifestations of Diabetes Mellitus: A Review.
Lima AL, Illing T, Schliemann S, Elsner P
Am J Clin Dermatol 2017 Aug;18(4):541-553. doi: 10.1007/s40257-017-0275-z. PMID: 28374407
Necrobiosis Lipoidica.
Sibbald C, Reid S, Alavi A
Dermatol Clin 2015 Jul;33(3):343-60. doi: 10.1016/j.det.2015.03.003. PMID: 26143418
Thiazolidinediones in dermatology.
Boyd AS
Int J Dermatol 2007 Jun;46(6):557-63. doi: 10.1111/j.1365-4632.2007.03273.x. PMID: 17550551
Diabetes mellitus.
Ahmed I, Goldstein B
Clin Dermatol 2006 Jul-Aug;24(4):237-46. doi: 10.1016/j.clindermatol.2006.04.009. PMID: 16828404

Prognosis

Cutaneous Manifestations of Diabetes Mellitus and Prediabetes.
Sanches MM, Roda Â, Pimenta R, Filipe PL, Freitas JP
Acta Med Port 2019 Jun 28;32(6):459-465. doi: 10.20344/amp.10738. PMID: 31292028
Necrobiosis Lipoidica.
Sibbald C, Reid S, Alavi A
Dermatol Clin 2015 Jul;33(3):343-60. doi: 10.1016/j.det.2015.03.003. PMID: 26143418
Palmar erythema.
Serrao R, Zirwas M, English JC
Am J Clin Dermatol 2007;8(6):347-56. doi: 10.2165/00128071-200708060-00004. PMID: 18039017
Diabetes mellitus.
Ahmed I, Goldstein B
Clin Dermatol 2006 Jul-Aug;24(4):237-46. doi: 10.1016/j.clindermatol.2006.04.009. PMID: 16828404
Skin and diabetes.
Sibbald RG, Landolt SJ, Toth D
Endocrinol Metab Clin North Am 1996 Jun;25(2):463-72. doi: 10.1016/s0889-8529(05)70334-0. PMID: 8799710

Clinical prediction guides

Role of NLRP3 inflammasome in diabetes and COVID-19 role of NLRP3 inflammasome in the pathogenesis and treatment of COVID-19 and diabetes NLRP3 inflammasome in diabetes and COVID-19 intervention.
Zhang J, Ma X, Liu F, Zhang D, Ling J, Zhu Z, Chen Y, Yang P, Yang Y, Liu X, Zhang J, Liu J, Yu P
Front Immunol 2023;14:1203389. Epub 2023 Oct 5 doi: 10.3389/fimmu.2023.1203389. PMID: 37868953Free PMC Article
Non-infectious granulomatous dermatoses.
Schmitt A, Volz A
J Dtsch Dermatol Ges 2019 May;17(5):518-533. doi: 10.1111/ddg.13848. PMID: 31115996
Clinical Features and Comorbidities of Patients With Necrobiosis Lipoidica With or Without Diabetes.
Hashemi DA, Brown-Joel ZO, Tkachenko E, Nelson CA, Noe MH, Imadojemu S, Vleugels RA, Mostaghimi A, Wanat KA, Rosenbach M
JAMA Dermatol 2019 Apr 1;155(4):455-459. doi: 10.1001/jamadermatol.2018.5635. PMID: 30785603Free PMC Article
Panniculitides, an algorithmic approach.
Zelger B
G Ital Dermatol Venereol 2013 Aug;148(4):351-70. PMID: 23900158
Diabetic scleredema.
Toyota T, Umezu M, Oikawa N, Sanoyama R, Suzuki S, Suzuki H, Nakajima Y, Goto Y
Tohoku J Exp Med 1983 Dec;141(4):457-61. doi: 10.1620/tjem.141.457. PMID: 6670101

Recent systematic reviews

Treatment options for necrobiosis lipoidica: a systematic review.
Nihal A, Caplan AS, Rosenbach M, Damsky W, Mangold AR, Shields BE
Int J Dermatol 2023 Dec;62(12):1529-1537. Epub 2023 Sep 29 doi: 10.1111/ijd.16856. PMID: 37772666
Use of Janus kinase inhibitors for granulomatous dermatoses: A systematic review.
Sood S, Heung M, Georgakopoulos JR, Mufti A, Prajapati VH, Yeung J
J Am Acad Dermatol 2023 Aug;89(2):357-359. Epub 2023 Mar 28 doi: 10.1016/j.jaad.2023.03.024. PMID: 36990321
Intralesional biologics for inflammatory dermatoses: A systematic review.
Seivright JR, Villa NM, De DR, Hsiao JL, Shi VY
Dermatol Ther 2022 Feb;35(2):e15234. Epub 2021 Dec 8 doi: 10.1111/dth.15234. PMID: 34825744
A systematic review of the relationship between glycemic control and necrobiosis lipoidica diabeticorum in patients with diabetes mellitus.
Mistry BD, Alavi A, Ali S, Mistry N
Int J Dermatol 2017 Dec;56(12):1319-1327. Epub 2017 Jun 26 doi: 10.1111/ijd.13610. PMID: 28650076
Ultraviolet A phototherapy for sclerotic skin diseases: a systematic review.
Kroft EB, Berkhof NJ, van de Kerkhof PC, Gerritsen RM, de Jong EM
J Am Acad Dermatol 2008 Dec;59(6):1017-30. Epub 2008 Oct 2 doi: 10.1016/j.jaad.2008.07.042. PMID: 18835066

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