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Necrobiosis

MedGen UID:
102470
•Concept ID:
C0162812
•
Pathologic Function
Synonyms: Disorder, Necrobiotic; Disorders, Necrobiotic; Necrobioses; Necrobiotic Disorder; Necrobiotic Disorders
SNOMED CT: Necrobiosis (68463000)

Definition

A group of disorders characterized by swelling, basophilia, and distortion of collagen bundles in the dermis. [from MeSH]

Professional guidelines

PubMed

Laser and light therapies for the treatment of necrobiosis lipoidica.
Rajabi-Estarabadi A, Aickara DJ, Hirsch M, Williams NM, Maranda EL, Van Badiavas E
Lasers Med Sci 2021 Apr;36(3):497-506. Epub 2020 Sep 24 doi: 10.1007/s10103-020-03147-3. PMID: 32970197
The Promise of JAK Inhibitors for Treatment of Sarcoidosis and Other Inflammatory Disorders with Macrophage Activation: A Review of the Literature.
Wang A, Singh K, Ibrahim W, King B, Damsky W
Yale J Biol Med 2020 Mar;93(1):187-195. Epub 2020 Mar 27 PMID: 32226347Free PMC Article
Update: Treatment of necrobiosis lipoidica.
Peckruhn M, Tittelbach J, Elsner P
J Dtsch Dermatol Ges 2017 Feb;15(2):151-157. doi: 10.1111/ddg.13186. PMID: 28214312

Recent clinical studies

Etiology

The Immunogenetics of Granulomatous Diseases.
Kök GF, Türsen Ü
Adv Exp Med Biol 2022;1367:349-368. doi: 10.1007/978-3-030-92616-8_13. PMID: 35286702
Cutaneous Granulomatosis: a Comprehensive Review.
Terziroli Beretta-Piccoli B, Mainetti C, Peeters MA, Laffitte E
Clin Rev Allergy Immunol 2018 Feb;54(1):131-146. doi: 10.1007/s12016-017-8666-8. PMID: 29352388
What is new in the histogenesis of granulomatous skin diseases?
Asai J
J Dermatol 2017 Mar;44(3):297-303. doi: 10.1111/1346-8138.13662. PMID: 28256762
Granulomatous & histiocytic dermatitides.
Wick MR
Semin Diagn Pathol 2017 May;34(3):301-311. Epub 2016 Dec 14 doi: 10.1053/j.semdp.2016.12.003. PMID: 28094163
Necrobiosis lipoidica.
Grillo E, Rodriguez-Muñoz D, González-Garcia A, Jaén P
Aust Fam Physician 2014 Mar;43(3):129-30. PMID: 24600675

Diagnosis

Cutaneous Manifestations of Diabetes.
Hines A, Alavi A, Davis MDP
Med Clin North Am 2021 Jul;105(4):681-697. doi: 10.1016/j.mcna.2021.04.008. PMID: 34059245
Cutaneous Manifestations of Diabetes Mellitus and Prediabetes.
Sanches MM, Roda Â, Pimenta R, Filipe PL, Freitas JP
Acta Med Port 2019 Jun 28;32(6):459-465. doi: 10.20344/amp.10738. PMID: 31292028
Cutaneous Granulomatosis: a Comprehensive Review.
Terziroli Beretta-Piccoli B, Mainetti C, Peeters MA, Laffitte E
Clin Rev Allergy Immunol 2018 Feb;54(1):131-146. doi: 10.1007/s12016-017-8666-8. PMID: 29352388
Cutaneous Manifestations of Diabetes Mellitus: A Review.
Lima AL, Illing T, Schliemann S, Elsner P
Am J Clin Dermatol 2017 Aug;18(4):541-553. doi: 10.1007/s40257-017-0275-z. PMID: 28374407
Panniculitis: A summary.
Wick MR
Semin Diagn Pathol 2017 May;34(3):261-272. Epub 2016 Dec 27 doi: 10.1053/j.semdp.2016.12.004. PMID: 28129926

Therapy

Pentoxifylline in dermatology.
Balazic E, Axler E, Konisky H, Khanna U, Kobets K
J Cosmet Dermatol 2023 Feb;22(2):410-417. Epub 2022 Oct 31 doi: 10.1111/jocd.15445. PMID: 36208009
Janus kinase inhibitors in dermatology: Part II. A comprehensive review.
Chapman S, Gold LS, Lim HW
J Am Acad Dermatol 2022 Feb;86(2):414-422. Epub 2021 Jul 3 doi: 10.1016/j.jaad.2021.06.873. PMID: 34228996
Cutaneous Manifestations of Diabetes Mellitus: A Review.
Lima AL, Illing T, Schliemann S, Elsner P
Am J Clin Dermatol 2017 Aug;18(4):541-553. doi: 10.1007/s40257-017-0275-z. PMID: 28374407
Update: Treatment of necrobiosis lipoidica.
Peckruhn M, Tittelbach J, Elsner P
J Dtsch Dermatol Ges 2017 Feb;15(2):151-157. doi: 10.1111/ddg.13186. PMID: 28214312
Necrobiosis Lipoidica.
Sibbald C, Reid S, Alavi A
Dermatol Clin 2015 Jul;33(3):343-60. doi: 10.1016/j.det.2015.03.003. PMID: 26143418

Prognosis

Cutaneous Manifestations of Diabetes Mellitus and Prediabetes.
Sanches MM, Roda Â, Pimenta R, Filipe PL, Freitas JP
Acta Med Port 2019 Jun 28;32(6):459-465. doi: 10.20344/amp.10738. PMID: 31292028
Necrobiosis Lipoidica.
Sibbald C, Reid S, Alavi A
Dermatol Clin 2015 Jul;33(3):343-60. doi: 10.1016/j.det.2015.03.003. PMID: 26143418
Palmar erythema.
Serrao R, Zirwas M, English JC
Am J Clin Dermatol 2007;8(6):347-56. doi: 10.2165/00128071-200708060-00004. PMID: 18039017
Diabetes mellitus.
Ahmed I, Goldstein B
Clin Dermatol 2006 Jul-Aug;24(4):237-46. doi: 10.1016/j.clindermatol.2006.04.009. PMID: 16828404
Skin and diabetes.
Sibbald RG, Landolt SJ, Toth D
Endocrinol Metab Clin North Am 1996 Jun;25(2):463-72. doi: 10.1016/s0889-8529(05)70334-0. PMID: 8799710

Clinical prediction guides

Histopathologic features of necrobiosis lipoidica.
Johnson E, Patel MH, Brumfiel CM, Severson KJ, Bhullar P, Boudreaux B, Butterfield RJ, DiCaudo DJ, Nelson SA, Pittelkow MR, Mangold AR
J Cutan Pathol 2022 Aug;49(8):692-700. Epub 2022 Apr 25 doi: 10.1111/cup.14238. PMID: 35403265
Non-infectious granulomatous dermatoses.
Schmitt A, Volz A
J Dtsch Dermatol Ges 2019 May;17(5):518-533. doi: 10.1111/ddg.13848. PMID: 31115996
Clinical Features and Comorbidities of Patients With Necrobiosis Lipoidica With or Without Diabetes.
Hashemi DA, Brown-Joel ZO, Tkachenko E, Nelson CA, Noe MH, Imadojemu S, Vleugels RA, Mostaghimi A, Wanat KA, Rosenbach M
JAMA Dermatol 2019 Apr 1;155(4):455-459. doi: 10.1001/jamadermatol.2018.5635. PMID: 30785603Free PMC Article
Panniculitides, an algorithmic approach.
Zelger B
G Ital Dermatol Venereol 2013 Aug;148(4):351-70. PMID: 23900158
Diabetic scleredema.
Toyota T, Umezu M, Oikawa N, Sanoyama R, Suzuki S, Suzuki H, Nakajima Y, Goto Y
Tohoku J Exp Med 1983 Dec;141(4):457-61. doi: 10.1620/tjem.141.457. PMID: 6670101

Recent systematic reviews

Use of Janus kinase inhibitors for granulomatous dermatoses: A systematic review.
Sood S, Heung M, Georgakopoulos JR, Mufti A, Prajapati VH, Yeung J
J Am Acad Dermatol 2023 Aug;89(2):357-359. Epub 2023 Mar 28 doi: 10.1016/j.jaad.2023.03.024. PMID: 36990321
Intralesional biologics for inflammatory dermatoses: A systematic review.
Seivright JR, Villa NM, De DR, Hsiao JL, Shi VY
Dermatol Ther 2022 Feb;35(2):e15234. Epub 2021 Dec 8 doi: 10.1111/dth.15234. PMID: 34825744
A systematic review of the relationship between glycemic control and necrobiosis lipoidica diabeticorum in patients with diabetes mellitus.
Mistry BD, Alavi A, Ali S, Mistry N
Int J Dermatol 2017 Dec;56(12):1319-1327. Epub 2017 Jun 26 doi: 10.1111/ijd.13610. PMID: 28650076
Specific skin signs as a cutaneous marker of diabetes mellitus and the prediabetic state - a systematic review.
Bustan RS, Wasim D, Yderstræde KB, Bygum A
Dan Med J 2017 Jan;64(1) PMID: 28007053
Ultraviolet A phototherapy for sclerotic skin diseases: a systematic review.
Kroft EB, Berkhof NJ, van de Kerkhof PC, Gerritsen RM, de Jong EM
J Am Acad Dermatol 2008 Dec;59(6):1017-30. Epub 2008 Oct 2 doi: 10.1016/j.jaad.2008.07.042. PMID: 18835066

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