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Necatoriasis

MedGen UID:
10277
•Concept ID:
C0027528
•
Disease or Syndrome
Synonym: Necatoriases
SNOMED CT: Necatoriasis (36667009); Necatorosis (36667009)
 
Monarch Initiative: MONDO:0005870

Definition

A disorder caused by an infection with hookworms of the genus Necator, which settle in the host''s small intestine, and cause abdominal pain, diarrhea, weight loss, and anemia. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNecatoriasis

Professional guidelines

PubMed

Cytokine and chemokine responses in patients co-infected with Entamoeba histolytica/dispar, Necator americanus and Mansonella perstans and changes after anti-parasite treatment.
Soboslay PT, Hamm DM, Pfäfflin F, Fendt J, Banla M, Schulz-Key H
Microbes Infect 2006 Jan;8(1):238-47. Epub 2005 Sep 12 doi: 10.1016/j.micinf.2005.06.019. PMID: 16239120
Necatoriasis: treatment and developmental therapeutics.
Georgiev VS
Expert Opin Investig Drugs 2000 May;9(5):1065-78. doi: 10.1517/13543784.9.5.1065. PMID: 11060728
Parasitic infections. Treatment and developmental therapeutics. 1. Necatoriasis.
Georgiev VS
Curr Pharm Des 1999 Jul;5(7):545-54. PMID: 10438896

Recent clinical studies

Etiology

Genotypic profile of benzimidazole resistance associated with SNP F167Y in the beta-tubulin gene of Necator americanus helminths obtained from Brazilian populations.
Furtado LFV, Dos Santos TR, de Oliveira VNGM, Rabelo ÉML
Infect Genet Evol 2020 Dec;86:104594. Epub 2020 Oct 17 doi: 10.1016/j.meegid.2020.104594. PMID: 33080381
New Insights Into the Kinetics and Variability of Egg Excretion in Controlled Human Hookworm Infections.
Hoogerwerf MA, Coffeng LE, Brienen EAT, Janse JJ, Langenberg MCC, Kruize YCM, Gootjes C, Manurung MD, Dekker M, Becker L, Erkens MAA, van der Beek MT, Ganesh MS, Feijt C, Winkel BMF, Westra IM, Meij P, Loukas A, Visser LG, de Vlas SJ, Yazdanbakhsh M, van Lieshout L, Roestenberg M
J Infect Dis 2019 Aug 9;220(6):1044-1048. doi: 10.1093/infdis/jiz218. PMID: 31077279
Necator americanus and helminth co-infections: further down-modulation of hookworm-specific type 1 immune responses.
Geiger SM, Alexander ND, Fujiwara RT, Brooker S, Cundill B, Diemert DJ, Correa-Oliveira R, Bethony JM
PLoS Negl Trop Dis 2011 Sep;5(9):e1280. Epub 2011 Sep 6 doi: 10.1371/journal.pntd.0001280. PMID: 21909439Free PMC Article
The changing epidemiology of human hookworm infection in Australia.
Prociv P, Luke RA
Med J Aust 1995 Feb 6;162(3):150-4. doi: 10.5694/j.1326-5377.1995.tb138481.x. PMID: 7854229
IgE levels in intestinal juice.
Belut D, Moneret-Vautrin DA, Nicolas JP, Grilliat JP
Dig Dis Sci 1980 May;25(5):323-32. doi: 10.1007/BF01308055. PMID: 7371471

Diagnosis

Hookworm infection in central China: morphological and molecular diagnosis.
Xu FF, Niu YF, Chen WQ, Liu SS, Li JR, Jiang P, Wang ZQ, Cui J, Zhang X
Parasit Vectors 2021 Oct 14;14(1):537. doi: 10.1186/s13071-021-05035-3. PMID: 34649597Free PMC Article
Hookworm in the eye.
Tao Z, Wang Y, Yu S, Yin ZQ, Liu Y, Li S
Lancet Infect Dis 2018 May;18(5):582. doi: 10.1016/S1473-3099(18)30097-5. PMID: 29695368
Multiple infections with helminths--whipworm, hookworm, and roundworm.
Inoue K, Ozaka S, Okamoto K, Ogawa R, Mizukami K, Okimoto T, Kodama M, Kobayashi T, Eshita Y, Hasegawa H, Murakami K
Endoscopy 2014;46 Suppl 1 UCTN:E117-8. Epub 2014 Mar 27 doi: 10.1055/s-0034-1364887. PMID: 24676818
Hookworm detected by capsule endoscopy.
Morales CP, Ferrer G, Zuckerman MJ
Gastrointest Endosc 2005 Nov;62(5):782-3; discussion 783. doi: 10.1016/j.gie.2005.04.038. PMID: 16246698
Immunodiagnosis of Strongyloides stercoralis infection: a method for increasing the specificity of the indirect ELISA.
Conway DJ, Atkins NS, Lillywhite JE, Bailey JW, Robinson RD, Lindo JF, Bundy DA, Bianco AE
Trans R Soc Trop Med Hyg 1993 Mar-Apr;87(2):173-6. doi: 10.1016/0035-9203(93)90477-8. PMID: 8337720

Therapy

Dynamics of the bacterial gut microbiota during controlled human infection with Necator americanus larvae.
Ducarmon QR, Hoogerwerf MA, Janse JJ, Geelen AR, Koopman JPR, Zwittink RD, Goeman JJ, Kuijper EJ, Roestenberg M
Gut Microbes 2020 Nov 9;12(1):1-15. doi: 10.1080/19490976.2020.1840764. PMID: 33222610Free PMC Article
Impact of experimental hookworm infection on the human gut microbiota.
Cantacessi C, Giacomin P, Croese J, Zakrzewski M, Sotillo J, McCann L, Nolan MJ, Mitreva M, Krause L, Loukas A
J Infect Dis 2014 Nov 1;210(9):1431-4. Epub 2014 May 3 doi: 10.1093/infdis/jiu256. PMID: 24795483Free PMC Article
Hookworm vaccines.
Diemert DJ, Bethony JM, Hotez PJ
Clin Infect Dis 2008 Jan 15;46(2):282-8. doi: 10.1086/524070. PMID: 18171264
Hookworm infection.
Hotez PJ, Pritchard DI
Sci Am 1995 Jun;272(6):68-74. doi: 10.1038/scientificamerican0695-68. PMID: 7761817
Chemotherapy of human intestinal parasitic diseases.
Botero D
Annu Rev Pharmacol Toxicol 1978;18:1-15. doi: 10.1146/annurev.pa.18.040178.000245. PMID: 348055

Prognosis

New Insights Into the Kinetics and Variability of Egg Excretion in Controlled Human Hookworm Infections.
Hoogerwerf MA, Coffeng LE, Brienen EAT, Janse JJ, Langenberg MCC, Kruize YCM, Gootjes C, Manurung MD, Dekker M, Becker L, Erkens MAA, van der Beek MT, Ganesh MS, Feijt C, Winkel BMF, Westra IM, Meij P, Loukas A, Visser LG, de Vlas SJ, Yazdanbakhsh M, van Lieshout L, Roestenberg M
J Infect Dis 2019 Aug 9;220(6):1044-1048. doi: 10.1093/infdis/jiz218. PMID: 31077279
Early stage-specific immune responses in primary experimental human hookworm infection.
Geiger SM, Fujiwara RT, Santiago H, Corrêa-Oliveira R, Bethony JM
Microbes Infect 2008 Nov-Dec;10(14-15):1524-35. Epub 2008 Sep 23 doi: 10.1016/j.micinf.2008.09.003. PMID: 18848637
Allergy controls the population density of Necator americanus in the small intestine.
Croese J, Wood MJ, Melrose W, Speare R
Gastroenterology 2006 Aug;131(2):402-9. doi: 10.1053/j.gastro.2006.05.019. PMID: 16890593
The innate allergenicity of helminth parasites.
Falcone FH, Loukas A, Quinnell RJ, Pritchard DI
Clin Rev Allergy Immunol 2004 Feb;26(1):61-72. doi: 10.1385/CRIAI:26:1:61. PMID: 14755076
Reinfection with hookworm after chemotherapy in Papua New Guinea.
Quinnell RJ, Slater AF, Tighe P, Walsh EA, Keymer AE, Pritchard DI
Parasitology 1993 May;106 ( Pt 4):379-85. doi: 10.1017/s0031182000067123. PMID: 8316435

Clinical prediction guides

Controlled human hookworm infection remodels plasmacytoid dendritic cells and regulatory T cells towards profiles seen in natural infections in endemic areas.
Manurung MD, Sonnet F, Hoogerwerf MA, Janse JJ, Kruize Y, Bes-Roeleveld L, König M, Loukas A, Dewals BG, Supali T, Jochems SP, Roestenberg M, Coppola M, Yazdanbakhsh M
Nat Commun 2024 Jul 16;15(1):5960. doi: 10.1038/s41467-024-50313-0. PMID: 39013877Free PMC Article
Restoration of hookworm egg development after prolonged storage in stool suspension.
Na-Ek P, Sanpool O, Jongthawin J, Anamnart W, Intapan PM, Chamavit P, Maleewong W
Parasitol Res 2016 Jul;115(7):2817-23. Epub 2016 Apr 6 doi: 10.1007/s00436-016-5031-4. PMID: 27053130
Impact of experimental hookworm infection on the human gut microbiota.
Cantacessi C, Giacomin P, Croese J, Zakrzewski M, Sotillo J, McCann L, Nolan MJ, Mitreva M, Krause L, Loukas A
J Infect Dis 2014 Nov 1;210(9):1431-4. Epub 2014 May 3 doi: 10.1093/infdis/jiu256. PMID: 24795483Free PMC Article
A case of severe anemia by Necator americanus infection in Korea.
Hyun HJ, Kim EM, Park SY, Jung JO, Chai JY, Hong ST
J Korean Med Sci 2010 Dec;25(12):1802-4. Epub 2010 Nov 24 doi: 10.3346/jkms.2010.25.12.1802. PMID: 21165298Free PMC Article
IgE levels in intestinal juice.
Belut D, Moneret-Vautrin DA, Nicolas JP, Grilliat JP
Dig Dis Sci 1980 May;25(5):323-32. doi: 10.1007/BF01308055. PMID: 7371471

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