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Necatoriasis

MedGen UID:
10277
•Concept ID:
C0027528
•
Disease or Syndrome
Synonym: Necatoriases
SNOMED CT: Necatoriasis (36667009); Necatorosis (36667009)
 
Monarch Initiative: MONDO:0005870

Definition

A disorder caused by an infection with hookworms of the genus Necator, which settle in the host''s small intestine, and cause abdominal pain, diarrhea, weight loss, and anemia. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNecatoriasis

Professional guidelines

PubMed

Necatoriasis: treatment and developmental therapeutics.
Georgiev VS
Expert Opin Investig Drugs 2000 May;9(5):1065-78. doi: 10.1517/13543784.9.5.1065. PMID: 11060728
Parasitic infections. Treatment and developmental therapeutics. 1. Necatoriasis.
Georgiev VS
Curr Pharm Des 1999 Jul;5(7):545-54. PMID: 10438896
Evaluation of albendazole, pyrantel, bephenium, pyrantel-praziquantel and pyrantel-bephenium for single-dose mass treatment of necatoriasis.
Nahmias J, Kennet R, Goldsmith R, Greenberg Z
Ann Trop Med Parasitol 1989 Dec;83(6):625-9. doi: 10.1080/00034983.1989.11812397. PMID: 2619378

Recent clinical studies

Etiology

Molecular features of hookworm larvae (Necator spp.) raised by coproculture from Ugandan chimpanzees and Gabonese gorillas and humans.
Hasegawa H, Shigyo M, Yanai Y, McLennan MR, Fujita S, Makouloutou P, Tsuchida S, Ando C, Sato H, Huffman MA
Parasitol Int 2017 Apr;66(2):12-15. Epub 2016 Nov 10 doi: 10.1016/j.parint.2016.11.003. PMID: 27840196
Humans and great apes cohabiting the forest ecosystem in central african republic harbour the same hookworms.
Hasegawa H, Modrý D, Kitagawa M, Shutt KA, Todd A, Kalousová B, Profousová I, Petrželková KJ
PLoS Negl Trop Dis 2014 Mar;8(3):e2715. Epub 2014 Mar 20 doi: 10.1371/journal.pntd.0002715. PMID: 24651493Free PMC Article
A history of hookworm vaccine development.
Schneider B, Jariwala AR, Periago MV, Gazzinelli MF, Bose SN, Hotez PJ, Diemert DJ, Bethony JM
Hum Vaccin 2011 Nov;7(11):1234-44. Epub 2011 Nov 1 doi: 10.4161/hv.7.11.18443. PMID: 22064562Free PMC Article
The changing epidemiology of human hookworm infection in Australia.
Prociv P, Luke RA
Med J Aust 1995 Feb 6;162(3):150-4. doi: 10.5694/j.1326-5377.1995.tb138481.x. PMID: 7854229
A comparative trial of oxantel-pyrantel and mebendazole in multiple helminth infection in school children.
Dissanaike AS
Drugs 1978;15 Suppl 1:73-7. doi: 10.2165/00003495-197800151-00015. PMID: 350569

Diagnosis

Hookworm in the eye.
Tao Z, Wang Y, Yu S, Yin ZQ, Liu Y, Li S
Lancet Infect Dis 2018 May;18(5):582. doi: 10.1016/S1473-3099(18)30097-5. PMID: 29695368
Necatoriasis: treatment and developmental therapeutics.
Georgiev VS
Expert Opin Investig Drugs 2000 May;9(5):1065-78. doi: 10.1517/13543784.9.5.1065. PMID: 11060728
Parasitic infections. Treatment and developmental therapeutics. 1. Necatoriasis.
Georgiev VS
Curr Pharm Des 1999 Jul;5(7):545-54. PMID: 10438896
Ascariasis and hookworm.
Sarinas PS, Chitkara RK
Semin Respir Infect 1997 Jun;12(2):130-7. PMID: 9195678
Immunodiagnosis of Strongyloides stercoralis infection: a method for increasing the specificity of the indirect ELISA.
Conway DJ, Atkins NS, Lillywhite JE, Bailey JW, Robinson RD, Lindo JF, Bundy DA, Bianco AE
Trans R Soc Trop Med Hyg 1993 Mar-Apr;87(2):173-6. doi: 10.1016/0035-9203(93)90477-8. PMID: 8337720

Therapy

Hookworm vaccines.
Diemert DJ, Bethony JM, Hotez PJ
Clin Infect Dis 2008 Jan 15;46(2):282-8. doi: 10.1086/524070. PMID: 18171264
Necatoriasis: treatment and developmental therapeutics.
Georgiev VS
Expert Opin Investig Drugs 2000 May;9(5):1065-78. doi: 10.1517/13543784.9.5.1065. PMID: 11060728
Parasitic infections. Treatment and developmental therapeutics. 1. Necatoriasis.
Georgiev VS
Curr Pharm Des 1999 Jul;5(7):545-54. PMID: 10438896
Ascariasis and hookworm.
Sarinas PS, Chitkara RK
Semin Respir Infect 1997 Jun;12(2):130-7. PMID: 9195678
Hookworm infection.
Hotez PJ, Pritchard DI
Sci Am 1995 Jun;272(6):68-74. doi: 10.1038/scientificamerican0695-68. PMID: 7761817

Prognosis

Vaccination of human participants with attenuated Necator americanus hookworm larvae and human challenge in Australia: a dose-finding study and randomised, placebo-controlled, phase 1 trial.
Chapman PR, Webster R, Giacomin P, Llewellyn S, Becker L, Pearson MS, De Labastida Rivera F, O'Rourke P, Engwerda CR, Loukas A, McCarthy JS
Lancet Infect Dis 2021 Dec;21(12):1725-1736. Epub 2021 Aug 19 doi: 10.1016/S1473-3099(21)00153-5. PMID: 34419209Free PMC Article
An environmental assessment and risk map of Ascaris lumbricoides and Necator americanus distributions in Manufahi District, Timor-Leste.
Wardell R, Clements ACA, Lal A, Summers D, Llewellyn S, Campbell SJ, McCarthy J, Gray DJ, V Nery S
PLoS Negl Trop Dis 2017 May;11(5):e0005565. Epub 2017 May 10 doi: 10.1371/journal.pntd.0005565. PMID: 28489889Free PMC Article
Improved insights into the transcriptomes of the human hookworm Necator americanus--fundamental and biotechnological implications.
Rabelo EM, Hall RS, Loukas A, Cooper L, Hu M, Ranganathan S, Gasser RB
Biotechnol Adv 2009 Mar-Apr;27(2):122-32. Epub 2008 Oct 18 doi: 10.1016/j.biotechadv.2008.10.002. PMID: 18977428
The innate allergenicity of helminth parasites.
Falcone FH, Loukas A, Quinnell RJ, Pritchard DI
Clin Rev Allergy Immunol 2004 Feb;26(1):61-72. doi: 10.1385/CRIAI:26:1:61. PMID: 14755076
Evaluation of albendazole, pyrantel, bephenium, pyrantel-praziquantel and pyrantel-bephenium for single-dose mass treatment of necatoriasis.
Nahmias J, Kennet R, Goldsmith R, Greenberg Z
Ann Trop Med Parasitol 1989 Dec;83(6):625-9. doi: 10.1080/00034983.1989.11812397. PMID: 2619378

Clinical prediction guides

Old friends and friendly fire: Pregnancy, hookworm infection, and anemia among tropical horticulturalists.
Anderson AS, Trumble BC, Hové C, Kraft TS, Kaplan H, Gurven M, Blackwell AD
Am J Hum Biol 2020 Mar;32(2):e23337. Epub 2019 Oct 23 doi: 10.1002/ajhb.23337. PMID: 31642576Free PMC Article
Humans and great apes cohabiting the forest ecosystem in central african republic harbour the same hookworms.
Hasegawa H, Modrý D, Kitagawa M, Shutt KA, Todd A, Kalousová B, Profousová I, Petrželková KJ
PLoS Negl Trop Dis 2014 Mar;8(3):e2715. Epub 2014 Mar 20 doi: 10.1371/journal.pntd.0002715. PMID: 24651493Free PMC Article
Improved insights into the transcriptomes of the human hookworm Necator americanus--fundamental and biotechnological implications.
Rabelo EM, Hall RS, Loukas A, Cooper L, Hu M, Ranganathan S, Gasser RB
Biotechnol Adv 2009 Mar-Apr;27(2):122-32. Epub 2008 Oct 18 doi: 10.1016/j.biotechadv.2008.10.002. PMID: 18977428
Single dose mebendazole therapy for soil-transmitted nematodes.
Abadi K
Am J Trop Med Hyg 1985 Jan;34(1):129-33. doi: 10.4269/ajtmh.1985.34.129. PMID: 3970305
Albendazole: a new broad spectrum anthelmintic. Double-blind multicenter clinical trial.
Pene P, Mojon M, Garin JP, Coulaud JP, Rossignol JF
Am J Trop Med Hyg 1982 Mar;31(2):263-6. doi: 10.4269/ajtmh.1982.31.263. PMID: 7041665

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