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Nicotine withdrawal

MedGen UID:
10346
•Concept ID:
C0028047
•
Mental or Behavioral Dysfunction
Synonyms: Nicotine Withdrawal; Nicotine withdrawal syndrome
SNOMED CT: Nicotine withdrawal (90755006); Nicotine withdrawal syndrome (90755006)

Definition

A condition which occurs following suspension of nicotine use. Clinical features may include nicotine craving, irritability, anxiety, depression and increased appetite. The onset of symptoms may be rapid with severity proportional to length and amount of nicotine use. Unsuccessful management of symptoms may prompt a return to nicotine use. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNicotine withdrawal

Professional guidelines

PubMed

Clinical approach to the treatment of e-cigarette use among adolescents.
Kaliamurthy S, Camenga DR
Curr Probl Pediatr Adolesc Health Care 2022 Jun;52(6):101203. Epub 2022 May 7 doi: 10.1016/j.cppeds.2022.101203. PMID: 35534404
Cognitive function during nicotine withdrawal: Implications for nicotine dependence treatment.
Ashare RL, Falcone M, Lerman C
Neuropharmacology 2014 Jan;76 Pt B(0 0):581-91. Epub 2013 Apr 29 doi: 10.1016/j.neuropharm.2013.04.034. PMID: 23639437Free PMC Article
Bupropion for the treatment of nicotine withdrawal and craving.
Mooney ME, Sofuoglu M
Expert Rev Neurother 2006 Jul;6(7):965-81. doi: 10.1586/14737175.6.7.965. PMID: 16831112

Recent clinical studies

Etiology

Mindfulness for smoking cessation.
Jackson S, Brown J, Norris E, Livingstone-Banks J, Hayes E, Lindson N
Cochrane Database Syst Rev 2022 Apr 14;4(4):CD013696. doi: 10.1002/14651858.CD013696.pub2. PMID: 35420700Free PMC Article
Smoking reduction interventions for smoking cessation.
Lindson N, Klemperer E, Hong B, Ordóñez-Mena JM, Aveyard P
Cochrane Database Syst Rev 2019 Sep 30;9(9):CD013183. doi: 10.1002/14651858.CD013183.pub2. PMID: 31565800Free PMC Article
Nicotine replacement therapy versus control for smoking cessation.
Hartmann-Boyce J, Chepkin SC, Ye W, Bullen C, Lancaster T
Cochrane Database Syst Rev 2018 May 31;5(5):CD000146. doi: 10.1002/14651858.CD000146.pub5. PMID: 29852054Free PMC Article
Effects of nicotine on sleep during consumption, withdrawal and replacement therapy.
Jaehne A, Loessl B, Bárkai Z, Riemann D, Hornyak M
Sleep Med Rev 2009 Oct;13(5):363-77. Epub 2009 Apr 2 doi: 10.1016/j.smrv.2008.12.003. PMID: 19345124
Pharmacology of nicotine: addiction, smoking-induced disease, and therapeutics.
Benowitz NL
Annu Rev Pharmacol Toxicol 2009;49:57-71. doi: 10.1146/annurev.pharmtox.48.113006.094742. PMID: 18834313Free PMC Article

Diagnosis

Anhedonia in Nicotine Dependence.
Gilbert DG, Stone BM
Curr Top Behav Neurosci 2022;58:167-184. doi: 10.1007/7854_2022_320. PMID: 35507287
Neurobiological Mechanisms of Nicotine Reward and Aversion.
Wills L, Ables JL, Braunscheidel KM, Caligiuri SPB, Elayouby KS, Fillinger C, Ishikawa M, Moen JK, Kenny PJ
Pharmacol Rev 2022 Jan;74(1):271-310. doi: 10.1124/pharmrev.121.000299. PMID: 35017179
Smoking cessation for improving mental health.
Taylor GM, Lindson N, Farley A, Leinberger-Jabari A, Sawyer K, Te Water Naudé R, Theodoulou A, King N, Burke C, Aveyard P
Cochrane Database Syst Rev 2021 Mar 9;3(3):CD013522. doi: 10.1002/14651858.CD013522.pub2. PMID: 33687070Free PMC Article
Smoking Cessation in Chronic Obstructive Pulmonary Disease.
Tashkin DP
Semin Respir Crit Care Med 2015 Aug;36(4):491-507. Epub 2015 Aug 3 doi: 10.1055/s-0035-1555610. PMID: 26238637
Brain serotonin, carbohydrate-craving, obesity and depression.
Wurtman RJ, Wurtman JJ
Obes Res 1995 Nov;3 Suppl 4:477S-480S. doi: 10.1002/j.1550-8528.1995.tb00215.x. PMID: 8697046

Therapy

Rodent models for nicotine withdrawal.
Chellian R, Behnood-Rod A, Bruijnzeel DM, Wilson R, Pandy V, Bruijnzeel AW
J Psychopharmacol 2021 Oct;35(10):1169-1187. Epub 2021 Apr 22 doi: 10.1177/02698811211005629. PMID: 33888006Free PMC Article
Smoking reduction interventions for smoking cessation.
Lindson N, Klemperer E, Hong B, Ordóñez-Mena JM, Aveyard P
Cochrane Database Syst Rev 2019 Sep 30;9(9):CD013183. doi: 10.1002/14651858.CD013183.pub2. PMID: 31565800Free PMC Article
Nicotine replacement therapy versus control for smoking cessation.
Hartmann-Boyce J, Chepkin SC, Ye W, Bullen C, Lancaster T
Cochrane Database Syst Rev 2018 May 31;5(5):CD000146. doi: 10.1002/14651858.CD000146.pub5. PMID: 29852054Free PMC Article
Nicotine replacement therapy for smoking cessation.
Stead LF, Perera R, Bullen C, Mant D, Hartmann-Boyce J, Cahill K, Lancaster T
Cochrane Database Syst Rev 2012 Nov 14;11:CD000146. doi: 10.1002/14651858.CD000146.pub4. PMID: 23152200
Effects of nicotine on sleep during consumption, withdrawal and replacement therapy.
Jaehne A, Loessl B, Bárkai Z, Riemann D, Hornyak M
Sleep Med Rev 2009 Oct;13(5):363-77. Epub 2009 Apr 2 doi: 10.1016/j.smrv.2008.12.003. PMID: 19345124

Prognosis

Age-specific impacts of nicotine and withdrawal on hippocampal neuregulin signalling.
Keady J, Fisher M, Anderson E, LeMalefant R, Turner J
Eur J Neurosci 2022 Sep;56(6):4705-4719. Epub 2022 Aug 30 doi: 10.1111/ejn.15780. PMID: 35899607Free PMC Article
Rodent models for nicotine withdrawal.
Chellian R, Behnood-Rod A, Bruijnzeel DM, Wilson R, Pandy V, Bruijnzeel AW
J Psychopharmacol 2021 Oct;35(10):1169-1187. Epub 2021 Apr 22 doi: 10.1177/02698811211005629. PMID: 33888006Free PMC Article
Smoking cessation for improving mental health.
Taylor GM, Lindson N, Farley A, Leinberger-Jabari A, Sawyer K, Te Water Naudé R, Theodoulou A, King N, Burke C, Aveyard P
Cochrane Database Syst Rev 2021 Mar 9;3(3):CD013522. doi: 10.1002/14651858.CD013522.pub2. PMID: 33687070Free PMC Article
Translational Research on Nicotine Dependence.
Falcone M, Lee B, Lerman C, Blendy JA
Curr Top Behav Neurosci 2016;28:121-50. doi: 10.1007/7854_2015_5005. PMID: 26873019
Nicotine withdrawal.
McLaughlin I, Dani JA, De Biasi M
Curr Top Behav Neurosci 2015;24:99-123. doi: 10.1007/978-3-319-13482-6_4. PMID: 25638335Free PMC Article

Clinical prediction guides

Age-specific impacts of nicotine and withdrawal on hippocampal neuregulin signalling.
Keady J, Fisher M, Anderson E, LeMalefant R, Turner J
Eur J Neurosci 2022 Sep;56(6):4705-4719. Epub 2022 Aug 30 doi: 10.1111/ejn.15780. PMID: 35899607Free PMC Article
Rodent models for nicotine withdrawal.
Chellian R, Behnood-Rod A, Bruijnzeel DM, Wilson R, Pandy V, Bruijnzeel AW
J Psychopharmacol 2021 Oct;35(10):1169-1187. Epub 2021 Apr 22 doi: 10.1177/02698811211005629. PMID: 33888006Free PMC Article
Health effects of electronic cigarette (e‑cigarette) use on organ systems and its implications for public health.
Seiler-Ramadas R, Sandner I, Haider S, Grabovac I, Dorner TE
Wien Klin Wochenschr 2021 Oct;133(19-20):1020-1027. Epub 2020 Jul 20 doi: 10.1007/s00508-020-01711-z. PMID: 32691214Free PMC Article
Smoking Cessation in Chronic Obstructive Pulmonary Disease.
Tashkin DP
Semin Respir Crit Care Med 2015 Aug;36(4):491-507. Epub 2015 Aug 3 doi: 10.1055/s-0035-1555610. PMID: 26238637
Effects of nicotine on sleep during consumption, withdrawal and replacement therapy.
Jaehne A, Loessl B, Bárkai Z, Riemann D, Hornyak M
Sleep Med Rev 2009 Oct;13(5):363-77. Epub 2009 Apr 2 doi: 10.1016/j.smrv.2008.12.003. PMID: 19345124

Recent systematic reviews

Mindfulness for smoking cessation.
Jackson S, Brown J, Norris E, Livingstone-Banks J, Hayes E, Lindson N
Cochrane Database Syst Rev 2022 Apr 14;4(4):CD013696. doi: 10.1002/14651858.CD013696.pub2. PMID: 35420700Free PMC Article
Smoking cessation for improving mental health.
Taylor GM, Lindson N, Farley A, Leinberger-Jabari A, Sawyer K, Te Water Naudé R, Theodoulou A, King N, Burke C, Aveyard P
Cochrane Database Syst Rev 2021 Mar 9;3(3):CD013522. doi: 10.1002/14651858.CD013522.pub2. PMID: 33687070Free PMC Article
Smoking reduction interventions for smoking cessation.
Lindson N, Klemperer E, Hong B, Ordóñez-Mena JM, Aveyard P
Cochrane Database Syst Rev 2019 Sep 30;9(9):CD013183. doi: 10.1002/14651858.CD013183.pub2. PMID: 31565800Free PMC Article
Nicotine replacement therapy versus control for smoking cessation.
Hartmann-Boyce J, Chepkin SC, Ye W, Bullen C, Lancaster T
Cochrane Database Syst Rev 2018 May 31;5(5):CD000146. doi: 10.1002/14651858.CD000146.pub5. PMID: 29852054Free PMC Article
Nicotine replacement therapy for smoking cessation.
Stead LF, Perera R, Bullen C, Mant D, Hartmann-Boyce J, Cahill K, Lancaster T
Cochrane Database Syst Rev 2012 Nov 14;11:CD000146. doi: 10.1002/14651858.CD000146.pub4. PMID: 23152200

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