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Myxoid leiomyosarcoma

MedGen UID:
104725
Concept ID:
C0205816
Neoplastic Process
Synonyms: Leiomyosarcoma, Myxoid; Leiomyosarcomas, Myxoid; Myxoid Leiomyosarcoma; Myxoid Leiomyosarcomas
SNOMED CT: Myxoid leiomyosarcoma (16090008)
 
Monarch Initiative: MONDO:0003359

Definition

A morphologic variant of leiomyosarcoma characterized by the presence of cellular pleomorphism, malignant cells with large nuclei, and a myxoid stroma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMyxoid leiomyosarcoma

Professional guidelines

PubMed

Busca A, Parra-Herran C
Adv Anat Pathol 2017 Nov;24(6):354-361. doi: 10.1097/PAP.0000000000000164. PMID: 28787279
Kilpatrick SE, Ward WG, Bos GD
Cancer 2000 Jun 25;90(3):167-77. doi: 10.1002/1097-0142(20000625)90:3<167::aid-cncr5>3.0.co;2-z. PMID: 10896330
Clement PB, Young RH, Scully RE
Am J Surg Pathol 1992 Jan;16(1):26-32. doi: 10.1097/00000478-199201000-00004. PMID: 1309411

Recent clinical studies

Etiology

Thiryayi SA, Turashvili G, Latta EK, Swanson D, Zhang L, Antonescu CR, Dickson BC
Genes Chromosomes Cancer 2021 Oct;60(10):713-717. Epub 2021 Jul 8 doi: 10.1002/gcc.22980. PMID: 34184333Free PMC Article
Shukla PS, Mittal K
Arch Pathol Lab Med 2019 Jan;143(1):122-129. Epub 2018 Jul 2 doi: 10.5858/arpa.2017-0575-RA. PMID: 29965784
Petscavage-Thomas JM, Walker EA, Logie CI, Clarke LE, Duryea DM, Murphey MD
Radiographics 2014 Jul-Aug;34(4):964-80. doi: 10.1148/rg.344130110. PMID: 25019435
Burch DM, Tavassoli FA
Histopathology 2011 Dec;59(6):1144-55. doi: 10.1111/j.1365-2559.2011.04053.x. PMID: 22175894
Oliva E, Clement PB, Young RH
Adv Anat Pathol 2000 Sep;7(5):257-81. doi: 10.1097/00125480-200007050-00001. PMID: 10976906

Diagnosis

Shukla PS, Mittal K
Arch Pathol Lab Med 2019 Jan;143(1):122-129. Epub 2018 Jul 2 doi: 10.5858/arpa.2017-0575-RA. PMID: 29965784
Busca A, Parra-Herran C
Adv Anat Pathol 2017 Nov;24(6):354-361. doi: 10.1097/PAP.0000000000000164. PMID: 28787279
Lu B, Shi H, Zhang X
Hum Pathol 2017 Jan;59:139-146. Epub 2016 Oct 4 doi: 10.1016/j.humpath.2016.09.014. PMID: 27717885
Parra-Herran C, Schoolmeester JK, Yuan L, Dal Cin P, Fletcher CD, Quade BJ, Nucci MR
Am J Surg Pathol 2016 Mar;40(3):285-301. doi: 10.1097/PAS.0000000000000593. PMID: 26866354
Salm R, Evans DJ
Histopathology 1985 Feb;9(2):159-69. doi: 10.1111/j.1365-2559.1985.tb02432.x. PMID: 3988243

Therapy

Torrence D, Xie Z, Zhang L, Chi P, Antonescu CR
Genes Chromosomes Cancer 2021 Dec;60(12):789-795. Epub 2021 Aug 25 doi: 10.1002/gcc.22991. PMID: 34398495Free PMC Article
Botsis D, Koliopoulos C, Kondi-Pafitis A, Creatsas G
Int J Gynecol Pathol 2006 Apr;25(2):173-5. doi: 10.1097/01.pgp.0000185407.93308.ce. PMID: 16633068
Fukunishi H, Yukimura N, Takeuchi S, Kitazawa S
Int J Gynaecol Obstet 1994 Sep;46(3):321-4. doi: 10.1016/0020-7292(94)90413-8. PMID: 7806003
Kunzel KE, Mills NZ, Muderspach LI, d'Ablaing G 3rd
Gynecol Oncol 1993 Feb;48(2):277-80. doi: 10.1006/gyno.1993.1048. PMID: 8428703

Prognosis

Busca A, Parra-Herran C
Adv Anat Pathol 2017 Nov;24(6):354-361. doi: 10.1097/PAP.0000000000000164. PMID: 28787279
Lu B, Shi H, Zhang X
Hum Pathol 2017 Jan;59:139-146. Epub 2016 Oct 4 doi: 10.1016/j.humpath.2016.09.014. PMID: 27717885
Zhang L, Li Y, Qu Q, Wen K
Eur J Gynaecol Oncol 2016;37(6):870-872. PMID: 29943940
Parra-Herran C, Schoolmeester JK, Yuan L, Dal Cin P, Fletcher CD, Quade BJ, Nucci MR
Am J Surg Pathol 2016 Mar;40(3):285-301. doi: 10.1097/PAS.0000000000000593. PMID: 26866354
Salm R, Evans DJ
Histopathology 1985 Feb;9(2):159-69. doi: 10.1111/j.1365-2559.1985.tb02432.x. PMID: 3988243

Clinical prediction guides

Busca A, Parra-Herran C
Adv Anat Pathol 2017 Nov;24(6):354-361. doi: 10.1097/PAP.0000000000000164. PMID: 28787279
Schaefer IM, Hornick JL, Sholl LM, Quade BJ, Nucci MR, Parra-Herran C
Histopathology 2017 Jun;70(7):1138-1146. Epub 2017 Mar 20 doi: 10.1111/his.13176. PMID: 28130839
Lu B, Shi H, Zhang X
Hum Pathol 2017 Jan;59:139-146. Epub 2016 Oct 4 doi: 10.1016/j.humpath.2016.09.014. PMID: 27717885
Parra-Herran C, Schoolmeester JK, Yuan L, Dal Cin P, Fletcher CD, Quade BJ, Nucci MR
Am J Surg Pathol 2016 Mar;40(3):285-301. doi: 10.1097/PAS.0000000000000593. PMID: 26866354
Kasahara K, Nishida M, Iijima S, Kaneko M
Obstet Gynecol 2000 Jun;95(6 Pt 2):1004-6. doi: 10.1016/s0029-7844(00)00877-2. PMID: 10808004

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