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Ossification of posterior longitudinal ligament

MedGen UID:
104849
•Concept ID:
C0206366
•
Pathologic Function
Synonyms: Calcification of Posterior Longitudinal Ligament; Ossification of Posterior Longitudinal Ligament; Posterior Longitudinal Ligament Calcification; Posterior Longitudinal Ligament Ossification
SNOMED CT: Ossification of the posterior longitudinal ligament (90448008); Posterior longitudinal ligament calcification (90448008); Ossification of posterior longitudinal ligament (90448008)

Definition

A disorder characterized by benign depositions of calcium in the posterior longitudinal ligament. Signs and symptoms result from the compression of nerve roots and include motor and sensory disturbances in the lower and upper extremities, and pain in the neck and arms. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOssification of posterior longitudinal ligament

Professional guidelines

PubMed

Consensus statement on diagnosis and treatment of cervical ossification of posterior longitudinal ligament from Asia Pacific Spine Society (APSS) 2020.
Sun XF, Wang Y, Sun JC, Xu XM, Kong QJ, Chen Y, Yang HS, Liu Y, Guo YF, Shi GD, Chen XS, Chen DY, Shen Y, Hao DJ, Shen HX, Zhu QS, Yuan W, Jia LS, Shi JG
J Orthop Surg (Hong Kong) 2020 Sep-Dec;28(3):2309499020975213. doi: 10.1177/2309499020975213. PMID: 33355038
Multicenter cross-sectional study of the clinical features and types of treatment of spinal cord-related pain syndrome.
Nakajima H, Uchida K, Taguchi T, Yamashita T, Tominaga T, Tanaka M, Yamagata M, Kaito T, Ushida T
J Orthop Sci 2019 Sep;24(5):798-804. Epub 2019 Feb 15 doi: 10.1016/j.jos.2019.01.012. PMID: 30777363
Transforaminal thoracic interbody fusion : Treatment of thoracic myelopathy caused by anterior compression.
Yu LJ, Li WJ, Guo SG, Zhao Y
Orthopade 2018 Dec;47(12):986-992. doi: 10.1007/s00132-018-3588-6. PMID: 29881916

Recent clinical studies

Etiology

Risk factors for the development of degenerative cervical myelopathy: a review of the literature.
Baucher G, Taskovic J, Troude L, Molliqaj G, Nouri A, Tessitore E
Neurosurg Rev 2022 Apr;45(2):1675-1689. Epub 2021 Nov 30 doi: 10.1007/s10143-021-01698-9. PMID: 34845577
Intraoperative evoked potentials in patients with ossification of posterior longitudinal ligament.
Yoo M, Park YG, Cho YE, Lim CH, Chung SY, Kim D, Park J
J Clin Monit Comput 2022 Feb;36(1):247-258. Epub 2021 Feb 6 doi: 10.1007/s10877-020-00646-0. PMID: 33548015
Kinematics after cervical laminoplasty: risk factors for cervical kyphotic deformity after laminoplasty.
Kim BJ, Cho SM, Hur JW, Cha J, Kim SH
Spine J 2021 Nov;21(11):1822-1829. Epub 2021 Jun 10 doi: 10.1016/j.spinee.2021.06.010. PMID: 34118416
Ossification of posterior longitudinal ligament and fluorosis.
Reddy KVS, Mudumba VS, Tokala IM, Reddy DR
Neurol India 2018 Sep-Oct;66(5):1394-1399. doi: 10.4103/0028-3886.241343. PMID: 30233012
Surgical treatment of ossification of the posterior longitudinal ligament and its outcomes: posterior surgery by laminoplasty.
Matsumoto M, Chiba K, Toyama Y
Spine (Phila Pa 1976) 2012 Mar 1;37(5):E303-8. doi: 10.1097/BRS.0b013e318239cca0. PMID: 22020585

Diagnosis

Ossification of the Posterior Longitudinal Ligament: Pathophysiology, Diagnosis, and Management.
Le HV, Wick JB, Van BW, Klineberg EO
J Am Acad Orthop Surg 2022 Sep 1;30(17):820-830. Epub 2022 May 18 doi: 10.5435/JAAOS-D-22-00049. PMID: 35587949
Kinematics after cervical laminoplasty: risk factors for cervical kyphotic deformity after laminoplasty.
Kim BJ, Cho SM, Hur JW, Cha J, Kim SH
Spine J 2021 Nov;21(11):1822-1829. Epub 2021 Jun 10 doi: 10.1016/j.spinee.2021.06.010. PMID: 34118416
Consensus statement on diagnosis and treatment of cervical ossification of posterior longitudinal ligament from Asia Pacific Spine Society (APSS) 2020.
Sun XF, Wang Y, Sun JC, Xu XM, Kong QJ, Chen Y, Yang HS, Liu Y, Guo YF, Shi GD, Chen XS, Chen DY, Shen Y, Hao DJ, Shen HX, Zhu QS, Yuan W, Jia LS, Shi JG
J Orthop Surg (Hong Kong) 2020 Sep-Dec;28(3):2309499020975213. doi: 10.1177/2309499020975213. PMID: 33355038
Ossification of the posterior longitudinal ligament in the cervical spine: a review.
Boody BS, Lendner M, Vaccaro AR
Int Orthop 2019 Apr;43(4):797-805. Epub 2018 Aug 16 doi: 10.1007/s00264-018-4106-5. PMID: 30116867
Diagnosis and surgical management of cervical ossification of the posterior longitudinal ligament.
Epstein N
Spine J 2002 Nov-Dec;2(6):436-49. doi: 10.1016/s1529-9430(02)00394-7. PMID: 14589269

Therapy

To infer the probability of cervical ossification of the posterior longitudinal ligament and explore its impact on cervical surgery.
Zhu J, Lu Q, Zhan X, Huang S, Zhou C, Wu S, Chen T, Yao Y, Liao S, Yu C, Fan B, Yang Z, Gu W, Wang Y, Wei W, Liu C
Sci Rep 2023 Jun 17;13(1):9816. doi: 10.1038/s41598-023-36992-7. PMID: 37330595Free PMC Article
Kinematics after cervical laminoplasty: risk factors for cervical kyphotic deformity after laminoplasty.
Kim BJ, Cho SM, Hur JW, Cha J, Kim SH
Spine J 2021 Nov;21(11):1822-1829. Epub 2021 Jun 10 doi: 10.1016/j.spinee.2021.06.010. PMID: 34118416
Long-term outcome of laminectomy for cervical ossification of the posterior longitudinal ligament.
Lee SE, Chung CK, Jahng TA, Kim HJ
J Neurosurg Spine 2013 May;18(5):465-71. Epub 2013 Mar 1 doi: 10.3171/2013.1.SPINE12779. PMID: 23452249
Conservative management of ossification of the posterior longitudinal ligament. A review.
Pham MH, Attenello FJ, Lucas J, He S, Stapleton CJ, Hsieh PC
Neurosurg Focus 2011 Mar;30(3):E2. doi: 10.3171/2011.1.FOCUS10273. PMID: 21434818
Cervical laminoplasty.
Steinmetz MP, Resnick DK
Spine J 2006 Nov-Dec;6(6 Suppl):274S-281S. doi: 10.1016/j.spinee.2006.04.023. PMID: 17097547

Prognosis

Kinematics after cervical laminoplasty: risk factors for cervical kyphotic deformity after laminoplasty.
Kim BJ, Cho SM, Hur JW, Cha J, Kim SH
Spine J 2021 Nov;21(11):1822-1829. Epub 2021 Jun 10 doi: 10.1016/j.spinee.2021.06.010. PMID: 34118416
Ossification of posterior longitudinal ligament and fluorosis.
Reddy KVS, Mudumba VS, Tokala IM, Reddy DR
Neurol India 2018 Sep-Oct;66(5):1394-1399. doi: 10.4103/0028-3886.241343. PMID: 30233012
Role of Runx2 polymorphisms in risk and prognosis of ossification of posterior longitudinal ligament.
Chang F, Li L, Gao G, Ding S, Yang J, Zhang T, Zuo G
J Clin Lab Anal 2017 Jul;31(4) Epub 2016 Oct 5 doi: 10.1002/jcla.22068. PMID: 27704615Free PMC Article
Ossification of the posterior longitudinal ligament of the cervical spine: etiology and natural history.
Matsunaga S, Sakou T
Spine (Phila Pa 1976) 2012 Mar 1;37(5):E309-14. doi: 10.1097/BRS.0b013e318241ad33. PMID: 22146284
Surgical treatment of ossification of the posterior longitudinal ligament and its outcomes: posterior surgery by laminoplasty.
Matsumoto M, Chiba K, Toyama Y
Spine (Phila Pa 1976) 2012 Mar 1;37(5):E303-8. doi: 10.1097/BRS.0b013e318239cca0. PMID: 22020585

Clinical prediction guides

Ossification of the Posterior Longitudinal Ligament: Pathophysiology, Diagnosis, and Management.
Le HV, Wick JB, Van BW, Klineberg EO
J Am Acad Orthop Surg 2022 Sep 1;30(17):820-830. Epub 2022 May 18 doi: 10.5435/JAAOS-D-22-00049. PMID: 35587949
Kinematics after cervical laminoplasty: risk factors for cervical kyphotic deformity after laminoplasty.
Kim BJ, Cho SM, Hur JW, Cha J, Kim SH
Spine J 2021 Nov;21(11):1822-1829. Epub 2021 Jun 10 doi: 10.1016/j.spinee.2021.06.010. PMID: 34118416
Ossification of posterior longitudinal ligament and fluorosis.
Reddy KVS, Mudumba VS, Tokala IM, Reddy DR
Neurol India 2018 Sep-Oct;66(5):1394-1399. doi: 10.4103/0028-3886.241343. PMID: 30233012
Ossification of the posterior longitudinal ligament of the cervical spine: etiology and natural history.
Matsunaga S, Sakou T
Spine (Phila Pa 1976) 2012 Mar 1;37(5):E309-14. doi: 10.1097/BRS.0b013e318241ad33. PMID: 22146284
Ossification of the posterior longitudinal ligament: pathogenesis, management, and current surgical approaches. A review.
Smith ZA, Buchanan CC, Raphael D, Khoo LT
Neurosurg Focus 2011 Mar;30(3):E10. doi: 10.3171/2011.1.FOCUS10256. PMID: 21361748

Recent systematic reviews

Molecular and Genetic Mechanisms of Spinal Stenosis Formation: Systematic Review.
Byvaltsev VA, Kalinin AA, Hernandez PA, Shepelev VV, Pestryakov YY, Aliyev MA, Giers MB
Int J Mol Sci 2022 Nov 3;23(21) doi: 10.3390/ijms232113479. PMID: 36362274Free PMC Article
Comparison of Interventions for Cervical Ossification of Posterior Longitudinal Ligament: A Systematic Review and Network Meta-Analysis.
Wang H, Yang R, Liu H, Meng Y, Hong Y
World Neurosurg 2021 Nov;155:1-12. Epub 2021 Aug 5 doi: 10.1016/j.wneu.2021.07.138. PMID: 34365049
Comparison of laminoplasty versus laminectomy and fusion in the treatment of multilevel cervical ossification of the posterior longitudinal ligament: A systematic review and meta-analysis.
Ma L, Liu FY, Huo LS, Zhao ZQ, Sun XZ, Li F, Ding WY
Medicine (Baltimore) 2018 Jul;97(29):e11542. doi: 10.1097/MD.0000000000011542. PMID: 30024545Free PMC Article
Anterior versus posterior approach for the treatment of cervical compressive myelopathy due to ossification of the posterior longitudinal ligament: A systematic review and meta-analysis.
Feng F, Ruan W, Liu Z, Li Y, Cai L
Int J Surg 2016 Mar;27:26-33. Epub 2016 Jan 19 doi: 10.1016/j.ijsu.2016.01.038. PMID: 26804354
Genetics and heritability of cervical spondylotic myelopathy and ossification of the posterior longitudinal ligament: results of a systematic review.
Wilson JR, Patel AA, Brodt ED, Dettori JR, Brodke DS, Fehlings MG
Spine (Phila Pa 1976) 2013 Oct 15;38(22 Suppl 1):S123-46. doi: 10.1097/BRS.0b013e3182a7f478. PMID: 23963008

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