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Ossification of posterior longitudinal ligament

MedGen UID:
104849
Concept ID:
C0206366
Pathologic Function
Synonyms: Calcification of Posterior Longitudinal Ligament; Ossification of Posterior Longitudinal Ligament; Posterior Longitudinal Ligament Calcification; Posterior Longitudinal Ligament Ossification
SNOMED CT: Ossification of the posterior longitudinal ligament (90448008); Posterior longitudinal ligament calcification (90448008); Ossification of posterior longitudinal ligament (90448008)

Definition

A disorder characterized by benign depositions of calcium in the posterior longitudinal ligament. Signs and symptoms result from the compression of nerve roots and include motor and sensory disturbances in the lower and upper extremities, and pain in the neck and arms. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOssification of posterior longitudinal ligament

Professional guidelines

PubMed

Ma X, Wang B, Chen Y, Ge S, Zou X, Zhang S, Xia H
Oper Neurosurg (Hagerstown) 2021 Aug 16;21(3):118-125. doi: 10.1093/ons/opab193. PMID: 34097732
Sun XF, Wang Y, Sun JC, Xu XM, Kong QJ, Chen Y, Yang HS, Liu Y, Guo YF, Shi GD, Chen XS, Chen DY, Shen Y, Hao DJ, Shen HX, Zhu QS, Yuan W, Jia LS, Shi JG
J Orthop Surg (Hong Kong) 2020 Sep-Dec;28(3):2309499020975213. doi: 10.1177/2309499020975213. PMID: 33355038
Nakajima H, Uchida K, Taguchi T, Yamashita T, Tominaga T, Tanaka M, Yamagata M, Kaito T, Ushida T
J Orthop Sci 2019 Sep;24(5):798-804. Epub 2019 Feb 15 doi: 10.1016/j.jos.2019.01.012. PMID: 30777363

Recent clinical studies

Etiology

Kimchi G, Maimon T, Geva LL, Knoller N, Peled A, Yaniv G, Orlev A, Klug M, Harel R
World Neurosurg 2023 Nov;179:e256-e261. Epub 2023 Aug 22 doi: 10.1016/j.wneu.2023.08.064. PMID: 37619842
Kato H, Braddock DT, Ito N
Curr Osteoporos Rep 2023 Oct;21(5):552-566. Epub 2023 Aug 2 doi: 10.1007/s11914-023-00814-6. PMID: 37530996Free PMC Article
Fujita R, Endo T, Takahata M, Koike Y, Yoneoka D, Suzuki R, Tanaka M, Yamada K, Sudo H, Hasegawa T, Terkawi MA, Kadoya K, Iwasaki N
Spine J 2023 Oct;23(10):1461-1470. Epub 2023 Jul 10 doi: 10.1016/j.spinee.2023.06.400. PMID: 37437695
Fukada S, Endo T, Takahata M, Kanayama M, Koike Y, Fujita R, Suzuki R, Murakami T, Hasegawa T, Terkawi MA, Hashimoto T, Yamada K, Sudo H, Kadoya K, Iwasaki N
Spine J 2023 Sep;23(9):1287-1295. Epub 2023 May 7 doi: 10.1016/j.spinee.2023.05.005. PMID: 37160167
Reddy KVS, Mudumba VS, Tokala IM, Reddy DR
Neurol India 2018 Sep-Oct;66(5):1394-1399. doi: 10.4103/0028-3886.241343. PMID: 30233012

Diagnosis

Kato H, Braddock DT, Ito N
Curr Osteoporos Rep 2023 Oct;21(5):552-566. Epub 2023 Aug 2 doi: 10.1007/s11914-023-00814-6. PMID: 37530996Free PMC Article
Le HV, Wick JB, Van BW, Klineberg EO
J Am Acad Orthop Surg 2022 Sep 1;30(17):820-830. Epub 2022 May 18 doi: 10.5435/JAAOS-D-22-00049. PMID: 35587949
Boody BS, Lendner M, Vaccaro AR
Int Orthop 2019 Apr;43(4):797-805. Epub 2018 Aug 16 doi: 10.1007/s00264-018-4106-5. PMID: 30116867
Saetia K, Cho D, Lee S, Kim DH, Kim SD
Neurosurg Focus 2011 Mar;30(3):E1. doi: 10.3171/2010.11.focus10276. PMID: 21434817
Epstein N
Spine J 2002 Nov-Dec;2(6):436-49. doi: 10.1016/s1529-9430(02)00394-7. PMID: 14589269

Therapy

Lee SE, Chung CK, Jahng TA, Kim HJ
J Neurosurg Spine 2013 May;18(5):465-71. Epub 2013 Mar 1 doi: 10.3171/2013.1.SPINE12779. PMID: 23452249
Baaj AA, Smith DA, Vale FL, Uribe JS
J Clin Neurosci 2012 Mar;19(3):349-51. Epub 2012 Jan 16 doi: 10.1016/j.jocn.2011.05.025. PMID: 22249019
Pham MH, Attenello FJ, Lucas J, He S, Stapleton CJ, Hsieh PC
Neurosurg Focus 2011 Mar;30(3):E2. doi: 10.3171/2011.1.FOCUS10273. PMID: 21434818
Steinmetz MP, Resnick DK
Spine J 2006 Nov-Dec;6(6 Suppl):274S-281S. doi: 10.1016/j.spinee.2006.04.023. PMID: 17097547
Epstein N
Spine J 2002 Nov-Dec;2(6):436-49. doi: 10.1016/s1529-9430(02)00394-7. PMID: 14589269

Prognosis

Zheng LD, Cao YT, Yang YT, Xu ML, Zeng HZ, Zhu SJ, Jin C, Yuan Q, Zhu R
J Biomech Eng 2023 Dec 1;145(12) doi: 10.1115/1.4063194. PMID: 37578172
Kato H, Braddock DT, Ito N
Curr Osteoporos Rep 2023 Oct;21(5):552-566. Epub 2023 Aug 2 doi: 10.1007/s11914-023-00814-6. PMID: 37530996Free PMC Article
Yoo M, Park YG, Cho YE, Lim CH, Chung SY, Kim D, Park J
J Clin Monit Comput 2022 Feb;36(1):247-258. Epub 2021 Feb 6 doi: 10.1007/s10877-020-00646-0. PMID: 33548015
Reddy KVS, Mudumba VS, Tokala IM, Reddy DR
Neurol India 2018 Sep-Oct;66(5):1394-1399. doi: 10.4103/0028-3886.241343. PMID: 30233012
Matsunaga S, Sakou T
Spine (Phila Pa 1976) 2012 Mar 1;37(5):E309-14. doi: 10.1097/BRS.0b013e318241ad33. PMID: 22146284

Clinical prediction guides

Le HV, Wick JB, Van BW, Klineberg EO
J Am Acad Orthop Surg 2022 Sep 1;30(17):820-830. Epub 2022 May 18 doi: 10.5435/JAAOS-D-22-00049. PMID: 35587949
Reddy KVS, Mudumba VS, Tokala IM, Reddy DR
Neurol India 2018 Sep-Oct;66(5):1394-1399. doi: 10.4103/0028-3886.241343. PMID: 30233012
Matsunaga S, Sakou T
Spine (Phila Pa 1976) 2012 Mar 1;37(5):E309-14. doi: 10.1097/BRS.0b013e318241ad33. PMID: 22146284
Pham MH, Attenello FJ, Lucas J, He S, Stapleton CJ, Hsieh PC
Neurosurg Focus 2011 Mar;30(3):E2. doi: 10.3171/2011.1.FOCUS10273. PMID: 21434818
Smith ZA, Buchanan CC, Raphael D, Khoo LT
Neurosurg Focus 2011 Mar;30(3):E10. doi: 10.3171/2011.1.FOCUS10256. PMID: 21361748

Recent systematic reviews

Tayal A, Pahwa B, Garg K
Neurosurg Rev 2023 Nov 24;46(1):313. doi: 10.1007/s10143-023-02215-w. PMID: 37996772
Byvaltsev VA, Kalinin AA, Hernandez PA, Shepelev VV, Pestryakov YY, Aliyev MA, Giers MB
Int J Mol Sci 2022 Nov 3;23(21) doi: 10.3390/ijms232113479. PMID: 36362274Free PMC Article
Wang H, Yang R, Liu H, Meng Y, Hong Y
World Neurosurg 2021 Nov;155:1-12. Epub 2021 Aug 5 doi: 10.1016/j.wneu.2021.07.138. PMID: 34365049
Ma L, Liu FY, Huo LS, Zhao ZQ, Sun XZ, Li F, Ding WY
Medicine (Baltimore) 2018 Jul;97(29):e11542. doi: 10.1097/MD.0000000000011542. PMID: 30024545Free PMC Article
Pham MH, Attenello FJ, Lucas J, He S, Stapleton CJ, Hsieh PC
Neurosurg Focus 2011 Mar;30(3):E2. doi: 10.3171/2011.1.FOCUS10273. PMID: 21434818

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