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Adenosquamous carcinoma

MedGen UID:
104901
Concept ID:
C0206623
Neoplastic Process
Synonyms: Adenosquamous Carcinoma; Adenosquamous Carcinomas; Carcinoma, Adenosquamous; Carcinomas, Adenosquamous
SNOMED CT: Adenosquamous cell carcinoma (403902008); Adenosquamous carcinoma (403902008); Adenosquamous carcinoma (59367005); Mixed adenocarcinoma and squamous cell carcinoma (59367005); Mixed adenocarcinoma and epidermoid carcinoma (59367005)
 
Monarch Initiative: MONDO:0006074

Definition

An invasive carcinoma composed of malignant glandular cells and malignant squamous cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdenosquamous carcinoma

Professional guidelines

PubMed

Garajová I, Peroni M, Gelsomino F, Leonardi F
Curr Oncol 2023 Oct 31;30(11):9587-9601. doi: 10.3390/curroncol30110694. PMID: 37999114Free PMC Article
Nica A, Marchocki Z, Gien LT, Kupets R, Vicus D, Covens A
Int J Gynecol Cancer 2021 Mar;31(3):447-451. doi: 10.1136/ijgc-2020-001785. PMID: 33649012
López F, Williams MD, Cardesa A, Hunt JL, Strojan P, Rinaldo A, Nixon IJ, Rodrigo JP, Saba NF, Mendenhall WM, Quer M, Suárez C, Ferlito A
Eur Arch Otorhinolaryngol 2017 Jul;274(7):2709-2726. Epub 2017 Mar 31 doi: 10.1007/s00405-017-4533-8. PMID: 28364287

Recent clinical studies

Etiology

Sakakida T, Ishikawa T, Doi T, Morita R, Kataoka S, Miyake H, Yamaguchi K, Moriguchi M, Sogame Y, Yasuda H, Iwasaku M, Konishi H, Takayama K, Itoh Y
J Gastroenterol 2023 Jun;58(6):575-585. Epub 2023 Apr 7 doi: 10.1007/s00535-023-01986-9. PMID: 37029223Free PMC Article
Mikuz G
Anal Quant Cytopathol Histpathol 2015 Feb;37(1):39-47. PMID: 26072633
Chen YY, Li AF, Huang KH, Lan YT, Chen MH, Chao Y, Lo SS, Wu CW, Shyr YM, Fang WL
Pathol Oncol Res 2015 Jul;21(3):547-51. Epub 2015 Jan 8 doi: 10.1007/s12253-014-9890-7. PMID: 25567665
Creutzberg CL, van Putten WL, Koper PC, Lybeert ML, Jobsen JJ, Wárlám-Rodenhuis CC, De Winter KA, Lutgens LC, van den Bergh AC, van de Steen-Banasik E, Beerman H, van Lent M
Lancet 2000 Apr 22;355(9213):1404-11. doi: 10.1016/s0140-6736(00)02139-5. PMID: 10791524
Cavanagh D, Marsden DE, Ruffolo EH
Obstet Gynecol Annu 1984;13:211-60. PMID: 6371616

Diagnosis

Zhang W, Zhang J, Liang X, Ding J
Cell Oncol (Dordr) 2023 Feb;46(1):1-15. Epub 2022 Nov 1 doi: 10.1007/s13402-022-00732-2. PMID: 36316580
White VA, Hyrcza MD, Lennerz JK, Thierauf J, Lokuhetty D, Cree IA, Indave BI
Mod Pathol 2022 Oct;35(10):1484-1493. Epub 2022 Jul 23 doi: 10.1038/s41379-022-01100-z. PMID: 35871081Free PMC Article
Stauffer JA, Asbun HJ
Surg Clin North Am 2018 Feb;98(1):169-188. doi: 10.1016/j.suc.2017.09.013. PMID: 29191273
Chen YY, Li AF, Huang KH, Lan YT, Chen MH, Chao Y, Lo SS, Wu CW, Shyr YM, Fang WL
Pathol Oncol Res 2015 Jul;21(3):547-51. Epub 2015 Jan 8 doi: 10.1007/s12253-014-9890-7. PMID: 25567665
Rao N
Semin Diagn Pathol 2014 Jul;31(4):271-7. Epub 2014 Jun 11 doi: 10.1053/j.semdp.2014.06.004. PMID: 25002356

Therapy

Tewari KS, Colombo N, Monk BJ, Dubot C, Cáceres MV, Hasegawa K, Shapira-Frommer R, Salman P, Yañez E, Gümüs M, Olivera Hurtado de Mendoza M, Samouëlian V, Castonguay V, Arkhipov A, Tekin C, Li K, Toker S, Keefe SM, Lorusso D
JAMA Oncol 2024 Feb 1;10(2):185-192. doi: 10.1001/jamaoncol.2023.5410. PMID: 38095881Free PMC Article
Oaknin A, Gladieff L, Martínez-García J, Villacampa G, Takekuma M, De Giorgi U, Lindemann K, Woelber L, Colombo N, Duska L, Leary A, Godoy-Ortiz A, Nishio S, Angelergues A, Rubio MJ, Fariñas-Madrid L, Yamaguchi S, Lorusso D, Ray-Coquard I, Manso L, Joly F, Alarcón J, Follana P, Romero I, Lebreton C, Pérez-Fidalgo JA, Yunokawa M, Dahlstrand H, D'Hondt V, Randall LM; ENGOT-Cx10–GEICO 68-C–JGOG1084–GOG-3030 Investigators
Lancet 2024 Jan 6;403(10421):31-43. Epub 2023 Dec 1 doi: 10.1016/S0140-6736(23)02405-4. PMID: 38048793
Tewari KS, Monk BJ, Vergote I, Miller A, de Melo AC, Kim HS, Kim YM, Lisyanskaya A, Samouëlian V, Lorusso D, Damian F, Chang CL, Gotovkin EA, Takahashi S, Ramone D, Pikiel J, Maćkowiak-Matejczyk B, Guerra Alía EM, Colombo N, Makarova Y, Rischin D, Lheureux S, Hasegawa K, Fujiwara K, Li J, Jamil S, Jankovic V, Chen CI, Seebach F, Weinreich DM, Yancopoulos GD, Lowy I, Mathias M, Fury MG, Oaknin A; Investigators for GOG Protocol 3016 and ENGOT Protocol En-Cx9
N Engl J Med 2022 Feb 10;386(6):544-555. doi: 10.1056/NEJMoa2112187. PMID: 35139273
Pötter R, Tanderup K, Schmid MP, Jürgenliemk-Schulz I, Haie-Meder C, Fokdal LU, Sturdza AE, Hoskin P, Mahantshetty U, Segedin B, Bruheim K, Huang F, Rai B, Cooper R, van der Steen-Banasik E, Van Limbergen E, Pieters BR, Tan LT, Nout RA, De Leeuw AAC, Ristl R, Petric P, Nesvacil N, Kirchheiner K, Kirisits C, Lindegaard JC; EMBRACE Collaborative Group
Lancet Oncol 2021 Apr;22(4):538-547. doi: 10.1016/S1470-2045(20)30753-1. PMID: 33794207
Ramirez PT, Frumovitz M, Pareja R, Lopez A, Vieira M, Ribeiro R, Buda A, Yan X, Shuzhong Y, Chetty N, Isla D, Tamura M, Zhu T, Robledo KP, Gebski V, Asher R, Behan V, Nicklin JL, Coleman RL, Obermair A
N Engl J Med 2018 Nov 15;379(20):1895-1904. Epub 2018 Oct 31 doi: 10.1056/NEJMoa1806395. PMID: 30380365

Prognosis

Kaiser J, Hinz U, Mayer P, Hank T, Niesen W, Hackert T, Gaida MM, Büchler MW, Strobel O
Eur J Surg Oncol 2021 Jul;47(7):1734-1741. Epub 2021 Feb 16 doi: 10.1016/j.ejso.2021.02.011. PMID: 33622577
Ramirez PT, Frumovitz M, Pareja R, Lopez A, Vieira M, Ribeiro R, Buda A, Yan X, Shuzhong Y, Chetty N, Isla D, Tamura M, Zhu T, Robledo KP, Gebski V, Asher R, Behan V, Nicklin JL, Coleman RL, Obermair A
N Engl J Med 2018 Nov 15;379(20):1895-1904. Epub 2018 Oct 31 doi: 10.1056/NEJMoa1806395. PMID: 30380365
Melamed A, Margul DJ, Chen L, Keating NL, Del Carmen MG, Yang J, Seagle BL, Alexander A, Barber EL, Rice LW, Wright JD, Kocherginsky M, Shahabi S, Rauh-Hain JA
N Engl J Med 2018 Nov 15;379(20):1905-1914. Epub 2018 Oct 31 doi: 10.1056/NEJMoa1804923. PMID: 30379613Free PMC Article
Chen YY, Li AF, Huang KH, Lan YT, Chen MH, Chao Y, Lo SS, Wu CW, Shyr YM, Fang WL
Pathol Oncol Res 2015 Jul;21(3):547-51. Epub 2015 Jan 8 doi: 10.1007/s12253-014-9890-7. PMID: 25567665
Schick U, Pusztaszeri M, Betz M, Ghadjar P, Demiroz C, Kaanders JH, Ozsahin M
Oral Surg Oral Med Oral Pathol Oral Radiol 2013 Sep;116(3):313-20. Epub 2013 Jul 10 doi: 10.1016/j.oooo.2013.05.003. PMID: 23850369

Clinical prediction guides

Suzuki Y, Ohkura Y, Koseki M, Nomura K, Matsui A, Ueno M, Kikuchi D, Ohashi K, Hoteya S
Esophagus 2023 Jul;20(3):484-491. Epub 2023 Apr 10 doi: 10.1007/s10388-023-01003-1. PMID: 37036546
Wu CH, Lai CL, Teng CJ, Fang WL, Huang KH, Fen-Yau Li A, Yu HY, Chiang NJ, Chao Y, Hung YP, Chen MH
J Chin Med Assoc 2023 Jun 1;86(6):542-548. Epub 2023 Mar 29 doi: 10.1097/JCMA.0000000000000922. PMID: 36989495
Moslim MA, Lefton MD, Ross EA, Mackrides N, Reddy SS
J Surg Res 2021 Mar;259:350-356. Epub 2020 Nov 13 doi: 10.1016/j.jss.2020.09.024. PMID: 33190924Free PMC Article
Mikuz G
Anal Quant Cytopathol Histpathol 2015 Feb;37(1):39-47. PMID: 26072633
Rotman M, Sedlis A, Piedmonte MR, Bundy B, Lentz SS, Muderspach LI, Zaino RJ
Int J Radiat Oncol Biol Phys 2006 May 1;65(1):169-76. Epub 2006 Jan 19 doi: 10.1016/j.ijrobp.2005.10.019. PMID: 16427212

Recent systematic reviews

Zhang W, Zhang J, Liang X, Ding J
Cell Oncol (Dordr) 2023 Feb;46(1):1-15. Epub 2022 Nov 1 doi: 10.1007/s13402-022-00732-2. PMID: 36316580
White VA, Hyrcza MD, Lennerz JK, Thierauf J, Lokuhetty D, Cree IA, Indave BI
Mod Pathol 2022 Oct;35(10):1484-1493. Epub 2022 Jul 23 doi: 10.1038/s41379-022-01100-z. PMID: 35871081Free PMC Article
Shoji T, Takatori E, Murakami K, Kaido Y, Takeuchi S, Kikuchi A, Sugiyama T
J Ovarian Res 2016 Aug 11;9(1):48. doi: 10.1186/s13048-016-0255-6. PMID: 27514842Free PMC Article
Guitarte C, Alagkiozidis I, Mize B, Stevens E, Salame G, Lee YC
Gynecol Oncol 2014 May;133(2):186-91. Epub 2014 Feb 4 doi: 10.1016/j.ygyno.2014.01.048. PMID: 24503463
Lee JY, Lee C, Hahn S, Kim MA, Kim HS, Chung HH, Kim JW, Park NH, Song YS
Int J Gynecol Cancer 2014 Feb;24(2):289-94. doi: 10.1097/IGC.0000000000000063. PMID: 24407572

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