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Smooth muscle tumor

MedGen UID:
104911
•Concept ID:
C0206658
•
Neoplastic Process
Synonyms: Muscle Tumor, Smooth; Muscle Tumors, Smooth; Smooth Muscle Tumor; Smooth Muscle Tumors; Tumor, Smooth Muscle; Tumors, Smooth Muscle
SNOMED CT: Smooth muscle tumor (75109009); Smooth muscle tumor of uncertain malignant potential (75109009)
 
Monarch Initiative: MONDO:0006975

Definition

A benign or malignant myomatous neoplasm arising from smooth muscle. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSmooth muscle tumor

Professional guidelines

PubMed

Top 10 Differential Diagnoses for Desmoplastic Melanoma.
Fernandez-Flores A, Singh R, Cassarino DS
Head Neck Pathol 2023 Mar;17(1):143-153. Epub 2023 Mar 16 doi: 10.1007/s12105-023-01536-y. PMID: 36928737Free PMC Article
The Usefulness of Immunohistochemistry in the Differential Diagnosis of Lesions Originating from the Myometrium.
Rubisz P, Ciebiera M, Hirnle L, Zgliczyńska M, Łoziński T, Dzięgiel P, Kobierzycki C
Int J Mol Sci 2019 Mar 6;20(5) doi: 10.3390/ijms20051136. PMID: 30845657Free PMC Article
Perivascular epithelioid cell tumor in the duodenum: challenge in differential diagnosis.
Chen Z, Shi H, Peng J, Yuan Y, Chen J, Song W
Int J Clin Exp Pathol 2015;8(7):8555-62. Epub 2015 Jul 1 PMID: 26339433Free PMC Article

Recent clinical studies

Etiology

Molecular prognostication of uterine smooth muscle neoplasms: From CGH array to CINSARC signature and beyond.
Croce S, Chibon F
Genes Chromosomes Cancer 2021 Mar;60(3):129-137. Epub 2020 Nov 11 doi: 10.1002/gcc.22906. PMID: 33099852
Beyond Smooth Muscle-Other Mesenchymal Neoplasms of the Uterus.
Dickson BC
Surg Pathol Clin 2019 Mar;12(1):107-137. Epub 2018 Dec 24 doi: 10.1016/j.path.2018.10.005. PMID: 30709439
Cutaneous Smooth Muscle Tumors: A Review.
Lau SK, Koh SS
Adv Anat Pathol 2018 Jul;25(4):282-290. doi: 10.1097/PAP.0000000000000188. PMID: 29649005
Smooth muscle tumors of soft tissue and non-uterine viscera: biology and prognosis.
Miettinen M
Mod Pathol 2014 Jan;27 Suppl 1(Suppl 1):S17-29. doi: 10.1038/modpathol.2013.178. PMID: 24384850Free PMC Article
Gastrointestinal stromal tumours.
Miettinen M, Sarlomo-Rikala M, Lasota J
Ann Chir Gynaecol 1998;87(4):278-81. PMID: 9891765

Diagnosis

Smooth Muscle Tumor of Uncertain Malignant Potential (STUMP): A Comprehensive Multidisciplinary Update.
Tinelli A, D'Oria O, Civino E, Morciano A, Hashmi AA, Baldini GM, Stefanovic R, Malvasi A, Pecorella G
Medicina (Kaunas) 2023 Jul 27;59(8) doi: 10.3390/medicina59081371. PMID: 37629661Free PMC Article
Mesenchymal Neoplasms of the Liver.
Papke DJ Jr
Surg Pathol Clin 2023 Sep;16(3):609-634. Epub 2023 Jun 11 doi: 10.1016/j.path.2023.04.013. PMID: 37536892
Cutaneous Smooth Muscle Tumors: A Review.
Lau SK, Koh SS
Adv Anat Pathol 2018 Jul;25(4):282-290. doi: 10.1097/PAP.0000000000000188. PMID: 29649005
Primary iris leiomyoma.
Yeaney GA, Platt S, Singh AD
Surv Ophthalmol 2017 May-Jun;62(3):366-370. Epub 2016 Nov 24 doi: 10.1016/j.survophthal.2016.11.007. PMID: 27890619
Epstein-Barr Virus-Associated Smooth Muscle Tumor.
Dekate J, Chetty R
Arch Pathol Lab Med 2016 Jul;140(7):718-22. doi: 10.5858/arpa.2015-0120-RS. PMID: 27362573

Therapy

Uterine smooth muscle tumors with uncertain malignant potential: analysis following fertility-saving procedures.
Richtarova A, Boudova B, Dundr P, Lisa Z, Hlinecka K, Zizka Z, Fruhauf F, Kuzel D, Slama J, Mara M
Int J Gynecol Cancer 2023 May 1;33(5):701-706. doi: 10.1136/ijgc-2022-004038. PMID: 36898699Free PMC Article
Molecular prognostication of uterine smooth muscle neoplasms: From CGH array to CINSARC signature and beyond.
Croce S, Chibon F
Genes Chromosomes Cancer 2021 Mar;60(3):129-137. Epub 2020 Nov 11 doi: 10.1002/gcc.22906. PMID: 33099852
PD-L1 Expression and Tumor-infiltrating Lymphocytes in Uterine Smooth Muscle Tumors: Implications for Immunotherapy.
Shanes ED, Friedman LA, Mills AM
Am J Surg Pathol 2019 Jun;43(6):792-801. doi: 10.1097/PAS.0000000000001254. PMID: 31009388
Epstein-Barr virus-associated smooth muscle tumors after lung transplantation.
Hirama T, Tikkanen J, Pal P, Cleary S, Binnie M
Transpl Infect Dis 2019 Jun;21(3):e13068. Epub 2019 Mar 27 doi: 10.1111/tid.13068. PMID: 30864272
Epstein-Barr Virus(+) Smooth Muscle Tumors as Manifestation of Primary Immunodeficiency Disorders.
Magg T, Schober T, Walz C, Ley-Zaporozhan J, Facchetti F, Klein C, Hauck F
Front Immunol 2018;9:368. Epub 2018 Feb 27 doi: 10.3389/fimmu.2018.00368. PMID: 29535735Free PMC Article

Prognosis

Uterine inflammatory myofibroblastic tumor.
Karpathiou G, Devouassoux-Shisheboran M, Stolnicu S, Chauleur C, Péoc'h M
Pathol Res Pract 2023 Feb;242:154335. Epub 2023 Jan 23 doi: 10.1016/j.prp.2023.154335. PMID: 36706588
Uterine smooth muscle tumor of uncertain malignant potential: A review of current knowledge.
Liu HT, Wong CN, Wong CN, Liu FS
Taiwan J Obstet Gynecol 2022 Nov;61(6):935-940. doi: 10.1016/j.tjog.2022.08.003. PMID: 36427995
Smooth Muscle Tumors of the Female Genital Tract.
Devereaux KA, Schoolmeester JK
Surg Pathol Clin 2019 Jun;12(2):397-455. doi: 10.1016/j.path.2019.02.004. PMID: 31097110
Uterine sarcomas.
Mbatani N, Olawaiye AB, Prat J
Int J Gynaecol Obstet 2018 Oct;143 Suppl 2:51-58. doi: 10.1002/ijgo.12613. PMID: 30306577
Smooth muscle tumors of soft tissue and non-uterine viscera: biology and prognosis.
Miettinen M
Mod Pathol 2014 Jan;27 Suppl 1(Suppl 1):S17-29. doi: 10.1038/modpathol.2013.178. PMID: 24384850Free PMC Article

Clinical prediction guides

Diagnostic and prognostic value of Bcl-2 in uterine leiomyosarcoma.
Travaglino A, Raffone A, Raimondo D, Gencarelli A, Esposito I, Gallo C, Improda FP, Vitale SG, Mollo A, Casadio P, Seracchioli R, Zullo F, Insabato L
Arch Gynecol Obstet 2023 Feb;307(2):379-386. Epub 2022 Mar 28 doi: 10.1007/s00404-022-06531-2. PMID: 35344084Free PMC Article
Smooth Muscle Tumors of the Visceral Adnexal and Uterine Ligaments and Adnexal Connective Tissue: A Clinicopathologic Study of 67 Cases.
Patel V, Xing D, Feely M, Schoolmeester JK
Int J Gynecol Pathol 2020 Jan;39(1):55-67. doi: 10.1097/PGP.0000000000000578. PMID: 30702465
PD-L1 Expression and Tumor-infiltrating Lymphocytes in Uterine Smooth Muscle Tumors: Implications for Immunotherapy.
Shanes ED, Friedman LA, Mills AM
Am J Surg Pathol 2019 Jun;43(6):792-801. doi: 10.1097/PAS.0000000000001254. PMID: 31009388
The Usefulness of Immunohistochemistry in the Differential Diagnosis of Lesions Originating from the Myometrium.
Rubisz P, Ciebiera M, Hirnle L, Zgliczyńska M, Łoziński T, Dzięgiel P, Kobierzycki C
Int J Mol Sci 2019 Mar 6;20(5) doi: 10.3390/ijms20051136. PMID: 30845657Free PMC Article
Atypical Uterine Smooth Muscle Tumors: A Retrospective Evaluation of Clinical and Pathologic Features.
Maltese G, Fontanella C, Lepori S, Scaffa C, Fucà G, Bogani G, Provenzano S, Carcangiu ML, Raspagliesi F, Lorusso D
Oncology 2018;94(1):1-6. Epub 2017 Sep 5 doi: 10.1159/000479818. PMID: 28869928

Recent systematic reviews

Diagnostic and prognostic value of Bcl-2 in uterine leiomyosarcoma.
Travaglino A, Raffone A, Raimondo D, Gencarelli A, Esposito I, Gallo C, Improda FP, Vitale SG, Mollo A, Casadio P, Seracchioli R, Zullo F, Insabato L
Arch Gynecol Obstet 2023 Feb;307(2):379-386. Epub 2022 Mar 28 doi: 10.1007/s00404-022-06531-2. PMID: 35344084Free PMC Article
Ki67 as a prognostic marker in uterine leiomyosarcoma: A quantitative systematic review.
Travaglino A, Raffone A, Catena U, De Luca M, Toscano P, Del Prete E, Vecchione ML, Lionetti R, Zullo F, Insabato L
Eur J Obstet Gynecol Reprod Biol 2021 Nov;266:119-124. Epub 2021 Sep 28 doi: 10.1016/j.ejogrb.2021.09.026. PMID: 34624740
p53, p16 and ki67 as immunohistochemical prognostic markers in uterine smooth muscle tumors of uncertain malignant potential (STUMP).
Travaglino A, Raffone A, Gencarelli A, Neola D, Oliviero DA, Alfano R, Campanino MR, Cariati F, Zullo F, Mollo A, Insabato L
Pathol Res Pract 2021 Oct;226:153592. Epub 2021 Aug 25 doi: 10.1016/j.prp.2021.153592. PMID: 34481212
Role of surgery in treating epstein-barr virus-associated smooth muscle tumor (EBV-SMT) with central nervous system invasion: A systemic review from 1997 to 2019.
Lau KW, Hsu YW, Lin YT, Chen KT
Cancer Med 2021 Mar;10(5):1473-1484. Epub 2021 Feb 11 doi: 10.1002/cam4.3770. PMID: 33576167Free PMC Article
Epstein Barr virus associated smooth muscle tumors in the central nervous system: a case report and systematic review of the literature.
Willeke VM, Anderson MP, Mahadevan A, Rojas R, Bhadelia R, Thomas AJ, Kasper EM
J Neurooncol 2020 Apr;147(2):247-260. Epub 2020 Mar 5 doi: 10.1007/s11060-020-03426-7. PMID: 32140976

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