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Smooth muscle tumor

MedGen UID:: 104911
•Concept ID:: C0206658
•: Neoplastic Process

Synonyms:	Muscle Tumor, Smooth; Muscle Tumors, Smooth; Smooth Muscle Tumor; Smooth Muscle Tumors; Tumor, Smooth Muscle; Tumors, Smooth Muscle
SNOMED CT:	Smooth muscle tumor (75109009); Smooth muscle tumor of uncertain malignant potential (75109009)

Monarch Initiative:	MONDO:0006975

Definition

A benign or malignant myomatous neoplasm arising from smooth muscle. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVSmooth muscle tumor

Disease
- Disorder by Site
  - Connective and Soft Tissue Disorder
    - Connective and soft tissue neoplasm
      - Mesenchymal cell neoplasm
        Myomatous neoplasm
        Smooth muscle tumor
        Benign smooth muscle neoplasm
        Leiomyoma
        Angioleiomyoma
        Bizarre leiomyoma
        Bladder leiomyoma
        Bone Leiomyoma
        Breast leiomyoma
        Cellular leiomyoma
        Central nervous system leiomyoma
        Cervical Leiomyoma
        Cutaneous leiomyoma
        Deep leiomyoma
        Digestive System Leiomyoma
        Epithelioid Cell Type Gastrointestinal Stromal Tumor
        Fallopian tube leiomyoma
        Kidney Leiomyoma
        Laryngeal leiomyoma
        Leiomyoma of ciliary body
        Leiomyomatosis
        Lung leiomyoma
        Mediastinum leiomyoma
        Myxoid Leiomyoma
        Oral Cavity Leiomyoma
        Ovarian Leiomyoma
        Paratesticular Leiomyoma
        Penile Leiomyoma
        Pericardium leiomyoma
        Prostate leiomyoma
        Sinonasal Leiomyoma
        Thyroid Gland Leiomyoma
        Trachea leiomyoma
        Ureter leiomyoma
        Urethra leiomyoma
        Uterine leiomyoma
        Uterine Ligament Leiomyoma
        Vaginal leiomyoma
        Vulvar leiomyoma
        EBV-Associated Smooth Muscle Tumor
        Female Reproductive System Smooth Muscle Tumor of Uncertain Malignant Potential
        Ovarian Smooth Muscle Tumor of Uncertain Malignant Potential
        Uterine Corpus Smooth Muscle Tumor of Uncertain Malignant Potential
        Uterine Corpus Epithelioid Smooth Muscle Tumor of Uncertain Malignant Potential
        Uterine Corpus Myxoid Smooth Muscle Tumor of Uncertain Malignant Potential
        Uterine Corpus Spindle Smooth Muscle Tumor of Uncertain Malignant Potential
        Vaginal Smooth Muscle Tumor of Uncertain Malignant Potential
        Vulvar Smooth Muscle Tumor of Uncertain Malignant Potential
        Ovarian Smooth Muscle Neoplasm
        Ovary leiomyosarcoma
        Skin Smooth Muscle Neoplasm
        Cutaneous leiomyosarcoma
        Smooth muscle cancer
        Leiomyosarcoma
        Adult Leiomyosarcoma
        Bladder Leiomyosarcoma
        Bone leiomyosarcoma
        Breast leiomyosarcoma
        Broad Ligament Leiomyosarcoma
        Central nervous system leiomyosarcoma
        Childhood Leiomyosarcoma
        Conjunctival Leiomyosarcoma
        Conventional leiomyosarcoma
        Digestive System Leiomyosarcoma
        EBV-Related Leiomyosarcoma
        Epithelioid leiomyosarcoma
        Fallopian tube leiomyosarcoma
        Granular cell leiomyosarcoma
        Heart leiomyosarcoma
        Inflammatory leiomyosarcoma
        Kidney leiomyosarcoma
        Laryngeal leiomyosarcoma
        Leiomyosarcoma NCI Grade 2
        Leiomyosarcoma NCI Grade 3
        Leiomyosarcoma of Deep Soft Tissue
        Leiomyosarcoma of the cervix uteri
        Leiomyosarcoma of Vessels
        Localized Leiomyosarcoma
        Lung leiomyosarcoma
        Mediastinum leiomyosarcoma
        Metastatic Leiomyosarcoma
        Myxoid leiomyosarcoma
        Paratesticular Leiomyosarcoma
        Penile Leiomyosarcoma
        Pleomorphic Leiomyosarcoma
        Prostate leiomyosarcoma
        Recurrent Leiomyosarcoma
        Refractory Leiomyosarcoma
        Resectable Leiomyosarcoma
        Sinonasal Leiomyosarcoma
        Thyroid Gland Leiomyosarcoma
        Unresectable Leiomyosarcoma
        Uterine leiomyosarcoma
        Vagina leiomyosarcoma
        Vulvar leiomyosarcoma
        Well Differentiated Leiomyosarcoma
        Uterine Corpus Smooth Muscle Neoplasm

Professional guidelines

PubMed

Top 10 Differential Diagnoses for Desmoplastic Melanoma.

Fernandez-Flores A, Singh R, Cassarino DS
Head Neck Pathol 2023 Mar;17(1):143-153. Epub 2023 Mar 16 doi: 10.1007/s12105-023-01536-y. PMID: 36928737 Free PMC Article

The Usefulness of Immunohistochemistry in the Differential Diagnosis of Lesions Originating from the Myometrium.

Rubisz P, Ciebiera M, Hirnle L, Zgliczyńska M, Łoziński T, Dzięgiel P, Kobierzycki C
Int J Mol Sci 2019 Mar 6;20(5) doi: 10.3390/ijms20051136. PMID: 30845657 Free PMC Article

Perivascular epithelioid cell tumor in the duodenum: challenge in differential diagnosis.

Chen Z, Shi H, Peng J, Yuan Y, Chen J, Song W
Int J Clin Exp Pathol 2015;8(7):8555-62. Epub 2015 Jul 1 PMID: 26339433 Free PMC Article

See all (7)

Recent clinical studies

Etiology

Molecular prognostication of uterine smooth muscle neoplasms: From CGH array to CINSARC signature and beyond.

Croce S, Chibon F
Genes Chromosomes Cancer 2021 Mar;60(3):129-137. Epub 2020 Nov 11 doi: 10.1002/gcc.22906. PMID: 33099852

Beyond Smooth Muscle-Other Mesenchymal Neoplasms of the Uterus.

Dickson BC
Surg Pathol Clin 2019 Mar;12(1):107-137. Epub 2018 Dec 24 doi: 10.1016/j.path.2018.10.005. PMID: 30709439

Cutaneous Smooth Muscle Tumors: A Review.

Lau SK, Koh SS
Adv Anat Pathol 2018 Jul;25(4):282-290. doi: 10.1097/PAP.0000000000000188. PMID: 29649005

Smooth muscle tumors of soft tissue and non-uterine viscera: biology and prognosis.

Miettinen M
Mod Pathol 2014 Jan;27 Suppl 1(Suppl 1):S17-29. doi: 10.1038/modpathol.2013.178. PMID: 24384850 Free PMC Article

Gastrointestinal stromal tumours.

Miettinen M, Sarlomo-Rikala M, Lasota J
Ann Chir Gynaecol 1998;87(4):278-81. PMID: 9891765

See all (183)

Diagnosis

Mesenchymal Neoplasms of the Liver.

Papke DJ Jr
Surg Pathol Clin 2023 Sep;16(3):609-634. Epub 2023 Jun 11 doi: 10.1016/j.path.2023.04.013. PMID: 37536892

Cutaneous Smooth Muscle Tumors: A Review.

Lau SK, Koh SS
Adv Anat Pathol 2018 Jul;25(4):282-290. doi: 10.1097/PAP.0000000000000188. PMID: 29649005

Smooth-Muscle Tumors.

Domansk HA, Walther CS
Monogr Clin Cytol 2017;22:64-67. Epub 2017 Jul 27 doi: 10.1159/000475096. PMID: 28750380

Primary iris leiomyoma.

Yeaney GA, Platt S, Singh AD
Surv Ophthalmol 2017 May-Jun;62(3):366-370. Epub 2016 Nov 24 doi: 10.1016/j.survophthal.2016.11.007. PMID: 27890619

Epstein-Barr Virus-Associated Smooth Muscle Tumor.

Dekate J, Chetty R
Arch Pathol Lab Med 2016 Jul;140(7):718-22. doi: 10.5858/arpa.2015-0120-RS. PMID: 27362573

See all (473)

Therapy

Molecular prognostication of uterine smooth muscle neoplasms: From CGH array to CINSARC signature and beyond.

Croce S, Chibon F
Genes Chromosomes Cancer 2021 Mar;60(3):129-137. Epub 2020 Nov 11 doi: 10.1002/gcc.22906. PMID: 33099852

Epstein-Barr Virus-Associated Smooth Muscle Tumor of the Spine After Bone Marrow Transplant: Case Report and Review of Literature.

Calafiore R, Mouchtouris N, Flomenberg N, Harrop JS
World Neurosurg 2020 Mar;135:192-196. Epub 2019 Dec 3 doi: 10.1016/j.wneu.2019.11.160. PMID: 31809898

PD-L1 Expression and Tumor-infiltrating Lymphocytes in Uterine Smooth Muscle Tumors: Implications for Immunotherapy.

Shanes ED, Friedman LA, Mills AM
Am J Surg Pathol 2019 Jun;43(6):792-801. doi: 10.1097/PAS.0000000000001254. PMID: 31009388

Epstein-Barr virus-associated smooth muscle tumors after lung transplantation.

Hirama T, Tikkanen J, Pal P, Cleary S, Binnie M
Transpl Infect Dis 2019 Jun;21(3):e13068. Epub 2019 Mar 27 doi: 10.1111/tid.13068. PMID: 30864272

Epstein-Barr Virus(+) Smooth Muscle Tumors as Manifestation of Primary Immunodeficiency Disorders.

Magg T, Schober T, Walz C, Ley-Zaporozhan J, Facchetti F, Klein C, Hauck F
Front Immunol 2018;9:368. Epub 2018 Feb 27 doi: 10.3389/fimmu.2018.00368. PMID: 29535735 Free PMC Article

See all (73)

Prognosis

Uterine smooth muscle tumor of uncertain malignant potential: A review of current knowledge.

Liu HT, Wong CN, Wong CN, Liu FS
Taiwan J Obstet Gynecol 2022 Nov;61(6):935-940. doi: 10.1016/j.tjog.2022.08.003. PMID: 36427995

Intraocular leiomyoma: Current concepts.

Tomar AS, Finger PT, Iacob CE
Surv Ophthalmol 2020 Jul-Aug;65(4):421-437. Epub 2020 Jan 7 doi: 10.1016/j.survophthal.2019.12.008. PMID: 31923479

Smooth Muscle Tumors of the Female Genital Tract.

Devereaux KA, Schoolmeester JK
Surg Pathol Clin 2019 Jun;12(2):397-455. doi: 10.1016/j.path.2019.02.004. PMID: 31097110

Uterine sarcomas.

Mbatani N, Olawaiye AB, Prat J
Int J Gynaecol Obstet 2018 Oct;143 Suppl 2:51-58. doi: 10.1002/ijgo.12613. PMID: 30306577

Smooth muscle tumors of soft tissue and non-uterine viscera: biology and prognosis.

Miettinen M
Mod Pathol 2014 Jan;27 Suppl 1(Suppl 1):S17-29. doi: 10.1038/modpathol.2013.178. PMID: 24384850 Free PMC Article

See all (206)

Clinical prediction guides

Clinical and Histopathological Predictors of Recurrence in Uterine Smooth Muscle Tumor of Uncertain Malignant Potential (STUMP): A Multicenter Retrospective Cohort Study of Tertiary Centers.

Borella F, Cosma S, Ferraioli D, Ray-Coquard I, Chopin N, Meeus P, Cockenpot V, Valabrega G, Scotto G, Turinetto M, Biglia N, Fuso L, Mariani L, Franchi D, Vidal Urbinati AM, Pino I, Bertschy G, Preti M, Benedetto C, Castellano I, Cassoni P, Bertero L
Ann Surg Oncol 2022 Dec;29(13):8302-8314. Epub 2022 Aug 17 doi: 10.1245/s10434-022-12353-y. PMID: 35976464 Free PMC Article

Smooth Muscle Tumors of the Visceral Adnexal and Uterine Ligaments and Adnexal Connective Tissue: A Clinicopathologic Study of 67 Cases.

Patel V, Xing D, Feely M, Schoolmeester JK
Int J Gynecol Pathol 2020 Jan;39(1):55-67. doi: 10.1097/PGP.0000000000000578. PMID: 30702465

PD-L1 Expression and Tumor-infiltrating Lymphocytes in Uterine Smooth Muscle Tumors: Implications for Immunotherapy.

Shanes ED, Friedman LA, Mills AM
Am J Surg Pathol 2019 Jun;43(6):792-801. doi: 10.1097/PAS.0000000000001254. PMID: 31009388

The Usefulness of Immunohistochemistry in the Differential Diagnosis of Lesions Originating from the Myometrium.

Rubisz P, Ciebiera M, Hirnle L, Zgliczyńska M, Łoziński T, Dzięgiel P, Kobierzycki C
Int J Mol Sci 2019 Mar 6;20(5) doi: 10.3390/ijms20051136. PMID: 30845657 Free PMC Article

Atypical Uterine Smooth Muscle Tumors: A Retrospective Evaluation of Clinical and Pathologic Features.

Maltese G, Fontanella C, Lepori S, Scaffa C, Fucà G, Bogani G, Provenzano S, Carcangiu ML, Raspagliesi F, Lorusso D
Oncology 2018;94(1):1-6. Epub 2017 Sep 5 doi: 10.1159/000479818. PMID: 28869928

See all (122)

Recent systematic reviews

Diagnostic and prognostic value of Bcl-2 in uterine leiomyosarcoma.

Travaglino A, Raffone A, Raimondo D, Gencarelli A, Esposito I, Gallo C, Improda FP, Vitale SG, Mollo A, Casadio P, Seracchioli R, Zullo F, Insabato L
Arch Gynecol Obstet 2023 Feb;307(2):379-386. Epub 2022 Mar 28 doi: 10.1007/s00404-022-06531-2. PMID: 35344084 Free PMC Article

Ki67 as a prognostic marker in uterine leiomyosarcoma: A quantitative systematic review.

Travaglino A, Raffone A, Catena U, De Luca M, Toscano P, Del Prete E, Vecchione ML, Lionetti R, Zullo F, Insabato L
Eur J Obstet Gynecol Reprod Biol 2021 Nov;266:119-124. Epub 2021 Sep 28 doi: 10.1016/j.ejogrb.2021.09.026. PMID: 34624740

p53, p16 and ki67 as immunohistochemical prognostic markers in uterine smooth muscle tumors of uncertain malignant potential (STUMP).

Travaglino A, Raffone A, Gencarelli A, Neola D, Oliviero DA, Alfano R, Campanino MR, Cariati F, Zullo F, Mollo A, Insabato L
Pathol Res Pract 2021 Oct;226:153592. Epub 2021 Aug 25 doi: 10.1016/j.prp.2021.153592. PMID: 34481212

Role of surgery in treating epstein-barr virus-associated smooth muscle tumor (EBV-SMT) with central nervous system invasion: A systemic review from 1997 to 2019.

Lau KW, Hsu YW, Lin YT, Chen KT
Cancer Med 2021 Mar;10(5):1473-1484. Epub 2021 Feb 11 doi: 10.1002/cam4.3770. PMID: 33576167 Free PMC Article

Epstein Barr virus associated smooth muscle tumors in the central nervous system: a case report and systematic review of the literature.

Willeke VM, Anderson MP, Mahadevan A, Rojas R, Bhadelia R, Thomas AJ, Kasper EM
J Neurooncol 2020 Apr;147(2):247-260. Epub 2020 Mar 5 doi: 10.1007/s11060-020-03426-7. PMID: 32140976

See all (5)

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Smooth muscle tumor

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Clinical resources

Practice guidelines

Consumer resources

Reviews

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