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Giant Cell Carcinoma

MedGen UID:
104920
•Concept ID:
C0206703
•
Neoplastic Process
Synonyms: Carcinoma, Giant Cell; Carcinomas, Giant Cell; Cell Carcinoma, Giant; Cell Carcinomas, Giant; Giant Cell Carcinomas
SNOMED CT: Giant cell carcinoma (42596004)

Definition

A malignant epithelial neoplasm composed of giant, pleomorphic cells. [from NCI]

Professional guidelines

PubMed

Osteoclast-Like Giant Cell Tumors of the Pancreas: Clinical Characteristics, Genetic Testing, and Treatment Modalities.
Ueberroth BE, Liu AJ, Graham RP, Bekaii-Saab TS, McWilliams RR, Mahipal A, Truty MJ, Mody K, Sonbol MB, Halfdanarson TR
Pancreas 2021 Aug 1;50(7):952-956. doi: 10.1097/MPA.0000000000001858. PMID: 34369897
Anaplastic giant cell carcinoma of the thyroid gland: treatment and survival over a 25-year period.
Nilsson O, Lindeberg J, Zedenius J, Ekman E, Tennvall J, Blomgren H, Grimelius L, Lundell G, Wallin G
World J Surg 1998 Jul;22(7):725-30. doi: 10.1007/s002689900460. PMID: 9606289
Anaplastic giant-cell carcinoma of the thyroid. A study of treatment and prognosis.
Jereb B, Stjernswärd J, Löwhagen T
Cancer 1975 May;35(5):1293-5. doi: 10.1002/1097-0142(197505)35:5<1293::aid-cncr2820350504>3.0.co;2-w. PMID: 1122480

Recent clinical studies

Etiology

Pleomorphic giant cell carcinoma of the prostate: clinicopathologic analysis and oncological outcomes.
Bilé-Silva A, Lopez-Beltran A, Rasteiro H, Vau N, Blanca A, Gomez E, Gaspar F, Cheng L
Virchows Arch 2023 Mar;482(3):493-505. Epub 2023 Jan 5 doi: 10.1007/s00428-022-03481-7. PMID: 36600115Free PMC Article
Pulmonary Sarcomatoid carcinoma: a surgical diagnosis and prognostic factors.
Smadhi H, Boudaya MS, Abdannadher M, BenAbdelghaffar H, Kamoun H, Ayadi A, Fekih L, Marghli A, Megdiche ML
Tunis Med 2019 Jan;97(1):128-132. PMID: 31535704
Osteoclast-like giant cell-rich carcinomas of the lung: a clinicopathological, immunohistochemical, and molecular study of 3 cases.
Lindholm KE, Kalhor N, Moran CA
Hum Pathol 2019 Mar;85:168-173. Epub 2018 Nov 14 doi: 10.1016/j.humpath.2018.10.030. PMID: 30447297
Histologic classification of prostate cancer.
Mikuz G
Anal Quant Cytopathol Histpathol 2015 Feb;37(1):39-47. PMID: 26072633
Histological variants of prostatic carcinoma and their significance.
Humphrey PA
Histopathology 2012 Jan;60(1):59-74. doi: 10.1111/j.1365-2559.2011.04039.x. PMID: 22212078

Diagnosis

Pleomorphic giant cell carcinoma of the prostate: clinicopathologic analysis and oncological outcomes.
Bilé-Silva A, Lopez-Beltran A, Rasteiro H, Vau N, Blanca A, Gomez E, Gaspar F, Cheng L
Virchows Arch 2023 Mar;482(3):493-505. Epub 2023 Jan 5 doi: 10.1007/s00428-022-03481-7. PMID: 36600115Free PMC Article
Pleomorphic (giant cell) carcinoma revisited: A historical perspective and conceptual reappraisal.
Agaimy A
Semin Diagn Pathol 2021 Nov;38(6):187-192. Epub 2021 Sep 20 doi: 10.1053/j.semdp.2021.09.003. PMID: 34583859
Pulmonary Sarcomatoid carcinoma: a surgical diagnosis and prognostic factors.
Smadhi H, Boudaya MS, Abdannadher M, BenAbdelghaffar H, Kamoun H, Ayadi A, Fekih L, Marghli A, Megdiche ML
Tunis Med 2019 Jan;97(1):128-132. PMID: 31535704
Endometrial giant cell carcinoma: a case series and review of the spectrum of endometrial neoplasms containing giant cells.
Mulligan AM, Plotkin A, Rouzbahman M, Soslow RA, Gilks CB, Clarke BA
Am J Surg Pathol 2010 Aug;34(8):1132-8. doi: 10.1097/PAS.0b013e3181e6579c. PMID: 20588176
Anaplastic giant cell thyroid carcinoma.
Wallin G, Lundell G, Tennvall J
Scand J Surg 2004;93(4):272-7. doi: 10.1177/145749690409300404. PMID: 15658667

Therapy

The glottic-subglottic laryngectomy: Surgical technique, oncological, and functional outcomes.
Bertolin A, Lionello M, Baldovin M, Ghirardo G, Rizzotto G
J Surg Oncol 2022 Feb;125(2):145-150. Epub 2021 Sep 20 doi: 10.1002/jso.26675. PMID: 34542917
Histomolecular profiling of pleomorphic, spindle cell, and giant cell carcinoma of the lung for targeted therapies.
Forest F, Yvorel V, Karpathiou G, Stachowicz ML, Vergnon JM, Fournel P, Tiffet O, Trombert B, Péoc'h M
Hum Pathol 2016 Mar;49:99-106. Epub 2015 Nov 2 doi: 10.1016/j.humpath.2015.10.006. PMID: 26826416
Polyomavirus (BK)-associated pleomorphic giant cell carcinoma of the urinary bladder: a case report.
Alexiev BA, Papadimitriou JC, Chai TC, Ramos E, Staats PN, Drachenberg CB
Pathol Res Pract 2013 Apr;209(4):255-9. Epub 2013 Mar 6 doi: 10.1016/j.prp.2013.01.008. PMID: 23481349
Anaplastic giant cell thyroid carcinoma.
Wallin G, Lundell G, Tennvall J
Scand J Surg 2004;93(4):272-7. doi: 10.1177/145749690409300404. PMID: 15658667
Combination therapy for anaplastic giant cell thyroid carcinoma.
Schlumberger M, Parmentier C, Delisle MJ, Couette JE, Droz JP, Sarrazin D
Cancer 1991 Feb 1;67(3):564-6. doi: 10.1002/1097-0142(19910201)67:3<564::aid-cncr2820670306>3.0.co;2-e. PMID: 1985750

Prognosis

Pleomorphic giant cell carcinoma of prostate: Rare tumor with unique clinicopathological, immunohistochemical, and molecular features.
El-Zaatari ZM, Thomas JS, Divatia MK, Shen SS, Ayala AG, Monroig-Bosque P, Shehabeldin A, Ro JY
Ann Diagn Pathol 2021 Jun;52:151719. Epub 2021 Feb 17 doi: 10.1016/j.anndiagpath.2021.151719. PMID: 33640702
Variants of Papillary Thyroid Carcinoma: Multiple Faces of a Familiar Tumor.
Sak SD
Turk Patoloji Derg 2015;31 Suppl 1:34-47. doi: 10.5146/tjpath.2015.01313. PMID: 26177316
Histologic classification of prostate cancer.
Mikuz G
Anal Quant Cytopathol Histpathol 2015 Feb;37(1):39-47. PMID: 26072633
Sarcomatoid neoplasms of the lung and pleura.
Travis WD
Arch Pathol Lab Med 2010 Nov;134(11):1645-58. doi: 10.5858/2010-0086-RAR.1. PMID: 21043818
Endometrial giant cell carcinoma: a case series and review of the spectrum of endometrial neoplasms containing giant cells.
Mulligan AM, Plotkin A, Rouzbahman M, Soslow RA, Gilks CB, Clarke BA
Am J Surg Pathol 2010 Aug;34(8):1132-8. doi: 10.1097/PAS.0b013e3181e6579c. PMID: 20588176

Clinical prediction guides

Clinicopathological features and prognostic nomogram of giant cell carcinoma of the lung: A population-based study.
He J, Ni JP, Li GB, Yao J, Ni B
Clin Respir J 2023 Mar;17(3):197-210. Epub 2023 Jan 31 doi: 10.1111/crj.13586. PMID: 36718941Free PMC Article
Pleomorphic giant cell carcinoma of the prostate: clinicopathologic analysis and oncological outcomes.
Bilé-Silva A, Lopez-Beltran A, Rasteiro H, Vau N, Blanca A, Gomez E, Gaspar F, Cheng L
Virchows Arch 2023 Mar;482(3):493-505. Epub 2023 Jan 5 doi: 10.1007/s00428-022-03481-7. PMID: 36600115Free PMC Article
Variants of Papillary Thyroid Carcinoma: Multiple Faces of a Familiar Tumor.
Sak SD
Turk Patoloji Derg 2015;31 Suppl 1:34-47. doi: 10.5146/tjpath.2015.01313. PMID: 26177316
Histologic classification of prostate cancer.
Mikuz G
Anal Quant Cytopathol Histpathol 2015 Feb;37(1):39-47. PMID: 26072633
Endometrial giant cell carcinoma: a case series and review of the spectrum of endometrial neoplasms containing giant cells.
Mulligan AM, Plotkin A, Rouzbahman M, Soslow RA, Gilks CB, Clarke BA
Am J Surg Pathol 2010 Aug;34(8):1132-8. doi: 10.1097/PAS.0b013e3181e6579c. PMID: 20588176

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