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Gonadal tissue neoplasm

MedGen UID:: 104925
•Concept ID:: C0206722
•: Neoplastic Process

Synonyms:	Gonadal Tissue Neoplasm; Gonadal Tissue Neoplasms; Neoplasm, Gonadal Tissue; Neoplasms, Gonadal Tissue; Tissue Neoplasm, Gonadal; Tissue Neoplasms, Gonadal

Monarch Initiative:	MONDO:0006773

Definition

Neoplasms composed of tissues of the ovary or the testis, not neoplasms located in the ovaries or testes. Gonadal tissues include germ cells, cells from the sex cord, and gonadal stromal cells. [from MONDO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVGonadal tissue neoplasm

Pathological Conditions, Signs and Symptoms
- Pathological process
  - Disease
    - Neoplasm
      - Neoplasms by Histologic Type
        Gonadal tissue neoplasm
        Gonadoblastoma
        Ovarian gonadoblastoma
        Testicular gonadoblastoma
        Sex cord-stromal tumor
        Adrenal Cortical Sex Cord-Stromal Tumor
        Granulosa cell tumor
        Adult Granulosa Cell Tumor
        Juvenile Granulosa Cell Tumor
        Malignant Granulosa Cell Tumor
        Ovarian granulosa cell tumor
        Testicular granulosa cell tumor
        Leydig cell tumor
        Benign Leydig cell tumor
        Malignant Leydig cell tumor
        Ovarian Leydig Cell Tumor, Not Otherwise Specified
        Testicular Leydig cell tumor
        Malignant Sex Cord-Stromal Tumor
        Malignant sex cord stromal tumor of ovary
        Malignant Testicular Sex Cord-Stromal Tumor
        Ovarian sex cord-stromal tumor
        Benign ovarian sex cord-stromal tumor
        Juvenile type ovarian granulosa cell tumor
        Ovarian Granulosa-Stromal Cell Tumor
        Ovarian gynandroblastoma
        Ovarian sertoli-stromal cell tumor
        Ovarian Sex Cord Tumor with Annular Tubules
        Ovarian Sex Cord-Stromal Tumor Associated with Peutz-Jeghers Syndrome
        Ovarian Sex Cord-Stromal Tumor, Not Otherwise Specified
        Ovarian Steroid Cell Tumor
        Ovarian Stromal Tumor with Minor Sex Cord Elements
        Ovarian thecoma
        Ovarian Stromal Luteoma
        Sertoli cell tumor
        Benign sertoli cell tumor
        Malignant Sertoli cell tumor
        Ovarian Sertoli Cell Tumor
        Testicular sertoli cell tumor
        Sertoli-Leydig cell tumor
        Testicular sex cord-stromal neoplasm
        Intratubular Large Cell Hyalinizing Sertoli Cell Neoplasia
        Mixed Testicular Sex Cord-Stromal Tumor
        Testicular Tumor of the Thecoma/Fibroma Group
        Unclassified Testicular Sex Cord-Stromal Tumor
        Thecoma
        Testicular thecoma
        Tumor of the Thecoma/Fibroma Group
        Ovarian Tumor of the Thecoma/Fibroma Group

Professional guidelines

PubMed

Gonadal Failure and Infertility in Cancer Survivors: Clinical Management and Strategies for Prevention.

Zavattaro M, Lanfranco F, Salvagno F, Motta G, Sestero M, Marinelli L, Canosa S, Revelli A
Front Horm Res 2021;54:58-68. Epub 2021 May 6 doi: 10.1159/000515460. PMID: 33957624

Risk Factors and Treatment Outcomes of 1,375 Patients with Testicular Leydig Cell Tumors: Analysis of Published Case Series Data.

Fankhauser CD, Grogg JB, Hayoz S, Wettstein MS, Dieckmann KP, Sulser T, Bode PK, Clarke NW, Beyer J, Hermanns T
J Urol 2020 May;203(5):949-956. Epub 2019 Dec 17 doi: 10.1097/JU.0000000000000705. PMID: 31845841

Gynaecomastia--pathophysiology, diagnosis and treatment.

Narula HS, Carlson HE
Nat Rev Endocrinol 2014 Nov;10(11):684-98. Epub 2014 Aug 12 doi: 10.1038/nrendo.2014.139. PMID: 25112235

See all (157)

Recent clinical studies

Etiology

Juvenile granulosa cell tumor of the ovary: A comprehensive clinicopathologic analysis of 15 cases.

Parikshaa G, Ariba Z, Pranab D, Nalini G, Manish R, Vanita S, Bhavana R, Devi D, Ram S, Prema M, Arvind R, Radhika S
Ann Diagn Pathol 2021 Jun;52:151721. Epub 2021 Feb 10 doi: 10.1016/j.anndiagpath.2021.151721. PMID: 33725665

Risk Factors and Treatment Outcomes of 1,375 Patients with Testicular Leydig Cell Tumors: Analysis of Published Case Series Data.

Gonadoblastoma: origin and outcome.

Roth LM, Cheng L
Hum Pathol 2020 Jun;100:47-53. Epub 2019 Dec 2 doi: 10.1016/j.humpath.2019.11.005. PMID: 31805291

Ovarian sex cord-stromal tumours and their mimics.

Young RH
Pathology 2018 Jan;50(1):5-15. Epub 2017 Nov 11 doi: 10.1016/j.pathol.2017.09.007. PMID: 29132723

Androgen insensitivity syndrome.

Tadokoro-Cuccaro R, Hughes IA
Curr Opin Endocrinol Diabetes Obes 2014 Dec;21(6):499-503. doi: 10.1097/MED.0000000000000107. PMID: 25354046

See all (1157)

Diagnosis

Update on Ovarian Sex Cord-Stromal Tumors.

Ordulu Z
Surg Pathol Clin 2022 Jun;15(2):235-258. doi: 10.1016/j.path.2022.02.004. PMID: 35715160

Risk Factors and Treatment Outcomes of 1,375 Patients with Testicular Leydig Cell Tumors: Analysis of Published Case Series Data.

Practical Review of Ovarian Sex Cord-Stromal Tumors.

Hanley KZ, Mosunjac MB
Surg Pathol Clin 2019 Jun;12(2):587-620. doi: 10.1016/j.path.2019.02.005. PMID: 31097116

Ovarian sex cord-stromal tumours and their mimics.

Young RH
Pathology 2018 Jan;50(1):5-15. Epub 2017 Nov 11 doi: 10.1016/j.pathol.2017.09.007. PMID: 29132723

Androgen insensitivity syndrome.

Tadokoro-Cuccaro R, Hughes IA
Curr Opin Endocrinol Diabetes Obes 2014 Dec;21(6):499-503. doi: 10.1097/MED.0000000000000107. PMID: 25354046

See all (2220)

Therapy

The biological and pharmacological connections between diabetes and various types of cancer.

Wang X, Ding S
Pathol Res Pract 2021 Nov;227:153641. Epub 2021 Sep 29 doi: 10.1016/j.prp.2021.153641. PMID: 34619575

From Editor's desk.

Agrawal R
Indian J Pathol Microbiol 2020 Jan-Mar;63(1):1-2. doi: 10.4103/0377-4929.277437. PMID: 32031112

The differences between gonadal and extra-gonadal malignant teratomas in both genders and the effects of chemotherapy.

Sun H, Ding H, Wang J, Zhang E, Fang Y, Li Z, Yu X, Wang C, Zhao Y, Chen K, Wen S, Li L, Shan S, Hong L, Chen F, Su P
BMC Cancer 2019 Apr 30;19(1):408. doi: 10.1186/s12885-019-5598-0. PMID: 31039746 Free PMC Article

Obesity and cancer.

Ungefroren H, Gieseler F, Fliedner S, Lehnert H
Horm Mol Biol Clin Investig 2015 Jan;21(1):5-15. doi: 10.1515/hmbci-2014-0046. PMID: 25719336

Testicular tumours.

Peckham MJ, McElwain TJ
Clin Endocrinol Metab 1975 Nov;4(3):665-92. doi: 10.1016/s0300-595x(75)80052-1. PMID: 58746

See all (537)

Prognosis

Update on Ovarian Sex Cord-Stromal Tumors.

Ordulu Z
Surg Pathol Clin 2022 Jun;15(2):235-258. doi: 10.1016/j.path.2022.02.004. PMID: 35715160

An introduction to the WHO 5th edition 2022 classification of testicular tumours.

Berney DM, Cree I, Rao V, Moch H, Srigley JR, Tsuzuki T, Amin MB, Comperat EM, Hartmann A, Menon S, Netto GJ, Rubin MA, Turajlic S, Raspollini MR, Tickoo SK
Histopathology 2022 Oct;81(4):459-466. Epub 2022 Jul 1 doi: 10.1111/his.14675. PMID: 35502823 Free PMC Article

Risk Factors and Treatment Outcomes of 1,375 Patients with Testicular Leydig Cell Tumors: Analysis of Published Case Series Data.

Practical Review of Ovarian Sex Cord-Stromal Tumors.

Hanley KZ, Mosunjac MB
Surg Pathol Clin 2019 Jun;12(2):587-620. doi: 10.1016/j.path.2019.02.005. PMID: 31097116

Androgen insensitivity syndrome.

Tadokoro-Cuccaro R, Hughes IA
Curr Opin Endocrinol Diabetes Obes 2014 Dec;21(6):499-503. doi: 10.1097/MED.0000000000000107. PMID: 25354046

See all (1019)

Clinical prediction guides

Ovarian microcystic stromal tumour: from morphological observations to syndromic associations.

Parra-Herran C, McCluggage WG
Histopathology 2022 May;80(6):898-904. Epub 2022 Feb 28 doi: 10.1111/his.14616. PMID: 35020947

Risk Factors and Treatment Outcomes of 1,375 Patients with Testicular Leydig Cell Tumors: Analysis of Published Case Series Data.

The differences between gonadal and extra-gonadal malignant teratomas in both genders and the effects of chemotherapy.

Androgen insensitivity syndrome.

Tadokoro-Cuccaro R, Hughes IA
Curr Opin Endocrinol Diabetes Obes 2014 Dec;21(6):499-503. doi: 10.1097/MED.0000000000000107. PMID: 25354046

Transplantation of reproductive organs.

Lee S, Mao L, Wang Y, D'Silva M, Yoo CH, Wolf P, Chung WS, Takahashi E, Chung DY, Gittes RF
Microsurgery 1995;16(4):191-8. doi: 10.1002/micr.1920160406. PMID: 7674907

See all (760)

Recent systematic reviews

Progress in the management of ovarian granulosa cell tumor: A review.

Li J, Chu R, Chen Z, Meng J, Yao S, Song K, Kong B
Acta Obstet Gynecol Scand 2021 Oct;100(10):1771-1778. Epub 2021 Jul 16 doi: 10.1111/aogs.14189. PMID: 34027996

Myoid gonadal tumor. Case series, systematic review, and Bayesian analysis.

Renne SL, Valeri M, Tosoni A, Bertolotti A, Rossi R, Renne G, Colecchia M
Virchows Arch 2021 Apr;478(4):727-734. Epub 2020 Nov 2 doi: 10.1007/s00428-020-02957-8. PMID: 33140129

Granulosa cell tumor of ovary: A systematic review of recent evidence.

Levin G, Zigron R, Haj-Yahya R, Matan LS, Rottenstreich A
Eur J Obstet Gynecol Reprod Biol 2018 Jun;225:57-61. Epub 2018 Apr 11 doi: 10.1016/j.ejogrb.2018.04.002. PMID: 29665458

Fertility Preservation in Children and Adolescents With Cancer.

Long CJ, Ginsberg JP, Kolon TF
Urology 2016 May;91:190-6. Epub 2016 Jan 11 doi: 10.1016/j.urology.2015.10.047. PMID: 26790587

Relationships of sex steroid hormone levels in benign and cancerous breast tissue and blood: A critical appraisal of current science.

Stanczyk FZ, Mathews BW, Sherman ME
Steroids 2015 Jul;99(Pt A):91-102. Epub 2014 Dec 30 doi: 10.1016/j.steroids.2014.12.011. PMID: 25554581

See all (26)

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Gonadal tissue neoplasm

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Clinical resources

Practice guidelines

Consumer resources

Reviews

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