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Gonadal tissue neoplasm

MedGen UID:: 104925
•Concept ID:: C0206722
•: Neoplastic Process

Synonyms:	Gonadal Tissue Neoplasm; Gonadal Tissue Neoplasms; Neoplasm, Gonadal Tissue; Neoplasms, Gonadal Tissue; Tissue Neoplasm, Gonadal; Tissue Neoplasms, Gonadal

Monarch Initiative:	MONDO:0006773

Definition

Neoplasms composed of tissues of the ovary or the testis, not neoplasms located in the ovaries or testes. Gonadal tissues include germ cells, cells from the sex cord, and gonadal stromal cells. [from MONDO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVGonadal tissue neoplasm

Pathological Conditions, Signs and Symptoms
- Pathological process
  - Disease
    - Neoplasm
      - Neoplasms by Histologic Type
        Gonadal tissue neoplasm
        Gonadoblastoma
        Ovarian gonadoblastoma
        Testicular gonadoblastoma
        Sex cord-stromal tumor
        Adrenal Cortical Sex Cord-Stromal Tumor
        Granulosa cell tumor
        Adult Granulosa Cell Tumor
        Juvenile Granulosa Cell Tumor
        Malignant Granulosa Cell Tumor
        Ovarian granulosa cell tumor
        Testicular granulosa cell tumor
        Leydig cell tumor
        Benign Leydig cell tumor
        Malignant Leydig cell tumor
        Ovarian Leydig Cell Tumor, Not Otherwise Specified
        Testicular Leydig cell tumor
        Malignant Sex Cord-Stromal Tumor
        Malignant sex cord stromal tumor of ovary
        Malignant Testicular Sex Cord-Stromal Tumor
        Ovarian sex cord-stromal tumor
        Benign ovarian sex cord-stromal tumor
        Juvenile type ovarian granulosa cell tumor
        Ovarian Granulosa-Stromal Cell Tumor
        Ovarian gynandroblastoma
        Ovarian sertoli-stromal cell tumor
        Ovarian Sex Cord Tumor with Annular Tubules
        Ovarian Sex Cord-Stromal Tumor Associated with Peutz-Jeghers Syndrome
        Ovarian Sex Cord-Stromal Tumor, Not Otherwise Specified
        Ovarian Steroid Cell Tumor
        Ovarian Stromal Tumor with Minor Sex Cord Elements
        Ovarian thecoma
        Ovarian Stromal Luteoma
        Sertoli cell tumor
        Benign sertoli cell tumor
        Malignant Sertoli cell tumor
        Ovarian Sertoli Cell Tumor
        Testicular sertoli cell tumor
        Sertoli-Leydig cell tumor
        Testicular sex cord-stromal neoplasm
        Intratubular Large Cell Hyalinizing Sertoli Cell Neoplasia
        Testicular Mixed Sex Cord-Stromal Tumor
        Testicular Sex Cord-Stromal Tumor, Not Otherwise Specified
        Testicular Tumor of the Thecoma/Fibroma Group
        Thecoma
        Testicular thecoma
        Tumor of the Thecoma/Fibroma Group
        Ovarian Tumor of the Thecoma/Fibroma Group

Professional guidelines

PubMed

Risk Factors and Treatment Outcomes of 1,375 Patients with Testicular Leydig Cell Tumors: Analysis of Published Case Series Data.

Fankhauser CD, Grogg JB, Hayoz S, Wettstein MS, Dieckmann KP, Sulser T, Bode PK, Clarke NW, Beyer J, Hermanns T
J Urol 2020 May;203(5):949-956. Epub 2019 Dec 17 doi: 10.1097/JU.0000000000000705. PMID: 31845841

Treatment of ovarian cancer in young women.

Gershenson DM
Clin Obstet Gynecol 2012 Mar;55(1):65-74. doi: 10.1097/GRF.0b013e318248045b. PMID: 22343230

Management of ovarian disease in pregnancy.

Phelan N, Conway GS
Best Pract Res Clin Endocrinol Metab 2011 Dec;25(6):985-92. doi: 10.1016/j.beem.2011.07.007. PMID: 22115171

See all (160)

Recent clinical studies

Etiology

Sex Cord-Stromal Tumors of the Ovary.

Sertic M, Devins KM, Oliva E, Lee SI, Kilcoyne A
Radiol Clin North Am 2023 Jul;61(4):595-608. Epub 2023 Mar 31 doi: 10.1016/j.rcl.2023.02.005. PMID: 37169426

Testicular Lesions in Infertile Men.

Dupeux M, Maxwell F, Rocher L, Izard V, Guettier C, Ferlicot S
Am J Clin Pathol 2022 Jun 7;157(6):936-941. doi: 10.1093/ajcp/aqab214. PMID: 34935941

Ovarian sex cord-stromal tumours and their mimics.

Young RH
Pathology 2018 Jan;50(1):5-15. Epub 2017 Nov 11 doi: 10.1016/j.pathol.2017.09.007. PMID: 29132723

Gynecologic Manifestations of the DICER1 Syndrome.

Stewart CJ, Charles A, Foulkes WD
Surg Pathol Clin 2016 Jun;9(2):227-41. Epub 2016 Apr 9 doi: 10.1016/j.path.2016.01.002. PMID: 27241106

Androgen insensitivity syndrome.

Tadokoro-Cuccaro R, Hughes IA
Curr Opin Endocrinol Diabetes Obes 2014 Dec;21(6):499-503. doi: 10.1097/MED.0000000000000107. PMID: 25354046

See all (1225)

Diagnosis

Sertoli-Leydig cell tumor.

Villegas Cruz C, Berlanga Narro S, Saltijeral SN, Roman Montalvo MA
Int J Gynecol Cancer 2024 Sep 2;34(9):1476-1478. doi: 10.1136/ijgc-2023-004321. PMID: 38088150

Update on Ovarian Sex Cord-Stromal Tumors.

Ordulu Z
Clin Lab Med 2023 Jun;43(2):245-274. doi: 10.1016/j.cll.2023.03.001. PMID: 37169445

Sex Cord-Stromal Tumors of the Ovary.

Sertic M, Devins KM, Oliva E, Lee SI, Kilcoyne A
Radiol Clin North Am 2023 Jul;61(4):595-608. Epub 2023 Mar 31 doi: 10.1016/j.rcl.2023.02.005. PMID: 37169426

Ovarian sex cord-stromal tumours and their mimics.

Young RH
Pathology 2018 Jan;50(1):5-15. Epub 2017 Nov 11 doi: 10.1016/j.pathol.2017.09.007. PMID: 29132723

Testicular tumors.

Markland C
Curr Probl Surg 1968 Sep:3-51. doi: 10.1016/s0011-3840(68)80001-2. PMID: 4386486

See all (2323)

Therapy

Testicular tumors of adrenogenital syndrome: From physiopathology to therapy.

Naouar S, Braiek S, El Kamel R
Presse Med 2017 Jun;46(6 Pt 1):572-578. Epub 2017 May 23 doi: 10.1016/j.lpm.2017.05.006. PMID: 28549629

Management of Ovarian Cancer In Younger Women.

Uma Devi K, Purushotham N, Jayashree N
Rev Recent Clin Trials 2015;10(4):263-9. doi: 10.2174/1574887110666150923112047. PMID: 26411956

Fertility-preserving surgical procedures for patients with gynecologic malignancies.

Rasool N, Rose PG
Clin Obstet Gynecol 2010 Dec;53(4):804-14. doi: 10.1097/GRF.0b013e3181f97d02. PMID: 21048447

Sexual precocity.

Bierich JR
Clin Endocrinol Metab 1975 Mar;4(1):107-42. doi: 10.1016/s0300-595x(75)80036-3. PMID: 166775

Testicular tumours.

Peckham MJ, McElwain TJ
Clin Endocrinol Metab 1975 Nov;4(3):665-92. doi: 10.1016/s0300-595x(75)80052-1. PMID: 58746

See all (552)

Prognosis

Update on Ovarian Sex Cord-Stromal Tumors.

Ordulu Z
Clin Lab Med 2023 Jun;43(2):245-274. doi: 10.1016/j.cll.2023.03.001. PMID: 37169445

Sex Cord-Stromal Tumors of the Ovary.

Sertic M, Devins KM, Oliva E, Lee SI, Kilcoyne A
Radiol Clin North Am 2023 Jul;61(4):595-608. Epub 2023 Mar 31 doi: 10.1016/j.rcl.2023.02.005. PMID: 37169426

Granulosa cell tumors (GCTs) of the ovary: What is the role of radiotherapy?

Barcellini A, Mangili G, Fodor A, Secondino S, Zerbetto F, Charalampopoulou A, Pignata S, Orlandi E, Bergamini A
Crit Rev Oncol Hematol 2023 Jan;181:103889. Epub 2022 Nov 26 doi: 10.1016/j.critrevonc.2022.103889. PMID: 36503888

Update on Ovarian Sex Cord-Stromal Tumors.

Ordulu Z
Surg Pathol Clin 2022 Jun;15(2):235-258. doi: 10.1016/j.path.2022.02.004. PMID: 35715160

An introduction to the WHO 5th edition 2022 classification of testicular tumours.

Berney DM, Cree I, Rao V, Moch H, Srigley JR, Tsuzuki T, Amin MB, Comperat EM, Hartmann A, Menon S, Netto GJ, Rubin MA, Turajlic S, Raspollini MR, Tickoo SK
Histopathology 2022 Oct;81(4):459-466. Epub 2022 Jul 1 doi: 10.1111/his.14675. PMID: 35502823 Free PMC Article

See all (1073)

Clinical prediction guides

Risk Factors and Treatment Outcomes of 1,375 Patients with Testicular Leydig Cell Tumors: Analysis of Published Case Series Data.

Ovarian Sex Cord-Stromal Tumors.

Schultz KA, Harris AK, Schneider DT, Young RH, Brown J, Gershenson DM, Dehner LP, Hill DA, Messinger YH, Frazier AL
J Oncol Pract 2016 Oct;12(10):940-946. doi: 10.1200/JOP.2016.016261. PMID: 27858560 Free PMC Article

Androgen insensitivity syndrome.

Tadokoro-Cuccaro R, Hughes IA
Curr Opin Endocrinol Diabetes Obes 2014 Dec;21(6):499-503. doi: 10.1097/MED.0000000000000107. PMID: 25354046

Testicular and testicular adnexa tumors in the elderly.

Gigantino V, La Mantia E, Franco R, Cecere S, Rossetti S, Di Napoli M, Pisano C, Berretta M, Galzerano A, Botti G, Pignata S, Facchini G
Anticancer Drugs 2013 Mar;24(3):228-36. doi: 10.1097/CAD.0b013e32835a3598. PMID: 23059385

Leydig cell tumor and hyperplasia: a review.

Colecchia M, Nistal M, Gonzalez-Peramato P, Carmignani L, Salvioni R, Nicolai N, Regadera J
Anal Quant Cytol Histol 2007 Jun;29(3):139-47. PMID: 17672373

See all (806)

Recent systematic reviews

Progress in the management of ovarian granulosa cell tumor: A review.

Li J, Chu R, Chen Z, Meng J, Yao S, Song K, Kong B
Acta Obstet Gynecol Scand 2021 Oct;100(10):1771-1778. Epub 2021 Jul 16 doi: 10.1111/aogs.14189. PMID: 34027996

The estrogen-macrophage interplay in the homeostasis of the female reproductive tract.

Pepe G, Locati M, Della Torre S, Mornata F, Cignarella A, Maggi A, Vegeto E
Hum Reprod Update 2018 Nov 1;24(6):652-672. doi: 10.1093/humupd/dmy026. PMID: 30256960

Granulosa cell tumor of ovary: A systematic review of recent evidence.

Levin G, Zigron R, Haj-Yahya R, Matan LS, Rottenstreich A
Eur J Obstet Gynecol Reprod Biol 2018 Jun;225:57-61. Epub 2018 Apr 11 doi: 10.1016/j.ejogrb.2018.04.002. PMID: 29665458

Hormone therapy in ovarian granulosa cell tumors: a systematic review.

van Meurs HS, van Lonkhuijzen LR, Limpens J, van der Velden J, Buist MR
Gynecol Oncol 2014 Jul;134(1):196-205. Epub 2014 Apr 5 doi: 10.1016/j.ygyno.2014.03.573. PMID: 24713548

Burkitt's lymphoma of the ovary: case report and review of the literature.

Shacham-Abulafia A, Nagar R, Eitan R, Levavi H, Sabah G, Vidal L, Shpilberg O, Raanani P
Acta Haematol 2013;129(3):169-74. Epub 2012 Dec 13 doi: 10.1159/000345248. PMID: 23257666

See all (28)

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Gonadal tissue neoplasm

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Clinical resources

Practice guidelines

Consumer resources

Reviews

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