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Sex cord-stromal tumor

MedGen UID:
104926
Concept ID:
C0206724
Neoplastic Process
Synonym: Sex cord stromal tumor, somatic
SNOMED CT: Specialized gonadal neoplasm (115221000)
 
Monarch Initiative: MONDO:0006055

Definition

A neoplasm arising in the ovary or testis. It is composed of granulosa cells, Leydig cells, Sertoli cells, and fibroblasts. Each of these cell types may constitute the only cellular component that is present in the neoplasm or it may be mixed with other cell types in various combinations. The prognosis can not always be predicted on histologic grounds alone. Approximately, 10% of these tumors may metastasize. Representative examples include granulosa cell tumor, Leydig cell tumor, Sertoli cell tumor, and tumors of the thecoma-fibroma group. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • Sex cord-stromal tumor

Professional guidelines

PubMed

Nasioudis D, Orfanelli T, Frey MK, Chapman-Davis E, Caputo TA, Witkin SS, Holcomb K
J Gynecol Oncol 2019 Mar;30(2):e19. Epub 2018 Nov 12 doi: 10.3802/jgo.2019.30.e19. PMID: 30740951Free PMC Article
Peng Y, Lin J, Guan J, Chen L, Zhang X, Li S, Wang H, Liu M, Guo Y
Abdom Radiol (NY) 2018 Aug;43(8):2156-2168. doi: 10.1007/s00261-017-1419-6. PMID: 29198011
Uma Devi K, Purushotham N, Jayashree N
Rev Recent Clin Trials 2015;10(4):263-9. doi: 10.2174/1574887110666150923112047. PMID: 26411956

Recent clinical studies

Etiology

Wang G, Amin MB, Grossmann P, Ptáková N, Hayes M, Hartmann A, Agaimy A, Lopez JI, Michal M, Hes O
Virchows Arch 2022 Feb;480(2):349-358. Epub 2021 Nov 13 doi: 10.1007/s00428-021-03235-x. PMID: 34775513
Edmund LN, Salama AM, Murali R
Cancer Cytopathol 2022 Jan;130(1):55-71. Epub 2021 Aug 19 doi: 10.1002/cncy.22502. PMID: 34411449Free PMC Article
Al-Obaidy KI, Idrees MT
Adv Anat Pathol 2021 Jul 1;28(4):258-275. doi: 10.1097/PAP.0000000000000302. PMID: 33871428
Uma Devi K, Purushotham N, Jayashree N
Rev Recent Clin Trials 2015;10(4):263-9. doi: 10.2174/1574887110666150923112047. PMID: 26411956
Horta M, Cunha TM
Diagn Interv Radiol 2015 Jul-Aug;21(4):277-86. doi: 10.5152/dir.2015.34414. PMID: 26054417Free PMC Article

Diagnosis

Ordulu Z
Clin Lab Med 2023 Jun;43(2):245-274. doi: 10.1016/j.cll.2023.03.001. PMID: 37169445
Ordulu Z
Surg Pathol Clin 2022 Jun;15(2):235-258. doi: 10.1016/j.path.2022.02.004. PMID: 35715160
Edmund LN, Salama AM, Murali R
Cancer Cytopathol 2022 Jan;130(1):55-71. Epub 2021 Aug 19 doi: 10.1002/cncy.22502. PMID: 34411449Free PMC Article
Li J, Chu R, Chen Z, Meng J, Yao S, Song K, Kong B
Acta Obstet Gynecol Scand 2021 Oct;100(10):1771-1778. Epub 2021 Jul 16 doi: 10.1111/aogs.14189. PMID: 34027996
Al-Obaidy KI, Idrees MT
Adv Anat Pathol 2021 Jul 1;28(4):258-275. doi: 10.1097/PAP.0000000000000302. PMID: 33871428

Therapy

Barcellini A, Mangili G, Fodor A, Secondino S, Zerbetto F, Charalampopoulou A, Pignata S, Orlandi E, Bergamini A
Crit Rev Oncol Hematol 2023 Jan;181:103889. Epub 2022 Nov 26 doi: 10.1016/j.critrevonc.2022.103889. PMID: 36503888
Mayer R, Dandulakis M, Richards S, Roque DM, Staats PN
Int J Gynecol Pathol 2020 Nov;39(6):567-572. doi: 10.1097/PGP.0000000000000651. PMID: 31789679
Uma Devi K, Purushotham N, Jayashree N
Rev Recent Clin Trials 2015;10(4):263-9. doi: 10.2174/1574887110666150923112047. PMID: 26411956
van Meurs HS, van Lonkhuijzen LR, Limpens J, van der Velden J, Buist MR
Gynecol Oncol 2014 Jul;134(1):196-205. Epub 2014 Apr 5 doi: 10.1016/j.ygyno.2014.03.573. PMID: 24713548
Hofmann M, Schlegel PG, Hippert F, Schmidt P, von-Schweinitz D, Leuschner I, Göbel U, Calaminus G, Schneider DT; MAKEI study group
Pediatr Blood Cancer 2013 Oct;60(10):1651-5. Epub 2013 Jun 3 doi: 10.1002/pbc.24607. PMID: 23733594

Prognosis

Ordulu Z
Clin Lab Med 2023 Jun;43(2):245-274. doi: 10.1016/j.cll.2023.03.001. PMID: 37169445
Ordulu Z
Surg Pathol Clin 2022 Jun;15(2):235-258. doi: 10.1016/j.path.2022.02.004. PMID: 35715160
Li J, Chu R, Chen Z, Meng J, Yao S, Song K, Kong B
Acta Obstet Gynecol Scand 2021 Oct;100(10):1771-1778. Epub 2021 Jul 16 doi: 10.1111/aogs.14189. PMID: 34027996
Hanley KZ, Mosunjac MB
Surg Pathol Clin 2019 Jun;12(2):587-620. doi: 10.1016/j.path.2019.02.005. PMID: 31097116
Horta M, Cunha TM
Diagn Interv Radiol 2015 Jul-Aug;21(4):277-86. doi: 10.5152/dir.2015.34414. PMID: 26054417Free PMC Article

Clinical prediction guides

McCluggage WG, Rivera B, Chong AS, Clarke BA, Schultz KAP, Dehner LP, Tchrakian N, Apellaniz-Ruiz M, Gilks CB, Kommoss F, Stewart CJR, Foulkes WD
Am J Surg Pathol 2023 Apr 1;47(4):490-496. Epub 2022 Dec 30 doi: 10.1097/PAS.0000000000002010. PMID: 36583307
Morinaga S, Aoki S, Tsuzuki T, Kanematsu K, Kawai N, Sato S, Nakamizu K, Goto K, Niwa M, Nomura I, Sawada T, Futamachi R, Morita F, Yamada Y
J Med Case Rep 2022 Nov 6;16(1):406. doi: 10.1186/s13256-022-03640-z. PMID: 36335378Free PMC Article
Sun TT, Cheng NH, Cao DY, Peng P
J Ovarian Res 2020 Dec 8;13(1):142. doi: 10.1186/s13048-020-00749-x. PMID: 33292402Free PMC Article
Bueno MT, Martínez-Ríos C, la Puente Gregorio A, Ahyad RA, Villani A, Druker H, van Engelen K, Gallinger B, Aronoff L, Grant R, Malkin D, Greer MC
Pediatr Radiol 2017 Sep;47(10):1292-1301. Epub 2017 May 4 doi: 10.1007/s00247-017-3875-0. PMID: 28474256
Blake EA, Carter CM, Kashani BN, Kodama M, Mabuchi S, Yoshino K, Matsuo K
Eur J Obstet Gynecol Reprod Biol 2014 Apr;175:1-7. Epub 2013 Dec 25 doi: 10.1016/j.ejogrb.2013.12.025. PMID: 24439718

Recent systematic reviews

Li J, Chu R, Chen Z, Meng J, Yao S, Song K, Kong B
Acta Obstet Gynecol Scand 2021 Oct;100(10):1771-1778. Epub 2021 Jul 16 doi: 10.1111/aogs.14189. PMID: 34027996
Miao X, Li Y, Zhou T, Lv M
Asian J Surg 2021 Dec;44(12):1503-1509. Epub 2021 Apr 21 doi: 10.1016/j.asjsur.2021.03.016. PMID: 33893031
Bercow A, Nitecki R, Brady PC, Rauh-Hain JA
J Minim Invasive Gynecol 2021 Mar;28(3):527-536.e1. Epub 2020 Aug 26 doi: 10.1016/j.jmig.2020.08.018. PMID: 32861046
van Meurs HS, van Lonkhuijzen LR, Limpens J, van der Velden J, Buist MR
Gynecol Oncol 2014 Jul;134(1):196-205. Epub 2014 Apr 5 doi: 10.1016/j.ygyno.2014.03.573. PMID: 24713548
Blake EA, Carter CM, Kashani BN, Kodama M, Mabuchi S, Yoshino K, Matsuo K
Eur J Obstet Gynecol Reprod Biol 2014 Apr;175:1-7. Epub 2013 Dec 25 doi: 10.1016/j.ejogrb.2013.12.025. PMID: 24439718

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