U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Abnormal psychotic pattern

MedGen UID:
1050011
Concept ID:
CN375802
Finding
HPO: HP:5200430

Definition

Any abnormal pattern of psychotic experiences, where an individual has significant disturbances in their thoughts, perceptions, emotions, and behavior, resulting in a loss of touch with reality. [from HPO]

Professional guidelines

PubMed

Crump CJ, Good ME, Abuelazm H, El-Mallakh RS
Expert Opin Pharmacother 2023 Jun;24(9):1039-1052. Epub 2023 May 1 doi: 10.1080/14656566.2023.2208269. PMID: 37102321
Vanes LD, Mouchlianitis E, Collier T, Averbeck BB, Shergill SS
Psychol Med 2018 Oct;48(14):2418-2427. Epub 2018 Feb 14 doi: 10.1017/S0033291718000041. PMID: 29439750Free PMC Article
Griswold KS, Del Regno PA, Berger RC
Am Fam Physician 2015 Jun 15;91(12):856-63. PMID: 26131945

Recent clinical studies

Etiology

Xu Z, Zhang X, Chang H, Kong Y, Ni Y, Liu R, Zhang X, Hu Y, Yang Z, Hou M, Mao R, Liu WT, Du Y, Yu S, Wang Z, Ji M, Zhou Z
Nat Neurosci 2021 Jun;24(6):818-830. Epub 2021 Apr 15 doi: 10.1038/s41593-021-00837-1. PMID: 33859437
Osborne LM
Obstet Gynecol Clin North Am 2018 Sep;45(3):455-468. doi: 10.1016/j.ogc.2018.04.005. PMID: 30092921Free PMC Article
Holder SD, Edmunds AL, Morgan S
FP Essent 2017 Apr;455:23-29. PMID: 28437058
Edmunds AL
FP Essent 2017 Apr;455:11-17. PMID: 28437056
Kahn RS, Sommer IE, Murray RM, Meyer-Lindenberg A, Weinberger DR, Cannon TD, O'Donovan M, Correll CU, Kane JM, van Os J, Insel TR
Nat Rev Dis Primers 2015 Nov 12;1:15067. doi: 10.1038/nrdp.2015.67. PMID: 27189524

Diagnosis

Rosso M, Fremion E, Santoro SL, Oreskovic NM, Chitnis T, Skotko BG, Santoro JD
Pediatrics 2020 Jun;145(6) doi: 10.1542/peds.2019-2939. PMID: 32471843
Osborne LM
Obstet Gynecol Clin North Am 2018 Sep;45(3):455-468. doi: 10.1016/j.ogc.2018.04.005. PMID: 30092921Free PMC Article
Kahn RS, Sommer IE, Murray RM, Meyer-Lindenberg A, Weinberger DR, Cannon TD, O'Donovan M, Correll CU, Kane JM, van Os J, Insel TR
Nat Rev Dis Primers 2015 Nov 12;1:15067. doi: 10.1038/nrdp.2015.67. PMID: 27189524
Arciniegas DB
Continuum (Minneap Minn) 2015 Jun;21(3 Behavioral Neurology and Neuropsychiatry):715-36. doi: 10.1212/01.CON.0000466662.89908.e7. PMID: 26039850Free PMC Article
Otter M, Schrander-Stumpel CT, Curfs LM
Eur J Hum Genet 2010 Mar;18(3):265-71. Epub 2009 Jul 1 doi: 10.1038/ejhg.2009.109. PMID: 19568271Free PMC Article

Therapy

Monahan K, Cuzens-Sutton J, Siskind D, Kisely S
Aust N Z J Psychiatry 2021 Aug;55(8):772-783. Epub 2020 Oct 16 doi: 10.1177/0004867420965693. PMID: 33059460
Owen MJ, Sawa A, Mortensen PB
Lancet 2016 Jul 2;388(10039):86-97. Epub 2016 Jan 15 doi: 10.1016/S0140-6736(15)01121-6. PMID: 26777917Free PMC Article
Kahn RS, Sommer IE, Murray RM, Meyer-Lindenberg A, Weinberger DR, Cannon TD, O'Donovan M, Correll CU, Kane JM, van Os J, Insel TR
Nat Rev Dis Primers 2015 Nov 12;1:15067. doi: 10.1038/nrdp.2015.67. PMID: 27189524
Piacentino D, Kotzalidis GD, Del Casale A, Aromatario MR, Pomara C, Girardi P, Sani G
Curr Neuropharmacol 2015 Jan;13(1):101-21. doi: 10.2174/1570159X13666141210222725. PMID: 26074746Free PMC Article
Arciniegas DB
Continuum (Minneap Minn) 2015 Jun;21(3 Behavioral Neurology and Neuropsychiatry):715-36. doi: 10.1212/01.CON.0000466662.89908.e7. PMID: 26039850Free PMC Article

Prognosis

Davies C, Segre G, Estradé A, Radua J, De Micheli A, Provenzani U, Oliver D, Salazar de Pablo G, Ramella-Cravaro V, Besozzi M, Dazzan P, Miele M, Caputo G, Spallarossa C, Crossland G, Ilyas A, Spada G, Politi P, Murray RM, McGuire P, Fusar-Poli P
Lancet Psychiatry 2020 May;7(5):399-410. Epub 2020 Mar 24 doi: 10.1016/S2215-0366(20)30057-2. PMID: 32220288
Hickie IB, Scott EM, Cross SP, Iorfino F, Davenport TA, Guastella AJ, Naismith SL, Carpenter JS, Rohleder C, Crouse JJ, Hermens DF, Koethe D, Markus Leweke F, Tickell AM, Sawrikar V, Scott J
Med J Aust 2019 Nov;211 Suppl 9:S3-S46. doi: 10.5694/mja2.50383. PMID: 31679171
Thakkar KN, Silverstein SM, Brascamp JW
Neurosci Biobehav Rev 2019 Jun;101:68-77. Epub 2019 Mar 30 doi: 10.1016/j.neubiorev.2019.03.021. PMID: 30940436Free PMC Article
Sheffield JM, Karcher NR, Barch DM
Neuropsychol Rev 2018 Dec;28(4):509-533. Epub 2018 Oct 20 doi: 10.1007/s11065-018-9388-2. PMID: 30343458Free PMC Article
Griswold KS, Del Regno PA, Berger RC
Am Fam Physician 2015 Jun 15;91(12):856-63. PMID: 26131945

Clinical prediction guides

Song X, Chen X, Yuksel C, Yuan J, Pizzagalli DA, Forester B, Öngür D, Du F
Mol Psychiatry 2021 Jun;26(6):2483-2492. Epub 2021 Jan 4 doi: 10.1038/s41380-020-00993-z. PMID: 33398087Free PMC Article
Davies C, Segre G, Estradé A, Radua J, De Micheli A, Provenzani U, Oliver D, Salazar de Pablo G, Ramella-Cravaro V, Besozzi M, Dazzan P, Miele M, Caputo G, Spallarossa C, Crossland G, Ilyas A, Spada G, Politi P, Murray RM, McGuire P, Fusar-Poli P
Lancet Psychiatry 2020 May;7(5):399-410. Epub 2020 Mar 24 doi: 10.1016/S2215-0366(20)30057-2. PMID: 32220288
Hickie IB, Scott EM, Cross SP, Iorfino F, Davenport TA, Guastella AJ, Naismith SL, Carpenter JS, Rohleder C, Crouse JJ, Hermens DF, Koethe D, Markus Leweke F, Tickell AM, Sawrikar V, Scott J
Med J Aust 2019 Nov;211 Suppl 9:S3-S46. doi: 10.5694/mja2.50383. PMID: 31679171
Grant P, Green MJ, Mason OJ
Schizophr Bull 2018 Oct 15;44(suppl_2):S556-S563. doi: 10.1093/schbul/sby012. PMID: 29474661Free PMC Article
Hama R, Bennett CL
Acta Neurol Scand 2017 Feb;135(2):148-160. Epub 2016 Jun 30 doi: 10.1111/ane.12629. PMID: 27364959Free PMC Article

Recent systematic reviews

Monahan K, Cuzens-Sutton J, Siskind D, Kisely S
Aust N Z J Psychiatry 2021 Aug;55(8):772-783. Epub 2020 Oct 16 doi: 10.1177/0004867420965693. PMID: 33059460
Pijnenborg GHM, Larabi DI, Xu P, Hasson-Ohayon I, de Vos AE, Ćurčić-Blake B, Aleman A, Van der Meer L
Neurosci Biobehav Rev 2020 Sep;116:301-336. Epub 2020 Jun 20 doi: 10.1016/j.neubiorev.2020.06.022. PMID: 32569706
Davies C, Segre G, Estradé A, Radua J, De Micheli A, Provenzani U, Oliver D, Salazar de Pablo G, Ramella-Cravaro V, Besozzi M, Dazzan P, Miele M, Caputo G, Spallarossa C, Crossland G, Ilyas A, Spada G, Politi P, Murray RM, McGuire P, Fusar-Poli P
Lancet Psychiatry 2020 May;7(5):399-410. Epub 2020 Mar 24 doi: 10.1016/S2215-0366(20)30057-2. PMID: 32220288
Davies G, Haddock G, Yung AR, Mulligan LD, Kyle SD
Sleep Med Rev 2017 Feb;31:25-38. Epub 2016 Jan 14 doi: 10.1016/j.smrv.2016.01.001. PMID: 26920092
Piacentino D, Kotzalidis GD, Del Casale A, Aromatario MR, Pomara C, Girardi P, Sani G
Curr Neuropharmacol 2015 Jan;13(1):101-21. doi: 10.2174/1570159X13666141210222725. PMID: 26074746Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...