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Decreased circulating complement component 1s concentration

MedGen UID:
1052754
•Concept ID:
CN376755
•
Finding
Synonym: C1s low in blood
 
HPO: HP:6000242

Definition

The concentration of complement component 1s (C1s) in the blood circulation is below the lower limit of normal. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDecreased circulating complement component 1s concentration

Professional guidelines

PubMed

Circulating immune complexes and C1 activation in patients with rapidly progressive glomerulonephritis, before and after treatment with immunosuppression and plasma exchange.
Sjöholm AG, Brun C, Larsen S, Thysell H
Int Arch Allergy Appl Immunol 1983;72(1):9-15. doi: 10.1159/000234833. PMID: 6874103

Recent clinical studies

Etiology

Sequential studies of complement activation in systemic lupus erythematosus.
Sturfelt G, Johnson U, Sjöholm AG
Scand J Rheumatol 1985;14(2):184-96. doi: 10.3109/03009748509165503. PMID: 4001891

Therapy

Combined IgG2, IgG4 and IgA deficiency: low C1q concentrations and the presence of excess C1r and C1s in an adult patient with recurrent pneumococcal infections.
Prellner K, Braconier JH, Sjöholm AG
Acta Pathol Microbiol Immunol Scand C 1985 Dec;93(6):257-63. doi: 10.1111/j.1699-0463.1985.tb02954.x. PMID: 2424262
Complement activation, circulating C1q binding substances and inflammatory activity in rheumatoid arthritis: relations and changes on suppression of inflammation.
Berglund K, Laurell AB, Nived O, Sjoholm AG, Sturfelt G
J Clin Lab Immunol 1980 Jul;4(1):7-14. PMID: 7463476

Prognosis

Sequential studies of complement activation in systemic lupus erythematosus.
Sturfelt G, Johnson U, Sjöholm AG
Scand J Rheumatol 1985;14(2):184-96. doi: 10.3109/03009748509165503. PMID: 4001891

Clinical prediction guides

Sequential studies of complement activation in systemic lupus erythematosus.
Sturfelt G, Johnson U, Sjöholm AG
Scand J Rheumatol 1985;14(2):184-96. doi: 10.3109/03009748509165503. PMID: 4001891
Combined IgG2, IgG4 and IgA deficiency: low C1q concentrations and the presence of excess C1r and C1s in an adult patient with recurrent pneumococcal infections.
Prellner K, Braconier JH, Sjöholm AG
Acta Pathol Microbiol Immunol Scand C 1985 Dec;93(6):257-63. doi: 10.1111/j.1699-0463.1985.tb02954.x. PMID: 2424262
Metabolism of human C1q. Studies in hypogammaglobulinemia, myeloma, and systemic lupus erythematosus.
Kohler PF, Müller-Eberhard HJ
J Clin Invest 1972 Apr;51(4):868-75. doi: 10.1172/JCI106881. PMID: 5014614Free PMC Article

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