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Myositis-specific autoantibody positivity

MedGen UID:
1052815
Concept ID:
CN377507
Finding
HPO: HP:6000678

Definition

The presence of autoantibodies (immunoglobulins) in the serum that display a high degree of specificity for idiopathic inflammatory myopathy (myositis-specific autoantibodies (MSAs)). MSAs are clinically useful biomarkers to help the diagnosis of polymyositis/dermatomyositis (PM/DM). Many of these are also associated with a unique clinical subset of PM/DM, making them useful in predicting and monitoring certain clinical manifestations. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMyositis-specific autoantibody positivity

Professional guidelines

PubMed

Teel A, Lu J, Park J, Singh N, Basharat P
Semin Arthritis Rheum 2022 Dec;57:152088. Epub 2022 Aug 31 doi: 10.1016/j.semarthrit.2022.152088. PMID: 36116345
Fujisawa T
Medicina (Kaunas) 2021 Apr 3;57(4) doi: 10.3390/medicina57040347. PMID: 33916864Free PMC Article
Fasano S, Gordon P, Hajji R, Loyo E, Isenberg DA
Rheumatology (Oxford) 2017 Jan;56(1):26-36. Epub 2016 Apr 27 doi: 10.1093/rheumatology/kew146. PMID: 27121778

Recent clinical studies

Etiology

Palmucci S, Di Mari A, Cancemi G, Pennisi I, Mauro LA, Sambataro G, Sambataro D, Galioto F, Fazio G, Ferlito A, Pino F, Basile A, Vancheri C
Medicina (Kaunas) 2022 Nov 30;58(12) doi: 10.3390/medicina58121757. PMID: 36556960Free PMC Article
Teel A, Lu J, Park J, Singh N, Basharat P
Semin Arthritis Rheum 2022 Dec;57:152088. Epub 2022 Aug 31 doi: 10.1016/j.semarthrit.2022.152088. PMID: 36116345
Fujisawa T
Medicina (Kaunas) 2021 Apr 3;57(4) doi: 10.3390/medicina57040347. PMID: 33916864Free PMC Article
Allenbach Y, Benveniste O, Stenzel W, Boyer O
Nat Rev Rheumatol 2020 Dec;16(12):689-701. Epub 2020 Oct 22 doi: 10.1038/s41584-020-00515-9. PMID: 33093664
Allenbach Y, Uzunhan Y, Toquet S, Leroux G, Gallay L, Marquet A, Meyer A, Guillaud C, Limal N, Gagnadoux F, Hervier B, Borie R, Deligny C, Terrier B, Berezne A, Audia S, Champtiaux N, Devilliers H, Voermans N, Diot E, Servettaz A, Marhadour T, Castelain V, Humbert S, Blanchard-Delaunay C, Tieulie N, Charles P, Gerin M, Mekinian A, Priou P, Meurice JC, Tazi A, Cottin V, Miyara M, Grange B, Israël-Biet D, Phin-Huynh S, Bron C, De Saint Martin L, Fabien N, Mariampillai K, Nunes H, Benveniste O; French Myositis Network
Neurology 2020 Jul 7;95(1):e70-e78. Epub 2020 Jun 2 doi: 10.1212/WNL.0000000000009727. PMID: 32487712Free PMC Article

Diagnosis

Palmucci S, Di Mari A, Cancemi G, Pennisi I, Mauro LA, Sambataro G, Sambataro D, Galioto F, Fazio G, Ferlito A, Pino F, Basile A, Vancheri C
Medicina (Kaunas) 2022 Nov 30;58(12) doi: 10.3390/medicina58121757. PMID: 36556960Free PMC Article
Akiyama C, Shirai T, Sato H, Fujii H, Ishii T, Harigae H
Rheumatol Int 2022 Jul;42(7):1271-1280. Epub 2021 Apr 10 doi: 10.1007/s00296-021-04851-1. PMID: 33837447
Allenbach Y, Benveniste O, Stenzel W, Boyer O
Nat Rev Rheumatol 2020 Dec;16(12):689-701. Epub 2020 Oct 22 doi: 10.1038/s41584-020-00515-9. PMID: 33093664
Riddell V, Bagby S, McHugh N
Curr Opin Rheumatol 2020 Nov;32(6):548-552. doi: 10.1097/BOR.0000000000000742. PMID: 32890028
Satoh M, Tanaka S, Ceribelli A, Calise SJ, Chan EK
Clin Rev Allergy Immunol 2017 Feb;52(1):1-19. doi: 10.1007/s12016-015-8510-y. PMID: 26424665Free PMC Article

Therapy

Teel A, Lu J, Park J, Singh N, Basharat P
Semin Arthritis Rheum 2022 Dec;57:152088. Epub 2022 Aug 31 doi: 10.1016/j.semarthrit.2022.152088. PMID: 36116345
Sugimoto T, Mokuda S, Kohno H, Ishitoku M, Araki K, Watanabe H, Tokunaga T, Yoshida Y, Hirata S, Sugiyama E
Rheumatology (Oxford) 2022 May 5;61(5):2006-2015. doi: 10.1093/rheumatology/keab681. PMID: 34498053
Allenbach Y, Benveniste O, Stenzel W, Boyer O
Nat Rev Rheumatol 2020 Dec;16(12):689-701. Epub 2020 Oct 22 doi: 10.1038/s41584-020-00515-9. PMID: 33093664
Mecoli CA, Christopher-Stine L
Curr Rheumatol Rep 2018 Apr 10;20(5):27. doi: 10.1007/s11926-018-0731-7. PMID: 29637383
Fasano S, Gordon P, Hajji R, Loyo E, Isenberg DA
Rheumatology (Oxford) 2017 Jan;56(1):26-36. Epub 2016 Apr 27 doi: 10.1093/rheumatology/kew146. PMID: 27121778

Prognosis

Vu TTT, Brown KK, Solomon JJ
Curr Opin Pulm Med 2023 Sep 1;29(5):427-435. Epub 2023 Jul 11 doi: 10.1097/MCP.0000000000001000. PMID: 37435671
Fujisawa T
Medicina (Kaunas) 2021 Apr 3;57(4) doi: 10.3390/medicina57040347. PMID: 33916864Free PMC Article
Allenbach Y, Benveniste O, Stenzel W, Boyer O
Nat Rev Rheumatol 2020 Dec;16(12):689-701. Epub 2020 Oct 22 doi: 10.1038/s41584-020-00515-9. PMID: 33093664
Allenbach Y, Uzunhan Y, Toquet S, Leroux G, Gallay L, Marquet A, Meyer A, Guillaud C, Limal N, Gagnadoux F, Hervier B, Borie R, Deligny C, Terrier B, Berezne A, Audia S, Champtiaux N, Devilliers H, Voermans N, Diot E, Servettaz A, Marhadour T, Castelain V, Humbert S, Blanchard-Delaunay C, Tieulie N, Charles P, Gerin M, Mekinian A, Priou P, Meurice JC, Tazi A, Cottin V, Miyara M, Grange B, Israël-Biet D, Phin-Huynh S, Bron C, De Saint Martin L, Fabien N, Mariampillai K, Nunes H, Benveniste O; French Myositis Network
Neurology 2020 Jul 7;95(1):e70-e78. Epub 2020 Jun 2 doi: 10.1212/WNL.0000000000009727. PMID: 32487712Free PMC Article
Satoh M, Tanaka S, Ceribelli A, Calise SJ, Chan EK
Clin Rev Allergy Immunol 2017 Feb;52(1):1-19. doi: 10.1007/s12016-015-8510-y. PMID: 26424665Free PMC Article

Clinical prediction guides

Garra W, Levy Y
Eur J Intern Med 2023 Nov;117:98-102. Epub 2023 Jul 13 doi: 10.1016/j.ejim.2023.07.010. PMID: 37453844
Vu TTT, Brown KK, Solomon JJ
Curr Opin Pulm Med 2023 Sep 1;29(5):427-435. Epub 2023 Jul 11 doi: 10.1097/MCP.0000000000001000. PMID: 37435671
Palmucci S, Di Mari A, Cancemi G, Pennisi I, Mauro LA, Sambataro G, Sambataro D, Galioto F, Fazio G, Ferlito A, Pino F, Basile A, Vancheri C
Medicina (Kaunas) 2022 Nov 30;58(12) doi: 10.3390/medicina58121757. PMID: 36556960Free PMC Article
Fujisawa T
Medicina (Kaunas) 2021 Apr 3;57(4) doi: 10.3390/medicina57040347. PMID: 33916864Free PMC Article
Satoh M, Tanaka S, Ceribelli A, Calise SJ, Chan EK
Clin Rev Allergy Immunol 2017 Feb;52(1):1-19. doi: 10.1007/s12016-015-8510-y. PMID: 26424665Free PMC Article

Recent systematic reviews

Teel A, Lu J, Park J, Singh N, Basharat P
Semin Arthritis Rheum 2022 Dec;57:152088. Epub 2022 Aug 31 doi: 10.1016/j.semarthrit.2022.152088. PMID: 36116345
Van Horebeek N, Vulsteke JB, Bossuyt X, Claeys KG, Dillaerts D, Poesen K, Lenaerts J, Van Damme P, Blockmans D, De Haes P, De Langhe E
Semin Arthritis Rheum 2021 Apr;51(2):486-494. Epub 2021 Mar 27 doi: 10.1016/j.semarthrit.2021.03.012. PMID: 33831755
Gerami P, Schope JM, McDonald L, Walling HW, Sontheimer RD
J Am Acad Dermatol 2006 Apr;54(4):597-613. Epub 2006 Jan 23 doi: 10.1016/j.jaad.2005.10.041. PMID: 16546580

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