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Failure to increase oxygen saturation on hyperoxia test

MedGen UID:
1053031
Concept ID:
CN376741
Finding
HPO: HP:6000228

Definition

Hyperoxia test is the initial method to distinguish critical congenital heart disease (CCHD) from pulmonary disease. The test consists in measuring an arterial blood gas at room air and 100% inspired oxygen after 10 minutes. Neonates with congenital heart disease are usually not able to increase PaO2 above 100 mm Hg during 100% oxygen administration. In patients with pulmonary disease, PaO2 generally increased greater than or equal to 100 mm Hg with 100% oxygen as ventilation-perfusion discrepancies are overcome. A positive result indicates the cardiac origin and further cardiac workup is indicated to rule out CCHD. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFailure to increase oxygen saturation on hyperoxia test

Recent clinical studies

Therapy

Dimopoulos S, Tzanis G, Manetos C, Tasoulis A, Mpouchla A, Tseliou E, Vasileiadis I, Diakos N, Terrovitis J, Nanas S
Respir Care 2013 Dec;58(12):2134-41. Epub 2013 May 28 doi: 10.4187/respcare.02113. PMID: 23716709

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