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Enlarged fetal lungs

MedGen UID:
1053128
•Concept ID:
CN377445
•
Finding
HPO: HP:6000613

Definition

The size (volume) of the lungs of a fetus above the upper limit of normal for the gestational age. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEnlarged fetal lungs

Professional guidelines

PubMed

SMPD1 expression profile and mutation landscape help decipher genotype-phenotype association and precision diagnosis for acid sphingomyelinase deficiency.
Wang R, Qin Z, Huang L, Luo H, Peng H, Zhou X, Zhao Z, Liu M, Yang P, Shi T
Hereditas 2023 Mar 13;160(1):11. doi: 10.1186/s41065-023-00272-1. PMID: 36907956Free PMC Article
Fetal bronchoscopy as a useful procedure in a case with prenatal diagnosis of congenital microcystic adenomatoid malformation.
Cruz-Martinez R, Méndez A, Perez-Garcilita O, Monroy A, Aguilar-Vidales K, Cruz-Martinez MA, Martinez-Morales C
Fetal Diagn Ther 2015;37(1):75-80. Epub 2014 Aug 14 doi: 10.1159/000361015. PMID: 25138479
Obstetrical care in gestational diabetes and management of preterm labour.
Thiebaugeorges O, Guyard-Boileau B
Diabetes Metab 2010 Dec;36(6 Pt 2):672-81. doi: 10.1016/j.diabet.2010.11.017. PMID: 21163429

Recent clinical studies

Etiology

Conditional knockout of ITGB4 in bronchial epithelial cells directs bronchopulmonary dysplasia.
Chen Y, Jiang W, Wang JM, Ma XD, Wu D, Liu LX, Ji M, Qu XP, Liu C, Liu HJ, Qin XQ, Xiang Y
J Cell Mol Med 2023 Dec;27(23):3760-3772. Epub 2023 Sep 12 doi: 10.1111/jcmm.17948. PMID: 37698050Free PMC Article
Inorganic arsenic induces sex-dependent pathological hypertrophy in the heart.
Kabir R, Sinha P, Mishra S, Ebenebe OV, Taube N, Oeing CU, Keceli G, Chen R, Paolocci N, Rule A, Kohr MJ
Am J Physiol Heart Circ Physiol 2021 Apr 1;320(4):H1321-H1336. Epub 2021 Jan 22 doi: 10.1152/ajpheart.00435.2020. PMID: 33481702Free PMC Article
Fetal brain morphometry on prenatal magnetic resonance imaging in congenital diaphragmatic hernia.
Radhakrishnan R, Merhar SL, Burns P, Zhang B, Lim FY, Kline-Fath BM
Pediatr Radiol 2019 Feb;49(2):217-223. Epub 2018 Oct 6 doi: 10.1007/s00247-018-4272-z. PMID: 30293137
Prenatal Factors Associated with Postnatal Brain Injury in Infants with Congenital Diaphragmatic Hernia.
Radhakrishnan R, Merhar SL, Su W, Zhang B, Burns P, Lim FY, Kline-Fath BM
AJNR Am J Neuroradiol 2018 Mar;39(3):558-562. Epub 2017 Dec 21 doi: 10.3174/ajnr.A5500. PMID: 29269406Free PMC Article
Fetal echocardiographic diagnosis of congenital heart disease.
Fyfe DA, Kline CH
Pediatr Clin North Am 1990 Feb;37(1):45-67. doi: 10.1016/s0031-3955(16)36831-6. PMID: 2408003

Diagnosis

The heart after surviving twin-to-twin transfusion syndrome.
Torres X, Bennasar M, Bautista-Rodríguez C, Martínez-Portilla RJ, Gómez O, Micheletti T, Eixarch E, Crispi F, Gratacós E, Martínez JM
Am J Obstet Gynecol 2022 Sep;227(3):502.e1-502.e25. Epub 2022 Mar 26 doi: 10.1016/j.ajog.2022.03.049. PMID: 35351412
The Functions of Long Non-Coding RNA (lncRNA) H19 in the Heart.
Wang Y, Sun X, Sun X
Heart Lung Circ 2022 Mar;31(3):341-349. Epub 2021 Nov 25 doi: 10.1016/j.hlc.2021.10.022. PMID: 34840062
Nanoparticle Delivery of STAT3 Alleviates Pulmonary Hypertension in a Mouse Model of Alveolar Capillary Dysplasia.
Sun F, Wang G, Pradhan A, Xu K, Gomez-Arroyo J, Zhang Y, Kalin GT, Deng Z, Vagnozzi RJ, He H, Dunn AW, Wang Y, York AJ, Hegde RS, Woods JC, Kalin TV, Molkentin JD, Kalinichenko VV
Circulation 2021 Aug 17;144(7):539-555. Epub 2021 Jun 11 doi: 10.1161/CIRCULATIONAHA.121.053980. PMID: 34111939Free PMC Article
Fetal therapy: state of the art.
Coleman BG, Adzick NS, Crombleholme TM, Johnson MP, Howell L, Horii SC, Langer JE, Nisenbaum HL, DeBari S, Iyoob C
J Ultrasound Med 2002 Nov;21(11):1257-88. doi: 10.7863/jum.2002.21.11.1257. PMID: 12418767
Fetal echocardiographic diagnosis of congenital heart disease.
Fyfe DA, Kline CH
Pediatr Clin North Am 1990 Feb;37(1):45-67. doi: 10.1016/s0031-3955(16)36831-6. PMID: 2408003

Therapy

Nanoparticle Delivery of STAT3 Alleviates Pulmonary Hypertension in a Mouse Model of Alveolar Capillary Dysplasia.
Sun F, Wang G, Pradhan A, Xu K, Gomez-Arroyo J, Zhang Y, Kalin GT, Deng Z, Vagnozzi RJ, He H, Dunn AW, Wang Y, York AJ, Hegde RS, Woods JC, Kalin TV, Molkentin JD, Kalinichenko VV
Circulation 2021 Aug 17;144(7):539-555. Epub 2021 Jun 11 doi: 10.1161/CIRCULATIONAHA.121.053980. PMID: 34111939Free PMC Article
rhIGF-1/BP3 Preserves Lung Growth and Prevents Pulmonary Hypertension in Experimental Bronchopulmonary Dysplasia.
Seedorf G, Kim C, Wallace B, Mandell EW, Nowlin T, Shepherd D, Abman SH
Am J Respir Crit Care Med 2020 May 1;201(9):1120-1134. doi: 10.1164/rccm.201910-1975OC. PMID: 32101461Free PMC Article
Heart and bile acids - Clinical consequences of altered bile acid metabolism.
Vasavan T, Ferraro E, Ibrahim E, Dixon P, Gorelik J, Williamson C
Biochim Biophys Acta Mol Basis Dis 2018 Apr;1864(4 Pt B):1345-1355. Epub 2018 Jan 6 doi: 10.1016/j.bbadis.2017.12.039. PMID: 29317337
Molecular physiopathogenetic mechanisms and development of new potential therapeutic strategies in persistent pulmonary hypertension of the newborn.
Distefano G, Sciacca P
Ital J Pediatr 2015 Feb 8;41:6. doi: 10.1186/s13052-015-0111-0. PMID: 25887340Free PMC Article
Lamb model of respiratory syncytial virus-associated lung disease: insights to pathogenesis and novel treatments.
Ackermann MR
ILAR J 2014;55(1):4-15. doi: 10.1093/ilar/ilu003. PMID: 24936027Free PMC Article

Prognosis

Molecular physiopathogenetic mechanisms and development of new potential therapeutic strategies in persistent pulmonary hypertension of the newborn.
Distefano G, Sciacca P
Ital J Pediatr 2015 Feb 8;41:6. doi: 10.1186/s13052-015-0111-0. PMID: 25887340Free PMC Article
Long term respiratory consequences of intrauterine growth restriction.
Pike K, Jane Pillow J, Lucas JS
Semin Fetal Neonatal Med 2012 Apr;17(2):92-8. Epub 2012 Jan 25 doi: 10.1016/j.siny.2012.01.003. PMID: 22277109
Fetal pleural effusions.
Yinon Y, Kelly E, Ryan G
Best Pract Res Clin Obstet Gynaecol 2008 Feb;22(1):77-96. doi: 10.1016/j.bpobgyn.2007.09.004. PMID: 18280793
Management of the fetus with a cystic adenomatoid malformation.
Adzick NS, Harrison MR
World J Surg 1993 May-Jun;17(3):342-9. doi: 10.1007/BF01658702. PMID: 8337881
Fetal thoracic lesions.
Adzick NS
Semin Pediatr Surg 1993 May;2(2):103-8. PMID: 8062026

Clinical prediction guides

Conditional knockout of ITGB4 in bronchial epithelial cells directs bronchopulmonary dysplasia.
Chen Y, Jiang W, Wang JM, Ma XD, Wu D, Liu LX, Ji M, Qu XP, Liu C, Liu HJ, Qin XQ, Xiang Y
J Cell Mol Med 2023 Dec;27(23):3760-3772. Epub 2023 Sep 12 doi: 10.1111/jcmm.17948. PMID: 37698050Free PMC Article
The heart after surviving twin-to-twin transfusion syndrome.
Torres X, Bennasar M, Bautista-Rodríguez C, Martínez-Portilla RJ, Gómez O, Micheletti T, Eixarch E, Crispi F, Gratacós E, Martínez JM
Am J Obstet Gynecol 2022 Sep;227(3):502.e1-502.e25. Epub 2022 Mar 26 doi: 10.1016/j.ajog.2022.03.049. PMID: 35351412
Fetal brain morphometry on prenatal magnetic resonance imaging in congenital diaphragmatic hernia.
Radhakrishnan R, Merhar SL, Burns P, Zhang B, Lim FY, Kline-Fath BM
Pediatr Radiol 2019 Feb;49(2):217-223. Epub 2018 Oct 6 doi: 10.1007/s00247-018-4272-z. PMID: 30293137
Heart and bile acids - Clinical consequences of altered bile acid metabolism.
Vasavan T, Ferraro E, Ibrahim E, Dixon P, Gorelik J, Williamson C
Biochim Biophys Acta Mol Basis Dis 2018 Apr;1864(4 Pt B):1345-1355. Epub 2018 Jan 6 doi: 10.1016/j.bbadis.2017.12.039. PMID: 29317337
Structural changes in the airways in asthma: observations and consequences.
Bai TR, Knight DA
Clin Sci (Lond) 2005 Jun;108(6):463-77. doi: 10.1042/CS20040342. PMID: 15896192

Recent systematic reviews

Obstetrical care in gestational diabetes and management of preterm labour.
Thiebaugeorges O, Guyard-Boileau B
Diabetes Metab 2010 Dec;36(6 Pt 2):672-81. doi: 10.1016/j.diabet.2010.11.017. PMID: 21163429

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