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Enlarged fetal lungs

MedGen UID:
1053128
•Concept ID:
CN377445
•
Finding
HPO: HP:6000613

Definition

The size (volume) of the lungs of a fetus above the upper limit of normal for the gestational age. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEnlarged fetal lungs

Conditions with this feature

Fraser syndrome 1
MedGen UID:
1639061
•Concept ID:
C4551480
•
Disease or Syndrome
Fraser syndrome is an autosomal recessive malformation disorder characterized by cryptophthalmos, syndactyly, and abnormalities of the respiratory and urogenital tract (summary by van Haelst et al., 2008). Genetic Heterogeneity of Fraser Syndrome Fraser syndrome-2 (FRASRS2) is caused by mutation in the FREM2 gene (608945) on chromosome 13q13, and Fraser syndrome-3 (FRASRS3; 617667) is caused by mutation in the GRIP1 gene (604597) on chromosome 12q14. See Bowen syndrome (211200) for a comparable but probably distinct syndrome of multiple congenital malformations.
See: Condition Record
Fraser syndrome 1

Professional guidelines

PubMed

Infant of a diabetic mother: clinical presentation, diagnosis and treatment.
Suda-Całus M, Dąbrowska K, Gulczyńska E
Pediatr Endocrinol Diabetes Metab 2024;30(1):36-41. doi: 10.5114/pedm.2024.137891. PMID: 39026477Free PMC Article
Obstetrical care in gestational diabetes and management of preterm labour.
Thiebaugeorges O, Guyard-Boileau B
Diabetes Metab 2010 Dec;36(6 Pt 2):672-81. doi: 10.1016/j.diabet.2010.11.017. PMID: 21163429
Prenatal diagnosis of dysplastic kidney disease.
Bartley JA, Golbus MS, Filly RA, Hall BD
Clin Genet 1977 May;11(5):375-8. doi: 10.1111/j.1399-0004.1977.tb01330.x. PMID: 862215

Recent clinical studies

Etiology

The Regenerative Effect of Portal Vein Injection of Liver Organoids by Retrorsine/Partial Hepatectomy in Rats.
Tsuchida T, Murata S, Matsuki K, Mori A, Matsuo M, Mikami S, Okamoto S, Ueno Y, Tadokoro T, Zheng YW, Taniguchi H
Int J Mol Sci 2019 Dec 26;21(1) doi: 10.3390/ijms21010178. PMID: 31887985Free PMC Article
Autopsy Findings in A Case of Pulmonary Langerhans Cell Histiocytosis-Associated Pulmonary Hypertension.
Taniyama D, Kamata H, Miyamoto K, Mashimo S, Sakamaki F
Am J Case Rep 2017 Dec 30;18:1401-1406. doi: 10.12659/AJCR.905860. PMID: 29301140Free PMC Article
Obstetrical care in gestational diabetes and management of preterm labour.
Thiebaugeorges O, Guyard-Boileau B
Diabetes Metab 2010 Dec;36(6 Pt 2):672-81. doi: 10.1016/j.diabet.2010.11.017. PMID: 21163429
Monitoring cardiovascular function in infants with chronic lung disease of prematurity.
Abman SH
Arch Dis Child Fetal Neonatal Ed 2002 Jul;87(1):F15-8. doi: 10.1136/fn.87.1.f15. PMID: 12091282Free PMC Article
Fetal renal structure and the genesis of amniotic fluid disorders.
Naeye RL, Blanc WA
Am J Pathol 1972 Apr;67(1):95-108. PMID: 4558222Free PMC Article

Diagnosis

Prenatal Diagnosis of Fetal Trisomy 5 Mosaicism with Congenital Pulmonary Airway Malformation Type 3: A Case Report.
Bonasoni MP, Comitini G, Tonni G, Asioli S, Barbieri V, Rinaldini M, Marinelli M
Fetal Pediatr Pathol 2022 Jun;41(3):516-522. Epub 2020 Oct 14 doi: 10.1080/15513815.2020.1831660. PMID: 33411590
Bilateral congenital pulmonary airway malformation in an extremely preterm infant.
Chandrasekaran P, Goergen S, Robinson A, Moghimi A, Malhotra A
BMJ Case Rep 2021 Apr 15;14(4) doi: 10.1136/bcr-2021-242228. PMID: 33858905Free PMC Article
Obstetrical care in gestational diabetes and management of preterm labour.
Thiebaugeorges O, Guyard-Boileau B
Diabetes Metab 2010 Dec;36(6 Pt 2):672-81. doi: 10.1016/j.diabet.2010.11.017. PMID: 21163429
Role of veins in regulation of pulmonary circulation.
Gao Y, Raj JU
Am J Physiol Lung Cell Mol Physiol 2005 Feb;288(2):L213-26. doi: 10.1152/ajplung.00103.2004. PMID: 15640520
Pulmonary arterial hypertension: a contemporary review.
Randall PA, Heitzman ER, Bull MJ, Scalzetti EM, Williams SK, Gordon LP, Markarian B
Radiographics 1989 Sep;9(5):905-27. doi: 10.1148/radiographics.9.5.2678297. PMID: 2678297

Therapy

The Regenerative Effect of Portal Vein Injection of Liver Organoids by Retrorsine/Partial Hepatectomy in Rats.
Tsuchida T, Murata S, Matsuki K, Mori A, Matsuo M, Mikami S, Okamoto S, Ueno Y, Tadokoro T, Zheng YW, Taniguchi H
Int J Mol Sci 2019 Dec 26;21(1) doi: 10.3390/ijms21010178. PMID: 31887985Free PMC Article
Heart and bile acids - Clinical consequences of altered bile acid metabolism.
Vasavan T, Ferraro E, Ibrahim E, Dixon P, Gorelik J, Williamson C
Biochim Biophys Acta Mol Basis Dis 2018 Apr;1864(4 Pt B):1345-1355. Epub 2018 Jan 6 doi: 10.1016/j.bbadis.2017.12.039. PMID: 29317337
Monitoring cardiovascular function in infants with chronic lung disease of prematurity.
Abman SH
Arch Dis Child Fetal Neonatal Ed 2002 Jul;87(1):F15-8. doi: 10.1136/fn.87.1.f15. PMID: 12091282Free PMC Article
Cardiac effects of short course dexamethasone in preterm infants.
Skelton R, Gill AB, Parsons JM
Arch Dis Child Fetal Neonatal Ed 1998 Mar;78(2):F133-7. doi: 10.1136/fn.78.2.f133. PMID: 9577285Free PMC Article
Cardiovascular effects of dexamethasone in the preterm infant.
Evans N
Arch Dis Child Fetal Neonatal Ed 1994 Jan;70(1):F25-30. doi: 10.1136/fn.70.1.f25. PMID: 8117123Free PMC Article

Prognosis

Congenital peribronchial myofibroblastic tumor: case report of an asymptomatic infant with a rapidly enlarging pulmonary mass and review of the literature.
Brock KE, Wall J, Esquivel M, Newman B, Marina N, Albanese C, Hazard FK
Ann Clin Lab Sci 2015 Winter;45(1):83-9. PMID: 25696016
Prenatal diagnosis of lobar bronchial atresia.
Bonnefoy C, Blanc P, Coste K, Delabaere A, Dechelotte PJ, Laurichesse-Delmas H, Labbe A, Jacquetin B, Lemery D, Sapin V, Gallot D
Ultrasound Obstet Gynecol 2011 Jan;37(1):110-2. doi: 10.1002/uog.8838. PMID: 20878667
Obstetrical care in gestational diabetes and management of preterm labour.
Thiebaugeorges O, Guyard-Boileau B
Diabetes Metab 2010 Dec;36(6 Pt 2):672-81. doi: 10.1016/j.diabet.2010.11.017. PMID: 21163429
Fetal pleural effusions.
Yinon Y, Kelly E, Ryan G
Best Pract Res Clin Obstet Gynaecol 2008 Feb;22(1):77-96. doi: 10.1016/j.bpobgyn.2007.09.004. PMID: 18280793
Observations on the pathogenesis and management of pulmonary hypertension.
Muller WH Jr
Am J Surg 1978 Mar;135(3):302-11. doi: 10.1016/0002-9610(78)90057-0. PMID: 626311

Clinical prediction guides

The Regenerative Effect of Portal Vein Injection of Liver Organoids by Retrorsine/Partial Hepatectomy in Rats.
Tsuchida T, Murata S, Matsuki K, Mori A, Matsuo M, Mikami S, Okamoto S, Ueno Y, Tadokoro T, Zheng YW, Taniguchi H
Int J Mol Sci 2019 Dec 26;21(1) doi: 10.3390/ijms21010178. PMID: 31887985Free PMC Article
Heart and bile acids - Clinical consequences of altered bile acid metabolism.
Vasavan T, Ferraro E, Ibrahim E, Dixon P, Gorelik J, Williamson C
Biochim Biophys Acta Mol Basis Dis 2018 Apr;1864(4 Pt B):1345-1355. Epub 2018 Jan 6 doi: 10.1016/j.bbadis.2017.12.039. PMID: 29317337
Congenital peribronchial myofibroblastic tumor: case report of an asymptomatic infant with a rapidly enlarging pulmonary mass and review of the literature.
Brock KE, Wall J, Esquivel M, Newman B, Marina N, Albanese C, Hazard FK
Ann Clin Lab Sci 2015 Winter;45(1):83-9. PMID: 25696016
Prenatal diagnosis of lobar bronchial atresia.
Bonnefoy C, Blanc P, Coste K, Delabaere A, Dechelotte PJ, Laurichesse-Delmas H, Labbe A, Jacquetin B, Lemery D, Sapin V, Gallot D
Ultrasound Obstet Gynecol 2011 Jan;37(1):110-2. doi: 10.1002/uog.8838. PMID: 20878667
Obstetrical care in gestational diabetes and management of preterm labour.
Thiebaugeorges O, Guyard-Boileau B
Diabetes Metab 2010 Dec;36(6 Pt 2):672-81. doi: 10.1016/j.diabet.2010.11.017. PMID: 21163429

Recent systematic reviews

Obstetrical care in gestational diabetes and management of preterm labour.
Thiebaugeorges O, Guyard-Boileau B
Diabetes Metab 2010 Dec;36(6 Pt 2):672-81. doi: 10.1016/j.diabet.2010.11.017. PMID: 21163429

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