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Coved type ST segment elevation

MedGen UID:
1053145
•Concept ID:
CN378336
•
Finding
HPO: HP:6000984

Definition

An ST-segment elevation of at least 2 mm in at least one right precordial lead (V1 to V3), followed by an r'-wave and a concave or straight ST segment. The descending ST segment crosses the isoelectric line and is followed by a negative and symmetric T-wave. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCoved type ST segment elevation

Professional guidelines

PubMed

Clinical approach to the patient with Brugada Syndrome: risk stratification and optimal management.
Marinković MM, Mujović NM, Potpara TS
Panminerva Med 2019 Dec;61(4):473-485. Epub 2019 Sep 6 doi: 10.23736/S0031-0808.19.03736-4. PMID: 31508925
Brugada syndrome in the paediatric population: a comprehensive approach to clinical manifestations, diagnosis, and management.
Gonzalez Corcia MC, de Asmundis C, Chierchia GB, Brugada P
Cardiol Young 2016 Aug;26(6):1044-55. Epub 2016 May 6 doi: 10.1017/S1047951116000548. PMID: 27151277
Spectrum and prevalence of mutations involving BrS1- through BrS12-susceptibility genes in a cohort of unrelated patients referred for Brugada syndrome genetic testing: implications for genetic testing.
Crotti L, Marcou CA, Tester DJ, Castelletti S, Giudicessi JR, Torchio M, Medeiros-Domingo A, Simone S, Will ML, Dagradi F, Schwartz PJ, Ackerman MJ
J Am Coll Cardiol 2012 Oct 9;60(15):1410-8. Epub 2012 Jul 25 doi: 10.1016/j.jacc.2012.04.037. PMID: 22840528Free PMC Article

Recent clinical studies

Etiology

Brugada syndrome clinical update.
Rojas R, Kaul R, Frenkel D, Hoch EG, Iwai S, Jacobson JT, Aronow WS
Hosp Pract (1995) 2021 Oct;49(4):255-261. Epub 2021 Mar 30 doi: 10.1080/21548331.2021.1906012. PMID: 33730522
Sudden Cardiac Death in Brugada Syndrome.
Kabra N, Gupta R, Aronow WS, Frishman WH
Cardiol Rev 2020 Jul/Aug;28(4):203-207. doi: 10.1097/CRD.0000000000000259. PMID: 31008774
Present Status of Brugada Syndrome: JACC State-of-the-Art Review.
Brugada J, Campuzano O, Arbelo E, Sarquella-Brugada G, Brugada R
J Am Coll Cardiol 2018 Aug 28;72(9):1046-1059. doi: 10.1016/j.jacc.2018.06.037. PMID: 30139433
The definition of the Brugada syndrome.
Sieira J, Brugada P
Eur Heart J 2017 Oct 21;38(40):3029-3034. doi: 10.1093/eurheartj/ehx490. PMID: 29020354
Brugada syndrome.
Antzelevitch C
Pacing Clin Electrophysiol 2006 Oct;29(10):1130-59. doi: 10.1111/j.1540-8159.2006.00507.x. PMID: 17038146Free PMC Article

Diagnosis

Brugada syndrome clinical update.
Rojas R, Kaul R, Frenkel D, Hoch EG, Iwai S, Jacobson JT, Aronow WS
Hosp Pract (1995) 2021 Oct;49(4):255-261. Epub 2021 Mar 30 doi: 10.1080/21548331.2021.1906012. PMID: 33730522
Epicardial Ablation in Brugada Syndrome.
Lambiase PD, Providência R
Card Electrophysiol Clin 2020 Sep;12(3):345-356. Epub 2020 Jun 27 doi: 10.1016/j.ccep.2020.04.006. PMID: 32771188
Sudden Cardiac Death in Brugada Syndrome.
Kabra N, Gupta R, Aronow WS, Frishman WH
Cardiol Rev 2020 Jul/Aug;28(4):203-207. doi: 10.1097/CRD.0000000000000259. PMID: 31008774
Present Status of Brugada Syndrome: JACC State-of-the-Art Review.
Brugada J, Campuzano O, Arbelo E, Sarquella-Brugada G, Brugada R
J Am Coll Cardiol 2018 Aug 28;72(9):1046-1059. doi: 10.1016/j.jacc.2018.06.037. PMID: 30139433
The definition of the Brugada syndrome.
Sieira J, Brugada P
Eur Heart J 2017 Oct 21;38(40):3029-3034. doi: 10.1093/eurheartj/ehx490. PMID: 29020354

Therapy

Brugada syndrome clinical update.
Rojas R, Kaul R, Frenkel D, Hoch EG, Iwai S, Jacobson JT, Aronow WS
Hosp Pract (1995) 2021 Oct;49(4):255-261. Epub 2021 Mar 30 doi: 10.1080/21548331.2021.1906012. PMID: 33730522
Electrocardiographic Effects of Propofol versus Etomidate in Patients with Brugada Syndrome.
Flamée P, Varnavas V, Dewals W, Carvalho H, Cools W, Bhutia JT, Beckers S, Umbrain V, Verborgh C, Forget P, Chierchia GB, Brugada P, Poelaert J, de Asmundis C
Anesthesiology 2020 Mar;132(3):440-451. doi: 10.1097/ALN.0000000000003030. PMID: 31743136
Brugada syndrome in the paediatric population: a comprehensive approach to clinical manifestations, diagnosis, and management.
Gonzalez Corcia MC, de Asmundis C, Chierchia GB, Brugada P
Cardiol Young 2016 Aug;26(6):1044-55. Epub 2016 May 6 doi: 10.1017/S1047951116000548. PMID: 27151277
Therapy for the Brugada syndrome.
Antzelevitch C, Fish JM
Handb Exp Pharmacol 2006;(171):305-30. doi: 10.1007/3-540-29715-4_12. PMID: 16610350Free PMC Article
Right bundle branch block and coved-type ST-segment elevation mimicked by acute cholecystitis.
Furuhashi M, Uno K, Satoh S, Hoshikawa K, Sakai E, Tsuchihashi K, Shimamoto K
Circ J 2003 Sep;67(9):802-4. doi: 10.1253/circj.67.802. PMID: 12939560

Prognosis

Clinical approach to the patient with Brugada Syndrome: risk stratification and optimal management.
Marinković MM, Mujović NM, Potpara TS
Panminerva Med 2019 Dec;61(4):473-485. Epub 2019 Sep 6 doi: 10.23736/S0031-0808.19.03736-4. PMID: 31508925
Multiple serial ECGs aid with the diagnosis and prognosis of Brugada syndrome.
Castro Hevia J, Dorantes Sanchez M, Martinez Lopez F, Castañeda Chirino O, Falcon Rodriguez R, Puga Bravo M, de Zayas Galguera J, Antzelevitch C
Int J Cardiol 2019 Feb 15;277:130-135. Epub 2018 Aug 30 doi: 10.1016/j.ijcard.2018.08.089. PMID: 30195842Free PMC Article
Should all individuals with a nondiagnostic Brugada-electrocardiogram undergo sodium-channel blocker test?
Zorzi A, Migliore F, Marras E, Marinelli A, Baritussio A, Allocca G, Leoni L, Perazzolo Marra M, Basso C, Buja G, Thiene G, Iliceto S, Delise P, Corrado D
Heart Rhythm 2012 Jun;9(6):909-16. Epub 2012 Feb 12 doi: 10.1016/j.hrthm.2012.02.009. PMID: 22334153
Variability of the diagnostic ECG pattern in an ICD patient population with Brugada syndrome.
Richter S, Sarkozy A, Veltmann C, Chierchia GB, Boussy T, Wolpert C, Schimpf R, Brugada J, Brugada R, Borggrefe M, Brugada P
J Cardiovasc Electrophysiol 2009 Jan;20(1):69-75. Epub 2008 Sep 4 doi: 10.1111/j.1540-8167.2008.01282.x. PMID: 18775043
Arrhythmogenic right ventricular dysplasia-cardiomyopathy and provocable coved-type ST-segment elevation in right precordial leads: clues from long-term follow-up.
Peters S
Europace 2008 Jul;10(7):816-20. Epub 2008 Feb 27 doi: 10.1093/europace/eun030. PMID: 18304999

Clinical prediction guides

Brugada Syndrome: Oligogenic or Mendelian Disease?
Monasky MM, Micaglio E, Ciconte G, Pappone C
Int J Mol Sci 2020 Mar 1;21(5) doi: 10.3390/ijms21051687. PMID: 32121523Free PMC Article
Sudden Cardiac Death in Brugada Syndrome.
Kabra N, Gupta R, Aronow WS, Frishman WH
Cardiol Rev 2020 Jul/Aug;28(4):203-207. doi: 10.1097/CRD.0000000000000259. PMID: 31008774
Present Status of Brugada Syndrome: JACC State-of-the-Art Review.
Brugada J, Campuzano O, Arbelo E, Sarquella-Brugada G, Brugada R
J Am Coll Cardiol 2018 Aug 28;72(9):1046-1059. doi: 10.1016/j.jacc.2018.06.037. PMID: 30139433
Induced Brugada syndrome: Possible sources of arrhythmogenesis.
Tomé G, Freitas J
Rev Port Cardiol 2017 Dec;36(12):945-956. Epub 2017 Dec 10 doi: 10.1016/j.repc.2017.06.015. PMID: 29233646
Arrhythmogenic right ventricular dysplasia-cardiomyopathy and provocable coved-type ST-segment elevation in right precordial leads: clues from long-term follow-up.
Peters S
Europace 2008 Jul;10(7):816-20. Epub 2008 Feb 27 doi: 10.1093/europace/eun030. PMID: 18304999

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