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Rokitansky-Aschoff gallbladder sinuses

MedGen UID:
1053350
•Concept ID:
CN377282
•
Finding
Synonyms: Adenomyomatosis of the gallbladder; Epithelial invaginations of the gallbladder forming cystic pockets
 
HPO: HP:6000450

Definition

Localized or diffuse epithelial proliferation with hypertrophy of the muscularis layer and invagination of the mucosa through the muscularis, forming intramural diverticula (i.e., small, bulging pouches in the wall of the gallbladder). [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRokitansky-Aschoff gallbladder sinuses

Professional guidelines

PubMed

Xanthogranulomatous cholecystitis: Diagnosis and management.
Giudicelli X, Rode A, Bancel B, Nguyen AT, Mabrut JY
J Visc Surg 2021 Aug;158(4):326-336. Epub 2021 Mar 23 doi: 10.1016/j.jviscsurg.2021.02.004. PMID: 33741306
Gallbladder adenomyomatosis: Diagnosis and management.
Golse N, Lewin M, Rode A, Sebagh M, Mabrut JY
J Visc Surg 2017 Oct;154(5):345-353. Epub 2017 Aug 24 doi: 10.1016/j.jviscsurg.2017.06.004. PMID: 28844704

Recent clinical studies

Etiology

Xanthogranulomatous cholecystitis: Diagnosis and management.
Giudicelli X, Rode A, Bancel B, Nguyen AT, Mabrut JY
J Visc Surg 2021 Aug;158(4):326-336. Epub 2021 Mar 23 doi: 10.1016/j.jviscsurg.2021.02.004. PMID: 33741306
Gallbladder adenomyomatosis: Diagnosis and management.
Golse N, Lewin M, Rode A, Sebagh M, Mabrut JY
J Visc Surg 2017 Oct;154(5):345-353. Epub 2017 Aug 24 doi: 10.1016/j.jviscsurg.2017.06.004. PMID: 28844704
Adenomyomatosis Concomitant with Primary Gallbladder Carcinoma.
Morikawa T, Okabayashi T, Shima Y, Sumiyoshi T, Kozuki A, Saisaka Y, Tokumaru T, Sui K, Iwata J, Matsumoto M, Morita S, Nishioka Y
Acta Med Okayama 2017 Apr;71(2):113-118. doi: 10.18926/AMO/54979. PMID: 28420892
Gallbladder and the risk of polyps and carcinoma in metachromatic leukodystrophy.
van Rappard DF, Bugiani M, Boelens JJ, van der Steeg AF, Daams F, de Meij TG, van Doorn MM, van Hasselt PM, Gouma DJ, Verbeke JI, Hollak CE, van Hecke W, Salomons GS, van der Knaap MS, Wolf NI
Neurology 2016 Jul 5;87(1):103-11. Epub 2016 Jun 3 doi: 10.1212/WNL.0000000000002811. PMID: 27261095
Imaging of adenomyomatosis of the gall bladder.
Stunell H, Buckley O, Geoghegan T, O'Brien J, Ward E, Torreggiani W
J Med Imaging Radiat Oncol 2008 Apr;52(2):109-17. doi: 10.1111/j.1440-1673.2008.01926.x. PMID: 18373800

Diagnosis

Cyst of the gallbladder.
Yamazaki S, Takahashi Y, Seki H, Ochi Y, Horiuchi I, Kusama Y, Imai S, Kobayashi A
Surgery 2021 Aug;170(2):e5-e6. Epub 2021 Mar 4 doi: 10.1016/j.surg.2021.01.024. PMID: 34238431
Imaging-based algorithmic approach to gallbladder wall thickening.
Gupta P, Marodia Y, Bansal A, Kalra N, Kumar-M P, Sharma V, Dutta U, Sandhu MS
World J Gastroenterol 2020 Oct 28;26(40):6163-6181. doi: 10.3748/wjg.v26.i40.6163. PMID: 33177791Free PMC Article
Benign gallbladder diseases: Imaging techniques and tips for differentiating with malignant gallbladder diseases.
Yu MH, Kim YJ, Park HS, Jung SI
World J Gastroenterol 2020 Jun 14;26(22):2967-2986. doi: 10.3748/wjg.v26.i22.2967. PMID: 32587442Free PMC Article
Gallbladder adenomyomatosis: Diagnosis and management.
Golse N, Lewin M, Rode A, Sebagh M, Mabrut JY
J Visc Surg 2017 Oct;154(5):345-353. Epub 2017 Aug 24 doi: 10.1016/j.jviscsurg.2017.06.004. PMID: 28844704
Xanthogranulomatous cholecystitis.
Goodman ZD, Ishak KG
Am J Surg Pathol 1981 Oct;5(7):653-9. doi: 10.1097/00000478-198110000-00007. PMID: 7337158

Therapy

Incidentally detected focal fundal gallbladder wall thickening: Differentiation contrast enhanced ultrasound features with high-resolution linear transducers.
Dong Y, Xu B, Cao Q, Zhang Q, Qiu Y, Yang D, Yu L, Wang WP
Clin Hemorheol Microcirc 2020;74(3):315-325. doi: 10.3233/CH-190697. PMID: 31524151
Chronic inflammatory changes seen in gallbladders of patients with pancreatico-biliary malunion years after transduodenal sphincterotomy: is it a precursor for gallbladder carcinoma?
Ali AE, Blythe AI, Ford WD
Pediatr Surg Int 2008 Sep;24(9):1005-8. Epub 2008 Jul 31 doi: 10.1007/s00383-008-2197-6. PMID: 18668255

Prognosis

Imaging-based algorithmic approach to gallbladder wall thickening.
Gupta P, Marodia Y, Bansal A, Kalra N, Kumar-M P, Sharma V, Dutta U, Sandhu MS
World J Gastroenterol 2020 Oct 28;26(40):6163-6181. doi: 10.3748/wjg.v26.i40.6163. PMID: 33177791Free PMC Article
Gallbladder adenomyomatosis: Diagnosis and management.
Golse N, Lewin M, Rode A, Sebagh M, Mabrut JY
J Visc Surg 2017 Oct;154(5):345-353. Epub 2017 Aug 24 doi: 10.1016/j.jviscsurg.2017.06.004. PMID: 28844704
A literature review of radiological findings to guide the diagnosis of gallbladder adenomyomatosis.
Hammad AY, Miura JT, Turaga KK, Johnston FM, Hohenwalter MD, Gamblin TC
HPB (Oxford) 2016 Feb;18(2):129-135. Epub 2016 Jan 6 doi: 10.1016/j.hpb.2015.09.006. PMID: 26902131Free PMC Article
Rokitansky-Aschoff sinuses mimicking adenocarcinoma of the gallbladder: a study of 8 cases.
Dorantes-Heredia R, Chablé-Montero F, Henson DE, Albores-Saavedra J
Am J Surg Pathol 2013 Aug;37(8):1269-74. doi: 10.1097/PAS.0b013e318286bd39. PMID: 23715158
Morphological changes in diseased gall bladder: a study of 415 cholecystectomies at Aligarh.
Tyagi SP, Tyagi N, Maheshwari V, Ashraf SM, Sahoo P
J Indian Med Assoc 1992 Jul;90(7):178-81. PMID: 1401974

Clinical prediction guides

Imaging-based algorithmic approach to gallbladder wall thickening.
Gupta P, Marodia Y, Bansal A, Kalra N, Kumar-M P, Sharma V, Dutta U, Sandhu MS
World J Gastroenterol 2020 Oct 28;26(40):6163-6181. doi: 10.3748/wjg.v26.i40.6163. PMID: 33177791Free PMC Article
A literature review of radiological findings to guide the diagnosis of gallbladder adenomyomatosis.
Hammad AY, Miura JT, Turaga KK, Johnston FM, Hohenwalter MD, Gamblin TC
HPB (Oxford) 2016 Feb;18(2):129-135. Epub 2016 Jan 6 doi: 10.1016/j.hpb.2015.09.006. PMID: 26902131Free PMC Article
Rokitansky-Aschoff sinuses mimicking adenocarcinoma of the gallbladder: a study of 8 cases.
Dorantes-Heredia R, Chablé-Montero F, Henson DE, Albores-Saavedra J
Am J Surg Pathol 2013 Aug;37(8):1269-74. doi: 10.1097/PAS.0b013e318286bd39. PMID: 23715158
Carcinoma in situ of the gallbladder with superficial extension into the Rokitansky-Aschoff sinuses and mucous glands.
Yamaguchi A, Hachisuka K, Isogai M, Tsubone M
Gastroenterol Jpn 1992 Dec;27(6):765-72. doi: 10.1007/BF02806530. PMID: 1468607
Morphological changes in diseased gall bladder: a study of 415 cholecystectomies at Aligarh.
Tyagi SP, Tyagi N, Maheshwari V, Ashraf SM, Sahoo P
J Indian Med Assoc 1992 Jul;90(7):178-81. PMID: 1401974

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