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Increased myocardial pyrophosphate uptake

MedGen UID:
1053579
•Concept ID:
CN376579
•
Finding
HPO: HP:6000067

Definition

Amount of pyrophosphate uptake by the myocardium as demonstrated by by technetium pyrophosphate (99mTc-PYP) scintigraphy above the upper limit of normal. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased myocardial pyrophosphate uptake

Professional guidelines

PubMed

Inflammatory response, neutrophil activation, and free radical production after acute myocardial infarction: effect of thrombolytic treatment.
Bell D, Jackson M, Nicoll JJ, Millar A, Dawes J, Muir AL
Br Heart J 1990 Feb;63(2):82-7. doi: 10.1136/hrt.63.2.82. PMID: 2317413Free PMC Article

Recent clinical studies

Therapy

Regional Variation in Technetium Pyrophosphate Uptake in Transthyretin Cardiac Amyloidosis and Impact on Mortality.
Sperry BW, Vranian MN, Tower-Rader A, Hachamovitch R, Hanna M, Brunken R, Phelan D, Cerqueira MD, Jaber WA
JACC Cardiovasc Imaging 2018 Feb;11(2 Pt 1):234-242. Epub 2017 Oct 5 doi: 10.1016/j.jcmg.2017.06.020. PMID: 28917675
Cold infarction areas of varying size in the presence of left ventricular dysfunction: the impact on left ventricular ejection fraction determination by gated SPECT compared to radionuclide ventriculography.
Canbaz F, Basoglu T, Semirgin SU, Yapici O, Yazici M
Hell J Nucl Med 2005 Sep-Dec;8(3):149-53. PMID: 16390019
Relevance of 99mTc-MIBI rest uptake, ejection fraction and location of contractile abnormality in predicting myocardial recovery after revascularization.
González JM, Castell-Conesa J, Candell-Riera J, Rosselló-Urgell J; Spanish Working Group of Nuclear Cardiology
Nucl Med Commun 2001 Jul;22(7):795-805. doi: 10.1097/00006231-200107000-00011. PMID: 11453053
Cerivastatin, an inhibitor of HMG-CoA reductase, inhibits urokinase/urokinase-receptor expression and MMP-9 secretion by peripheral blood monocytes--a possible protective mechanism against atherothrombosis.
Ganné F, Vasse M, Beaudeux JL, Peynet J, François A, Mishal Z, Chartier A, Tobelem G, Vannier JP, Soria J, Soria C
Thromb Haemost 2000 Oct;84(4):680-8. PMID: 11057870
Implications of delayed image on simultaneous thallium-201/technetium-99m pyrophosphate dual emission computed tomography early after acute myocardial infarction.
Sakata K, Yoshida H, Ono N, Ohtani S, Mori N, Yokoyama S, Hoshino T, Kaburagi T, Kurata C
Jpn Circ J 1993 Jan;57(1):27-36. doi: 10.1253/jcj.57.27. PMID: 8437339

Prognosis

Deep Learning-Enabled Quantification of (99m)Tc-Pyrophosphate SPECT/CT for Cardiac Amyloidosis.
Miller RJH, Shanbhag A, Michalowska AM, Kavanagh P, Liang JX, Builoff V, Fine NM, Dey D, Berman DS, Slomka PJ
J Nucl Med 2024 Jul 1;65(7):1144-1150. doi: 10.2967/jnumed.124.267542. PMID: 38724278Free PMC Article
Lymphocytic Myocarditis with Increased Left Ventricular Thickness: A Rare Presentation Mimicking Cardiac Amyloidosis.
Duan X, Qu L, Chen H
Am J Case Rep 2024 Mar 25;25:e942760. doi: 10.12659/AJCR.942760. PMID: 38523340Free PMC Article
Diagnostic performance characteristics of planar quantitative and semi-quantitative parameters of Tc(99m) pyrophosphate (PYP) imaging for diagnosis of transthyretin (ATTR) cardiac amyloidosis: the SCAN-MP study.
Pandey S, Teruya S, Rodriguez C, Deluca A, Kinkhabwala M, Johnson LL, Fine D, Sabogal N, Winburn M, Castillo M, Bhatia K, Malkovskaya R, Raiszadeh F, Kurian D, Miller EJ, Einstein AJ, Maurer MS, Ruberg FL
J Nucl Cardiol 2023 Aug;30(4):1414-1419. Epub 2023 Feb 23 doi: 10.1007/s12350-023-03203-9. PMID: 36823486Free PMC Article
Regional Variation in Technetium Pyrophosphate Uptake in Transthyretin Cardiac Amyloidosis and Impact on Mortality.
Sperry BW, Vranian MN, Tower-Rader A, Hachamovitch R, Hanna M, Brunken R, Phelan D, Cerqueira MD, Jaber WA
JACC Cardiovasc Imaging 2018 Feb;11(2 Pt 1):234-242. Epub 2017 Oct 5 doi: 10.1016/j.jcmg.2017.06.020. PMID: 28917675
Cardiac Abnormalities in Adult Patients With Polymyositis or Dermatomyositis as Assessed by Noninvasive Modalities.
Diederichsen LP, Simonsen JA, Diederichsen AC, Hvidsten S, Hougaard M, Junker P, Søndergaard K, Lundberg IE, Tvede N, Sandgaard NC, Christensen AF, Dreyer L, Kay S, Eskerud KS, Petersen H, Ejstrup L, Jacobsen S
Arthritis Care Res (Hoboken) 2016 Jul;68(7):1012-20. doi: 10.1002/acr.22772. PMID: 26502301

Clinical prediction guides

Deep Learning-Enabled Quantification of (99m)Tc-Pyrophosphate SPECT/CT for Cardiac Amyloidosis.
Miller RJH, Shanbhag A, Michalowska AM, Kavanagh P, Liang JX, Builoff V, Fine NM, Dey D, Berman DS, Slomka PJ
J Nucl Med 2024 Jul 1;65(7):1144-1150. doi: 10.2967/jnumed.124.267542. PMID: 38724278Free PMC Article
Diagnostic performance characteristics of planar quantitative and semi-quantitative parameters of Tc(99m) pyrophosphate (PYP) imaging for diagnosis of transthyretin (ATTR) cardiac amyloidosis: the SCAN-MP study.
Pandey S, Teruya S, Rodriguez C, Deluca A, Kinkhabwala M, Johnson LL, Fine D, Sabogal N, Winburn M, Castillo M, Bhatia K, Malkovskaya R, Raiszadeh F, Kurian D, Miller EJ, Einstein AJ, Maurer MS, Ruberg FL
J Nucl Cardiol 2023 Aug;30(4):1414-1419. Epub 2023 Feb 23 doi: 10.1007/s12350-023-03203-9. PMID: 36823486Free PMC Article
Regional Variation in Technetium Pyrophosphate Uptake in Transthyretin Cardiac Amyloidosis and Impact on Mortality.
Sperry BW, Vranian MN, Tower-Rader A, Hachamovitch R, Hanna M, Brunken R, Phelan D, Cerqueira MD, Jaber WA
JACC Cardiovasc Imaging 2018 Feb;11(2 Pt 1):234-242. Epub 2017 Oct 5 doi: 10.1016/j.jcmg.2017.06.020. PMID: 28917675
Cardiac Abnormalities in Adult Patients With Polymyositis or Dermatomyositis as Assessed by Noninvasive Modalities.
Diederichsen LP, Simonsen JA, Diederichsen AC, Hvidsten S, Hougaard M, Junker P, Søndergaard K, Lundberg IE, Tvede N, Sandgaard NC, Christensen AF, Dreyer L, Kay S, Eskerud KS, Petersen H, Ejstrup L, Jacobsen S
Arthritis Care Res (Hoboken) 2016 Jul;68(7):1012-20. doi: 10.1002/acr.22772. PMID: 26502301
Evaluation of myocardial uptake of 99mtechnetium pyrophosphate in clinical exercise-induced ventricular ischemia.
Berman DS, Salel AF, Amsterdam EA, DeNardo GL, Mason DT
Chest 1977 Mar;71(3):349-53. doi: 10.1378/chest.71.3.349. PMID: 189975

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