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Increased myocardial pyrophosphate uptake

MedGen UID:
1053579
•Concept ID:
CN376579
•
Finding
HPO: HP:6000067

Definition

Amount of pyrophosphate uptake by the myocardium as demonstrated by by technetium pyrophosphate (99mTc-PYP) scintigraphy above the upper limit of normal. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased myocardial pyrophosphate uptake

Professional guidelines

PubMed

Inflammatory response, neutrophil activation, and free radical production after acute myocardial infarction: effect of thrombolytic treatment.
Bell D, Jackson M, Nicoll JJ, Millar A, Dawes J, Muir AL
Br Heart J 1990 Feb;63(2):82-7. doi: 10.1136/hrt.63.2.82. PMID: 2317413Free PMC Article

Recent clinical studies

Etiology

Non-cardiac uptake of technetium-99m pyrophosphate in transthyretin cardiac amyloidosis.
Sperry BW, Gonzalez MH, Brunken R, Cerqueira MD, Hanna M, Jaber WA
J Nucl Cardiol 2019 Oct;26(5):1630-1637. Epub 2018 Jan 17 doi: 10.1007/s12350-017-1166-7. PMID: 29344917
Regional Variation in Technetium Pyrophosphate Uptake in Transthyretin Cardiac Amyloidosis and Impact on Mortality.
Sperry BW, Vranian MN, Tower-Rader A, Hachamovitch R, Hanna M, Brunken R, Phelan D, Cerqueira MD, Jaber WA
JACC Cardiovasc Imaging 2018 Feb;11(2 Pt 1):234-242. Epub 2017 Oct 5 doi: 10.1016/j.jcmg.2017.06.020. PMID: 28917675
Relevance of 99mTc-MIBI rest uptake, ejection fraction and location of contractile abnormality in predicting myocardial recovery after revascularization.
González JM, Castell-Conesa J, Candell-Riera J, Rosselló-Urgell J; Spanish Working Group of Nuclear Cardiology
Nucl Med Commun 2001 Jul;22(7):795-805. doi: 10.1097/00006231-200107000-00011. PMID: 11453053
Diagnosis and prognosis of right ventricular infarction.
Rodrigues EA, Dewhurst NG, Smart LM, Hannan WJ, Muir AL
Br Heart J 1986 Jul;56(1):19-26. doi: 10.1136/hrt.56.1.19. PMID: 3015175Free PMC Article
Measurement of myocardial infarct size by technetium pyrophosphate single-photon tomography.
Corbett JR, Lewis SE, Wolfe CL, Jansen DE, Lewis M, Rellas JS, Parkey RW, Rude RE, Buja LM, Willerson JT
Am J Cardiol 1984 Dec 1;54(10):1231-6. doi: 10.1016/s0002-9149(84)80072-7. PMID: 6095634

Diagnosis

Cardiac Amyloidosis Imaging, Part 2: Quantification and Technical Considerations.
Schockling EJ, Farrell MB, Embry-Dierson M, Warren J, Jerome S
J Nucl Med Technol 2023 Jun;51(2):90-98. Epub 2023 Jun 2 doi: 10.2967/jnmt.123.265416. PMID: 37268318
Improving evaluation for TTR amyloidosis by interactive filtering of Tc-99 m PYP SPECT images. The role for "clean blood pool" imaging.
Hansen CL
J Nucl Cardiol 2023 Dec;30(6):2418-2426. Epub 2023 May 12 doi: 10.1007/s12350-023-03291-7. PMID: 37173549
Diagnostic performance characteristics of planar quantitative and semi-quantitative parameters of Tc(99m) pyrophosphate (PYP) imaging for diagnosis of transthyretin (ATTR) cardiac amyloidosis: the SCAN-MP study.
Pandey S, Teruya S, Rodriguez C, Deluca A, Kinkhabwala M, Johnson LL, Fine D, Sabogal N, Winburn M, Castillo M, Bhatia K, Malkovskaya R, Raiszadeh F, Kurian D, Miller EJ, Einstein AJ, Maurer MS, Ruberg FL
J Nucl Cardiol 2023 Aug;30(4):1414-1419. Epub 2023 Feb 23 doi: 10.1007/s12350-023-03203-9. PMID: 36823486
Non-cardiac uptake of technetium-99m pyrophosphate in transthyretin cardiac amyloidosis.
Sperry BW, Gonzalez MH, Brunken R, Cerqueira MD, Hanna M, Jaber WA
J Nucl Cardiol 2019 Oct;26(5):1630-1637. Epub 2018 Jan 17 doi: 10.1007/s12350-017-1166-7. PMID: 29344917
Regional Variation in Technetium Pyrophosphate Uptake in Transthyretin Cardiac Amyloidosis and Impact on Mortality.
Sperry BW, Vranian MN, Tower-Rader A, Hachamovitch R, Hanna M, Brunken R, Phelan D, Cerqueira MD, Jaber WA
JACC Cardiovasc Imaging 2018 Feb;11(2 Pt 1):234-242. Epub 2017 Oct 5 doi: 10.1016/j.jcmg.2017.06.020. PMID: 28917675

Therapy

Regional Variation in Technetium Pyrophosphate Uptake in Transthyretin Cardiac Amyloidosis and Impact on Mortality.
Sperry BW, Vranian MN, Tower-Rader A, Hachamovitch R, Hanna M, Brunken R, Phelan D, Cerqueira MD, Jaber WA
JACC Cardiovasc Imaging 2018 Feb;11(2 Pt 1):234-242. Epub 2017 Oct 5 doi: 10.1016/j.jcmg.2017.06.020. PMID: 28917675
Cold infarction areas of varying size in the presence of left ventricular dysfunction: the impact on left ventricular ejection fraction determination by gated SPECT compared to radionuclide ventriculography.
Canbaz F, Basoglu T, Semirgin SU, Yapici O, Yazici M
Hell J Nucl Med 2005 Sep-Dec;8(3):149-53. PMID: 16390019
Relevance of 99mTc-MIBI rest uptake, ejection fraction and location of contractile abnormality in predicting myocardial recovery after revascularization.
González JM, Castell-Conesa J, Candell-Riera J, Rosselló-Urgell J; Spanish Working Group of Nuclear Cardiology
Nucl Med Commun 2001 Jul;22(7):795-805. doi: 10.1097/00006231-200107000-00011. PMID: 11453053
Implications of delayed image on simultaneous thallium-201/technetium-99m pyrophosphate dual emission computed tomography early after acute myocardial infarction.
Sakata K, Yoshida H, Ono N, Ohtani S, Mori N, Yokoyama S, Hoshino T, Kaburagi T, Kurata C
Jpn Circ J 1993 Jan;57(1):27-36. doi: 10.1253/jcj.57.27. PMID: 8437339
ST elevations in leads V1 to V5 may be caused by right coronary artery occlusion and acute right ventricular infarction.
Geft IL, Shah PK, Rodriguez L, Hulse S, Maddahi J, Berman DS, Ganz W
Am J Cardiol 1984 Apr 1;53(8):991-6. doi: 10.1016/0002-9149(84)90623-4. PMID: 6702712

Prognosis

Diagnostic performance characteristics of planar quantitative and semi-quantitative parameters of Tc(99m) pyrophosphate (PYP) imaging for diagnosis of transthyretin (ATTR) cardiac amyloidosis: the SCAN-MP study.
Pandey S, Teruya S, Rodriguez C, Deluca A, Kinkhabwala M, Johnson LL, Fine D, Sabogal N, Winburn M, Castillo M, Bhatia K, Malkovskaya R, Raiszadeh F, Kurian D, Miller EJ, Einstein AJ, Maurer MS, Ruberg FL
J Nucl Cardiol 2023 Aug;30(4):1414-1419. Epub 2023 Feb 23 doi: 10.1007/s12350-023-03203-9. PMID: 36823486
Regional Variation in Technetium Pyrophosphate Uptake in Transthyretin Cardiac Amyloidosis and Impact on Mortality.
Sperry BW, Vranian MN, Tower-Rader A, Hachamovitch R, Hanna M, Brunken R, Phelan D, Cerqueira MD, Jaber WA
JACC Cardiovasc Imaging 2018 Feb;11(2 Pt 1):234-242. Epub 2017 Oct 5 doi: 10.1016/j.jcmg.2017.06.020. PMID: 28917675
Cardiac Abnormalities in Adult Patients With Polymyositis or Dermatomyositis as Assessed by Noninvasive Modalities.
Diederichsen LP, Simonsen JA, Diederichsen AC, Hvidsten S, Hougaard M, Junker P, Søndergaard K, Lundberg IE, Tvede N, Sandgaard NC, Christensen AF, Dreyer L, Kay S, Eskerud KS, Petersen H, Ejstrup L, Jacobsen S
Arthritis Care Res (Hoboken) 2016 Jul;68(7):1012-20. doi: 10.1002/acr.22772. PMID: 26502301
Relevance of 99mTc-MIBI rest uptake, ejection fraction and location of contractile abnormality in predicting myocardial recovery after revascularization.
González JM, Castell-Conesa J, Candell-Riera J, Rosselló-Urgell J; Spanish Working Group of Nuclear Cardiology
Nucl Med Commun 2001 Jul;22(7):795-805. doi: 10.1097/00006231-200107000-00011. PMID: 11453053
Diagnosis and prognosis of right ventricular infarction.
Rodrigues EA, Dewhurst NG, Smart LM, Hannan WJ, Muir AL
Br Heart J 1986 Jul;56(1):19-26. doi: 10.1136/hrt.56.1.19. PMID: 3015175Free PMC Article

Clinical prediction guides

Diagnostic performance characteristics of planar quantitative and semi-quantitative parameters of Tc(99m) pyrophosphate (PYP) imaging for diagnosis of transthyretin (ATTR) cardiac amyloidosis: the SCAN-MP study.
Pandey S, Teruya S, Rodriguez C, Deluca A, Kinkhabwala M, Johnson LL, Fine D, Sabogal N, Winburn M, Castillo M, Bhatia K, Malkovskaya R, Raiszadeh F, Kurian D, Miller EJ, Einstein AJ, Maurer MS, Ruberg FL
J Nucl Cardiol 2023 Aug;30(4):1414-1419. Epub 2023 Feb 23 doi: 10.1007/s12350-023-03203-9. PMID: 36823486
Regional Variation in Technetium Pyrophosphate Uptake in Transthyretin Cardiac Amyloidosis and Impact on Mortality.
Sperry BW, Vranian MN, Tower-Rader A, Hachamovitch R, Hanna M, Brunken R, Phelan D, Cerqueira MD, Jaber WA
JACC Cardiovasc Imaging 2018 Feb;11(2 Pt 1):234-242. Epub 2017 Oct 5 doi: 10.1016/j.jcmg.2017.06.020. PMID: 28917675
Cardiac Abnormalities in Adult Patients With Polymyositis or Dermatomyositis as Assessed by Noninvasive Modalities.
Diederichsen LP, Simonsen JA, Diederichsen AC, Hvidsten S, Hougaard M, Junker P, Søndergaard K, Lundberg IE, Tvede N, Sandgaard NC, Christensen AF, Dreyer L, Kay S, Eskerud KS, Petersen H, Ejstrup L, Jacobsen S
Arthritis Care Res (Hoboken) 2016 Jul;68(7):1012-20. doi: 10.1002/acr.22772. PMID: 26502301
Relevance of 99mTc-MIBI rest uptake, ejection fraction and location of contractile abnormality in predicting myocardial recovery after revascularization.
González JM, Castell-Conesa J, Candell-Riera J, Rosselló-Urgell J; Spanish Working Group of Nuclear Cardiology
Nucl Med Commun 2001 Jul;22(7):795-805. doi: 10.1097/00006231-200107000-00011. PMID: 11453053
Evaluation of myocardial uptake of 99mtechnetium pyrophosphate in clinical exercise-induced ventricular ischemia.
Berman DS, Salel AF, Amsterdam EA, DeNardo GL, Mason DT
Chest 1977 Mar;71(3):349-53. doi: 10.1378/chest.71.3.349. PMID: 189975

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