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Decreased circulating ficolin 3 concentration

MedGen UID:
1053807
•Concept ID:
CN376702
•
Finding
HPO: HP:6000189

Definition

Concentration of ficolin 3 in the blood circulation below the lower limit of normal. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDecreased circulating ficolin 3 concentration

Recent clinical studies

Etiology

Hemodialysis leads to plasma depletion of lectin complement pathway initiator molecule ficolin-2.
Nielsen TL, Pilely K, Lund KP, Warming PE, Plesner LL, Iversen KK, Garred P
Hemodial Int 2021 Oct;25(4):479-488. Epub 2021 Jun 16 doi: 10.1111/hdi.12948. PMID: 34132045
Heparin-coated cardiopulmonary bypass circuits selectively deplete the pattern recognition molecule ficolin-2 of the lectin complement pathway in vivo.
Hein E, Munthe-Fog L, Thiara AS, Fiane AE, Mollnes TE, Garred P
Clin Exp Immunol 2015 Feb;179(2):294-9. doi: 10.1111/cei.12446. PMID: 25174443Free PMC Article
Circulating ficolin-2 and ficolin-3 in normal pregnancy and pre-eclampsia.
Halmos A, Rigó J Jr, Szijártó J, Füst G, Prohászka Z, Molvarec A
Clin Exp Immunol 2012 Jul;169(1):49-56. doi: 10.1111/j.1365-2249.2012.04590.x. PMID: 22670778Free PMC Article

Therapy

Hemodialysis leads to plasma depletion of lectin complement pathway initiator molecule ficolin-2.
Nielsen TL, Pilely K, Lund KP, Warming PE, Plesner LL, Iversen KK, Garred P
Hemodial Int 2021 Oct;25(4):479-488. Epub 2021 Jun 16 doi: 10.1111/hdi.12948. PMID: 34132045
Heparin-coated cardiopulmonary bypass circuits selectively deplete the pattern recognition molecule ficolin-2 of the lectin complement pathway in vivo.
Hein E, Munthe-Fog L, Thiara AS, Fiane AE, Mollnes TE, Garred P
Clin Exp Immunol 2015 Feb;179(2):294-9. doi: 10.1111/cei.12446. PMID: 25174443Free PMC Article

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