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Thickened mitral valve cusp

MedGen UID:
1054286
•Concept ID:
CN377150
•
Finding
HPO: HP:6000342

Definition

An abnormally increased thickness of a leaflet of the mitral valve. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVThickened mitral valve cusp

Professional guidelines

PubMed

Assessment of cardiac valve dysfunction in patients receiving cabergoline treatment for hyperprolactinaemia.
Tan T, Cabrita IZ, Hensman D, Grogono J, Dhillo WS, Baynes KC, Eliahoo J, Meeran K, Robinson S, Nihoyannopoulos P, Martin NM
Clin Endocrinol (Oxf) 2010 Sep;73(3):369-74. Epub 2010 Jun 9 doi: 10.1111/j.1365-2265.2010.03827.x. PMID: 20550538

Recent clinical studies

Etiology

Histopathological maladaptive changes in the explanted human mitral leaflets correlate with changes in echocardiographic leaflet morphology and the severity of ischaemic mitral regurgitation.
Avila-Vanzzini N, Lancellotti P, Fernandez Calix LA, De León López W, Berrios-Bárcenas E, Aranda-Fraustro A, Jordan-Rios A, Herrera-Bello H, Rivera-Lara P, Arias-Godínez JA, Vannan MA
Eur Heart J Cardiovasc Imaging 2023 Feb 17;24(3):392-400. doi: 10.1093/ehjci/jeac050. PMID: 35348652
Regression of cardiac valvulopathy related to ergot-derived dopamine agonists.
Zanettini R, Antonini A, Gatto G, Gentile R, Tesei S, Pezzoli G
Cardiovasc Ther 2011 Dec;29(6):404-10. Epub 2010 Jun 11 doi: 10.1111/j.1755-5922.2010.00169.x. PMID: 20553285
Abnormal aortic valve echoes in mitral prolapse. Echocardiographic features of floppy aortic valve.
Rodger JC, Morley P
Br Heart J 1982 Apr;47(4):337-43. doi: 10.1136/hrt.47.4.337. PMID: 7066118Free PMC Article
Echocardiographic changes in the thickness of porcine valves with time.
Alam M, Goldstein S, Lakier JB
Chest 1981 Jun;79(6):663-8. doi: 10.1378/chest.79.6.663. PMID: 7226955
Mitral valve pericardioplasty--a long-term follow-up study.
van der Spuy JC
Thorax 1972 Mar;27(2):207-11. doi: 10.1136/thx.27.2.207. PMID: 5034597Free PMC Article

Diagnosis

Upregulation of the 5-lipoxygenase pathway in human aortic valves correlates with severity of stenosis and leads to leukotriene-induced effects on valvular myofibroblasts.
Nagy E, Andersson DC, Caidahl K, Eriksson MJ, Eriksson P, Franco-Cereceda A, Hansson GK, Bäck M
Circulation 2011 Mar 29;123(12):1316-25. Epub 2011 Mar 14 doi: 10.1161/CIRCULATIONAHA.110.966846. PMID: 21403093
Doppler and echocardiographic features of normal and dysfunctioning bioprosthetic valves.
Alam M, Rosman HS, Lakier JB, Kemp S, Khaja F, Hautamaki K, Magilligan DJ Jr, Stein PD
J Am Coll Cardiol 1987 Oct;10(4):851-8. doi: 10.1016/s0735-1097(87)80280-2. PMID: 3309005
Abnormal aortic valve echoes in mitral prolapse. Echocardiographic features of floppy aortic valve.
Rodger JC, Morley P
Br Heart J 1982 Apr;47(4):337-43. doi: 10.1136/hrt.47.4.337. PMID: 7066118Free PMC Article
Aortic stenosis: echocardiographic cusp separation and surgical description of aortic valve in 22 patients.
Chang S, Clements S, Chang J
Am J Cardiol 1977 Apr;39(4):499-504. doi: 10.1016/s0002-9149(77)80157-4. PMID: 848433
Pathological features of hypertrophic obstructive cardiomyopathy.
Davies MJ, Pomerance A, Teare RD
J Clin Pathol 1974 Jul;27(7):529-35. doi: 10.1136/jcp.27.7.529. PMID: 4472994Free PMC Article

Therapy

Regression of cardiac valvulopathy related to ergot-derived dopamine agonists.
Zanettini R, Antonini A, Gatto G, Gentile R, Tesei S, Pezzoli G
Cardiovasc Ther 2011 Dec;29(6):404-10. Epub 2010 Jun 11 doi: 10.1111/j.1755-5922.2010.00169.x. PMID: 20553285
Assessment of cardiac valve dysfunction in patients receiving cabergoline treatment for hyperprolactinaemia.
Tan T, Cabrita IZ, Hensman D, Grogono J, Dhillo WS, Baynes KC, Eliahoo J, Meeran K, Robinson S, Nihoyannopoulos P, Martin NM
Clin Endocrinol (Oxf) 2010 Sep;73(3):369-74. Epub 2010 Jun 9 doi: 10.1111/j.1365-2265.2010.03827.x. PMID: 20550538
M mode and two dimensional echocardiographic features of porcine valve dysfunction.
Alam M, Madrazo AC, Magilligan DJ, Goldstein S
Am J Cardiol 1979 Mar;43(3):502-9. doi: 10.1016/0002-9149(79)90006-7. PMID: 420101

Prognosis

Regression of cardiac valvulopathy related to ergot-derived dopamine agonists.
Zanettini R, Antonini A, Gatto G, Gentile R, Tesei S, Pezzoli G
Cardiovasc Ther 2011 Dec;29(6):404-10. Epub 2010 Jun 11 doi: 10.1111/j.1755-5922.2010.00169.x. PMID: 20553285
Accessory mitral valve associated with aortic regurgitation in an elderly patient: report of a case.
Yao H, Miyamoto T, Mukai S, Yamamura M, Nakagawa T, Ryomoto M, Inai Y
Surg Today 2002;32(6):516-8. doi: 10.1007/s005950200088. PMID: 12107777
Valvulitis involving a bioprosthetic valve in a patient with systemic lupus erythematosus.
Gordon RJ, Weilbaecher D, Davy SM, Safi HJ, Quiñones MA, DeFelice CA, Zoghbi WA
J Am Soc Echocardiogr 1996 Jan-Feb;9(1):104-7. doi: 10.1016/s0894-7317(96)90112-1. PMID: 8679231
Cross-sectional echocardiographic localization of sites of left ventricular outflow tract obstruction.
Williams DE, Sahn DJ, Friedman WF
Am J Cardiol 1976 Feb;37(2):250-5. doi: 10.1016/0002-9149(76)90320-9. PMID: 942808
Mitral valve pericardioplasty--a long-term follow-up study.
van der Spuy JC
Thorax 1972 Mar;27(2):207-11. doi: 10.1136/thx.27.2.207. PMID: 5034597Free PMC Article

Clinical prediction guides

Regression of cardiac valvulopathy related to ergot-derived dopamine agonists.
Zanettini R, Antonini A, Gatto G, Gentile R, Tesei S, Pezzoli G
Cardiovasc Ther 2011 Dec;29(6):404-10. Epub 2010 Jun 11 doi: 10.1111/j.1755-5922.2010.00169.x. PMID: 20553285
Assessment of cardiac valve dysfunction in patients receiving cabergoline treatment for hyperprolactinaemia.
Tan T, Cabrita IZ, Hensman D, Grogono J, Dhillo WS, Baynes KC, Eliahoo J, Meeran K, Robinson S, Nihoyannopoulos P, Martin NM
Clin Endocrinol (Oxf) 2010 Sep;73(3):369-74. Epub 2010 Jun 9 doi: 10.1111/j.1365-2265.2010.03827.x. PMID: 20550538
Primary failure of Hancock porcine bioprosthetic valves: two dimensional echocardiographic assessment.
Nagata S, Arai K, Park YD, Beppu S, Kawazoe K, Kito Y, Fujita T, Sakakibara H, Nimura Y
Jpn Circ J 1986 Sep;50(9):880-3. doi: 10.1253/jcj.50.880. PMID: 3795462
Abnormal aortic valve echoes in mitral prolapse. Echocardiographic features of floppy aortic valve.
Rodger JC, Morley P
Br Heart J 1982 Apr;47(4):337-43. doi: 10.1136/hrt.47.4.337. PMID: 7066118Free PMC Article
Echocardiographic changes in the thickness of porcine valves with time.
Alam M, Goldstein S, Lakier JB
Chest 1981 Jun;79(6):663-8. doi: 10.1378/chest.79.6.663. PMID: 7226955

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