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Koebner Phenomenon

MedGen UID:
1054331
Concept ID:
CN378285
Finding
HPO: HP:6000933

Definition

The appearance of new skin lesions on previously unaffected skin secondary to trauma. This phenomenon is also termed the isomorphic (from Greek, equal shape) response, given the fact that the new lesions that appear are clinically and histologically identical to the patient's underlying cutaneous disease. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVKoebner Phenomenon

Professional guidelines

PubMed

Brandon A, Mufti A, Gary Sibbald R
Adv Skin Wound Care 2019 Feb;32(2):58-69. doi: 10.1097/01.ASW.0000550592.08674.43. PMID: 30653184
Goh BK, Pandya AG
Dermatol Clin 2017 Apr;35(2):135-144. doi: 10.1016/j.det.2016.11.004. PMID: 28317523
Ladizinski B, Lee KC, Wilmer E, Alavi A, Mistry N, Sibbald RG
Adv Skin Wound Care 2013 Jun;26(6):271-84; quiz 285-6. doi: 10.1097/01.ASW.0000429778.10020.67. PMID: 23669329

Recent clinical studies

Etiology

Brambilla L, Aromolo IF, Buffon S, Benaglia C, Tourlaki A
J Cutan Med Surg 2023 Mar-Apr;27(2):102-107. Epub 2023 Jan 18 doi: 10.1177/12034754221149658. PMID: 36653951
Huang YW, Tsai TF
Am J Clin Dermatol 2021 May;22(3):339-347. Epub 2021 Jan 18 doi: 10.1007/s40257-020-00585-1. PMID: 33460021Free PMC Article
Roszkiewicz M, Dopytalska K, Szymańska E, Jakimiuk A, Walecka I
Ann Agric Environ Med 2020 Sep 11;27(3):335-342. Epub 2019 Nov 12 doi: 10.26444/aaem/112107. PMID: 32955211
Chen L, Tsai TF
Br J Dermatol 2018 Apr;178(4):854-862. Epub 2018 Mar 2 doi: 10.1111/bjd.16083. PMID: 29072309
Powell JJ, Wojnarowska F
Lancet 1999 May 22;353(9166):1777-83. doi: 10.1016/s0140-6736(98)08228-2. PMID: 10348006

Diagnosis

Mathew S, Adarsh Aayilliath K
QJM 2023 Nov 24;116(11):952. doi: 10.1093/qjmed/hcad155. PMID: 37354536
Huang YW, Tsai TF
Am J Clin Dermatol 2021 May;22(3):339-347. Epub 2021 Jan 18 doi: 10.1007/s40257-020-00585-1. PMID: 33460021Free PMC Article
Furue K, Ito T, Tsuji G, Nakahara T, Furue M
Scand J Immunol 2020 Mar;91(3):e12846. Epub 2019 Nov 24 doi: 10.1111/sji.12846. PMID: 31692008
Brandon A, Mufti A, Gary Sibbald R
Adv Skin Wound Care 2019 Feb;32(2):58-69. doi: 10.1097/01.ASW.0000550592.08674.43. PMID: 30653184
Ladizinski B, Lee KC, Wilmer E, Alavi A, Mistry N, Sibbald RG
Adv Skin Wound Care 2013 Jun;26(6):271-84; quiz 285-6. doi: 10.1097/01.ASW.0000429778.10020.67. PMID: 23669329

Therapy

Karampinis E, Georgopoulou KE, Goudouras G, Lianou V, Kampra E, Roussaki Schulze AV, Zafiriou E
Medicina (Kaunas) 2024 Jul 20;60(7) doi: 10.3390/medicina60071177. PMID: 39064606Free PMC Article
Torre-Castro J, Nájera L, Suárez D, García-Fresnadillo D, Freites-Martínez A, Briz AS, Rodríguez Peralto JL, Requena L
Am J Dermatopathol 2022 Sep 1;44(9):632-649. Epub 2022 May 4 doi: 10.1097/DAD.0000000000002183. PMID: 35503881
Gualdi G, Fabiano A, Moro R, Venturuzzo A, Monari P, Calzavara-Pinton P, Amerio P
J Cosmet Dermatol 2021 Feb;20(2):602-604. Epub 2020 Jun 29 doi: 10.1111/jocd.13548. PMID: 32539240
Caldas R, Guimarães MJ, Pereira T
JAMA Dermatol 2020 Jul 1;156(7):805. doi: 10.1001/jamadermatol.2020.1077. PMID: 32459290
Orzan OA, Popa LG, Vexler ES, Olaru I, Voiculescu VM, Bumbăcea RS
J Med Life 2014;7 Spec No. 2(Spec Iss 2):65-8. PMID: 25870676Free PMC Article

Prognosis

Singh S, Narang T, Dogra S
Trans R Soc Trop Med Hyg 2024 Jan 2;118(1):77-79. doi: 10.1093/trstmh/trad066. PMID: 37632458
Chen L, Tsai TF
Br J Dermatol 2018 Apr;178(4):854-862. Epub 2018 Mar 2 doi: 10.1111/bjd.16083. PMID: 29072309
Goh BK, Pandya AG
Dermatol Clin 2017 Apr;35(2):135-144. doi: 10.1016/j.det.2016.11.004. PMID: 28317523
Rigopoulos D, Papanagiotou V, Daniel R 3rd, Piraccini BM
Mycoses 2017 Jan;60(1):6-10. Epub 2016 Aug 15 doi: 10.1111/myc.12542. PMID: 27523738
Habib A, Raza N
J Coll Physicians Surg Pak 2012 Jan;22(1):61-2. PMID: 22237197

Clinical prediction guides

Gualdi G, Fabiano A, Moro R, Venturuzzo A, Monari P, Calzavara-Pinton P, Amerio P
J Cosmet Dermatol 2021 Feb;20(2):602-604. Epub 2020 Jun 29 doi: 10.1111/jocd.13548. PMID: 32539240
Roszkiewicz M, Dopytalska K, Szymańska E, Jakimiuk A, Walecka I
Ann Agric Environ Med 2020 Sep 11;27(3):335-342. Epub 2019 Nov 12 doi: 10.26444/aaem/112107. PMID: 32955211
Chen L, Tsai TF
Br J Dermatol 2018 Apr;178(4):854-862. Epub 2018 Mar 2 doi: 10.1111/bjd.16083. PMID: 29072309
Habib A, Raza N
J Coll Physicians Surg Pak 2012 Jan;22(1):61-2. PMID: 22237197
Ueki H
Autoimmun Rev 2005 Apr;4(4):219-23. Epub 2004 Dec 18 doi: 10.1016/j.autrev.2004.11.007. PMID: 15893715

Recent systematic reviews

Timis TL, Florian IA, Mitrea DR, Orasan R
Medicina (Kaunas) 2021 Apr 23;57(5) doi: 10.3390/medicina57050410. PMID: 33922733Free PMC Article

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