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Diastolic dysfunction

MedGen UID:
105464
Concept ID:
C0520863
Pathologic Function
Synonym: Diastolic Dysfunction
SNOMED CT: Diastolic dysfunction (3545003)

Definition

Impairment in the filling of the ventricles during diastole. Causes include hypertrophic and restrictive cardiomyopathies, coronary artery disease, chronic high blood pressure, aortic stenosis, and aging. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • Diastolic dysfunction

Professional guidelines

PubMed

Chetan D, Mertens LL
Curr Opin Cardiol 2022 Jan 1;37(1):115-122. doi: 10.1097/HCO.0000000000000934. PMID: 34857719
Ommen SR, Mital S, Burke MA, Day SM, Deswal A, Elliott P, Evanovich LL, Hung J, Joglar JA, Kantor P, Kimmelstiel C, Kittleson M, Link MS, Maron MS, Martinez MW, Miyake CY, Schaff HV, Semsarian C, Sorajja P
Circulation 2020 Dec 22;142(25):e533-e557. Epub 2020 Nov 20 doi: 10.1161/CIR.0000000000000938. PMID: 33215938
Ommen SR, Mital S, Burke MA, Day SM, Deswal A, Elliott P, Evanovich LL, Hung J, Joglar JA, Kantor P, Kimmelstiel C, Kittleson M, Link MS, Maron MS, Martinez MW, Miyake CY, Schaff HV, Semsarian C, Sorajja P
Circulation 2020 Dec 22;142(25):e558-e631. Epub 2020 Nov 20 doi: 10.1161/CIR.0000000000000937. PMID: 33215931

Recent clinical studies

Etiology

Reichart D, Magnussen C, Zeller T, Blankenberg S
J Intern Med 2019 Oct;286(4):362-372. Epub 2019 Jul 29 doi: 10.1111/joim.12944. PMID: 31132311
Nadruz W, Shah AM, Solomon SD
Med Clin North Am 2017 Jan;101(1):7-17. doi: 10.1016/j.mcna.2016.08.013. PMID: 27884237
Ruiz-del-Árbol L, Serradilla R
World J Gastroenterol 2015 Nov 7;21(41):11502-21. doi: 10.3748/wjg.v21.i41.11502. PMID: 26556983Free PMC Article
Wan SH, Vogel MW, Chen HH
J Am Coll Cardiol 2014 Feb 11;63(5):407-16. Epub 2013 Nov 27 doi: 10.1016/j.jacc.2013.10.063. PMID: 24291270Free PMC Article
Ewy GA
J Insur Med 2004;36(4):292-7. PMID: 15683207

Diagnosis

Reichart D, Magnussen C, Zeller T, Blankenberg S
J Intern Med 2019 Oct;286(4):362-372. Epub 2019 Jul 29 doi: 10.1111/joim.12944. PMID: 31132311
Paolillo S, Marsico F, Prastaro M, Renga F, Esposito L, De Martino F, Di Napoli P, Esposito I, Ambrosio A, Ianniruberto M, Mennella R, Paolillo R, Gargiulo P
Heart Fail Clin 2019 Jul;15(3):341-347. Epub 2019 Apr 5 doi: 10.1016/j.hfc.2019.02.003. PMID: 31079692
Mitter SS, Shah SJ, Thomas JD
J Am Coll Cardiol 2017 Mar 21;69(11):1451-1464. doi: 10.1016/j.jacc.2016.12.037. PMID: 28302294
Ruiz-del-Árbol L, Serradilla R
World J Gastroenterol 2015 Nov 7;21(41):11502-21. doi: 10.3748/wjg.v21.i41.11502. PMID: 26556983Free PMC Article
Jeong EM, Dudley SC Jr
Circ J 2015;79(3):470-7. Epub 2015 Feb 5 doi: 10.1253/circj.CJ-15-0064. PMID: 25746522Free PMC Article

Therapy

Rubinstein J, Sanford D
Cardiol Clin 2019 Aug;37(3):267-273. Epub 2019 May 15 doi: 10.1016/j.ccl.2019.04.002. PMID: 31279420
Santos Mateo JJ, Sabater Molina M, Gimeno Blanes JR
Med Clin (Barc) 2018 Jun 8;150(11):434-442. Epub 2017 Nov 14 doi: 10.1016/j.medcli.2017.09.013. PMID: 29150126
Fontes-Carvalho R, Sampaio F, Teixeira M, Gama V, Leite-Moreira AF
Trials 2015 Mar 12;16:90. doi: 10.1186/s13063-015-0612-6. PMID: 25872588Free PMC Article
Jeong EM, Dudley SC Jr
Circ J 2015;79(3):470-7. Epub 2015 Feb 5 doi: 10.1253/circj.CJ-15-0064. PMID: 25746522Free PMC Article
Cleland JG, Tendera M, Adamus J, Freemantle N, Polonski L, Taylor J; PEP-CHF Investigators
Eur Heart J 2006 Oct;27(19):2338-45. Epub 2006 Sep 8 doi: 10.1093/eurheartj/ehl250. PMID: 16963472

Prognosis

Nair N
Rev Cardiovasc Med 2020 Dec 30;21(4):531-540. doi: 10.31083/j.rcm.2020.04.154. PMID: 33387998
Povar-Echeverría M, Auquilla-Clavijo PE, Povar-Marco BJ, Moreno-Esteban EM, Figueras-Villalba MP
Arch Cardiol Mex 2020;90(3):259-265. doi: 10.24875/ACM.19000238. PMID: 32952176
Reichart D, Magnussen C, Zeller T, Blankenberg S
J Intern Med 2019 Oct;286(4):362-372. Epub 2019 Jul 29 doi: 10.1111/joim.12944. PMID: 31132311
Colao A, Grasso LFS, Di Somma C, Pivonello R
Heart Fail Clin 2019 Jul;15(3):399-408. doi: 10.1016/j.hfc.2019.03.001. PMID: 31079698
Ryan TD, Chin C
Semin Pediatr Surg 2017 Aug;26(4):206-212. Epub 2017 Jul 26 doi: 10.1053/j.sempedsurg.2017.07.012. PMID: 28964475

Clinical prediction guides

Ommen SR, Mital S, Burke MA, Day SM, Deswal A, Elliott P, Evanovich LL, Hung J, Joglar JA, Kantor P, Kimmelstiel C, Kittleson M, Link MS, Maron MS, Martinez MW, Miyake CY, Schaff HV, Semsarian C, Sorajja P
Circulation 2020 Dec 22;142(25):e533-e557. Epub 2020 Nov 20 doi: 10.1161/CIR.0000000000000938. PMID: 33215938
Ommen SR, Mital S, Burke MA, Day SM, Deswal A, Elliott P, Evanovich LL, Hung J, Joglar JA, Kantor P, Kimmelstiel C, Kittleson M, Link MS, Maron MS, Martinez MW, Miyake CY, Schaff HV, Semsarian C, Sorajja P
Circulation 2020 Dec 22;142(25):e558-e631. Epub 2020 Nov 20 doi: 10.1161/CIR.0000000000000937. PMID: 33215931
Obokata M, Reddy YNV, Borlaug BA
JACC Cardiovasc Imaging 2020 Jan;13(1 Pt 2):245-257. Epub 2019 Jun 12 doi: 10.1016/j.jcmg.2018.12.034. PMID: 31202759Free PMC Article
Nagueh SF
JACC Cardiovasc Imaging 2020 Jan;13(1 Pt 2):228-244. Epub 2019 Apr 12 doi: 10.1016/j.jcmg.2018.10.038. PMID: 30982669
Muchtar E, Blauwet LA, Gertz MA
Circ Res 2017 Sep 15;121(7):819-837. doi: 10.1161/CIRCRESAHA.117.310982. PMID: 28912185

Recent systematic reviews

Zhuang C, Luo X, Wang Q, Wang W, Sun R, Zhang X, Yu J
Kardiol Pol 2021;79(10):1107-1115. Epub 2021 Sep 2 doi: 10.33963/KP.a2021.0101. PMID: 34472077
Ramadan MS, Bertolino L, Zampino R, Durante-Mangoni E; Monaldi Hospital Cardiovascular Infection Study Group
Clin Microbiol Infect 2021 Sep;27(9):1250-1261. Epub 2021 Jun 23 doi: 10.1016/j.cmi.2021.06.015. PMID: 34171458Free PMC Article
Depla AL, De Wit L, Steenhuis TJ, Slieker MG, Voormolen DN, Scheffer PG, De Heus R, Van Rijn BB, Bekker MN
Ultrasound Obstet Gynecol 2021 Apr;57(4):539-550. doi: 10.1002/uog.22163. PMID: 32730637Free PMC Article
Zheng SL, Chan FT, Nabeebaccus AA, Shah AM, McDonagh T, Okonko DO, Ayis S
Heart 2018 Mar;104(5):407-415. Epub 2017 Aug 5 doi: 10.1136/heartjnl-2017-311652. PMID: 28780577Free PMC Article
van Riet EE, Hoes AW, Wagenaar KP, Limburg A, Landman MA, Rutten FH
Eur J Heart Fail 2016 Mar;18(3):242-52. Epub 2016 Jan 4 doi: 10.1002/ejhf.483. PMID: 26727047

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