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Elevated circulating vasoactive intestinal peptide concentration

MedGen UID:
1054665
•Concept ID:
CN377396
•
Finding
HPO: HP:6000564

Definition

The concentration of vasoactive intestinal peptide (VIP) in the blood circulation is above the upper limit of normal. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVElevated circulating vasoactive intestinal peptide concentration

Recent clinical studies

Etiology

Circulating levels of vasoactive peptides in patients with acute bacterial meningitis.
Berg RM, Strauss GI, Tofteng F, Qvist T, Edvinsson L, Fahrenkrug J, Qvist J, Fonsmark L, Skinhøj P, Møller K
Intensive Care Med 2009 Sep;35(9):1604-8. Epub 2009 Jun 10 doi: 10.1007/s00134-009-1515-3. PMID: 19513693
Cutaneous reactions and sensations after intracutaneous injection of vasoactive intestinal polypeptide and acetylcholine in atopic eczema patients and healthy controls.
Rukwied R, Heyer G
Arch Dermatol Res 1998 Apr;290(4):198-204. doi: 10.1007/s004030050290. PMID: 9617439
Absence of vasoactive peptide release from brain to cerebral circulation during onset of migraine with aura.
Friberg L, Olesen J, Olsen TS, Karle A, Ekman R, Fahrenkrug J
Cephalalgia 1994 Feb;14(1):47-54. doi: 10.1046/j.1468-2982.1994.1401047.x. PMID: 7515329
Elevated plasma levels of vasoactive intestinal peptide in AIDS patients with refractory idiopathic diarrhoea. Effects of treatment with octreotide.
Manfredi R, Vezzadini P, Costigliola P, Ricchi E, Fanti MP, Chiodo F
AIDS 1993 Feb;7(2):223-6. doi: 10.1097/00002030-199302000-00010. PMID: 8466684

Diagnosis

Mitochondrial metabolism related markers GDF-15, FGF-21, and HIF-1α are elevated in pediatric migraine attacks.
Kilinc YB, Kilinc E, Danis A, Hanci F, Turay S, Ozge A, Bolay H
Headache 2023 Sep;63(8):1076-1086. Epub 2023 Aug 19 doi: 10.1111/head.14618. PMID: 37596867
Elevated plasma levels of vasoactive intestinal peptide in AIDS patients with refractory idiopathic diarrhoea. Effects of treatment with octreotide.
Manfredi R, Vezzadini P, Costigliola P, Ricchi E, Fanti MP, Chiodo F
AIDS 1993 Feb;7(2):223-6. doi: 10.1097/00002030-199302000-00010. PMID: 8466684
Direct coronary vasodilation induced by intracoronary vasoactive intestinal peptide.
Popma JJ, Smitherman TC, Bedotto JB, Eichhorn EJ, Said SI, Dehmer GJ
J Cardiovasc Pharmacol 1990 Dec;16(6):1000-6. doi: 10.1097/00005344-199012000-00021. PMID: 1704974
VIPoma syndrome.
Krejs GJ
Am J Med 1987 May 29;82(5B):37-48. doi: 10.1016/0002-9343(87)90425-6. PMID: 3035922
Peptide histidine-methionine immunoreactivity in plasma and tissue from patients with vasoactive intestinal peptide-secreting tumors and watery diarrhea syndrome.
Yiangou Y, Williams SJ, Bishop AE, Polak JM, Bloom SR
J Clin Endocrinol Metab 1987 Jan;64(1):131-9. doi: 10.1210/jcem-64-1-131. PMID: 3023426

Therapy

ECL-cell histamine mobilization in conscious rats: effects of locally applied regulatory peptides, candidate neurotransmitters and inflammatory mediators.
Norlén P, Bernsand M, Konagaya T, Håkanson R
Br J Pharmacol 2001 Dec;134(8):1767-77. doi: 10.1038/sj.bjp.0704419. PMID: 11739254Free PMC Article
Cutaneous reactions and sensations after intracutaneous injection of vasoactive intestinal polypeptide and acetylcholine in atopic eczema patients and healthy controls.
Rukwied R, Heyer G
Arch Dermatol Res 1998 Apr;290(4):198-204. doi: 10.1007/s004030050290. PMID: 9617439
Elevated plasma levels of vasoactive intestinal peptide in AIDS patients with refractory idiopathic diarrhoea. Effects of treatment with octreotide.
Manfredi R, Vezzadini P, Costigliola P, Ricchi E, Fanti MP, Chiodo F
AIDS 1993 Feb;7(2):223-6. doi: 10.1097/00002030-199302000-00010. PMID: 8466684
Direct coronary vasodilation induced by intracoronary vasoactive intestinal peptide.
Popma JJ, Smitherman TC, Bedotto JB, Eichhorn EJ, Said SI, Dehmer GJ
J Cardiovasc Pharmacol 1990 Dec;16(6):1000-6. doi: 10.1097/00005344-199012000-00021. PMID: 1704974
Coronary hemodynamic effects of intravenous vasoactive intestinal peptide in humans.
Smitherman TC, Popma JJ, Said SI, Krejs GJ, Dehmer GJ
Am J Physiol 1989 Oct;257(4 Pt 2):H1254-62. doi: 10.1152/ajpheart.1989.257.4.H1254. PMID: 2801984

Clinical prediction guides

Circulating gastrointestinal hormone changes in marathon running.
O'Connor AM, Johnston CF, Buchanan KD, Boreham C, Trinick TR, Riddoch CJ
Int J Sports Med 1995 Jul;16(5):283-7. doi: 10.1055/s-2007-973006. PMID: 7558523
Absence of vasoactive peptide release from brain to cerebral circulation during onset of migraine with aura.
Friberg L, Olesen J, Olsen TS, Karle A, Ekman R, Fahrenkrug J
Cephalalgia 1994 Feb;14(1):47-54. doi: 10.1046/j.1468-2982.1994.1401047.x. PMID: 7515329
VIPoma syndrome.
Krejs GJ
Am J Med 1987 May 29;82(5B):37-48. doi: 10.1016/0002-9343(87)90425-6. PMID: 3035922
Effect of somatostatin infusion on VIP-induced transport changes in the human jejunum.
Krejs GJ
Peptides 1984 Mar-Apr;5(2):271-6. doi: 10.1016/0196-9781(84)90218-3. PMID: 6147815
Effect of VIP infusion in water and ion transport in the human jejunum.
Krejs GJ, Fordtran JS, Fahrenkrug J, Schaffalitzky de Muckadell OB, Fischer JE, Humphrey CS, O'Dorisio TM, Said SI, Walsh JH, Shulkes AA
Gastroenterology 1980 Apr;78(4):722-7. PMID: 7353759

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