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Pancoast syndrome

MedGen UID:: 10553
•Concept ID:: C0030271
•: Neoplastic Process

Synonyms:	Pancoast Syndrome; Pancoast's Syndrome; Pancoasts Syndrome; Syndrome, Pancoast; Syndrome, Pancoast's
SNOMED CT:	Pancoast syndrome (278065000); Superior pulmonary sulcus syndrome (278065000); Pancoast's syndrome (278065000)

Monarch Initiative:	MONDO:0024674

Definition

A rare neoplastic syndrome characterized by obstruction of the thoracic outlet leading to compression of the brachial plexus and vessels within. It is usually caused by a malignant neoplasm in the superior pulmonary sulcus. The most commonly involved neoplasms are non-small cell lung carcinomas. Clinical signs include Horner''s syndrome, shoulder pain radiating down the arm in the ulnar distribution followed by edema and atrophy of the affected extremity. Clinical course usually leads to early local invasion of the bony thoracic structures. Prognosis is highly stage-dependent. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVPancoast syndrome

Disease, Respiratory Tract
- Disorder of lung
  - Neoplasm of lung
    - Pancoast syndrome

Professional guidelines

PubMed

Pancoast tumours: clinical assessment and long-term results of combined radiosurgical treatment.

Muscolino G, Valente M, Andreani S
Thorax 1997 Mar;52(3):284-6. doi: 10.1136/thx.52.3.284. PMID: 9093348 Free PMC Article

Management of pain associated with the Pancoast syndrome.

Batzdorf U, Brechner VL
Am J Surg 1979 May;137(5):638-46. doi: 10.1016/0002-9610(79)90038-2. PMID: 287389

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Recent clinical studies

Etiology

Trimodality therapy for Pancoast tumors: T4 is not a contraindication to radical surgery.

Waseda R, Klikovits T, Hoda MA, Hoetzenecker K, Bertoglio P, Dieckmann K, Zöchbauer-Müller S, Pirker R, Prosch H, Döme B, Klepetko W
J Surg Oncol 2017 Aug;116(2):227-235. Epub 2017 Apr 13 doi: 10.1002/jso.24629. PMID: 28407246

Management of locally advanced pancoast (superior sulcus) tumors with spine involvement.

Setzer M, Robinson LA, Vrionis FD
Cancer Control 2014 Apr;21(2):158-67. doi: 10.1177/107327481402100209. PMID: 24667403

Pancoast tumor: a modern perspective on an old problem.

Glassman LR, Hyman K
Curr Opin Pulm Med 2013 Jul;19(4):340-3. doi: 10.1097/MCP.0b013e3283621b31. PMID: 23702478

Chest wall resection for lung cancer: indications and techniques.

Stoelben E, Ludwig C
Eur J Cardiothorac Surg 2009 Mar;35(3):450-6. Epub 2009 Feb 1 doi: 10.1016/j.ejcts.2008.11.032. PMID: 19188079

Surgical treatment of Pancoast tumor.

Remmen HJ, Lacquet LK, Van Son JA, Morshuis WJ, Cox AL
J Cardiovasc Surg (Torino) 1993 Apr;34(2):157-61. PMID: 8320251

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Diagnosis

Pancoast tumour: current therapeutic options.

Palumbo VD, Fazzotta S, Fatica F, D'Orazio B, Caronia FP, Cajozzo M, Damiano G, Maffongelli A, Cudia BM, Messina M, Lo Monte AI
Clin Ter 2019 Jul-Aug;170(4):e291-e294. doi: 10.7417/CT.2019.2150. PMID: 31304518

Diagnosing and treating pancoast tumors.

Zarogoulidis K, Porpodis K, Domvri K, Eleftheriadou E, Ioannidou D, Zarogoulidis P
Expert Rev Respir Med 2016 Dec;10(12):1255-1258. Epub 2016 Oct 27 doi: 10.1080/17476348.2017.1246964. PMID: 27786592

Pancoast's syndrome secondary to infectious etiologies: a not so uncommon occurrence.

White HD, White BA, Boethel C, Arroliga AC
Am J Med Sci 2011 Apr;341(4):333-6. doi: 10.1097/MAJ.0b013e3181fa2e2d. PMID: 21030854

Superior sulcus tumors and Pancoast's syndrome.

Jett JR
Lung Cancer 2003 Dec;42 Suppl 2:S17-21. doi: 10.1016/j.lungcan.2003.08.006. PMID: 14644531

Superior sulcus tumors.

Wright CD, Mathisen DJ
Curr Treat Options Oncol 2001 Feb;2(1):43-9. doi: 10.1007/s11864-001-0015-7. PMID: 12057139

See all (194)

Therapy

Pancoast Tumor Presenting as Neck Pain in the Chiropractic Office: A Case Report and Literature Review.

Chu EC, Trager RJ, Shum JSF, Lai CR
Am J Case Rep 2022 Jul 7;23:e937052. doi: 10.12659/AJCR.937052. PMID: 35797264 Free PMC Article

Does induction chemoradiotherapy increase survival in patients with Pancoast tumour?

Buderi SI, Shackcloth M, Woolley S
Interact Cardiovasc Thorac Surg 2016 Nov;23(5):821-825. Epub 2016 Jun 29 doi: 10.1093/icvts/ivw216. PMID: 27365009

Pancoast tumor: a modern perspective on an old problem.

Glassman LR, Hyman K
Curr Opin Pulm Med 2013 Jul;19(4):340-3. doi: 10.1097/MCP.0b013e3283621b31. PMID: 23702478

Superior sulcus tumors.

Wright CD, Mathisen DJ
Curr Treat Options Oncol 2001 Feb;2(1):43-9. doi: 10.1007/s11864-001-0015-7. PMID: 12057139

Pancoast tumors.

Vallières E, Karmy-Jones R, Mulligan MS, Wood DE
Curr Probl Surg 2001 May;38(5):293-376. doi: 10.1067/msg.2001.113528. PMID: 11332249

See all (72)

Prognosis

Harlequin sign in Pancoast tumor.

Kumar R, Bhandari S, Kloecker GH
Curr Probl Cancer 2020 Apr;44(2):100506. Epub 2019 Nov 1 doi: 10.1016/j.currproblcancer.2019.100506. PMID: 31732238

Chest wall resection for lung cancer: indications and techniques.

Stoelben E, Ludwig C
Eur J Cardiothorac Surg 2009 Mar;35(3):450-6. Epub 2009 Feb 1 doi: 10.1016/j.ejcts.2008.11.032. PMID: 19188079

Superior sulcus tumors and Pancoast's syndrome.

Jett JR
Lung Cancer 2003 Dec;42 Suppl 2:S17-21. doi: 10.1016/j.lungcan.2003.08.006. PMID: 14644531

Pancoast tumors.

Vallières E, Karmy-Jones R, Mulligan MS, Wood DE
Curr Probl Surg 2001 May;38(5):293-376. doi: 10.1067/msg.2001.113528. PMID: 11332249

Pancoast (superior sulcus) tumors.

Detterbeck FC
Ann Thorac Surg 1997 Jun;63(6):1810-8. doi: 10.1016/s0003-4975(97)00360-3. PMID: 9205202

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Clinical prediction guides

A clinico-epidemiological, pathological, and molecular study of lung cancer in Northwestern India.

Darling HS, Viswanath S, Singh R, Ranjan S, Pathi N, Rathore A, Pathak A, Sud R
J Cancer Res Ther 2020 Jul-Sep;16(4):771-779. doi: 10.4103/jcrt.JCRT_473_17. PMID: 32930117

Eponyms in cardiothoracic radiology: Part I. Neoplasms.

Mohammed TL, Saettele MR, Saettele T, Patel V, Kanne JP
Curr Probl Diagn Radiol 2014 Mar-Apr;43(2):91-8. doi: 10.1067/j.cpradiol.2013.12.003. PMID: 24629662

Pulmonary resection after curative intent radiotherapy (>59 Gy) and concurrent chemotherapy in non-small-cell lung cancer.

Sonett JR, Suntharalingam M, Edelman MJ, Patel AB, Gamliel Z, Doyle A, Hausner P, Krasna M
Ann Thorac Surg 2004 Oct;78(4):1200-5; discussion 1206. doi: 10.1016/j.athoracsur.2004.04.085. PMID: 15464470

Principles of surgical treatment in localized non-small cell lung cancer.

Dienemann H
Lung Cancer 2001 Sep;33 Suppl 1:S3-8. doi: 10.1016/s0169-5002(01)00296-3. PMID: 11576701

Ultrasonography of Pancoast tumor.

Yang PC, Lee LN, Luh KT, Kuo SH, Yang SP
Chest 1988 Jul;94(1):124-8. doi: 10.1378/chest.94.1.124. PMID: 3289832

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