U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Pancoast syndrome

MedGen UID:
10553
Concept ID:
C0030271
Neoplastic Process
Synonyms: Pancoast Syndrome; Pancoast's Syndrome; Pancoasts Syndrome; Syndrome, Pancoast; Syndrome, Pancoast's
SNOMED CT: Pancoast syndrome (278065000); Superior pulmonary sulcus syndrome (278065000); Pancoast's syndrome (278065000)
 
Monarch Initiative: MONDO:0024674

Definition

A rare neoplastic syndrome characterized by obstruction of the thoracic outlet leading to compression of the brachial plexus and vessels within. It is usually caused by a malignant neoplasm in the superior pulmonary sulcus. The most commonly involved neoplasms are non-small cell lung carcinomas. Clinical signs include Horner''s syndrome, shoulder pain radiating down the arm in the ulnar distribution followed by edema and atrophy of the affected extremity. Clinical course usually leads to early local invasion of the bony thoracic structures. Prognosis is highly stage-dependent. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPancoast syndrome

Professional guidelines

PubMed

Muscolino G, Valente M, Andreani S
Thorax 1997 Mar;52(3):284-6. doi: 10.1136/thx.52.3.284. PMID: 9093348Free PMC Article
Batzdorf U, Brechner VL
Am J Surg 1979 May;137(5):638-46. doi: 10.1016/0002-9610(79)90038-2. PMID: 287389

Recent clinical studies

Etiology

Setzer M, Robinson LA, Vrionis FD
Cancer Control 2014 Apr;21(2):158-67. doi: 10.1177/107327481402100209. PMID: 24667403
Glassman LR, Hyman K
Curr Opin Pulm Med 2013 Jul;19(4):340-3. doi: 10.1097/MCP.0b013e3283621b31. PMID: 23702478
Stoelben E, Ludwig C
Eur J Cardiothorac Surg 2009 Mar;35(3):450-6. Epub 2009 Feb 1 doi: 10.1016/j.ejcts.2008.11.032. PMID: 19188079
Narayan S, Thomas CR Jr
Nat Clin Pract Oncol 2006 Sep;3(9):484-91. doi: 10.1038/ncponc0584. PMID: 16955087
Macchiarini P
Thorac Surg Clin 2004 May;14(2):229-40. doi: 10.1016/S1547-4127(04)00008-8. PMID: 15382299

Diagnosis

Palumbo VD, Fazzotta S, Fatica F, D'Orazio B, Caronia FP, Cajozzo M, Damiano G, Maffongelli A, Cudia BM, Messina M, Lo Monte AI
Clin Ter 2019 Jul-Aug;170(4):e291-e294. doi: 10.7417/CT.2019.2150. PMID: 31304518
Kratz JR, Woodard G, Jablons DM
Thorac Surg Clin 2017 May;27(2):149-157. doi: 10.1016/j.thorsurg.2017.01.008. PMID: 28363369
Zarogoulidis K, Porpodis K, Domvri K, Eleftheriadou E, Ioannidou D, Zarogoulidis P
Expert Rev Respir Med 2016 Dec;10(12):1255-1258. Epub 2016 Oct 27 doi: 10.1080/17476348.2017.1246964. PMID: 27786592
White HD, White BA, Boethel C, Arroliga AC
Am J Med Sci 2011 Apr;341(4):333-6. doi: 10.1097/MAJ.0b013e3181fa2e2d. PMID: 21030854
Wright CD, Mathisen DJ
Curr Treat Options Oncol 2001 Feb;2(1):43-9. doi: 10.1007/s11864-001-0015-7. PMID: 12057139

Therapy

Chen Z, Bernards N, Gregor A, Vannelli C, Kitazawa S, de Perrot M, Yasufuku K
J Thorac Cardiovasc Surg 2023 Mar;165(3):842-852.e5. Epub 2022 Sep 9 doi: 10.1016/j.jtcvs.2022.08.037. PMID: 36241449
Buderi SI, Shackcloth M, Woolley S
Interact Cardiovasc Thorac Surg 2016 Nov;23(5):821-825. Epub 2016 Jun 29 doi: 10.1093/icvts/ivw216. PMID: 27365009
Glassman LR, Hyman K
Curr Opin Pulm Med 2013 Jul;19(4):340-3. doi: 10.1097/MCP.0b013e3283621b31. PMID: 23702478
Wright CD, Mathisen DJ
Curr Treat Options Oncol 2001 Feb;2(1):43-9. doi: 10.1007/s11864-001-0015-7. PMID: 12057139
Vallières E, Karmy-Jones R, Mulligan MS, Wood DE
Curr Probl Surg 2001 May;38(5):293-376. doi: 10.1067/msg.2001.113528. PMID: 11332249

Prognosis

Kumar R, Bhandari S, Kloecker GH
Curr Probl Cancer 2020 Apr;44(2):100506. Epub 2019 Nov 1 doi: 10.1016/j.currproblcancer.2019.100506. PMID: 31732238
Stoelben E, Ludwig C
Eur J Cardiothorac Surg 2009 Mar;35(3):450-6. Epub 2009 Feb 1 doi: 10.1016/j.ejcts.2008.11.032. PMID: 19188079
Narayan S, Thomas CR Jr
Nat Clin Pract Oncol 2006 Sep;3(9):484-91. doi: 10.1038/ncponc0584. PMID: 16955087
Vallières E, Karmy-Jones R, Mulligan MS, Wood DE
Curr Probl Surg 2001 May;38(5):293-376. doi: 10.1067/msg.2001.113528. PMID: 11332249
Jones DR, Detterbeck FC
Curr Opin Pulm Med 1998 Jul;4(4):191-7. doi: 10.1097/00063198-199807000-00001. PMID: 10813231

Clinical prediction guides

Tsitsias T, Yasufuku K, Pierre A, Leighl N, Cho J, Waddell TK, Darling G, Cypel M, Donahoe L, Yeung J, Keshavjee S, de Perrot M
J Thorac Cardiovasc Surg 2023 May;165(5):1710-1719.e3. Epub 2022 Nov 2 doi: 10.1016/j.jtcvs.2022.10.033. PMID: 36481062
Darling HS, Viswanath S, Singh R, Ranjan S, Pathi N, Rathore A, Pathak A, Sud R
J Cancer Res Ther 2020 Jul-Sep;16(4):771-779. doi: 10.4103/jcrt.JCRT_473_17. PMID: 32930117
Mohammed TL, Saettele MR, Saettele T, Patel V, Kanne JP
Curr Probl Diagn Radiol 2014 Mar-Apr;43(2):91-8. doi: 10.1067/j.cpradiol.2013.12.003. PMID: 24629662
Sonett JR, Suntharalingam M, Edelman MJ, Patel AB, Gamliel Z, Doyle A, Hausner P, Krasna M
Ann Thorac Surg 2004 Oct;78(4):1200-5; discussion 1206. doi: 10.1016/j.athoracsur.2004.04.085. PMID: 15464470
Dienemann H
Lung Cancer 2001 Sep;33 Suppl 1:S3-8. doi: 10.1016/s0169-5002(01)00296-3. PMID: 11576701

Recent systematic reviews

Setzer M, Robinson LA, Vrionis FD
Cancer Control 2014 Apr;21(2):158-67. doi: 10.1177/107327481402100209. PMID: 24667403

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...