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Placenta neoplasm

MedGen UID:
105551
•Concept ID:
C0524541
•
Neoplastic Process
Synonym: Neoplasm of placenta
SNOMED CT: Neoplasm of placenta (126920004)
 
Monarch Initiative: MONDO:0021218

Definition

A benign or malignant neoplasm that affects the placenta. Representative examples include hemangioma and choriocarcinoma. [from NCI]

Professional guidelines

PubMed

Diagnosis and management of gestational trophoblastic disease: 2021 update.
Ngan HYS, Seckl MJ, Berkowitz RS, Xiang Y, Golfier F, Sekharan PK, Lurain JR, Massuger L
Int J Gynaecol Obstet 2021 Oct;155 Suppl 1(Suppl 1):86-93. doi: 10.1002/ijgo.13877. PMID: 34669197Free PMC Article
Treatment of gestational trophoblastic disease in the 2020s.
Clark JJ, Slater S, Seckl MJ
Curr Opin Obstet Gynecol 2021 Feb 1;33(1):7-12. doi: 10.1097/GCO.0000000000000674. PMID: 33337613Free PMC Article
Update on the diagnosis and management of gestational trophoblastic disease.
Ngan HYS, Seckl MJ, Berkowitz RS, Xiang Y, Golfier F, Sekharan PK, Lurain JR, Massuger L
Int J Gynaecol Obstet 2018 Oct;143 Suppl 2:79-85. doi: 10.1002/ijgo.12615. PMID: 30306586

Recent clinical studies

Etiology

Diagnosis and management of gestational trophoblastic disease: 2021 update.
Ngan HYS, Seckl MJ, Berkowitz RS, Xiang Y, Golfier F, Sekharan PK, Lurain JR, Massuger L
Int J Gynaecol Obstet 2021 Oct;155 Suppl 1(Suppl 1):86-93. doi: 10.1002/ijgo.13877. PMID: 34669197Free PMC Article
Gestational trophoblastic neoplasia: Novelties and challenges.
Silva ALMD, Monteiro KDN, Sun SY, Borbely AU
Placenta 2021 Dec;116:38-42. Epub 2021 Feb 25 doi: 10.1016/j.placenta.2021.02.013. PMID: 33685753
Treatment of gestational trophoblastic disease in the 2020s.
Clark JJ, Slater S, Seckl MJ
Curr Opin Obstet Gynecol 2021 Feb 1;33(1):7-12. doi: 10.1097/GCO.0000000000000674. PMID: 33337613Free PMC Article
Breast cancer, placenta and pregnancy.
Froehlich K, Schmidt A, Heger JI, Al-Kawlani B, Aberl CA, Jeschke U, Loibl S, Markert UR
Eur J Cancer 2019 Jul;115:68-78. Epub 2019 May 20 doi: 10.1016/j.ejca.2019.03.021. PMID: 31121525
Update on the diagnosis and management of gestational trophoblastic disease.
Ngan HYS, Seckl MJ, Berkowitz RS, Xiang Y, Golfier F, Sekharan PK, Lurain JR, Massuger L
Int J Gynaecol Obstet 2018 Oct;143 Suppl 2:79-85. doi: 10.1002/ijgo.12615. PMID: 30306586

Diagnosis

Diagnosis and management of gestational trophoblastic disease: 2021 update.
Ngan HYS, Seckl MJ, Berkowitz RS, Xiang Y, Golfier F, Sekharan PK, Lurain JR, Massuger L
Int J Gynaecol Obstet 2021 Oct;155 Suppl 1(Suppl 1):86-93. doi: 10.1002/ijgo.13877. PMID: 34669197Free PMC Article
Treatment of gestational trophoblastic disease in the 2020s.
Clark JJ, Slater S, Seckl MJ
Curr Opin Obstet Gynecol 2021 Feb 1;33(1):7-12. doi: 10.1097/GCO.0000000000000674. PMID: 33337613Free PMC Article
Breast cancer, placenta and pregnancy.
Froehlich K, Schmidt A, Heger JI, Al-Kawlani B, Aberl CA, Jeschke U, Loibl S, Markert UR
Eur J Cancer 2019 Jul;115:68-78. Epub 2019 May 20 doi: 10.1016/j.ejca.2019.03.021. PMID: 31121525
Update on the diagnosis and management of gestational trophoblastic disease.
Ngan HYS, Seckl MJ, Berkowitz RS, Xiang Y, Golfier F, Sekharan PK, Lurain JR, Massuger L
Int J Gynaecol Obstet 2018 Oct;143 Suppl 2:79-85. doi: 10.1002/ijgo.12615. PMID: 30306586
Vascular endothelial growth factor and its receptor system: physiological functions in angiogenesis and pathological roles in various diseases.
Shibuya M
J Biochem 2013 Jan;153(1):13-9. Epub 2012 Nov 21 doi: 10.1093/jb/mvs136. PMID: 23172303Free PMC Article

Therapy

Diagnosis and management of gestational trophoblastic disease: 2021 update.
Ngan HYS, Seckl MJ, Berkowitz RS, Xiang Y, Golfier F, Sekharan PK, Lurain JR, Massuger L
Int J Gynaecol Obstet 2021 Oct;155 Suppl 1(Suppl 1):86-93. doi: 10.1002/ijgo.13877. PMID: 34669197Free PMC Article
Treatment of gestational trophoblastic disease in the 2020s.
Clark JJ, Slater S, Seckl MJ
Curr Opin Obstet Gynecol 2021 Feb 1;33(1):7-12. doi: 10.1097/GCO.0000000000000674. PMID: 33337613Free PMC Article
Aflibercept.
Ciombor KK, Berlin J, Chan E
Clin Cancer Res 2013 Apr 15;19(8):1920-5. Epub 2013 Feb 26 doi: 10.1158/1078-0432.CCR-12-2911. PMID: 23444216Free PMC Article
Vascular endothelial growth factor and its receptor system: physiological functions in angiogenesis and pathological roles in various diseases.
Shibuya M
J Biochem 2013 Jan;153(1):13-9. Epub 2012 Nov 21 doi: 10.1093/jb/mvs136. PMID: 23172303Free PMC Article
ABCG2: a perspective.
Robey RW, To KK, Polgar O, Dohse M, Fetsch P, Dean M, Bates SE
Adv Drug Deliv Rev 2009 Jan 31;61(1):3-13. Epub 2008 Dec 16 doi: 10.1016/j.addr.2008.11.003. PMID: 19135109Free PMC Article

Prognosis

Treatment of gestational trophoblastic disease in the 2020s.
Clark JJ, Slater S, Seckl MJ
Curr Opin Obstet Gynecol 2021 Feb 1;33(1):7-12. doi: 10.1097/GCO.0000000000000674. PMID: 33337613Free PMC Article
Breast cancer, placenta and pregnancy.
Froehlich K, Schmidt A, Heger JI, Al-Kawlani B, Aberl CA, Jeschke U, Loibl S, Markert UR
Eur J Cancer 2019 Jul;115:68-78. Epub 2019 May 20 doi: 10.1016/j.ejca.2019.03.021. PMID: 31121525
Update on the diagnosis and management of gestational trophoblastic disease.
Ngan HYS, Seckl MJ, Berkowitz RS, Xiang Y, Golfier F, Sekharan PK, Lurain JR, Massuger L
Int J Gynaecol Obstet 2018 Oct;143 Suppl 2:79-85. doi: 10.1002/ijgo.12615. PMID: 30306586
An update on expression and function of P-gp/ABCB1 and BCRP/ABCG2 in the placenta and fetus.
Han LW, Gao C, Mao Q
Expert Opin Drug Metab Toxicol 2018 Aug;14(8):817-829. Epub 2018 Aug 3 doi: 10.1080/17425255.2018.1499726. PMID: 30010462Free PMC Article
Aflibercept.
Ciombor KK, Berlin J, Chan E
Clin Cancer Res 2013 Apr 15;19(8):1920-5. Epub 2013 Feb 26 doi: 10.1158/1078-0432.CCR-12-2911. PMID: 23444216Free PMC Article

Clinical prediction guides

Diagnosis and management of gestational trophoblastic disease: 2021 update.
Ngan HYS, Seckl MJ, Berkowitz RS, Xiang Y, Golfier F, Sekharan PK, Lurain JR, Massuger L
Int J Gynaecol Obstet 2021 Oct;155 Suppl 1(Suppl 1):86-93. doi: 10.1002/ijgo.13877. PMID: 34669197Free PMC Article
Breast cancer, placenta and pregnancy.
Froehlich K, Schmidt A, Heger JI, Al-Kawlani B, Aberl CA, Jeschke U, Loibl S, Markert UR
Eur J Cancer 2019 Jul;115:68-78. Epub 2019 May 20 doi: 10.1016/j.ejca.2019.03.021. PMID: 31121525
Update on the diagnosis and management of gestational trophoblastic disease.
Ngan HYS, Seckl MJ, Berkowitz RS, Xiang Y, Golfier F, Sekharan PK, Lurain JR, Massuger L
Int J Gynaecol Obstet 2018 Oct;143 Suppl 2:79-85. doi: 10.1002/ijgo.12615. PMID: 30306586
An update on expression and function of P-gp/ABCB1 and BCRP/ABCG2 in the placenta and fetus.
Han LW, Gao C, Mao Q
Expert Opin Drug Metab Toxicol 2018 Aug;14(8):817-829. Epub 2018 Aug 3 doi: 10.1080/17425255.2018.1499726. PMID: 30010462Free PMC Article
Aflibercept.
Ciombor KK, Berlin J, Chan E
Clin Cancer Res 2013 Apr 15;19(8):1920-5. Epub 2013 Feb 26 doi: 10.1158/1078-0432.CCR-12-2911. PMID: 23444216Free PMC Article

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