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Neurobehavioral Manifestations

MedGen UID:
105653
•Concept ID:
C0525041
•
Sign or Symptom
Synonyms: Cognitive Manifestation; Cognitive Manifestations; Cognitive Symptom; Cognitive Symptoms; Manifestation, Cognitive; Manifestation, Neurobehavioral; Manifestations, Cognitive; Manifestations, Neurobehavioral; Neurobehavioral Manifestation; Neurobehavioral Signs and Symptoms; Signs and Symptoms, Neurobehavioral; Symptom, Cognitive; Symptoms, Cognitive

Definition

Signs and symptoms of higher cortical dysfunction caused by organic conditions. These include certain behavioral alterations and impairments of skills involved in the acquisition, processing, and utilization of knowledge or information. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNeurobehavioral Manifestations

Professional guidelines

PubMed

Traumatic Brain Injury and Treatment of Behavioral Health Conditions.
Corrigan JD
Psychiatr Serv 2021 Sep 1;72(9):1057-1064. Epub 2021 Feb 24 doi: 10.1176/appi.ps.201900561. PMID: 33622044
Neurobehavioral Manifestations of Neurological Diseases: Diagnosis and Treatment.
Minagar A, Finney GR, Heilman KM
Neurol Clin 2016 Feb;34(1):xiii-xiv. doi: 10.1016/j.ncl.2015.10.001. PMID: 26614003
Neurobehavioral Manifestations of Human Immunodeficiency Virus/AIDS: Diagnosis and Treatment.
Singer EJ, Thames AD
Neurol Clin 2016 Feb;34(1):33-53. doi: 10.1016/j.ncl.2015.08.003. PMID: 26613994Free PMC Article

Recent clinical studies

Etiology

Prenatal caffeine consumption and neurobehavioral disorders - A systematic review.
Santana AB, Spelta LEW, Martinez-Sobalvarro JV, Garcia RCT, Dos Reis TM, Torres LH
Reprod Toxicol 2024 Apr;125:108563. Epub 2024 Feb 28 doi: 10.1016/j.reprotox.2024.108563. PMID: 38417581
Statins for Smith-Lemli-Opitz syndrome.
Ballout RA, Livinski A, Fu YP, Steiner RD, Remaley AT
Cochrane Database Syst Rev 2022 Nov 14;11(11):CD013521. doi: 10.1002/14651858.CD013521.pub2. PMID: 36373961Free PMC Article
Toxoplasma gondii infection and behavioral outcomes in humans: a systematic review.
Martinez VO, de Mendonça Lima FW, de Carvalho CF, Menezes-Filho JA
Parasitol Res 2018 Oct;117(10):3059-3065. Epub 2018 Aug 14 doi: 10.1007/s00436-018-6040-2. PMID: 30109417
Medical comorbidities in children and adolescents with autism spectrum disorders and attention deficit hyperactivity disorders: a systematic review.
Muskens JB, Velders FP, Staal WG
Eur Child Adolesc Psychiatry 2017 Sep;26(9):1093-1103. Epub 2017 Jul 3 doi: 10.1007/s00787-017-1020-0. PMID: 28674760Free PMC Article
Toxic leukoencephalopathy.
Filley CM
Clin Neuropharmacol 1999 Sep-Oct;22(5):249-60. PMID: 10516874

Diagnosis

Statins for Smith-Lemli-Opitz syndrome.
Ballout RA, Livinski A, Fu YP, Steiner RD, Remaley AT
Cochrane Database Syst Rev 2022 Nov 14;11(11):CD013521. doi: 10.1002/14651858.CD013521.pub2. PMID: 36373961Free PMC Article
Developmental and behavioral aspects of mucopolysaccharidoses with brain manifestations - Neurological signs and symptoms.
Shapiro EG, Jones SA, Escolar ML
Mol Genet Metab 2017 Dec;122S:1-7. Epub 2017 Aug 26 doi: 10.1016/j.ymgme.2017.08.009. PMID: 29074036
Neurobehavioral Manifestations of Neurological Diseases: Diagnosis and Treatment.
Minagar A, Finney GR, Heilman KM
Neurol Clin 2016 Feb;34(1):xiii-xiv. doi: 10.1016/j.ncl.2015.10.001. PMID: 26614003
Neurobehavioral Manifestations of Human Immunodeficiency Virus/AIDS: Diagnosis and Treatment.
Singer EJ, Thames AD
Neurol Clin 2016 Feb;34(1):33-53. doi: 10.1016/j.ncl.2015.08.003. PMID: 26613994Free PMC Article
Cognitive function in schizophrenia.
Weinberger DR, Gallhofer B
Int Clin Psychopharmacol 1997 Sep;12 Suppl 4:S29-36. doi: 10.1097/00004850-199709004-00006. PMID: 9352344

Therapy

Prenatal caffeine consumption and neurobehavioral disorders - A systematic review.
Santana AB, Spelta LEW, Martinez-Sobalvarro JV, Garcia RCT, Dos Reis TM, Torres LH
Reprod Toxicol 2024 Apr;125:108563. Epub 2024 Feb 28 doi: 10.1016/j.reprotox.2024.108563. PMID: 38417581
Statins for Smith-Lemli-Opitz syndrome.
Ballout RA, Livinski A, Fu YP, Steiner RD, Remaley AT
Cochrane Database Syst Rev 2022 Nov 14;11(11):CD013521. doi: 10.1002/14651858.CD013521.pub2. PMID: 36373961Free PMC Article
Developmental and behavioral aspects of mucopolysaccharidoses with brain manifestations - Neurological signs and symptoms.
Shapiro EG, Jones SA, Escolar ML
Mol Genet Metab 2017 Dec;122S:1-7. Epub 2017 Aug 26 doi: 10.1016/j.ymgme.2017.08.009. PMID: 29074036
Toxic leukoencephalopathy.
Filley CM
Clin Neuropharmacol 1999 Sep-Oct;22(5):249-60. PMID: 10516874
Pharmacotherapy of multiple sclerosis: current status.
Rudick RA, Goodkin DE, Ransohoff RM
Cleve Clin J Med 1992 May-Jun;59(3):267-77. doi: 10.3949/ccjm.59.3.267. PMID: 1516215

Prognosis

Apathy as a Predictor for Conversion From Mild Cognitive Impairment to Dementia: A Systematic Review and Meta-Analysis of Longitudinal Studies.
Fresnais D, Humble MB, Bejerot S, Meehan AD, Fure B
J Geriatr Psychiatry Neurol 2023 Jan;36(1):3-17. Epub 2022 Apr 21 doi: 10.1177/08919887221093361. PMID: 35446723Free PMC Article
Comprehensive investigation of DNA methylation and gene expression in trisomy 21 placenta.
Lim JH, Kim SY, Han JY, Kim MY, Park SY, Ryu HM
Placenta 2016 Jun;42:17-24. Epub 2016 Mar 24 doi: 10.1016/j.placenta.2016.03.012. PMID: 27238709
Toxic leukoencephalopathy.
Filley CM
Clin Neuropharmacol 1999 Sep-Oct;22(5):249-60. PMID: 10516874
The cycloid type and its differentiation from core schizophrenia: a phenomenological approach.
Sigmund D, Mundt C
Compr Psychiatry 1999 Jan-Feb;40(1):4-18. doi: 10.1016/s0010-440x(99)90070-6. PMID: 9924871
Cognitive function in schizophrenia.
Weinberger DR, Gallhofer B
Int Clin Psychopharmacol 1997 Sep;12 Suppl 4:S29-36. doi: 10.1097/00004850-199709004-00006. PMID: 9352344

Clinical prediction guides

Prenatal caffeine consumption and neurobehavioral disorders - A systematic review.
Santana AB, Spelta LEW, Martinez-Sobalvarro JV, Garcia RCT, Dos Reis TM, Torres LH
Reprod Toxicol 2024 Apr;125:108563. Epub 2024 Feb 28 doi: 10.1016/j.reprotox.2024.108563. PMID: 38417581
Gestational lead exposure and its effects on fetal/infant development - A systematic review.
Santana AB, Spelta LEW, Sobalvarro JVM, Podestá MHMC, Garcia RCT, Dos Reis TM, Torres LH
Reprod Toxicol 2023 Apr;117:108342. Epub 2023 Feb 8 doi: 10.1016/j.reprotox.2023.108342. PMID: 36758879
Apathy as a Predictor for Conversion From Mild Cognitive Impairment to Dementia: A Systematic Review and Meta-Analysis of Longitudinal Studies.
Fresnais D, Humble MB, Bejerot S, Meehan AD, Fure B
J Geriatr Psychiatry Neurol 2023 Jan;36(1):3-17. Epub 2022 Apr 21 doi: 10.1177/08919887221093361. PMID: 35446723Free PMC Article
Family caregiver competence in managing behavioral and psychological symptoms of dementia: A concept synthesis.
Jung S, Song JA, Kim J, Cheon H, Kim J
Jpn J Nurs Sci 2022 Apr;19(2):e12462. Epub 2021 Nov 17 doi: 10.1111/jjns.12462. PMID: 34787364
Cognitive function in schizophrenia.
Weinberger DR, Gallhofer B
Int Clin Psychopharmacol 1997 Sep;12 Suppl 4:S29-36. doi: 10.1097/00004850-199709004-00006. PMID: 9352344

Recent systematic reviews

Prenatal caffeine consumption and neurobehavioral disorders - A systematic review.
Santana AB, Spelta LEW, Martinez-Sobalvarro JV, Garcia RCT, Dos Reis TM, Torres LH
Reprod Toxicol 2024 Apr;125:108563. Epub 2024 Feb 28 doi: 10.1016/j.reprotox.2024.108563. PMID: 38417581
Apathy as a Predictor for Conversion From Mild Cognitive Impairment to Dementia: A Systematic Review and Meta-Analysis of Longitudinal Studies.
Fresnais D, Humble MB, Bejerot S, Meehan AD, Fure B
J Geriatr Psychiatry Neurol 2023 Jan;36(1):3-17. Epub 2022 Apr 21 doi: 10.1177/08919887221093361. PMID: 35446723Free PMC Article
Statins for Smith-Lemli-Opitz syndrome.
Ballout RA, Livinski A, Fu YP, Steiner RD, Remaley AT
Cochrane Database Syst Rev 2022 Nov 14;11(11):CD013521. doi: 10.1002/14651858.CD013521.pub2. PMID: 36373961Free PMC Article
Toxoplasma gondii infection and behavioral outcomes in humans: a systematic review.
Martinez VO, de Mendonça Lima FW, de Carvalho CF, Menezes-Filho JA
Parasitol Res 2018 Oct;117(10):3059-3065. Epub 2018 Aug 14 doi: 10.1007/s00436-018-6040-2. PMID: 30109417
Medical comorbidities in children and adolescents with autism spectrum disorders and attention deficit hyperactivity disorders: a systematic review.
Muskens JB, Velders FP, Staal WG
Eur Child Adolesc Psychiatry 2017 Sep;26(9):1093-1103. Epub 2017 Jul 3 doi: 10.1007/s00787-017-1020-0. PMID: 28674760Free PMC Article

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